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Rajat Singh, … , Gary J. Schwartz, Mark J. Czaja
Published October 12, 2009
Citation Information: J Clin Invest. 2009;119(11):3329-3339. https://doi.org/10.1172/JCI39228.
Citation Information: J Clin Invest. 2009;119(11):3329-3339. https://doi.org/10.1172/JCI39228.
Abstract
The relative balance between the quantity of white and brown adipose tissue can profoundly affect lipid storage and whole-body energy homeostasis. However, the mechanisms regulating the formation, expansion, and interconversion of these 2 distinct types of fat remain unknown. Recently, the lysosomal degradative pathway of macroautophagy has been identified as a regulator of cellular differentiation, suggesting that autophagy may modulate this process in adipocytes. The function of autophagy in adipose differentiation was therefore examined in the current study by genetic inhibition of the critical macroautophagy gene autophagy-related 7 (Atg7). Knockdown of Atg7 in 3T3-L1 preadipocytes inhibited lipid accumulation and decreased protein levels of adipocyte differentiation factors. Knockdown of Atg5 or pharmacological inhibition of autophagy or lysosome function also had similar effects. An adipocyte-specific mouse knockout of Atg7 generated lean mice with decreased white adipose mass and enhanced insulin sensitivity. White adipose tissue in knockout mice had increased features of brown adipocytes, which, along with an increase in normal brown adipose tissue, led to an elevated rate of fatty acid, β-oxidation, and a lean body mass. Autophagy therefore functions to regulate body lipid accumulation by controlling adipocyte differentiation and determining the balance between white and brown fat.
Authors
Rajat Singh, Youqing Xiang, Yongjun Wang, Kiran Baikati, Ana Maria Cuervo, Yen K. Luu, Yan Tang, Jeffrey E. Pessin, Gary J. Schwartz, Mark J. Czaja
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Citations to this article (410)
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Park SY, Cho HS, Chung KH, Lee BN, Kim SH, Kim WJ, Jung JY |
Journal of Dental Sciences | 2021 |
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Role of Mechanistic Target of Rapamycin and Autophagy in Alcohol-Induced Adipose Atrophy and Liver Injury
Y Li, X Chao, S Wang, JA Williams, HM Ni, WX Ding |
The American Journal of Pathology | 2020 |
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The Role of Autophagy in White Adipose Tissue Function: Implications for Metabolic Health
M Clemente-Postigo, A Tinahones, RE Bekay, MM Malagón, FJ Tinahones |
Metabolites | 2020 |
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Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system
KR Menikdiwela, L Ramalingam, F Rasha, S Wang, JM Dufour, NS Kalupahana, KK Sunahara, JO Martins, N Moustaid-Moussa |
Cell Death and Disease | 2020 |
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Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy
T Yamamuro, T Kawabata, A Fukuhara, S Saita, S Nakamura, H Takeshita, M Fujiwara, Y Enokidani, G Yoshida, K Tabata, M Hamasaki, A Kuma, K Yamamoto, I Shimomura, T Yoshimori |
Nature Communications | 2020 |
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Autophagy inhibition blunts PDGFRA adipose progenitors’ cell-autonomous fibrogenic response to high-fat diet
G Marcelin, CD Cunha, C Gamblin, N Suffee, C Rouault, A Leclerc, A Lacombe, N Sokolovska, EL Gautier, K Clément, I Dugail |
Autophagy | 2020 |
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Adipose Tissue and FoxO1: Bridging Physiology and Mechanisms
L Ioannilli, F Ciccarone, MR Ciriolo |
Cells | 2020 |
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Molecular Mechanisms of Adipogenesis: The Anti-adipogenic Role of AMP-Activated Protein Kinase
B Ahmad, CJ Serpell, IL Fong, EH Wong |
Frontiers in Molecular Biosciences | 2020 |
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Depletion of Adipocyte Becn1 Leads to Lipodystrophy and Metabolic Dysregulation
Y Jin, Y Ji, Y Song, SS Choe, YG Jeon, H Na, TW Nam, HJ Kim, H Nahmgoong, SM Kim, J Kim, KT Nam, JK Seong, D Hwang, CB Park, IH Lee, JB Kim, HW Lee |
Diabetes | 2020 |
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Mitophagy deficiency increases NLRP3 to induce brown fat dysfunction in mice
MS Ko, JY Yun, IJ Baek, JE Jang, JJ Hwang, SE Lee, SH Heo, DA Bader, CH Lee, J Han, JS Moon, JM Lee, EG Hong, IK Lee, SW Kim, JY Park, SM Hartig, UJ Kang, DD Moore, EH Koh, K Lee |
Autophagy | 2020 |
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EMT Transcription Factors Are Involved in the Altered Cell Adhesion under Simulated Microgravity Effect or Overloading by Regulation of E-cadherin
S Shi, Q Li, Q Cao, Y Diao, Y Zhang, L Yue, L Wei |
International journal of molecular sciences | 2020 |
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Involvement of TGF-β and Autophagy Pathways in Pathogenesis of Diabetes: A Comprehensive Review on Biological and Pharmacological Insights
F Heydarpour, S Sajadimajd, E Mirzarazi, P Haratipour, T Joshi, MH Farzaei, H Khan, J Echeverría |
Frontiers in pharmacology | 2020 |
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An AMPK-dependent, non-canonical p53 pathway plays a key role in adipocyte metabolic reprogramming
H Wang, X Wan, PF Pilch, LW Ellisen, SK Fried, L Liu |
eLife | 2020 |
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The Effect of FOXC2-AS1 on White Adipocyte Browning and the Possible Regulatory Mechanism
Y Wang, S Hua, X Cui, Y Cao, J Wen, X Chi, C Ji, LX Pang, L You |
Frontiers in Endocrinology | 2020 |
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Sestrin2 Phosphorylation by ULK1 Induces Autophagic Degradation of Mitochondria Damaged by Copper-Induced Oxidative Stress
H Kim, BT Jeon, IM Kim, SJ Bennett, CM Lorch, MP Viana, JF Myers, CJ Trupp, ZT Whipps, M Kundu, S Chung, X Sun, O Khalimonchuk, J Lee, SH Ro |
International journal of molecular sciences | 2020 |
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Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
YN Duan, X Ge, HW Jiang, HJ Zhang, Y Zhao, JL Li, W Zhang, JY Li |
Frontiers in Endocrinology | 2020 |
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LncRNA-modulated autophagy in plaque cells: a new paradigm of gene regulation in atherosclerosis?
K Ren, XD Xu, XH Yu, MQ Li, MW Shi, QX Liu, T Jiang, , K Yin, GJ Zhao |
Aging | 2020 |
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Calcium-Sensing Receptor in Adipose Tissue: Possible Association with Obesity-Related Elevated Autophagy
P Mattar, S Sanhueza, G Yuri, L Briones, C Perez-Leighton, A Rudich, S Lavandero, M Cifuentes |
International journal of molecular sciences | 2020 |
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SIRT3 Acts as a Positive Autophagy Regulator to Promote Lipid Mobilization in Adipocytes via Activating AMPK
T Zhang, J Liu, Q Tong, L Lin |
International journal of molecular sciences | 2020 |
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Thermogenic Activation Downregulates High Mitophagy Rate in Human Masked and Mature Beige Adipocytes
M Szatmári-Tóth, A Shaw, I Csomós, G Mocsár, P Fischer-Posovszky, M Wabitsch, Z Balajthy, C Lányi, F Győry, E Kristóf, L Fésüs |
International journal of molecular sciences | 2020 |
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Exercise Training in Obese Rats Does Not Induce Browning at Thermoneutrality and Induces a Muscle-Like Signature in Brown Adipose Tissue
P Aldiss, JE Lewis, I Lupini, I Bloor, R Chavoshinejad, DJ Boocock, AK Miles, FJ Ebling, H Budge, ME Symonds |
Frontiers in Endocrinology | 2020 |
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Mark4 Inhibited the Browning of White Adipose Tissue by Promoting Adipocytes Autophagy in Mice
K Yang, J Cai, M Pan, Q Sun, C Sun |
International journal of molecular sciences | 2020 |
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Adipocyte-specific Beclin1 deletion impairs lipolysis and mitochondrial integrity in adipose tissue
Y Son, YK Cho, A Saha, HJ Kwon, JH Park, M Kim, YS Jung, SN Kim, C Choi, JK Seong, RB Burl, JG Granneman, YH Lee |
Molecular Metabolism | 2020 |
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MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcoholic fatty liver disease
X Wu, KL Poulsen, C Sanz-Garcia, E Huang, MR McMullen, S Roychowdhury, S Dasarathy, LE Nagy |
Journal of Hepatology | 2020 |
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Role of Flavonoids in The Interactions among Obesity, Inflammation, and Autophagy.
García-Barrado MJ, Iglesias-Osma MC, Pérez-García E, Carrero S, Blanco EJ, Carretero-Hernández M, Carretero J |
Pharmaceuticals (Basel, Switzerland) | 2020 |
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Lipophagy: Molecular Mechanisms and Implications in Metabolic Disorders
Shin DW |
Molecules and Cells | 2020 |
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Epidemiology and risk factors for avascular necrosis in childhood systemic lupus erythematosus in a Taiwanese population
Tsai HL, Chang JW, Lu JH, Liu CS |
Scientific Reports | 2020 |
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Sigma-1 receptor ablation impedes adipocyte-like differentiation of mouse embryonic fibroblasts
Yang H, Shen H, Li J, Stanford KI, Guo LW |
Cellular Signalling | 2020 |
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S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis
Zhang L, Zhang Z, Li C, Zhu T, Gao J, Zhou H, Zheng Y, Chang Q, Wang M, Wu J, Ran L, Wu Y, Miao H, Zou X, Liang B |
Cellular and Molecular Gastroenterology and Hepatology | 2020 |
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Autophagy Reprograms Alveolar Progenitor Cell Metabolism in Response to Lung Injury
Li X, Wu J, Sun X, Wu Q, Li Y, Li K, Zhang Q, Li Y, Abel ED, Chen H |
Stem Cell Reports | 2020 |
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Eicosapentaenoic acid (EPA) activates PPARγ signaling leading to cell cycle exit, lipid accumulation, and autophagy in human meibomian gland epithelial cells (hMGEC).
Kim SW, Rho CR, Kim J, Xie Y, Prince RC, Mustafa K, Potma EO, Brown DJ, Jester JV |
The ocular surface | 2020 |
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Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages
Haidong Yu, Sedat Dilbaz, Jonas Coßmann, Anh Cuong Hoang, Victoria Diedrich, Annika Herwig, Akiko Harauma, Yukino Hoshi, Toru Moriguchi, Kathrin Landgraf, Antje Körner, Christina Lucas, Susanne Brodesser, Lajos Balogh, Julianna Thuroczy, Gopal Karemore, Michael Scott Kuefner, Edwards A. Park, Christine Rapp, Jeffrey B. Travers, Tamás Röszer |
Journal of Clinical Investigation | 2019 |
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Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice
Zhuzhen Zhang, Mengle Shao, Chelsea Hepler, Zhenzhen Zi, Shangang Zhao, Yu Aaron An, Yi Zhu, Alexandra L. Ghaben, May-yun Wang, Na Li, Toshiharu Onodera, Nolwenn Joffin, Clair Crewe, Qingzhang Zhu, Lavanya Vishvanath, Ashwani Kumar, Chao Xing, Qiong Wang, Laurent Gautron, Yingfeng Deng, Ruth Gordillo, Ilja Kruglikov, Christine Kusminski, Rana Gupta, Philipp E. Scherer |
Journal of Clinical Investigation | 2019 |
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Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
V Lahiri, WD Hawkins, DJ Klionsky |
Cell Metabolism | 2019 |
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The Effects of Calorie Restriction on Autophagy: Role on Aging Intervention
KW Chung, HY Chung |
Nutrients | 2019 |
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Comprehensive autophagy evaluation in cardiac disease models
N Kaludercic, MC Maiuri, S Kaushik, ÁF Fernández, J de Bruijn, F Castoldi, Y Chen, J Ito, R Mukai, T Murakawa, J Nah, F Pietrocola, T Saito, S Sebti, M Semenzato, L Tsansizi, S Sciarretta, J Madrigal-Matute |
Cardiovascular Research | 2019 |
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Obesity-associated inflammation triggers an autophagy–lysosomal response in adipocytes and causes degradation of perilipin 1
L Ju, J Han, X Zhang, Y Deng, H Yan, C Wang, X Li, S Chen, M Alimujiang, X Li, Q Fang, Y Yang, W Jia |
Cell Death and Disease | 2019 |
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Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation
A Bort, B Sánchez, P Mateos-Gómez, I Díaz-Laviada, N Rodríguez-Henche |
International journal of molecular sciences | 2019 |
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Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome
H Wu, Y Wang, W Li, H Chen, L Du, D Liu, X Wang, T Xu, L Liu, Q Chen |
Autophagy | 2019 |
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Beclin 1 regulates recycling endosome and is required for skin development in mice
S Noguchi, S Honda, T Saitoh, H Matsumura, E Nishimura, S Akira, S Shimizu |
2019 | |
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The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Lee, Park, Oh, Lee, Kim, Bae |
International journal of molecular sciences | 2019 |
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Fat‐specific protein 27α inhibits autophagy‐dependent lipid droplet breakdown in white adipocytes
S Nakajima, Y Nishimoto, S Tateya, Y Iwahashi, Y OkamatsuOgura, M Saito, W Ogawa, Y Tamori |
Journal of Diabetes Investigation | 2019 |
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Low-intensity pulsed ultrasound promotes chondrogenesis of mesenchymal stem cells via regulation of autophagy
X Wang, Q Lin, T Zhang, X Wang, K Cheng, M Gao, P Xia, X Li |
Stem Cell Research & Therapy | 2019 |
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Autophagy regulates lipid metabolism through selective turnover of NCoR1
T Saito, A Kuma, Y Sugiura, Y Ichimura, M Obata, H Kitamura, S Okuda, HC Lee, K Ikeda, Y Kanegae, I Saito, J Auwerx, H Motohashi, M Suematsu, T Soga, T Yokomizo, S Waguri, N Mizushima, M Komatsu |
Nature Communications | 2019 |
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Parkin controls brown adipose tissue plasticity in response to adaptive thermogenesis
M Cairó, L Campderrós, A GavaldàNavarro, R Cereijo, A DelgadoAnglés, T QuesadaLópez, M Giralt, J Villarroya, F Villarroya |
EMBO reports | 2019 |
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Angiotensin II Increases Endoplasmic Reticulum Stress in Adipose Tissue and Adipocytes
KR Menikdiwela, L Ramalingam, L Allen, S Scoggin, NS Kalupahana, N Moustaid-Moussa |
Scientific Reports | 2019 |
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Role of autophagy in the regulation of adipose tissue biology
M Romero, A Zorzano |
Cell cycle (Georgetown, Tex.) | 2019 |
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Altered adipocyte differentiation and unbalanced autophagy in type 2 Familial Partial Lipodystrophy: an in vitro and in vivo study of adipose tissue browning
C Pellegrini, M Columbaro, E Schena, S Prencipe, D Andrenacci, P Iozzo, MA Guzzardi, C Capanni, E Mattioli, M Loi, D Araujo-Vilar, S Squarzoni, S Cinti, P Morselli, A Giorgetti, L Zanotti, A Gambineri, G Lattanzi |
Experimental & molecular medicine | 2019 |
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Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism
X Zhang, D Wu, C Wang, Y Luo, X Ding, X Yang, F Silva, S Arenas, JM Weaver, M Mandell, V Deretic, M Liu |
Autophagy | 2019 |
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m 6 A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7
X Wang, R Wu, Y Liu, Y Zhao, Z Bi, Y Yao, Q Liu, H Shi, F Wang, Y Wang |
Autophagy | 2019 |
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Small molecules re-establish neural cell fate of human fibroblasts via autophagy activation
N Rujanapun, N Heebkaew, W Promjantuek, A Sotthibundhu, P Kunhorm, N Chaicharoenaudomrung, P Noisa |
In vitro cellular & developmental biology. Animal | 2019 |
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Dysregulation of TFEB contributes to manganese-induced autophagic failure and mitochondrial dysfunction in astrocytes
Z Zhang, J Yan, AB Bowman, MR Bryan, R Singh, M Aschner |
Autophagy | 2019 |
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Autophagy in Adipocyte Browning: Emerging Drug Target for Intervention in Obesity
SH Ro, Y Jang, J Bae, IM Kim, C Schaecher, ZD Shomo |
Frontiers in physiology | 2019 |
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Integrative Genomics Analysis Unravels Tissue-Specific Pathways, Networks, and Key Regulators of Blood Pressure Regulation
Y Zhao, M Blencowe, X Shi, L Shu, C Levian, IS Ahn, SK Kim, T Huan, D Levy, X Yang |
Frontiers in Cardiovascular Medicine | 2019 |
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Porcine Reproductive and Respiratory Syndrome Virus Activates Lipophagy To Facilitate Viral Replication through Downregulation of NDRG1 Expression
J Wang, JY Liu, KY Shao, YQ Han, GL Li, SL Ming, BQ Su, YK Du, ZH Liu, GP Zhang, GY Yang, BB Chu, RE Dutch |
Journal of virology | 2019 |
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Increased Gene Expression of RUNX2 and SOX9 in Mesenchymal Circulating Progenitors Is Associated with Autophagy during Physical Activity
LD Carbonare, M Mottes, S Cheri, M Deiana, F Zamboni, D Gabbiani, F Schena, GL Salvagno, G Lippi, MT Valenti |
Oxidative medicine and cellular longevity | 2019 |
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Autophagy Modulators: Mechanistic Aspects and Drug Delivery Systems
Tavakol, Ashrafizadeh, Deng, Azarian, Abdoli, Motavaf, Poormoghadam, Khanbabaei, Afshar, Mandegary, Pardakhty, Yap, Mohammadinejad, Kumar |
Biomolecules | 2019 |
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Transcriptional Regulation of Autophagy Genes via Stage-Specific Activation of CEBPB and PPARG during Adipogenesis: A Systematic Study Using Public Gene Expression and Transcription Factor Binding Datasets
M Ahmed, TH Lai, JS Hwang, S Zada, TM Pham, DR Kim |
Cells | 2019 |
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TP53INP2 Promotes Bovine Adipocytes Differentiation Through Autophagy Activation
W Zhang, P Li, S Wang, G Cheng, L Wang, X Mi, X Su, Y Wang, L Zan |
Animals | 2019 |
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Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release
F Li, H Li, X Jin, Y Zhang, X Kang, Z Zhang, M Xu, Z Qian, Z Ma, X Gao, L Zhao, S Wu, H Sun |
Cell cycle (Georgetown, Tex.) | 2019 |
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Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening
J Deng, Y Guo, F Yuan, S Chen, H Yin, X Jiang, F Jiao, F Wang, H Ji, G Hu, H Ying, Y Chen, Q Zhai, F Xiao, F Guo |
Autophagy | 2019 |
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脂噬对脂质代谢的调节作用及其分子机制
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2019 | |
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Autophagy and synaptic plasticity: epigenetic regulation
Hwang JY, Yan J, Zukin RS |
Current Opinion in Neurobiology | 2019 |
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Curcumin Induces Neural Differentiation of Human Pluripotent Embryonal Carcinoma Cells through the Activation of Autophagy
Heebkaew N, Rujanapun N, Kunhorm P, Jaroonwitchawan T, Chaicharoenaudomrung N, Promjantuek W, Noisa P |
BioMed Research International | 2019 |
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The Immunity-related GTPase M rs13361189 variant does not increase the risk for prevalent or incident steatosis; results from the Framingham Heart Study
Simon TG, Deng X, Liu CT, Chung RT, Long MT |
Liver international : official journal of the International Association for the Study of the Liver | 2019 |
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Novel Genetic Locus of Visceral Fat and Systemic Inflammation
Shin J, Syme C, Wang D, Richer L, Pike GB, Gaudet D, Paus T, Pausova Z |
The Journal of clinical endocrinology and metabolism | 2019 |
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Cell organelles and yeast longevity: an intertwined regulation.
Banerjee R, Joshi N, Nagotu S |
Current Genetics | 2019 |
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SNAP23 regulates BAX-dependent adipocyte programmed cell death independent of canonical macroautophagy
Daorong Feng, Dulguun Amgalan, Rajat Singh, Jianwen Wei, Jennifer Wen, Tszki Peter Wei, Timothy E. McGraw, Richard N Kitsis, Jeffrey E. Pessin |
Journal of Clinical Investigation | 2018 |
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The Multifaceted Roles of Autophagy in Flavivirus-Host Interactions
PY Ke |
International journal of molecular sciences | 2018 |
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A novel Atg5 -shRNA mouse model enables temporal control of Autophagy in vivo
LD Cassidy, AR Young, PA Pérez-Mancera, B Nimmervoll, A Jaulim, HC Chen, DJ McIntyre, R Brais, T Ricketts, S Pacey, MD Roche, RJ Gilbertson, DC Rubinsztein, M Narita |
Autophagy | 2018 |
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Classical and alternative roles for autophagy in lipid metabolism:
X Zhang, TD Evans, SJ Jeong, B Razani |
Current Opinion in Lipidology | 2018 |
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Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
Y Chun, J Kim |
Cells | 2018 |
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Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
Y Zhang, AT Whaley-Connell, JR Sowers, J Ren |
Pharmacology & Therapeutics | 2018 |
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Impaired Endothelial Autophagy Promotes Liver Fibrosis By Aggravating The Oxidative Stress Response During Acute Liver Injury
M Ruart, L Chavarria, G Campreciós, N Suárez-Herrera, C Montironi, S Guixé-Muntet, J Bosch, SL Friedman, JC Garcia-Pagán, V Hernández-Gea |
Journal of Hepatology | 2018 |
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Carvacrol reduces adipogenic differentiation by modulating autophagy and ChREBP expression
S Spalletta, V Flati, E Toniato, JD Gregorio, A Marino, L Pierdomenico, M Marchisio, G DOrazi, I Cacciatore, I Robuffo, V Trajkovic |
PloS one | 2018 |
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Myeloid ATG16L1 does not affect adipose tissue inflammation or body mass in mice fed high fat diet
EM Litwinoff, MY Gold, K Singh, J Hu, H Li, K Cadwell, AM Schmidt |
Obesity Research & Clinical Practice | 2018 |
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Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk
J Cai, KM Pires, M Ferhat, B Chaurasia, MA Buffolo, R Smalling, A Sargsyan, DL Atkinson, SA Summers, TE Graham, S Boudina |
Cell Reports | 2018 |
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Lipid Droplets in Cancer: Guardians of Fat in a Stressful World
T Petan, E Jarc, M Jusović |
Molecules (Basel, Switzerland) | 2018 |
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The E3 ligase March5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes
ST Bond, SC Moody, Y Liu, M Civelek, CJ Villanueva, P Gregorevic, BA Kingwell, AL Hevener, AJ Lusis, DC Henstridge, AC Calkin, BG Drew |
American journal of physiology. Endocrinology and metabolism | 2018 |
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Lymphocyte Autophagy in Homeostasis, Activation, and Inflammatory Diseases
F Arbogast, F Gros |
Frontiers in immunology | 2018 |
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Autophagy is a gatekeeper of hepatic differentiation and carcinogenesis by controlling the degradation of Yap
YA Lee, LA Noon, KM Akat, MD Ybanez, TF Lee, ML Berres, N Fujiwara, N Goossens, HI Chou, FP Parvin-Nejad, B Khambu, EG Kramer, R Gordon, C Pfleger, D Germain, GR John, KN Campbell, Z Yue, XM Yin, AM Cuervo, MJ Czaja, MI Fiel, Y Hoshida, SL Friedman |
Nature Communications | 2018 |
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Autophagy in Adipose Tissue Physiology and Pathophysiology
M Ferhat, K Funai, S Boudina |
Antioxidants & Redox Signaling | 2018 |
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Autophagy Dysregulation and Obesity-Associated Pathologies
Sim Namkoong, Chun-Seok Cho, Ian Semple, Jun Hee Lee |
Molecules and Cells | 2018 |
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Functional genomics of lipid metabolism in the oleaginous yeast Rhodosporidium toruloides
ST Coradetti, D Pinel, GM Geiselman, M Ito, SJ Mondo, MC Reilly, YF Cheng, S Bauer, IV Grigoriev, JM Gladden, BA Simmons, RB Brem, AP Arkin, JM Skerker |
eLife | 2018 |
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Autophagy upregulation as a possible mechanism of arsenic induced diabetes
M Zeinvand-Lorestani, H Kalantari, MJ Khodayar, A Teimoori, N Saki, A Ahangarpour, F Rahim, S Alboghobeish |
Scientific Reports | 2018 |
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Estradiol signaling mediates gender difference in visceral adiposity via autophagy
Z Tao, LD Zheng, C Smith, J Luo, A Robinson, FA Almeida, Z Wang, AF Olumi, D Liu, Z Cheng |
Cell Death and Disease | 2018 |
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Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity
MC Löffler, AE Mayer, JT Viera, AL Valdes, R ElMerahbi, CP Ade, T Karwen, W Schmitz, A Slotta, M Erk, S JanakiRaman, N Matesanz, JL Torres, M Marcos, G Sabio, M Eilers, A Schulze, G Sumara |
The EMBO Journal | 2018 |
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ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion
R Wang, J Tan, T Chen, H Han, R Tian, Y Tan, Y Wu, J Cui, F Chen, J Li, L Lv, X Guan, S Shang, J Lu, Z Zhang |
The Journal of Cell Biology | 2018 |
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AMPK Activation Mediated by Hinokitiol Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells through Autophagy Flux
JH Lee, JK Jeong, SY Park |
International Journal of Endocrinology | 2018 |
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Beneficial Autophagic Activities, Mitochondrial Function, and Metabolic Phenotype Adaptations Promoted by High-Intensity Interval Training in a Rat Model
FH Li, T Li, JY Ai, L Sun, Z Min, R Duan, L Zhu, Y Liu, TC Liu |
Frontiers in physiology | 2018 |
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Co-Expression Network Analysis of AMPK and Autophagy Gene Products during Adipocyte Differentiation
M Ahmed, J Hwang, T Lai, S Zada, H Nguyen, T Pham, M Yun, D Kim |
International journal of molecular sciences | 2018 |
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Novel role of autophagy-associated Pik3c3 gene in gonadal white adipose tissue browning in aged C57/Bl6 male mice
AK Ghosh, T Mau, M OBrien, R Yung |
Aging | 2018 |
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Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism
X Lu, S Altshuler-Keylin, Q Wang, Y Chen, CH Sponton, K Ikeda, P Maretich, T Yoneshiro, S Kajimura |
Science signaling | 2018 |
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Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice
J Yan, MW Porch, B Court-Vazquez, MV Bennett, RS Zukin |
Proceedings of the National Academy of Sciences | 2018 |
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p62 is linked to mitophagy in oleic acid-induced adipogenesis in human adipose-derived stromal cells
R Zeng, Y Fang, Y Zhang, S Bai |
Lipids in Health and Disease | 2018 |
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The Role of Autophagy in Systemic Metabolism and Human-Type Diabetes
Jinyoung Kim, Yu-Mi Lim, Myung-Shik Lee |
Molecules and Cells | 2018 |
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SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated Autophagy.
Zhao W, Zhang L, Chen R, Lu H, Sui M, Zhu Y, Zeng L |
Frontiers in physiology | 2018 |
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Autophagy in C. elegans development
Palmisano NJ, Meléndez A |
Developmental Biology | 2018 |
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Systematic characterization of autophagy-related genes during the adipocyte differentiation using public-access data.
Ahmed M, Nguyen HQ, Hwang JS, Zada S, Lai TH, Kang SS, Kim DR |
Oncotarget | 2018 |
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Strontium ranelate-induced anti-adipocytic effects are involved in negative regulation of autophagy in rat bone marrow mesenchymal stem cells.
Xu Z, Bai X |
International Orthopaedics | 2018 |
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p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes.
Igawa H, Kikuchi A, Misu H, Ishii KA, Kaneko S, Takamura T |
Journal of Diabetes Investigation | 2018 |
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IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease.
Simon TG, Van Der Sloot KWJ, Chin SB, Joshi AD, Lochhead P, Ananthakrishnan AN, Xavier R, Chung RT, Khalili H |
Inflammatory Bowel Diseases | 2018 |
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Intermittent fasting preserves beta-cell mass in obesity-induced diabetes via the autophagy-lysosome pathway
H Liu, A Javaheri, RJ Godar, J Murphy, X Ma, N Rohatgi, J Mahadevan, K Hyrc, P Saftig, C Marshall, ML McDaniel, MS Remedi, B Razani, F Urano, A Diwan |
Autophagy | 2017 |
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Target acquired: Selective autophagy in cardiometabolic disease
TD Evans, I Sergin, X Zhang, B Razani |
Science signaling | 2017 |
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Exercise leads to unfavourable cardiac remodelling and enhanced metabolic homeostasis in obese mice with cardiac and skeletal muscle autophagy deficiency
Z Yan, A Kronemberger, J Blomme, JA Call, HM Caster, RO Pereira, H Zhao, VU de Melo, RC Laker, M Zhang, VA Lira |
Scientific Reports | 2017 |
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High intensity aerobic exercise training improves chronic intermittent hypoxia-induced insulin resistance without basal autophagy modulation
M Pauly, A Assense, A Rondon, A Thomas, H Dubouchaud, D Freyssenet, H Benoit, J Castells, P Flore |
Scientific Reports | 2017 |
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Adipose tissue autophagy and homeostasis in alcohol-induced liver injury
Y Li, WX Ding |
Liver Research | 2017 |
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Diabetes and dyslipidemia: characterizing lipoprotein metabolism
G Tomkin, D Owens |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy | 2017 |
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Adipose tissue autophagy related gene expression is associated with glucometabolic status in human obesity
Q Xu, EC Mariman, NJ Roumans, RG Vink, GH Goossens, EE Blaak, JW Jocken |
Adipocyte | 2017 |
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Amino acid starvation-induced autophagy is involved in reduced subcutaneous fat deposition in weaning piglets derived from sows fed low-protein diet during gestation and lactation: Autophagy is involved in reduced fat deposition in maternal low-protein piglets
S Pan, Y Jia, X Yang, D Cai, Z Liu, H Song, R Zhao |
European Journal of Nutrition | 2017 |
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Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy
RL Hoo, L Shu, KK Cheng, X Wu, B Liao, D Wu, Z Zhou, A Xu |
Scientific Reports | 2017 |
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Involvement of lysosomal dysfunction in autophagosome accumulation and early pathologies in adipose tissue of obese mice
Y Mizunoe, Y Sudo, N Okita, H Hiraoka, K Mikami, T Narahara, A Negishi, M Yoshida, R Higashibata, S Watanabe, H Kaneko, D Natori, T Furuichi, H Yasukawa, M Kobayashi, Y Higami |
Autophagy | 2017 |
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Itm2a silencing rescues lamin A mediated inhibition of 3T3-L1 adipocyte differentiation
SJ Davies, J Ryan, PB O'Connor, E Kenny, D Morris, PV Baranov, R O'Connor, TV McCarthy |
Adipocyte | 2017 |
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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
B Bilanges, S Alliouachene, W Pearce, D Morelli, G Szabadkai, YL Chung, G Chicanne, C Valet, JM Hill, PJ Voshol, L Collinson, C Peddie, K Ali, E Ghazaly, V Rajeeve, G Trichas, S Srinivas, C Chaussade, RS Salamon, JM Backer, CL Scudamore, MA Whitehead, EP Keaney, LO Murphy, RK Semple, B Payrastre, SA Tooze, B Vanhaesebroeck |
Nature Communications | 2017 |
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Icariin Inhibits AMPK-Dependent Autophagy and Adipogenesis in Adipocytes In vitro and in a Model of Graves' Orbitopathy In vivo
H Li, Y Yuan, Y Zhang, X Zhang, L Gao, R Xu |
Frontiers in physiology | 2017 |
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Mitochondrial homeostasis in adipose tissue remodeling
S Altshuler-Keylin, S Kajimura |
Science signaling | 2017 |
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Gene expression profile during proliferation and differentiation of rainbow trout adipocyte precursor cells
M Bou, J Montfort, AL Cam, C Rallière, V Lebret, JC Gabillard, C Weil, J Gutiérrez, PY Rescan, E Capilla, I Navarro |
BMC Genomics | 2017 |
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Autophagy in the Vertebrate Inner Ear
M Magariños, S Pulido, MR Aburto, RI Rodríguez, I Varela-Nieto |
Frontiers in Cell and Developmental Biology | 2017 |
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Breaking fat: The regulation and mechanisms of lipophagy
RJ Schulze, A Sathyanarayan, DG Mashek |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2017 |
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Effects of Epigallocatechin-3-Gallate on Autophagic Lipolysis in Adipocytes
SN Kim, HJ Kwon, S Akindehin, H Jeong, YH Lee |
Nutrients | 2017 |
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Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD-induced obese mice
M Li, A Sharma, C Yin, X Tan, Y Xiao |
Molecular medicine reports | 2017 |
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System-wide Benefits of Intermeal Fasting by Autophagy
N Martinez-Lopez, E Tarabra, M Toledo, M Garcia-Macia, S Sahu, L Coletto, A Batista-Gonzalez, N Barzilai, JE Pessin, GJ Schwartz, S Kersten, R Singh |
Cell Metabolism | 2017 |
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Effects of endurance training on autophagy and apoptotic signaling in visceral adipose tissue of prolonged high fat diet-fed rats.
Rocha-Rodrigues S, Gonçalves IO, Beleza J, Ascensão A, Magalhães J |
European Journal of Nutrition | 2017 |
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The role of mineralocorticoid receptor signaling in the cross-talk between adipose tissue and the vascular wall
Jia G, Aroor AR, Sowers JR |
Cardiovascular Research | 2017 |
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Autophagy and Obesity-Related Lung Disease
MA Pabon, KC Ma, AM Choi |
American journal of respiratory cell and molecular biology | 2016 |
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Emerging evidence for beneficial macrophage functions in atherosclerosis and obesity-induced insulin resistance
TP Fitzgibbons, MP Czech |
Journal of Molecular Medicine | 2016 |
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AMPK activators: mechanisms of action and physiological activities
J Kim, G Yang, Y Kim, J Kim, J Ha |
Experimental & molecular medicine | 2016 |
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Autophagy Is Dispensable for Macrophage-Mediated Lipid Homeostasis in Adipose Tissue
A Grijalva, X Xu, AW Ferrante |
Diabetes | 2016 |
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Impaired macrophage autophagy induces systemic insulin resistance in obesity
YH Kang, MH Cho, JY Kim, MS Kwon, JJ Peak, SW Kang, SY Yoon, Y Song |
Oncotarget | 2016 |
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Bif-1 deficiency impairs lipid homeostasis and causes obesity accompanied by insulin resistance
Y Liu, Y Takahashi, N Desai, J Zhang, JM Serfass, YG Shi, CJ Lynch, HG Wang |
Scientific Reports | 2016 |
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Autophagy: a new target for nonalcoholic fatty liver disease therapy
Y Mao, F Yu, J Wang, C Guo, X Fan |
Hepatic medicine : evidence and research | 2016 |
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Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis
HY Lee, J Kim, W Quan, JC Lee, MS Kim, SH Kim, JW Bae, KY Hur, MS Lee |
Autophagy | 2016 |
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Lipids, lysosomes, and autophagy
B Jaishy, ED Abel |
Journal of lipid research | 2016 |
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FoxO1 antagonist suppresses autophagy and lipid droplet growth in adipocytes
L Liu, LD Zheng, P Zou, J Brooke, C Smith, YC Long, FA Almeida, D Liu, Z Cheng |
Cell cycle (Georgetown, Tex.) | 2016 |
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Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway
J Zeng, Y Jing, R Shi, X Pan, F Lai, W Liu, R Li, L Gao, X Hou, M Wu, L Wei |
Cell cycle (Georgetown, Tex.) | 2016 |
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FoxO1-autophagy axis regulates lipid droplet growth via FSP27
S Jash, V Puri |
Cell cycle (Georgetown, Tex.) | 2016 |
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Autophagy regulates spermatid differentiation via degradation of PDLIM1
Y Shang, H Wang, P Jia, H Zhao, C Liu, W Liu, Z Song, Z Xu, L Yang, Y Wang, W Li |
Autophagy | 2016 |
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Decreased adiponectin links elevated adipose tissue autophagy with adipocyte endocrine dysfunction in obesity
N Slutsky, M Vatarescu, Y Haim, N Goldstein, B Kirshtein, I Harman-Boehm, Y Gepner, I Shai, N Bashan, M Blüher, A Rudich |
International Journal of Obesity | 2016 |
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Thermogenic activation represses autophagy in brown adipose tissue
M Cairó, J Villarroya, R Cereijo, L Campderrós, M Giralt, F Villarroya |
International Journal of Obesity | 2016 |
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FoxO1 interacts with transcription factor EB and differentially regulates mitochondrial uncoupling proteins via autophagy in adipocytes
L Liu, Z Tao, LD Zheng, JP Brooke, CM Smith, D Liu, YC Long, Z Cheng |
Cell Death Discovery | 2016 |
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The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy
RS Kim, D Hasegawa, N Goossens, T Tsuchida, V Athwal, X Sun, CL Robinson, D Bhattacharya, HI Chou, DY Zhang, BC Fuchs, Y Lee, Y Hoshida, SL Friedman |
Scientific Reports | 2016 |
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In situ characterization of the mTORC1 during adipogenesis of human adult stem cells on chip
X Wu, N Schneider, A Platen, I Mitra, M Blazek, R Zengerle, R Schüle, M Meier |
Proceedings of the National Academy of Sciences | 2016 |
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Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance
S Altshuler-Keylin, K Shinoda, Y Hasegawa, K Ikeda, H Hong, Q Kang, Y Yang, RM Perera, J Debnath, S Kajimura |
Cell Metabolism | 2016 |
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Regulation and Functions of Autophagic Lipolysis
F Cingolani, MJ Czaja |
Trends in Endocrinology & Metabolism | 2016 |
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18O-Tracer Metabolomics Reveals Protein Turnover and CDP-Choline Cycle Activity in Differentiating 3T3-L1 Pre-Adipocytes
JS Kirkwood, CL Miranda, G Bobe, CS Maier, JF Stevens, V Sanchez-Margalet |
PloS one | 2016 |
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The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment
YC Chang, SW Hee, ML Hsieh, YM Jeng, LM Chuang |
Analytical cellular pathology (Amsterdam) | 2015 |
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Chemokine ligand 2 and paraoxonase-1 in non-alcoholic fatty liver disease: The search for alternative causative factors
J Camps |
World journal of gastroenterology : WJG | 2015 |
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Absence of Intracellular Ion Channels TPC1 and TPC2 Leads to Mature-Onset Obesity in Male Mice, Due to Impaired Lipid Availability for Thermogenesis in Brown Adipose Tissue
PV Lear, D González-Touceda, BP Couto, P Viaño, V Guymer, E Remzova, R Tunn, A Chalasani, T García-Caballero, IP Hargreaves, PW Tynan, HC Christian, R Nogueiras, J Parrington, C Diéguez |
Endocrinology | 2015 |
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Active autophagy but not lipophagy in macrophages with defective lipolysis
M Goeritzer, N Vujic, S Schlager, PG Chandak, M Korbelius, B Gottschalk, C Leopold, S Obrowsky, S Rainer, P Doddapattar, E Aflaki, M Wegscheider, V Sachdev, WF Graier, D Kolb, B Radovic, D Kratky |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2015 |
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Unbreak My Heart: Targeting Mitochondrial Autophagy in Diabetic Cardiomyopathy
DA Kubli, ÅB Gustafsson |
Antioxidants & Redox Signaling | 2015 |
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Activation of Toll-like Receptor 4 (TLR4) Attenuates Adaptive Thermogenesis via Endoplasmic Reticulum Stress
M Okla, W Wang, I Kang, A Pashaj, T Carr, S Chung |
The Journal of biological chemistry | 2015 |
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Unsaturated fatty acids induce non-canonical autophagy
M Niso-Santano, SA Malik, F Pietrocola, JM Pedro, G Marino, V Cianfanelli, A Ben-Younes, R Troncoso, M Markaki, V Sica, V Izzo, K Chaba, C Bauvy, N Dupont, O Kepp, P Rockenfeller, H Wolinski, F Madeo, S Lavandero, P Codogno, F Harper, G Pierron, N Tavernarakis, F Cecconi, MC Maiuri, L Galluzzi, G Kroemer |
The EMBO Journal | 2015 |
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Autophagy in stem and progenitor cells
C Rodolfo, SD Bartolomeo, F Cecconi |
Cellular and Molecular Life Sciences | 2015 |
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High ω3-polyunsaturated fatty acids in fat-1 mice prevent streptozotocin-induced Purkinje cell degeneration through BDNF-mediated autophagy
DH Bak, E Zhang, MH Yi, DK Kim, K Lim, JJ Kim, DW Kim |
Scientific Reports | 2015 |
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Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis
O Lenoir, M Jasiek, C Hénique, L Guyonnet, B Hartleben, T Bork, A Chipont, K Flosseau, I Bensaada, A Schmitt, JM Massé, M Souyri, TB Huber, PL Tharaux |
Autophagy | 2015 |
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Autophagy at the crossroads of catabolism and anabolism
J Kaur, J Debnath |
Nature Reviews Molecular Cell Biology | 2015 |
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A defect of the vacuolar putative lipase Atg15 accelerates degradation of lipid droplets through lipolysis
Y Maeda, M Oku, Y Sakai |
Autophagy | 2015 |
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The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML
S Obba, Z Hizir, L Boyer, D Selimoglu-Buet, A Pfeifer, G Michel, MA Hamouda, D Gonçalvès, M Cerezo, S Marchetti, S Rocchi, N Droin, T Cluzeau, G Robert, F Luciano, B Robaye, M Foretz, B Viollet, L Legros, E Solary, P Auberger, A Jacquel |
Autophagy | 2015 |
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Effect of Berberine on promoting the excretion of cholesterol in high-fat diet-induced hyperlipidemic hamsters
XY Li, ZX Zhao, M Huang, R Feng, CY He, C Ma, SH Luo, J Fu, BY Wen, L Ren, JW Shou, F Guo, Y Chen, X Gao, Y Wang, JD Jiang |
Journal of Translational Medicine | 2015 |
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Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1
Y Haim, M Blüher, N Slutsky, N Goldstein, N Klöting, I Harman-Boehm, B Kirshtein, D Ginsberg, M Gericke, EG Jurado, J Kovsan, T Tarnovscki, L Kachko, N Bashan, Y Gepner, I Shai, A Rudich |
Autophagy | 2015 |
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Atg7 in development and disease: panacea or Pandora’s Box?
J Xiong |
Protein & Cell | 2015 |
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Autophagy Alleviates Melamine-Induced Cell Death in PC12 Cells Via Decreasing ROS Level
H Wang, N Gao, Z Li, Z Yang, T Zhang |
Molecular Neurobiology | 2015 |
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Autophagy Is Involved in the Reduction of Myelinating Schwann Cell Cytoplasm during Myelin Maturation of the Peripheral Nerve
SY Jang, YK Shin, SY Park, JY Park, SH Rha, JK Kim, HJ Lee, HT Park, H Nakano |
PloS one | 2015 |
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Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics
AS Rambold, S Cohen, J Lippincott-Schwartz |
Developmental Cell | 2015 |
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Hierarchal autophagic divergence of hematopoietic system
Y Cao, S Zhang, N Yuan, J Wang, X Li, F Xu, W Lin, L Song, Y Fang, Z Wang, Z Wang, H Zhang, Y Zhang, W Zhao, S Hu, X Zhang, J Wang |
The Journal of biological chemistry | 2015 |
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The lipid droplet—a well-connected organelle
Q Gao, JM Goodman |
Frontiers in Cell and Developmental Biology | 2015 |
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HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation
JB Carroll, A Deik, E Fossale, RM Weston, JR Guide, J Arjomand, S Kwak, CB Clish, ME MacDonald, S Humbert |
PloS one | 2015 |
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Emerging roles of autophagy in metabolism and metabolic disorders
A Rocchi, C He |
Frontiers in Biology | 2015 |
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The Whitening of Brown Fat and Its Implications for Weight Management in Obesity
I Shimizu, K Walsh |
Current Obesity Reports | 2015 |
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Roux-en-Y gastric bypass reduces lipid overaccumulation in liver by upregulating hepatic autophagy in obese diabetic rats.
He B, Liu L, Yu C, Wang Y, Han P |
Obesity surgery | 2015 |
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Vascular rarefaction mediates whitening of brown fat in obesity
Ippei Shimizu, Tamar R Aprahamian, Ryosuke Kikuchi, Ayako Shimizu, Kyriakos Papanicolaou, Susan Maclauchlan, Sonomi Maruyama, Kenneth Walsh |
Journal of Clinical Investigation | 2014 |
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Lipid-induced NOX2 activation inhibits autophagic flux by impairing lysosomal enzyme activity
B Jaishy, Q Zhang, HS Chung, C Riehle, J Soto, S Jenkins, P Abel, LA Cowart, JE van Eyk, ED Abel |
Journal of lipid research | 2014 |
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Autophagy in adipose tissue and the beta cell: implications for obesity and diabetes
R Stienstra, Y Haim, Y Riahi, M Netea, A Rudich, G Leibowitz |
Diabetologia | 2014 |
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Autophagy Modulation As a Potential Therapeutic Target for Liver Diseases
P Puri, A Chandra |
Journal of Clinical and Experimental Hepatology | 2014 |
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Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis
S Dang, H Xu, C Xu, W Cai, Q Li, Y Cheng, M Jin, RX Wang, Y Peng, Y Zhang, C Wu, X He, B Wan, Y Zhang |
Autophagy | 2014 |
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Autophagy in hepatitis C virus-host interactions: Potential roles and therapeutic targets for liver-associated diseases
PY Ke, SS Chen |
World journal of gastroenterology : WJG | 2014 |
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Autophagy—a key player in cellular and body metabolism
KH Kim, MS Lee |
Nature Reviews Endocrinology | 2014 |
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Emerging role of protein kinase C in energy homeostasis: A brief overview
KD Mehta |
World journal of diabetes | 2014 |
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Metabolic remodeling of white adipose tissue in obesity
TD Cummins, CR Holden, BE Sansbury, AA Gibb, J Shah, N Zafar, Y Tang, J Hellmann, SN Rai, M Spite, A Bhatnagar, BG Hill |
American journal of physiology. Endocrinology and metabolism | 2014 |
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KSRP Ablation Enhances Brown Fat Gene Program in White Adipose Tissue Through Reduced miR-150 Expression
CF Chou, YY Lin, HK Wang, X Zhu, M Giovarelli, P Briata, R Gherzi, WT Garvey, CY Chen |
Diabetes | 2014 |
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Palmitic acid induces autophagy in hepatocytes via JNK2 activation
Q Tu, R Zheng, J Li, L Hu, Y Chang, L Li, M Li, R Wang, D Huang, M Wu, H Hu, L Chen, H Wang |
Acta Pharmacologica Sinica | 2014 |
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Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein
X Feng, Y Yuan, C Wang, J Feng, Z Yuan, X Zhang, W Sui, P Hu, P Zheng, J Ye |
Lipids in Health and Disease | 2014 |
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Autophagy Facilitates Secretion and Protects against Degeneration of the Harderian Gland
U Koenig, M Fobker, B Lengauer, M Brandstetter, GP Resch, M Gröger, G Plenz, J Pammer, C Barresi, C Hartmann, H Rossiter |
Autophagy | 2014 |
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Berberine attenuates autophagy in adipocytes by targeting BECN1
Y Deng, J Xu, X Zhang, J Yang, D Zhang, J Huang, P Lv, W Shen, Y Yang |
Autophagy | 2014 |
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The generation of neutrophils in the bone marrow is controlled by autophagy
S Rožman, S Yousefi, K Oberson, T Kaufmann, C Benarafa, HU Simon |
Cell Death and Differentiation | 2014 |
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Molecular regulation of autophagy and its implications for metabolic diseases:
SW Ryter, JK Koo, AM Choi |
Current Opinion in Clinical Nutrition and Metabolic Care | 2014 |
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Human mesenchymal stem cells/multipotent stromal cells consume accumulated autophagosomes early in differentiation
A Nuschke, M Rodrigues, DB Stolz, CT Chu, L Griffith, A Wells |
Stem Cell Research & Therapy | 2014 |
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Autophagy is Required for Glucose Homeostasis and Lung Tumor Maintenance
G Karsli-Uzunbas, JY Guo, S Price, X Teng, SV Laddha, S Khor, NY Kalaany, T Jacks, CS Chan, JD Rabinowitz, E White |
Cancer Discovery | 2014 |
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Uncoupling Protein 2 Regulates Palmitic Acid-Induced Hepatoma Cell Autophagy
J Lou, Y Wang, X Wang, Y Jiang |
BioMed Research International | 2014 |
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Spermidine feeding decreases age-related locomotor activity loss and induces changes in lipid composition
N Minois, P Rockenfeller, TK Smith, D Carmona-Gutierrez |
PloS one | 2014 |
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Zinc and autophagy
JP Liuzzi, L Guo, C Yoo, TS Stewart |
BioMetals | 2014 |
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Genome Wide Meta-analysis Highlights the Role of Genetic Variation in RARRES2 in the Regulation of Circulating Serum Chemerin
A Tönjes, M Scholz, J Breitfeld, C Marzi, H Grallert, A Gross, C Ladenvall, D Schleinitz, K Krause, H Kirsten, E Laurila, J Kriebel, B Thorand, W Rathmann, L Groop, I Prokopenko, B Isomaa, F Beutner, J Kratzsch, J Thiery, M Fasshauer, N Klöting, C Gieger, M Blüher, M Stumvoll, P Kovacs, E Zeggini |
PLoS genetics | 2014 |
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Autophagy and cardiometabolic risk factors
JG Juárez-Rojas, G Reyes-Soffer, D Conlon, HN Ginsberg |
Reviews in Endocrine and Metabolic Disorders | 2014 |
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Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides
C López-Vicario, J Alcaraz-Quiles, V García-Alonso, B Rius, SH Hwang, E Titos, A Lopategi, BD Hammock, V Arroyo, J Clària |
Proceedings of the National Academy of Sciences | 2014 |
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Transcriptional Regulation of Adipocyte Differentiation: A Central Role for CCAAT/Enhancer-binding Protein (C/EBP) β
L Guo, X Li, QQ Tang |
The Journal of biological chemistry | 2014 |
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Lipid droplet and early autophagosomal membrane targeting of Atg2A and Atg14L in human tumor cells
SG Pfisterer, D Bakula, T Frickey, A Cezanne, D Brigger, MP Tschan, H Robenek, T Proikas-Cezanne |
Journal of lipid research | 2014 |
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Fyn phosphorylates AMPK to inhibit AMPK activity and AMP-dependent activation of autophagy
E Yamada, S Okada, CC Bastie, M Vatish, Y Nakajima, R Shibusawa, A Ozawa, JE Pessin, M Yamada |
Oncotarget | 2014 |
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Brown and beige fat: development, function and therapeutic potential
M Harms, P Seale |
Nature Medicine | 2013 |
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Vascular endothelial growth factor is important for brown adipose tissue development and maintenance
M Bagchi, LA Kim, J Boucher, TE Walshe, CR Kahn, PA D'Amore |
The FASEB Journal | 2013 |
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Identification of a loss-of-function mutation in Ube2l6 associated with obesity resistance
G Marcelin, SM Liu, GJ Schwartz, SC Chua |
Diabetes | 2013 |
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Obesity Activates a Program of Lysosomal-Dependent Lipid Metabolism in Adipose Tissue Macrophages Independently of Classic Activation
X Xu, A Grijalva, A Skowronski, M van Eijk, MJ Serlie, AW Ferrante |
Cell Metabolism | 2013 |
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Autophagy in stem cells
JL Guan, AK Simon, M Prescott, JA Menendez, F Liu, F Wang, C Wang, E Wolvetang, A Vazquez-Martin, J Zhang |
Autophagy | 2013 |
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Selective autophagy: talking with the UPS
C Park, AM Cuervo |
Cell Biochemistry and Biophysics | 2013 |
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Reciprocal effects of rab7 deletion in activated and neglected T cells
SG Roy, MW Stevens, L So, AL Edinger |
Autophagy | 2013 |
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Adipose tissue browning and metabolic health
A Bartelt, J Heeren |
Nature Reviews Endocrinology | 2013 |
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Adaptive thermogenesis in adipocytes: is beige the new brown?
J Wu, P Cohen, BM Spiegelman |
Genes & development | 2013 |
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Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism
KH Kim, MS Lee |
Reviews in Endocrine and Metabolic Disorders | 2013 |
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A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice
E Guirguis, S Hockman, YW Chung, F Ahmad, O Gavrilova, N Raghavachari, Y Yang, G Niu, X Chen, , S Liu, E Degerman, V Manganiello |
Endocrinology | 2013 |
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From NAFLD to NASH to cirrhosis—new insights into disease mechanisms
A Wree, L Broderick, A Canbay, HM Hoffman, AE Feldstein |
Nature Reviews Gastroenterology & Hepatology | 2013 |
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Mitophagy in hematopoietic stem cells: The case for exploration
A Joshi, M Kundu |
Autophagy | 2013 |
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A Novel Adipose-Specific Gene Deletion Model Demonstrates Potential Pitfalls of Existing Methods
SE Mullican, T Tomaru, CA Gaddis, LC Peed, A Sundaram, MA Lazar |
Molecular Endocrinology | 2013 |
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The role of autophagy in the pathogenesis of diabetic nephropathy
K Yamahara, M Yasuda, S Kume, D Koya, H Maegawa, T Uzu |
Journal of Diabetes Research | 2013 |
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Autophagy: A critical regulator of cellular metabolism and homeostasis
SW Ryter, SM Cloonan, AM Choi |
Molecules and Cells | 2013 |
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FIP200 is required for maintenance and differentiation of postnatal neural stem cells
C Wang, CC Liang, ZC Bian, Y Zhu, JL Guan |
Nature Neuroscience | 2013 |
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Role of Autophagy in the Control of Body Metabolism
W Quan, MS Lee |
Endocrinology and Metabolism | 2013 |
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Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development
N Martinez-Lopez, D Athonvarangkul, S Sahu, L Coletto, H Zong, CC Bastie, JE Pessin, GJ Schwartz, R Singh |
EMBO reports | 2013 |
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The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men
E Konings, S Timmers, MV Boekschoten, GH Goossens, JW Jocken, LA Afman, M Müller, P Schrauwen, EC Mariman, EE Blaak |
International Journal of Obesity | 2013 |
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Skeletal muscle, autophagy, and physical activity: the ménage à trois of metabolic regulation in health and disease
A Vainshtein, P Grumati, M Sandri, P Bonaldo |
Journal of Molecular Medicine | 2013 |
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Long-term fructose feeding changes the expression of leptin receptors and autophagy genes in the adipose tissue and liver of male rats: a possible link to elevated triglycerides
M Äijälä, E Malo, O Ukkola, R Bloigu, P Lehenkari, H Autio-Harmainen, M Santaniemi, YA Kesäniemi |
Genes & Nutrition | 2013 |
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You are what you eat: multifaceted functions of autophagy during C. elegans development
P Yang, H Zhang |
Cell Research | 2013 |
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Lipid droplet autophagy in the yeast Saccharomyces cerevisiae
T Zutphen, V Todde, R Boer, M Kreim, HF Hofbauer, H Wolinski, M Veenhuis, IJ van der Klei, SD Kohlwein |
Molecular biology of the cell | 2013 |
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Autophagy proteins regulate ERK phosphorylation
N Martinez-Lopez, D Athonvarangkul, P Mishall, S Sahu, R Singh |
Nature Communications | 2013 |
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FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment
DL Barbato, G Tatulli, K Aquilano, MR Ciriolo |
Cell Death and Disease | 2013 |
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Distinct functions of Ulk1 and Ulk2 in the regulation of lipid metabolism in adipocytes
SH Ro, CH Jung, WS Hahn, X Xu, YM Kim, YS Yun, JM Park, KH Kim, M Seo, TY Ha, EA Arriaga, DA Bernlohr, DH Kim |
Autophagy | 2013 |
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Autophagy genes are required for normal lipid levels in C. elegans
LR Lapierre, MJ Silvestrini, L Nuñez, K Ames, S Wong, TT Le, M Hansen, A Meléndez |
Autophagy | 2013 |
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β-adrenergic receptor-stimulated lipolysis requires the RAB7-mediated autolysosomal lipid degradation
A Lizaso, KT Tan, YH Lee |
Autophagy | 2013 |
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Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii
Z Duan, Y Chen, W Huang, Y Shang, P Chen, C Wang |
Autophagy | 2013 |
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Minireview: Endoplasmic Reticulum Stress: Control in Protein, Lipid, and Signal Homeostasis
J Mandl, T Mészáros, G Bánhegyi, M Csala |
Molecular Endocrinology | 2013 |
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Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
CH Tsao, MY Shiau, PH Chuang, YH Chang, J Hwang |
Journal of lipid research | 2013 |
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HIV protease inhibitors disrupt lipid metabolism by activating endoplasmic reticulum stress and inhibiting autophagy activity in adipocytes
BS Zha, X Wan, X Zhang, W Zha, J Zhou, M Wabitsch, G Wang, V Lyall, PB Hylemon, H Zhou |
PloS one | 2013 |
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The autophagic inhibitor 3-methyladenine potently stimulates PKA-dependent lipolysis in adipocytes
BL Heckmann, X Yang, X Zhang, J Liu |
British Journal of Pharmacology | 2013 |
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Skeletal Muscle-derived Myonectin Activates the Mammalian Target of Rapamycin (mTOR) Pathway to Suppress Autophagy in Liver
MM Seldin, X Lei, SY Tan, KP Stanson, Z Wei, GW Wong |
The Journal of biological chemistry | 2013 |
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Skeletal muscle autophagy: a new metabolic regulator
BA Neel, Y Lin, JE Pessin |
Trends in Endocrinology & Metabolism | 2013 |
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Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation: FIP200 IN BONE DEVELOPMENT AND OSTEOBLAST DIFFERENTIATION
F Liu, F Fang, H Yuan, D Yang, Y Chen, L Williams, SA Goldstein, PH Krebsbach, JL Guan |
Journal of Bone and Mineral Research | 2013 |
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Transactivation of Atg4b by C/EBPβ Promotes Autophagy To Facilitate Adipogenesis
L Guo, JX Huang, Y Liu, , SR Zhou, SW Qian, Y Liu, H Zhu, HY Huang, YJ Dang, QQ Tang |
Molecular and cellular biology | 2013 |
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The Mechanism and Physiological Function of Macroautophagy
Klionsky DJ, Codogno P |
Journal of Innate Immunity | 2013 |
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Role of hypothalamic autophagy in the control of whole body energy balance.
Kim MS, Quan W, Lee MS |
Reviews in endocrine & metabolic disorders | 2013 |
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CCAAT/enhancer-binding protein β (C/EBPβ) expression regulates dietary-induced inflammation in macrophages and adipose tissue in mice
SM Rahman, RC Janssen, M Choudhury, KC Baquero, RM Aikens, BA de la Houssaye, JE Friedman |
The Journal of biological chemistry | 2012 |
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Regulation of lipid stores and metabolism by lipophagy
K Liu, MJ Czaja |
Cell Death and Differentiation | 2012 |
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Targeting autophagy for the treatment of liver diseases
HM Ni, JA Williams, H Yang, YH Shi, J Fan, WX Ding |
Pharmacological Research | 2012 |
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The multifaceted role of mTORC1 in the control of lipid metabolism
SJ Ricoult, BD Manning |
EMBO reports | 2012 |
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Autophagy and Cancer Cell Metabolism
F Lozy, V Karantza |
Seminars in Cell and Developmental Biology | 2012 |
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Autophagy modulation as a potential therapeutic target for diverse diseases
DC Rubinsztein, P Codogno, B Levine |
Nature Reviews Drug Discovery | 2012 |
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Hepatitis C virus and cellular stress response: implications to molecular pathogenesis of liver diseases
PY Ke, SS Chen |
Viruses | 2012 |
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Autophagy during vertebrate development
MR Aburto, JM Hurlé, I Varela-Nieto, M Magariños |
Cells | 2012 |
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Androgens promote prostate cancer cell growth through induction of autophagy
Y Shi, JJ Han, JB Tennakoon, FF Mehta, FA Merchant, AR Burns, MK Howe, DP McDonnell, DE Frigo |
Molecular Endocrinology | 2012 |
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Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
KH Kim, YT Jeong, H Oh, SH Kim, JM Cho, YN Kim, SS Kim, DH Kim, KY Hur, HK Kim, TH Ko, J Han, HL Kim, J Kim, SH Back, M Komatsu, H Chen, DC Chan, M Konishi, N Itoh, CS Choi, MS Lee |
Nature Medicine | 2012 |
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Lipophagy: Connecting Autophagy and Lipid Metabolism
R Singh, AM Cuervo |
International Journal of Cell Biology | 2012 |
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Inflammation, Endoplasmic Reticulum Stress, Autophagy, and the Monocyte Chemoattractant Protein-1/CCR2 Pathway
PE Kolattukudy, J Niu, A Rosenzweig |
Circulation research | 2012 |
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Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
L Varela, TL Horvath |
EMBO reports | 2012 |
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Mapping Autophagy on to Your Metabolic Radar
E Yamada, R Singh |
Diabetes | 2012 |
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Impaired Osteoblastogenesis in a Murine Model of Dominant Osteogenesis Imperfecta: A New Target for Osteogenesis Imperfecta Pharmacological Therapy
R Gioia, C Panaroni, R Besio, G Palladini, G Merlini, V Giansanti, IA Scovassi, S Villani, I Villa, A Villa, P Vezzoni, R Tenni, A Rossi, JC Marini, A Forlino |
Stem Cells | 2012 |
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Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
B Coupé, Y Ishii, MO Dietrich, M Komatsu, TL Horvath, SG Bouret |
Cell Metabolism | 2012 |
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Autophagy: a novel therapeutic target for kidney diseases
S Kume, T Uzu, H Maegawa, D Koya |
Clinical and Experimental Nephrology | 2012 |
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Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging
K Phadwal, AS Watson, AK Simon |
Cellular and Molecular Life Sciences | 2012 |
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Regulation of adipocyte autophagy--the potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I
S Wang, D Peng |
Lipids in Health and Disease | 2012 |
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Weighing on autophagy
B Coupé, SG Bouret |
Cell cycle (Georgetown, Tex.) | 2012 |
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The ghrelin O-acyltransferase–ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes
A Rodríguez, J Gómez-Ambrosi, V Catalán, F Rotellar, V Valentí, C Silva, C Mugueta, MR Pulido, R Vázquez, J Salvador, MM Malagón, I Colina, G Frühbeck |
Diabetologia | 2012 |
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Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner
E Bejarano, H Girao, A Yuste, B Patel, C Marques, DC Spray, P Pereira, AM Cuervo, T Yoshimori |
Molecular biology of the cell | 2012 |
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FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling
R Zechner, R Zimmermann, TO Eichmann, SD Kohlwein, G Haemmerle, A Lass, F Madeo |
Cell Metabolism | 2012 |
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Antiapoptotic and Antiautophagic Effects of Eicosapentaenoic Acid in Cardiac Myoblasts Exposed to Palmitic Acid
S Cetrullo, B Tantini, F Flamigni, C Pazzini, A Facchini, C Stefanelli, CM Caldarera, C Pignatti |
Nutrients | 2012 |
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Rab32 Is Important for Autophagy and Lipid Storage in Drosophila
C Wang, Z Liu, X Huang |
PloS one | 2012 |
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Circadian autophagy rhythm: a link between clock and metabolism?
D Ma, S Li, MM Molusky, JD Lin |
Trends in Endocrinology & Metabolism | 2012 |
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Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues
V Hernández-Gea, Z Ghiassi-Nejad, R Rozenfeld, R Gordon, MI Fiel, Z Yue, MJ Czaja, SL Friedman |
Gastroenterology | 2012 |
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Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes
MV Stankov, D Panayotova-Dimitrova, M Leverkus, RE Schmidt, GM Behrens |
Antimicrobial agents and chemotherapy | 2012 |
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Integration of cellular bioenergetics with mitochondrial quality control and autophagy
BG Hill, GA Benavides, JR Lancaster, S Ballinger, L Dell'Italia, Z Jianhua, VM Darley-Usmar |
Biological Chemistry | 2012 |
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Induction of autophagy is essential for monocyte-macrophage differentiation
Y Zhang, MJ Morgan, K Chen, S Choksi, Z Liu |
Blood | 2012 |
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Inflammatory cause of metabolic syndrome via brain stress and NF-κB
Cai D, Liu T |
Aging | 2012 |
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Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice
RY Yang, L Yu, JL Graham, DK Hsu, KC Lloyd, PJ Havel, FT Liu |
Proceedings of the National Academy of Sciences | 2011 |
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Comprehensive Physiology
R Terjung |
Comprehensive Physiology | 2011 |
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Functions of Autophagy in Hepatic and Pancreatic Physiology and Disease
MJ Czaja |
Gastroenterology | 2011 |
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Autophagy in nonalcoholic steatohepatitis
M Amir, MJ Czaja |
Expert Review of Gastroenterology & Hepatology | 2011 |
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Autophagic Degradation of Mitochondria in White Adipose Tissue Differentiation
SJ Goldman, Y Zhang, S Jin |
Antioxidants & Redox Signaling | 2011 |
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Autophagy in Tumorigenesis and Energy Metabolism: Friend by Day, Foe by Night
R Mathew, E White |
Current Opinion in Genetics & Development | 2011 |
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Autophagy and disease: always two sides to a problem
S Sridhar, Y Botbol, F Macian, AM Cuervo |
The Journal of Pathology | 2011 |
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Role of autophagy in cancer prevention
HY Chen, E White |
Cancer prevention research (Philadelphia, Pa.) | 2011 |
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Autophagy regulates myeloid cell differentiation by p62/SQSTM1-mediated degradation of PML-RARα oncoprotein
Z Wang, L Cao, R Kang, M Yang, L Liu, Y Zhao, Y Yu, M Xie, X Yin, KM Livesey, D Tang |
Autophagy | 2011 |
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Temporal orchestration of circadian autophagy rhythm by C/EBPβ
D Ma, S Panda, JD Lin |
The EMBO Journal | 2011 |
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Systems biology of the autophagy-lysosomal pathway
AG Jegga, L Schneider, X Ouyang, J Zhang |
Autophagy | 2011 |
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Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase
M Ouimet, V Franklin, E Mak, X Liao, I Tabas, YL Marcel |
Cell Metabolism | 2011 |
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Prolonged QT interval and lipid alterations beyond β-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts
R Gélinas, J Thompson-Legault, B Bouchard, C Daneault, A Mansour, MA Gillis, G Charron, V Gavino, F Labarthe, CD Rosiers |
American journal of physiology. Heart and circulatory physiology | 2011 |
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Autophagy in the Cellular Energetic Balance
R Singh, AM Cuervo |
Cell Metabolism | 2011 |
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A lipid-droplet-targeted O-GlcNAcase isoform is a key regulator of the proteasome
CN Keembiyehetty, A Krzeslak, DC Love, JA Hanover |
Journal of cell science | 2011 |
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REGULATION OF LIPID DROPLETS BY AUTOPHAGY
H Dong, MJ Czaja |
Trends in endocrinology and metabolism: TEM | 2011 |
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Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance
S Kaushik, JA Rodriguez-Navarro, E Arias, R Kiffin, S Sahu, GJ Schwartz, AM Cuervo, R Singh |
Cell Metabolism | 2011 |
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Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway*
Q Meng, D Cai |
The Journal of biological chemistry | 2011 |
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Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy
K Wang, J Niu, H Kim, PE Kolattukudy |
Journal of Molecular Cell Biology | 2011 |
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A differential autophagic response to hyperglycemia in the developing murine embryo
KL Adastra, MM Chi, JK Riley, KH Moley |
Reproduction | 2011 |
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Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes
S Mei, HM Ni, S Manley, A Bockus, KM Kassel, JP Luyendyk, BL Copple, WX Ding |
The Journal of pharmacology and experimental therapeutics | 2011 |
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Prdm16 determines the thermogenic program of subcutaneous white adipose tissue
Patrick Seale, Heather Conroe, Jennifer Estall, Shingo Kajimura, Andrea Frontini, Jeff Ishibashi, Paul Cohen, Saverio Cinti, Bruce M. Spiegelman |
Journal of Clinical Investigation | 2010 |
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Hepatocyte death: a clear and present danger
H Malhi, ME Guicciardi, GJ Gores |
Physiological reviews | 2010 |
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Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease
GS Hotamisligil |
Cell | 2010 |
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Contributions Of Adipocyte Lipid Metabolism To Body Fat Content And Implications For The Treatment Of Obesity
G Marcelin, S Chua |
Current Opinion in Pharmacology | 2010 |
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Sensory and Metabolic Control of Energy Balance
W Meyerhof, U Beisiegel, HG Joost |
2010 | |
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Role of autophagy in suppression of inflammation and cancer
E White, C Karp, AM Strohecker, Y Guo, R Mathew |
Current Opinion in Cell Biology | 2010 |
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Autophagy in mammalian development and differentiation
N Mizushima, B Levine |
Nature Cell Biology | 2010 |
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Autophagy and the degradation of mitochondria
SJ Goldman, R Taylor, Y Zhang, S Jin |
Mitochondrion | 2010 |
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Attenuated mTOR Signaling and Enhanced Autophagy in Adipocytes from Obese Patients with Type 2 Diabetes
A Ost, K Svensson, I Ruishalme, C Brännmark, N Franck, H Krook, P Sandström, P Kjolhede, P Strålfors |
Molecular Medicine | 2010 |
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Insulin Resistance, Inflammation, and Obesity: Role of Monocyte Chemoattractant Protein-1 (orCCL2) in the Regulation of Metabolism
A Rull, J Camps, C Alonso-Villaverde, J Joven |
Mediators of Inflammation | 2010 |
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The Aging Stress Response
MC Haigis, BA Yankner |
Molecular Cell | 2010 |
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Autophagic pathways and metabolic stress
S Kaushik, R Singh, AM Cuervo |
Diabetes, Obesity and Metabolism | 2010 |
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Autophagy and lipids: tightening the knot
JA Rodriguez-Navarro, AM Cuervo |
Seminars in Immunopathology | 2010 |
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Stressin' Sestrins take an aging fight
AV Budanov, JH Lee, M Karin |
EMBO Molecular Medicine | 2010 |
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Role and mechanism of pancreatic β-cell death in diabetes: The emerging role of autophagy
KA Kim, MS Lee |
Journal of Diabetes Investigation | 2010 |
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Autophagy in health and disease. 2. Regulation of lipid metabolism and storage by autophagy: pathophysiological implications
MJ Czaja |
American journal of physiology. Cell physiology | 2010 |
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Autophagy and Metabolism
JD Rabinowitz, E White |
Science (New York, N.Y.) | 2010 |
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Circadian clock-coordinated hepatic lipid metabolism: only transcriptional regulation?
Gachon F, Bonnefont X |
Aging | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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