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Citations to this article

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma
Andreas Bonertz, … , Moritz Koch, Philipp Beckhove
Andreas Bonertz, … , Moritz Koch, Philipp Beckhove
Published October 5, 2009
Citation Information: J Clin Invest. 2009;119(11):3311-3321. https://doi.org/10.1172/JCI39608.
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Research Article Article has an altmetric score of 5

Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma

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Abstract

Spontaneous antitumor T cell responses in cancer patients are strongly controlled by Tregs, and increased numbers of tumor-infiltrating Tregs correlate with reduced survival. However, the tumor antigens recognized by Tregs in cancer patients and the impact of these cells on tumor-specific T cell responses have not been systematically characterized. Here we used a broad panel of long synthetic peptides of defined tumor antigens and normal tissue antigens to exploit a newly developed method to identify and compare ex vivo the antigen specificities of Tregs with those of effector/memory T cells in peripheral blood of colorectal cancer patients and healthy subjects. Tregs in tumor patients were highly specific for a distinct set of only a few tumor antigens, suggesting that Tregs exert T cell suppression in an antigen-selective manner. Tumor-specific effector T cells were detectable in the majority of colorectal cancer patients but not in healthy individuals. We detected differences in the repertoires of antigens recognized by Tregs and effector/memory T cells in the majority of colorectal cancer patients. In addition, only effector/memory T cell responses against antigens recognized by Tregs strongly increased after Treg depletion. The selection of antigens according to preexisting T cell responses may improve the efficacy of future immunotherapies for cancer and autoimmune disease.

Authors

Andreas Bonertz, Jürgen Weitz, Dong-Ho Kim Pietsch, Nuh N. Rahbari, Christoph Schlude, Yingzi Ge, Simone Juenger, Israel Vlodavsky, Khashayarsha Khazaie, Dirk Jaeger, Christoph Reissfelder, Dalibor Antolovic, Maximilian Aigner, Moritz Koch, Philipp Beckhove

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 Total
Citations: 4 2 3 4 5 4 4 8 14 9 5 12 11 12 7 104
Citation information
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Citations to this article in year 2022 (3)

Title and authors Publication Year
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy
M Khelil, Y Godet, S Abdeljaoued, C Borg, O Adotévi, R Loyon
Cancers 2022
Immunotherapeutic Strategies in Cancer and Atherosclerosis—Two Sides of the Same Coin
F Nettersheim, F Picard, F Hoyer, H Winkels
Frontiers in Cardiovascular Medicine 2022
Colorectal Cancer-Infiltrating Regulatory T Cells: Functional Heterogeneity, Metabolic Adaptation, and Therapeutic Targeting
Aristin Revilla S, Kranenburg O, Coffer PJ
Frontiers in immunology 2022

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