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Usage Information

The cellular response to hypoxia: tuning the system with microRNAs
Joseph Loscalzo
Joseph Loscalzo
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Commentary

The cellular response to hypoxia: tuning the system with microRNAs

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Abstract

Adaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also controlled by specific microRNAs and, in turn, controls the expression of other microRNAs, which fine-tune adaptation to low oxygen tension. In this issue of the JCI, Ghosh and colleagues identify a unique microRNA in hypoxic endothelial cells, miR424, that promotes HIF-1 stabilization and angiogenesis. The actions of this microRNA are considered in the context of the complex interactions that act to ensure optimal endothelial adaptation to this critical environmental condition.

Authors

Joseph Loscalzo

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Usage data is cumulative from August 2025 through August 2026.

Usage JCI PMC
Text version 1,025 70
PDF 211 11
Figure 131 1
Table 106 0
Citation downloads 185 0
Totals 1,658 82
Total Views 1,740
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ISSN: 0021-9738 (print), 1558-8238 (online)

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