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Maira G.R. Pitta, … , Sayda Hassan El-Safi, Alain Dessein
Published July 13, 2009
Citation Information: J Clin Invest. 2009;119(8):2379-2387. https://doi.org/10.1172/JCI38813.
Citation Information: J Clin Invest. 2009;119(8):2379-2387. https://doi.org/10.1172/JCI38813.
IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani
Abstract
IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have demonstrated a crucial role of IL-17 and IL-22 in protection against infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-γ. Analysis of Th1, Th2, and Th17 cytokine responses by cultured PBMCs from individuals in a cohort of subjects who developed KA or were protected against KA during a severe outbreak showed that IL-17 and IL-22 were strongly and independently associated with protection against KA. Our results suggest that, along with Th1 cytokines, IL-17 and IL-22 play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.
Authors
Maira G.R. Pitta, Audrey Romano, Sandrine Cabantous, Sandrine Henri, Awad Hammad, Bouréma Kouriba, Laurent Argiro, Musa el Kheir, Bruno Bucheton, Charles Mary, Sayda Hassan El-Safi, Alain Dessein
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PLoS neglected tropical diseases | 2014 |
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Dual Immune Modulatory Effect of Vitamin A in Human Visceral Leishmaniasis
Bruna L. Lima Maciel, Joanna Gardel Valverde, João Firmino Rodrigues-Neto, Francisco Freire-Neto, Tatjana S. L. Keesen, Selma Maria Bezerra Jeronimo |
PloS one | 2014 |
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A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments
WL dos-Santos, C Pagliari, LG Santos, VA Almeida, TL Silva, JJ Coutinho, T Souza, MI Duarte, LA de Freitas, CH Costa |
BMC Infectious Diseases | 2014 |
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Asymptomatic Leishmania Infection: A New Challenge for Leishmania Control
OP Singh, E Hasker, D Sacks, M Boelaert, S Sundar |
Clinical Infectious Diseases | 2014 |
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Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
DA Bermejo, SW Jackson, M Gorosito-Serran, EV Acosta-Rodriguez, MC Amezcua-Vesely, BD Sather, AK Singh, S Khim, J Mucci, D Liggitt, O Campetella, M Oukka, A Gruppi, DJ Rawlings |
Nature Immunology | 2013 |
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Analysis of localized immune responses reveals presence of Th17 and Treg cells in cutaneous leishmaniasis due to Leishmania tropica
GK Katara, A Raj, R Kumar, K Avishek, H Kaushal, NA Ansari, RA Bumb, P Salotra |
BMC Immunology | 2013 |
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Synthetic DNA vaccines: improved vaccine potency by electroporation and co-delivered genetic adjuvants
S Flingai, M Czerwonko, J Goodman, SB Kudchodkar, K Muthumani, DB Weiner |
Frontiers in immunology | 2013 |
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IL-17 mediates immunopathology in the absence of IL-10 following Leishmania major infection
C Gonzalez-Lombana, C Gimblet, O Bacellar, WW Oliveira, S Passos, LP Carvalho, M Goldschmidt, EM Carvalho, P Scott |
PLoS pathogens | 2013 |
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An early reduction in Treg cells correlates with enhanced local inflammation in cutaneous leishmaniasis in CCR6-deficient mice
T Barth, D Schmidt, C Botteron, TT Nguyen, U Ritter, DN Männel, A Lechner |
PloS one | 2012 |
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IL-22 Protects Against Liver Pathology and Lethality of an Experimental Blood-Stage Malaria Infection
B Mastelic, AP Rosario, M Veldhoen, JC Renauld, W Jarra, AM Sponaas, S Roetynck, B Stockinger, J Langhorne |
Frontiers in immunology | 2012 |
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Evidence for Involvement of Th17 Type Responses in Post Kala Azar Dermal Leishmaniasis (PKDL)
GK Katara, NA Ansari, A Singh, V Ramesh, P Salotra |
PLoS neglected tropical diseases | 2012 |
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Immunobiology of visceral leishmaniasis
R Kumar, S Nylén |
Frontiers in immunology | 2012 |
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Immunity to Visceral Leishmaniasis Using Genetically Defined Live-Attenuated Parasites
A Selvapandiyan, R Dey, S Gannavaram, I Lakhal-Naouar, R Duncan, P Salotra, HL Nakhasi |
Journal of Tropical Medicine | 2012 |
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T Helper1/T Helper2 Cells and Resistance/Susceptibility to Leishmania Infection: Is This Paradigm Still Relevant?
J Alexander, F Brombacher |
Frontiers in immunology | 2012 |
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Deficient Regulatory T Cell Activity and Low Frequency of IL-17-Producing T Cells Correlate with the Extent of Cardiomyopathy in Human Chagas' Disease
PM Guedes, FR Gutierrez, GK Silva, R Dellalibera-Joviliano, GJ Rodrigues, LM Bendhack, A Rassi, A Rassi, A Schmidt, BC Maciel, JA Neto, JS Silva |
PLoS neglected tropical diseases | 2012 |
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Vaccine Development Against Leishmania donovani
A Das, N Ali |
Frontiers in immunology | 2012 |
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Protective Immunity and Vaccination Against Cutaneous Leishmaniasis
I Okwor, Z Mou, D Liu, J Uzonna |
Frontiers in immunology | 2012 |
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Immunopathogenesis of non-healing American cutaneous leishmaniasis and progressive visceral leishmaniasis
L Soong, CA Henard, PC Melby |
Seminars in Immunopathology | 2012 |
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Protective and pathologic immune responses in human tegumentary leishmaniasis
LP Carvalho, S Passos, A Schriefer, EM Carvalho |
Frontiers in immunology | 2012 |
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Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol
J Ghosh, S Das, R Guha, D Ghosh, K Naskar, A Das, S Roy |
Journal of lipid research | 2012 |
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Previous exposure to a low infectious dose of Leishmania major exacerbates infection with Leishmania infantum in the susceptible BALB/c mouse
CS Nation, B Dondji, GA Stryker |
Parasitology Research | 2012 |
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IL-27 and IL-21 are Associated with T Cell IL-10 Responses in Human Visceral Leishmaniasis
NA Ansari, R Kumar, S Gautam, S Nylén, OP Singh, S Sundar, D Sacks |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
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Pathogenesis of Chagas' Disease: Parasite Persistence and Autoimmunity
AR Teixeira, MM Hecht, MC Guimaro, AO Sousa, N Nitz |
Clinical microbiology reviews | 2011 |
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IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection
R Novoa, O Bacellar, M Nascimento, TM Cardoso, R Ramasawmy, WN Oliveira, A Schriefer, EM Carvalho |
Parasite Immunology | 2011 |
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Evaluation of a broadly protective Chlamydia-cholera combination vaccine candidate
FO Eko, DN Okenu, UP Singh, Q He, C Black, JU Igietseme |
Vaccine | 2011 |
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Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
GF Sonnenberg, LA Fouser, D Artis |
Nature Immunology | 2011 |
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Restoration of immunocompetence and improved immune-dependent chemotherapy against leishmaniasis following inhibition of receptor tyrosine kinases
Jane Dalton, Asher Maroof, Benjamin Owens, Priyanka Narang, Katherine Johnson, Najmeeyah Brown, Lovisa Rosenquist, Lynette Beattie, Mark Coles, Paul M. Kaye |
Journal of Clinical Investigation | 2010 |
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The Th1 immune response to Plasmodium falciparum circumsporozoite protein is boosted by adenovirus vectors 35 and 26 with a homologous insert
K Radosevic, A Rodriguez, AA Lemckert, M der Meer, G Gillissen, C Warnar, R Eyben, MG Pau, J Goudsmit |
Clinical and vaccine immunology : CVI | 2010 |
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Th17 cytokines and vaccine-induced immunity
Y Lin, SR Slight, SA Khader |
Seminars in Immunopathology | 2010 |
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Immunological perspectives of leishmaniasis
S Nylén, S Gautam |
Journal of global infectious diseases | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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