Genomic amplicons target vesicle recycling in breast cancer
Gordon B. Mills, … , Yosef Yarden, Jim C. Norman
Gordon B. Mills, … , Yosef Yarden, Jim C. Norman
Published July 20, 2009
Citation Information: J Clin Invest. 2009;119(8):2123-2127. https://doi.org/10.1172/JCI40256.
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Commentary

Genomic amplicons target vesicle recycling in breast cancer

Abstract

Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a “driver” of the 8p11–12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

Authors

Gordon B. Mills, Igor Jurisica, Yosef Yarden, Jim C. Norman

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Figure 1

Role of RCP in integrin and RTK trafficking during tumor cell migration.

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Role of RCP in integrin and RTK trafficking during tumor cell migration....
(A) Activated RCP associates with β1 integrin and acts to link this integrin with RTKs at recycling endosomes. The consequence of RCP-dependent corecycling of integrin and RTK is enhanced signaling, which drives cell proliferation and cell migration in 2D and 3D matrices. (B) RCP recruits a spatially restricted cycling population of receptors to the tips of invasive pseudopods during tumor cell migration in 3D microenvironments.