Leptin is an adipose-derived hormone that signals to inform the brain of nutrient status; loss of leptin signaling results in marked hyperphagia and obesity. Recent work has identified several groups of neurons that contribute to the effects of leptin to regulate energy balance, but leptin receptors are distributed throughout the brain, and the function of leptin signaling in discrete neuronal populations outside of the hypothalamus has not been defined. In the current study, we produced mice in which the long form of the leptin receptor (Lepr) was selectively ablated using Cre-recombinase selectively expressed in the hindbrain under control of the paired-like homeobox 2b (Phox2b) promoter (Phox2b Cre Leprflox/flox mice). In these mice, Lepr was deleted from glucagon-like 1 peptide–expressing neurons resident in the nucleus of the solitary tract. Phox2b Cre Leprflox/flox mice were hyperphagic, displayed increased food intake after fasting, and gained weight at a faster rate than wild-type controls. Paradoxically, Phox2b Cre Leprflox/flox mice also exhibited an increased metabolic rate independent of a change in locomotor activity that was dependent on food intake, and glucose homeostasis was normal. Together, these data support a physiologically important role of direct leptin action in the hindbrain.
Michael M. Scott, Kevin W. Williams, Jari Rossi, Charlotte E. Lee, Joel K. Elmquist
Title and authors | Publication | Year |
---|---|---|
Investigation of vagal sensory neurons in mice using optical vagal stimulation and tracheal neuroanatomy
Moe AA, Bautista TG, Trewella MW, Korim WS, Yao ST, Behrens R, Driessen AK, McGovern AE, Mazzone SB |
iScience | 2024 |
Whole-brain inputs and outputs of Phox2b and GABAergic neurons in the nucleus tractus solitarii
Shao L, Kong F, Tian X, Deng T, Wang Y, Ji Y, Wang X, Yu H, Yuan F, Fu C, Wang S |
Frontiers in neuroscience | 2024 |
The Unrestrained Overeating Behavior and Clinical Perspective.
Engin A |
Advances in experimental medicine and biology | 2024 |
Molecular Ontology of the Nucleus of Solitary Tract
Gasparini S, Almeida\u2010Pereira G, Munuzuri AS, Resch JM, Geerling JC |
The Journal of Comparative Neurology | 2024 |
Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome
Tan J, Duron A, Sucov HM, Makita T |
iScience | 2024 |
Identification of a GABAergic neural circuit governing leptin signaling deficiency-induced obesity
Han Y, He Y, Harris L, Xu Y, Wu Q |
eLife | 2023 |
Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart.
Michel LYM |
International journal of molecular sciences | 2023 |
The Molecular Circadian Clock of Phox2b-expressing Cells Drives Daily Variation of the Hypoxic but Not Hypercapnic Ventilatory Response in Mice
Jones AA, Marino GM, Spears AR, Arble DM |
2023 | |
Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis.
Tenney AP, Di Gioia SA, Webb BD, Chan WM, de Boer E, Garnai SJ, Barry BJ, Ray T, Kosicki M, Robson CD, Zhang Z, Collins TE, Gelber A, Pratt BM, Fujiwara Y, Varshney A, Lek M, Warburton PE, Van Ryzin C, Lehky TJ, Zalewski C, King KA, Brewer CC, Thurm A, Snow J, Facio FM, Narisu N, Bonnycastle LL, Swift A, Chines PS, Bell JL, Mohan S, Whitman MC, Staffieri SE, Elder JE, Demer JL, Torres A, Rachid E, Al-Haddad C, Boustany RM, Mackey DA, Brady AF, Fenollar-Cortés M, Fradin M, Kleefstra T, Padberg GW, Raskin S, Sato MT, Orkin SH, Parker SCJ, Hadlock TA, Vissers LELM, van Bokhoven H, Jabs EW, Collins FS, Pennacchio LA, Manoli I, Engle EC |
Nature Genetics | 2023 |
Neurochemical Basis of Inter-Organ Crosstalk in Health and Obesity: Focus on the Hypothalamus and the Brainstem
Haspula D, Cui Z |
Cells | 2023 |
PIEZO2 in somatosensory neurons controls gastrointestinal transit
Servin-Vences MR, Lam RM, Koolen A, Wang Y, Saade DN, Loud M, Kacmaz H, Frausto S, Zhang Y, Beyder A, Marshall KL, Bönnemann CG, Chesler AT, Patapoutian A |
Cell | 2023 |
Insulin Preferentially Regulates the Activity of Parasympathetic Preganglionic Neurons over Sympathetic Preganglionic Neurons
Hyun U, Kweon YY, Sohn JW |
Endocrinology and Metabolism | 2023 |
The Diverse Network of Brain Histamine in Feeding: Dissect its Functions in a Circuit-Specific Way
Xu L, Lin W, Zheng Y, Wang Y, Chen Z |
Current neuropharmacology | 2023 |
CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors
Neyens DM, Brenner L, Calkins R, Winzenried ET, Ritter RC, Appleyard SM |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2023 |
Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Chern T, Achilleos A, Tong X, Hill MC, Saltzman AB, Reineke LC, Chaudhury A, Dasgupta SK, Redhead Y, Watkins D, Neilson JR, Thiagarajan P, Green JBA, Malovannaya A, Martin JF, Rosenblatt DS, Poché RA |
Nature Communications | 2022 |
Autonomic control of energy balance and glucose homeostasis.
Hyun U, Sohn JW |
Experimental & molecular medicine | 2022 |
GLP-1 receptor nitration contributes to loss of brain pericyte function in a mouse model of diabetes.
Bailey J, Coucha M, Bolduc DR, Burnett FN, Barrett AC, Ghaly M, Abdelsaid M |
Diabetologia | 2022 |
CTRP14 inactivation alters physical activity and food intake response to fasting and refeeding
Sarver DC, Xu C, Aja S, Wong GW |
American journal of physiology. Endocrinology and metabolism | 2022 |
Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism
D Borgmann, E Ciglieri, N Biglari, C Brandt, AL Cremer, H Backes, M Tittgemeyer, FT Wunderlich, JC Brüning, H Fenselau |
Cell Metabolism | 2021 |
Glucagon‐like peptide‐1 (GLP‐1) signalling in the brain: From neural circuits and metabolism to therapeutics
A Kabahizi, B Wallace, L Lieu, D Chau, Y Dong, E Hwang, K Williams |
British Journal of Pharmacology | 2021 |
A Neural Circuit Mechanism Controlling Breathing by Leptin in the Nucleus Tractus Solitarii
H Yu, L Shi, J Chen, S Jun, Y Hao, S Wang, C Fu, X Zhang, H Lu, S Wang, F Yuan |
Neuroscience Bulletin | 2021 |
Optical Imaging of Pancreatic Innervation
M Makhmutova, A Caicedo |
Frontiers in Endocrinology | 2021 |
Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function
EJ Golden, ED Larson, LA Shechtman, GD Trahan, D Gaillard, TJ Fellin, JK Scott, KL Jones, LA Barlow |
eLife | 2021 |
Machine learning approaches reveal subtle differences in breathing and sleep fragmentation in Phox2b -derived astrocytes ablated mice
TM Silva, JC Borniger, MJ Alves, DA Correa, J Zhao, P Fadda, AE Toland, AC Takakura, TS Moreira, CM Czeisler, JJ Otero |
Journal of neurophysiology | 2021 |
Pancreatic β-Cells Communicate With Vagal Sensory Neurons
M Makhmutova, J Weitz, A Tamayo, E Pereira, M Boulina, J Almaça, R Rodriguez-Diaz, A Caicedo |
Gastroenterology | 2021 |
The Physiological Control of Eating: Signals, Neurons, and Networks
A Watts, S Kanoski, G Sanchez-Watts, W Langhans |
Physiological reviews | 2021 |
MET Receptor Tyrosine Kinase Regulates Lifespan Ultrasonic Vocalization and Vagal Motor Neuron Development.
Kamitakahara AK, Ali Marandi Ghoddousi R, Lanjewar AL, Magalong VM, Wu HH, Levitt P |
Frontiers in neuroscience | 2021 |
Leptin receptor-expressing Nucleus Tractus Solitarius neurons suppress food intake independently of GLP1 in mice
Wenwen Cheng, Ermelinda Ndoka, Chelsea R. Hutch, Karen Roelofs, Andrew Mackinnon, Basma Khoury, Irwin J. Magrisso, Ki-Suk Kim, Christopher J. Rhodes, David P. Olson, Randy J. Seeley, Darleen A. Sandoval, Martin G. Myers Jr. |
JCI Insight | 2020 |
Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics
C Vastagh, I Farkas, MM Scott, Z Liposits |
Brain structure & function | 2020 |
Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus
JE Biddinger, RM Lazarenko, MM Scott, R Simerly |
eLife | 2020 |
Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells
T Georgescu, D Lyons, B Doslikova, AP Garcia, O Marston, LK Burke, R Chianese, BY Lam, GS Yeo, JJ Rochford, AS Garfield, LK Heisler |
Endocrinology | 2020 |
Dissecting the Role of Subtypes of Gastrointestinal Vagal Afferents
YB Wang, G de Lartigue, AJ Page |
Frontiers in physiology | 2020 |
Leptin Sensitizes NTS Neurons to Vagal Input by Increasing Postsynaptic NMDA Receptor Currents
D Neyens, H Zhao, NJ Huston, GA Wayman, RC Ritter, SM Appleyard |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2020 |
Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues
S Pereira, SM ODwyer, TD Webber, RK Baker, V So, CE Ellis, JS Yoon, M Mojibian, MM Glavas, S Karunakaran, SM Clee, SD Covey, TJ Kieffer |
Scientific Reports | 2019 |
The endocrine function of adipose tissues in health and cardiometabolic disease
L Scheja, J Heeren |
Nature Reviews Endocrinology | 2019 |
Potential metabolic and behavioural roles of the putative endocannabinoid receptors GPR18, GPR55 and GPR119 in feeding
RE Ramírez-Orozco, R García-Ruiz, P Morales, CM Villalón, JR Villafán-Bernal, BA Marichal-Cancino |
Current neuropharmacology | 2019 |
The leptin sensitizer celastrol reduces age-associated obesity and modulates behavioral rhythms
K Chellappa, IJ Perron, N Naidoo, JA Baur |
Aging Cell | 2019 |
Leptin Receptor Signaling in Sim1-Expressing Neurons Regulates Body Temperature and Adaptive Thermogenesis
I Cakir, M Diaz-Martinez, PL Pan, EB Welch, S Patel, M Ghamari-Langroudi |
Endocrinology | 2019 |
Activation of Phox2b-Expressing Neurons in the Nucleus Tractus Solitarii Drives Breathing in Mice
C Fu, L Shi, Z Wei, H Yu, Y Hao, Y Tian, Y Liu, Y Zhang, X Zhang, F Yuan, S Wang |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2019 |
Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin
DJ Merlino, JR Barton, BA Charsar, MD Byrne, JA Rappaport, RJ Smeyne, AC Lepore, AE Snook, SA Waldman |
Brain structure & function | 2019 |
Signalling from the periphery to the brain that regulates energy homeostasis
KS Kim, RJ Seeley, DA Sandoval |
Nature Reviews Neuroscience | 2018 |
Preproglucagon Neurons in the Nucleus of the Solitary Tract Are the Main Source of Brain GLP-1, Mediate Stress-Induced Hypophagia, and Limit Unusually Large Intakes of Food
MK Holt, JE Richards, DR Cook, DI Brierley, DL Williams, F Reimann, FM Gribble, S Trapp |
Diabetes | 2018 |
Cell-Type Identification in the Autonomic Nervous System
DS Liu, TL Xu |
Neuroscience Bulletin | 2018 |
The role of leptin in health and disease
AM Ramos-Lobo, J Donato |
Temperature | 2017 |
Changes in ambient temperature elicit divergent control of metabolic and cardiovascular actions by leptin
JM Carmo, AA da Silva, DG Romero, JE Hall |
The FASEB Journal | 2017 |
Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity
X Shi, S Chacko, F Li, D Li, D Burrin, L Chan, X Guan |
Molecular Metabolism | 2017 |
A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus
A Kamitakahara, K Bouyer, CH Wang, R Simerly |
The Journal of Comparative Neurology | 2017 |
Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1
V Krishnan, DC Stoppel, Y Nong, MA Johnson, MJ Nadler, E Ozkaynak, BL Teng, I Nagakura, F Mohammad, MA Silva, S Peterson, TJ Cruz, EM Kasper, R Arnaout, MP Anderson |
Nature | 2017 |
GLP-1 acts on habenular avoidance circuits to control nicotine intake
LM Tuesta, Z Chen, A Duncan, CD Fowler, M Ishikawa, BR Lee, XA Liu, Q Lu, M Cameron, MR Hayes, TM Kamenecka, M Pletcher, PJ Kenny |
Nature Neuroscience | 2017 |
Respiratory Network Stability and Modulatory Response to Substance P Require Nalcn
SY Yeh, WH Huang, W Wang, CS Ward, ES Chao, Z Wu, B Tang, J Tang, JJ Sun, ME van der Heijden, PA Gray, M Xue, RS Ray, D Ren, HY Zoghbi |
Neuron | 2017 |
The transcription factor Phox2b distinguishes between oral and non-oral sensory neurons in the geniculate ganglion
L Ohman-Gault, T Huang, R Krimm |
The Journal of Comparative Neurology | 2017 |
Phasic inhibition as a mechanism for generation of rapid respiratory rhythms
JM Cregg, KA Chu, TE Dick, LT Landmesser, J Silver |
Proceedings of the National Academy of Sciences | 2017 |
Leptin Controls Parasympathetic Wiring of the Pancreas during Embryonic Life
S Croizier, V Prevot, SG Bouret |
Cell Reports | 2016 |
Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research
A Parimisetty, AC Dorsemans, R Awada, P Ravanan, N Diotel, CL dHellencourt |
Journal of Neuroinflammation | 2016 |
A role for leptin-regulated neurocircuitry in subordination stress
JN Flak |
Physiology & Behavior | 2016 |
FGF21 Mediates Endocrine Control of Simple Sugar Intake and Sweet Taste Preference by the Liver
S von Holstein-Rathlou, LD BonDurant, L Peltekian, MC Naber, TC Yin, KE Claflin, AI Urizar, AN Madsen, C Ratner, B Holst, K Karstoft, A Vandenbeuch, CB Anderson, MD Cassell, AP Thompson, TP Solomon, K Rahmouni, SC Kinnamon, AA Pieper, MP Gillum, MJ Potthoff |
Cell Metabolism | 2016 |
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
K Nonomura, SH Woo, RB Chang, A Gillich, Z Qiu, AG Francisco, SS Ranade, SD Liberles, A Patapoutian |
Nature | 2016 |
Developmental specification of metabolic circuitry
AE Elson, RB Simerly |
Frontiers in Neuroendocrinology | 2015 |
Neural Control of Energy Balance: Translating Circuits to Therapies
L Gautron, JK Elmquist, KW Williams |
Cell | 2015 |
Limited impact on glucose homeostasis of leptin receptor deletion from insulin- or proglucagon-expressing cells
H Soedling, DJ Hodson, AE Adrianssens, FM Gribble, F Reimann, S Trapp, GA Rutter |
Molecular Metabolism | 2015 |
Dynamic expression of transcription factor Brn3b during mouse cranial nerve development: Brn3b in cranial nerve development
S Sajgo, S Ali, O Popescu, TC Badea |
The Journal of Comparative Neurology | 2015 |
Ablation of intact hypothalamic and/or hindbrain TrkB signaling leads to perturbations in energy balance
C Ozek, DJ Zimmer, BC de Jonghe, RG Kalb, KK Bence |
Molecular Metabolism | 2015 |
Glucagon-Like Peptide 1 Interacts with Ghrelin and Leptin to Regulate Glucose Metabolism and Food Intake through Vagal Afferent Neuron Signaling
CC Ronveaux, D Tome, HE Raybould |
The Journal of nutrition | 2015 |
Endogenous Glucagon-like Peptide-1 Suppresses High-Fat Food Intake by Reducing Synaptic Drive onto Mesolimbic Dopamine Neurons
XF Wang, JJ Liu, J Xia, J Liu, V Mirabella, ZP Pang |
Cell Reports | 2015 |
Ya-fish (Schizothorax prenanti) spexin: identification, tissue distribution and mRNA expression responses to periprandial and fasting
H Wu, F Lin, H Chen, J Liu, Y Gao, X Zhang, J Hao, D Chen, D Yuan, T Wang, Z Li |
Fish Physiology and Biochemistry | 2015 |
Area postrema undergoes dynamic postnatal changes in mice and humans: Dynamic Postnatal Changes of Area Postrema
HN Gokozan, F Baig, S Corcoran, FP Catacutan, PE Gygli, AC Takakura, TS Moreira, C Czeisler, JJ Otero |
The Journal of Comparative Neurology | 2015 |
Network of hypothalamic neurons that control appetite
Sohn JW |
BMB Reports | 2015 |
CNS GLP-1R mediate anorectic, not glucose-lowering, effects of liraglutide
Stephanie Sisley, RUTH GUTIERREZ-AGUILAR, Michael M. Scott, David D'Alessio, Darleen Sandoval, Randy Seeley |
Journal of Clinical Investigation | 2014 |
Liraglutide lowers body weight through regulation of CART, NPY, AGRP
Anna Secher, Jacob Jelsing, Arian B Gonzalez, Jacob Hecksher-Sørensen, Michael Cowley, Louise Dalbøge, Gitte Hansen, Kevin Grove, Charles Pyke, Kirsten Raun, Lauge Schäffer, Mads Tang-Christensen, Saurabh Verma, Brent Witgen, Niels Vrang, Lotte Bjerre Knudsen |
Journal of Clinical Investigation | 2014 |
Intestinal deletion of leptin signaling alters activity of nutrient transporters and delayed the onset of obesity in mice
A Tavernier, JB Cavin, ML Gall, R Ducroc, RG Denis, F Cluzeaud, S Guilmeau, Y Sakar, L Barbot, N Kapel, JL Beyec, F Joly, S Chua, S Luquet, A Bado |
The FASEB Journal | 2014 |
Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor
RC Tsou, KS Rak, DJ Zimmer, KK Bence |
Molecular Metabolism | 2014 |
Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity
G Lartigue, CC Ronveaux, HE Raybould |
Molecular Metabolism | 2014 |
Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance
JN Flak, CM Patterson, AS Garfield, G D'Agostino, PB Goforth, AK Sutton, PA Malec, JM Wong, M Germani, JC Jones, M Rajala, L Satin, CJ Rhodes, DP Olson, RT Kennedy, LK Heisler, MG Myers |
Nature Neuroscience | 2014 |
Long Term Exendin-4 Treatment Reduces Food Intake and Body Weight and Alters Expression of Brain Homeostatic and Reward Markers
Y Yang, AA Moghadam, ZA Cordner, NC Liang, TH Moran |
Endocrinology | 2014 |
PPARγ in Vagal Neurons Regulates High-Fat Diet Induced Thermogenesis
C Liu, AL Bookout, S Lee, K Sun, L Jia, C Lee, S Udit, Y Deng, PE Scherer, DJ Mangelsdorf, L Gautron, JK Elmquist |
Cell Metabolism | 2014 |
Targeted leptin receptor blockade: role of ventral tegmental area and nucleus of the solitary tract leptin receptors in body weight homeostasis
M Matheny, KY Strehler, M King, N Tumer, PJ Scarpace |
Journal of Endocrinology | 2014 |
Selective leptin resistance revisited
AL Mark |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2013 |
Brain regulation of energy balance and body weight
L Rui |
Reviews in Endocrine and Metabolic Disorders | 2013 |
Molecular anatomy of the gut-brain axis revealed with transgenic technologies: implications in metabolic research
S Udit, L Gautron |
Frontiers in neuroscience | 2013 |
Ion channels in the central regulation of energy and glucose homeostasis
JW Sohn |
Frontiers in neuroscience | 2013 |
A critical view of the use of genetic tools to unveil neural circuits: the case of leptin action in reproduction
CF Elias |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2013 |
Blockade of the cerebral aqueduct in rats provides evidence of antagonistic leptin responses in the forebrain and hindbrain
MI Vaill, BN Desai, RB Harris |
American journal of physiology. Endocrinology and metabolism | 2013 |
FGF21 regulates metabolism and circadian behavior by acting on the nervous system
AL Bookout, MH de Groot, BM Owen, S Lee, L Gautron, HL Lawrence, X Ding, JK Elmquist, JS Takahashi, DJ Mangelsdorf, SA Kliewer |
Nature Medicine | 2013 |
Neuronal circuits that regulate feeding behavior and metabolism
JW Sohn, JK Elmquist, KW Williams |
Trends in Neurosciences | 2013 |
Vagal innervation patterns following Roux-en-Y gastric bypass in the mouse
L Gautron, JF Zechner, V Aguirre |
International Journal of Obesity | 2013 |
Role of oxytocin signaling in the regulation of body weight
JE Blevins, JM Ho |
Reviews in Endocrine and Metabolic Disorders | 2013 |
C1q/TNF-related Protein 4 (CTRP4) Is a Unique Secreted Protein with Two Tandem C1q Domains That Functions in the Hypothalamus to Modulate Food Intake and Body Weight
MS Byerly, PS Petersen, S Ramamurthy, MM Seldin, X Lei, E Provost, Z Wei, GV Ronnett, GW Wong |
The Journal of biological chemistry | 2013 |
FoxO1 in the Ventromedial Hypothalamus Regulates Energy Balance
Ki Woo Kim, Jose Donato Jr, Eric Berglund, Yun-Hee Choi, Daisuke Kohno, Carol Elias, Ronald DePinho, Joel Elmquist |
Journal of Clinical Investigation | 2012 |
Functional Heterogeneity of Arcuate Nucleus Pro-Opiomelanocortin Neurons: Implications for Diverging Melanocortin Pathways
JW Sohn, KW Williams |
Molecular Neurobiology | 2012 |
Central Leptin Regulation of Obesity and Fertility
Q Tong, Y Xu |
Current Obesity Reports | 2012 |
Neurochemical Characterization of Body Weight-Regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract
AS Garfield, C Patterson, S Skora, FM Gribble, F Reimann, ML Evans, MG Myers, LK Heisler |
Endocrinology | 2012 |
Cannabinoid Receptor 1 in the Vagus Nerve Is Dispensable for Body Weight Homeostasis But Required for Normal Gastrointestinal Motility
CR Vianna, J Donato, J Rossi, M Scott, K Economides, L Gautron, S Pierpont, CF Elias, JK Elmquist |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2012 |
Endogenous leptin receptor signaling in the medial nucleus tractus solitarius affects meal size and potentiates intestinal satiation signals
SE Kanoski, S Zhao, DJ Guarnieri, RJ DiLeone, J Yan, BC de Jonghe, KK Bence, MR Hayes, HJ Grill |
American journal of physiology. Endocrinology and metabolism | 2012 |
Inactivation of Socs3 in the Hypothalamus Enhances the Hindbrain Response to Endogenous Satiety Signals via Oxytocin Signaling
V Matarazzo, F Schaller, E Nedelec, A Benani, L Penicaud, F Muscatelli, E Moyse, S Bauer |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2012 |
From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior
KW Williams, JK Elmquist |
Nature Neuroscience | 2012 |
Hindbrain Ghrelin Receptor Signaling Is Sufficient to Maintain Fasting Glucose
MM Scott, M Perello, JC Chuang, I Sakata, L Gautron, CE Lee, D Lauzon, JK Elmquist, JM Zigman |
PloS one | 2012 |
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency
BC de Jonghe, MR Hayes, DJ Zimmer, SE Kanoski, HJ Grill, KK Bence |
American journal of physiology. Endocrinology and metabolism | 2012 |
Leptin action through hypothalamic nitric oxide synthase-1-expressing neurons controls energy balance
RL Leshan, M Greenwald-Yarnell, CM Patterson, IE Gonzalez, MG Myers |
Nature Medicine | 2012 |
Neuroanatomy of Body Weight Control: Lessons Learned from Leptin
Diana Williams, Michael W Schwartz |
Journal of Clinical Investigation | 2011 |
Central nervous control of energy and glucose balance: focus on the central melanocortin system
Y Xu, JK Elmquist, M Fukuda |
Annals of the New York Academy of Sciences | 2011 |
Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
JR Speakman, DA Levitsky, DB Allison, MS Bray, JM de Castro, DJ Clegg, JC Clapham, AG Dulloo, L Gruer, S Haw, J Hebebrand, MM Hetherington, S Higgs, SA Jebb, RJ Loos, S Luckman, A Luke, V Mohammed-Ali, S ORahilly, M Pereira, L Perusse, TN Robinson, B Rolls, ME Symonds, MS Westerterp-Plantenga |
Disease models & mechanisms | 2011 |
New clues and new questions regarding leptin and brain metabolism
MC McKenna |
Journal of Cerebral Blood Flow & Metabolism | 2011 |