IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have demonstrated a crucial role of IL-17 and IL-22 in protection against infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-γ. Analysis of Th1, Th2, and Th17 cytokine responses by cultured PBMCs from individuals in a cohort of subjects who developed KA or were protected against KA during a severe outbreak showed that IL-17 and IL-22 were strongly and independently associated with protection against KA. Our results suggest that, along with Th1 cytokines, IL-17 and IL-22 play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.
Maira G.R. Pitta, Audrey Romano, Sandrine Cabantous, Sandrine Henri, Awad Hammad, Bouréma Kouriba, Laurent Argiro, Musa el Kheir, Bruno Bucheton, Charles Mary, Sayda Hassan El-Safi, Alain Dessein
Title and authors | Publication | Year |
---|---|---|
An Insight Into Systemic Immune Response in Leishmania donovani Mediated Atypical Cutaneous Leishmaniasis in the New Endemic State of Himachal Pradesh, India
Thakur L, Madaan P, Jain A, Shankar V, Negi A, Chauhan SB, Sundar S, Singh OP, Jain M |
Frontiers in immunology | 2022 |
A Historic Review of the Role of CD4+ T-Cell Subsets in Development of the Immune Responses against Cutaneous and Visceral Leishmaniases
Alimohmmadian MH, Ajdary S, Bahrami F |
Iranian Biomedical Journal | 2022 |
IMMUNE RESPONSE UPON THE ADMINISTRATION OF RECOMBINANT PROTEIN ANTIBODIES Ag-38 KDa Mycobacterium tuberculosis AND RIFAMPICIN EX-VIVO
Raras TY, Fahrinda A, Yuliati, Nurhidayati DY, Sujuti H, Prawiro SR |
African Journal of Infectious Diseases | 2022 |
TREM-1 Expression on the Surface of Neutrophils in Patients With Visceral Leishmaniasis Is Associated With Immunopathogenesis
Bomfim LG, Magalhães LS, Rodrigues LS, Barreto AS, Santos CN, dos Santos PL, Corrêa CB, Fukutani KF, Filho DC, da Silva AM, Lipscomb MW, de Moura TR |
Frontiers in Cellular and Infection Microbiology | 2022 |
IL-17 and IL-17-producing cells in protection versus pathology
Mills KH |
Nature reviews. Immunology | 2022 |
Expression Profile of Genes Related to the Th17 Pathway in Macrophages Infected by Leishmania major and Leishmania amazonensis: The Use of Gene Regulatory Networks in Modeling This Pathway
Gonçalves LO, Pulido AF, Mathias FA, Enes AE, Carvalho MG, de Melo Resende D, Polak ME, Ruiz JC |
Frontiers in Cellular and Infection Microbiology | 2022 |
Comparison of serum cytokine levels in symptomatic and asymptomatic HIV-Leishmania coinfected individuals from a Brazilian visceral leishmaniasis endemic area
Guedes DL, da Silva ED, Castro MC, Júnior WL, Ibarra-Meneses AV, Tsoumanis A, Adriaensen W, van Griensven J, Pereira VR, de Medeiros ZM |
PLoS neglected tropical diseases | 2022 |
The role of mucosal-associated invariant T cells in visceral leishmaniasis
Moreira MD, Borges-Fernandes LO, Pascoal-Xavier MA, Ribeiro ÁL, Pereira VH, Pediongco T, Araújo MS, Teixeira-Carvalho A, de Carvalho AL, Mourão MV, Campos FA, Borges M, Carneiro M, Chen Z, Saunders E, McConville M, Tsuji M, McCluskey J, Martins-Filho OA, Eckle SB, Coelho-dos-Reis JG, Peruhype-Magalhães V |
Frontiers in immunology | 2022 |
Visceral Leishmaniasis after Anti-Interleukin 17A (IL-17A) Therapy in a Patient Affected by Psoriatic Arthritis.
Lupia T, Corcione S, Fornari V, Rizzello B, Bosio R, Brusa MT, De Rosa FG |
Tropical Medicine and Infectious Disease | 2022 |