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Abstract
Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant activated protein C (APC) is able to cross the blood–spinal cord barrier in mice and signal to both neuronal and non-neuronal cells (see the related article beginning on page 3437). This signaling resulted in the suppression of mutant SOD1 synthesis and retarded disease progression in a murine model of ALS. Here we discuss the potential importance of these data and possible relevance to human neurodegenerative diseases.
Authors
Charles T. Esmon, Jonathan D. Glass
Citation information
Citations to this article in year 2019 (1)
| Title and authors | Publication | Year |
|---|---|---|
|
Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier
S Garbuzova-Davis, C Kurien, E Haller, DJ Eve, S Navarro, G Steiner, A Mahendrasah, S Hailu, M Khatib, KJ Boccio, CV Borlongan, HR Loveren, SH Appel, PR Sanberg |
Scientific Reports | 2019 |
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