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Citations to this article

Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice
Eric Camerer, … , Rajita Pappu, Shaun R. Coughlin
Eric Camerer, … , Rajita Pappu, Shaun R. Coughlin
Published June 15, 2009
Citation Information: J Clin Invest. 2009;119(7):1871-1879. https://doi.org/10.1172/JCI38575.
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Research Article Vascular biology

Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice

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Abstract

Maintenance of vascular integrity is critical for homeostasis, and temporally and spatially regulated vascular leak is a central feature of inflammation. Sphingosine-1-phosphate (S1P) can regulate endothelial barrier function, but the sources of the S1P that provide this activity in vivo and its importance in modulating different inflammatory responses are unknown. We report here that mutant mice engineered to selectively lack S1P in plasma displayed increased vascular leak and impaired survival after anaphylaxis, administration of platelet-activating factor (PAF) or histamine, and exposure to related inflammatory challenges. Increased leak was associated with increased interendothelial cell gaps in venules and was reversed by transfusion with wild-type erythrocytes (which restored plasma S1P levels) and by acute treatment with an agonist for the S1P receptor 1 (S1pr1). S1pr1 agonist did not protect wild-type mice from PAF-induced leak, consistent with plasma S1P levels being sufficient for S1pr1 activation in wild-type mice. However, an agonist for another endothelial cell Gi-coupled receptor, Par2, did protect wild-type mice from PAF-induced vascular leak, and systemic treatment with pertussis toxin prevented rescue by Par2 agonist and sensitized wild-type mice to leak-inducing stimuli in a manner that resembled the loss of plasma S1P. Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak. This pathway prevents lethal responses to leak-inducing mediators in mouse models.

Authors

Eric Camerer, Jean B. Regard, Ivo Cornelissen, Yoga Srinivasan, Daniel N. Duong, Daniel Palmer, Trung H. Pham, Jinny S. Wong, Rajita Pappu, Shaun R. Coughlin

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Circulation research 2016
Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function
Z Touat-Hamici, H Weidmann, Y Blum, C Proust, H Durand, F Iannacci, V Codoni, P Gaignard, P Thérond, M Civelek, SA Karabina, AJ Lusis, F Cambien, E Ninio
Cardiovascular Research 2016
Sphingosine 1-phosphate and its carrier apolipoprotein M in human sepsis and in Escherichia coli sepsis in baboons
C Frej, A Linder, KE Happonen, FB Taylor, F Lupu, B Dahlbäck
Journal of Cellular and Molecular Medicine 2016
Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases
EA Middleton, AS Weyrich, GA Zimmerman
Physiological reviews 2016
Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system
K Wang, R Xu, AJ Snider, J Schrandt, Y Li, AB Bialkowska, M Li, J Zhou, YA Hannun, LM Obeid, VW Yang, C Mao
Cell Death and Disease 2016
Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis
L Sasset, Y Zhang, TM Dunn, AD Lorenzo
Trends in Endocrinology & Metabolism 2016
Speciated High-Density Lipoprotein Biogenesis and Functionality
C Rosales, WS Davidson, BK Gillard, AM Gotto, HJ Pownall
Current Atherosclerosis Reports 2016
The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
L Jin, WR Liu, MX Tian, J Fan, YH Shi
World journal of surgical oncology 2016
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia
K Sun, Y Zhang, A DAlessandro, T Nemkov, A Song, H Wu, H Liu, M Adebiyi, A Huang, YE Wen, MV Bogdanov, A Vila, J OBrien, RE Kellems, W Dowhan, AW Subudhi, SJ Houten, CG Julian, AT Lovering, M Safo, KC Hansen, RC Roach, Y Xia
Nature Communications 2016
Oxidative Stress and Nuclear Factor κB (NF-κB) Increase Peritoneal Filtration and Contribute to Ascites Formation in Nephrotic Syndrome
K Udwan, G Brideau, M Fila, A Edwards, B Vogt, A Doucet
The Journal of biological chemistry 2016
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
HC Tsai, MH Han
Drugs 2016
Emerging biology of sphingosine-1-phosphate: Role in pathogenesis and therapy
Richard Proia, Timothy Hla
Journal of Clinical Investigation 2015
Decreased serum concentrations of sphingosine-1-phosphate in sepsis
MS Winkler, A Nierhaus, M Holzmann, E Mudersbach, A Bauer, L Robbe, C Zahrte, M Geffken, S Peine, E Schwedhelm, G Daum, S Kluge, C Zoellner
Critical Care 2015
Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation
S Mahajan-Thakur, A Böhm, G Jedlitschky, K Schrör, BH Rauch
Mediators of Inflammation 2015
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
S Vettorazzi, C Bode, L Dejager, L Frappart, E Shelest, C Klaßen, A Tasdogan, HM Reichardt, C Libert, M Schneider, F Weih, NH Uhlenhaut, JP David, M Gräler, A Kleiman, JP Tuckermann
Nature Communications 2015
The role of sphingolipids in endothelial barrier function
PL Jernigan, AT Makley, RS Hoehn, MJ Edwards, TA Pritts
Biological Chemistry 2015
Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury
SK Verma, BA Molitoris
Seminars in Nephrology 2015
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
C Nussbaum, S Bannenberg, P Keul, MH Gräler, CF Gonçalves-de-Albuquerque, H Korhonen, KW Lipinski, G Heusch, HC de Neto, I Rohwedder, JR Göthert, VP Prasad, G Haufe, B Lange-Sperandio, S Offermanns, M Sperandio, B Levkau
Nature Communications 2015
Blood cells and endothelial barrier function
SF Rodrigues, DN Granger
Tissue Barriers 2015
Contribution of pertussis toxin to the pathogenesis of pertussis disease: Graphical Abstract Figure
NH Carbonetti, D Rasko
Pathogens and Disease 2015
Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function
JM Kulinski, R Muñoz-Cano, A Olivera
European Journal of Pharmacology 2015
Platelets in Inflammation: Regulation of Leukocyte Activities and Vascular Repair
Aà Gros, Và Ollivier, Bà Ho-Tin-Noé
Frontiers in immunology 2015
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity in human and mice
K Sun, Y Zhang, MV Bogdanov, H Wu, A Song, J Li, W Dowhan, M Idowu, HS Juneja, JG Molina, MR Blackburn, RE Kellems, Y Xia
Blood 2015
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
A Checa, N Xu, DG Sar, JZ Haeggström, M Ståhle, CE Wheelock
Scientific Reports 2015
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure
A Cantalupo, Y Zhang, M Kothiya, S Galvani, H Obinata, M Bucci, FJ Giordano, XC Jiang, T Hla, AD Lorenzo
Nature Medicine 2015
Exit Strategies: S1P Signaling and T Cell Migration
A Baeyens, V Fang, C Chen, SR Schwab
Trends in Immunology 2015
The Lung Endothelial Barrier in Acute Inflammation
Müller-Redetzky HC, Lienau J, Witzenrath M
2015
Mapping Sphingosine-1-Phosphate Receptor 1 Activation in vivo
Mari Kono, Ana Tucker, Jennifer Tran, Jennifer Bergner, Ewa Turner, Richard Proia
Journal of Clinical Investigation 2014
Sexually dimorphic S1PR2 expression enhances susceptibility to CNS autoimmunity
Lillian Cruz-Orengo, Brian P. Daniels, Denise Dorsey, Sarah Alison Basak, Jose G. Grajales-Reyes, Erin E. McCandless, Laura Piccio, Robert E Schmidt, Anne H. Cross, Seth D. Crosby, Robyn S. Klein
Journal of Clinical Investigation 2014
Sphingosine-1-phosphate contributes to sickle cell disease by promoting sickling
Yujin Zhang, Vladimir Berka, Anren Song, Kaiqi Sun, Wei Wang, Weiru Zhang, Chen Ning, Chonghua Li, Qibo Zhang, Mikhail Bogdanov, Danny C Alexander, Michael Milburn, Mostafa H. Ahmed, Han Lin, Modupe Idowu, Jun Zhang, Gregory Kato, Osheiza Y Abdulmalik, Wenzheng Zhang, William Dowhan, Rodney E Kellems, Pumin Zhang, Jian-Ping Jin, Martin Safo, Ah-Lim Tsai, Harinder S Juneja, Yang Xia
Journal of Clinical Investigation 2014
Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production
V Hox, A Desai, G Bandara, AM Gilfillan, DD Metcalfe, A Olivera
Journal of Allergy and Clinical Immunology 2014
Lysophospholipid receptor nomenclature review: IUPHAR Review 8: Lysophospholipid receptor nomenclature
Y Kihara, M Maceyka, S Spiegel, J Chun
British Journal of Pharmacology 2014
The role of sphingosine-1-phosphate in endothelial barrier function
BA Wilkerson, KM Argraves
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2014
Imaging S1P1 activation in vivo
M Kono, RL Proia
Experimental Cell Research 2014
Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss
J Chen, N Ingham, J Kelly, S Jadeja, D Goulding, J Pass, VB Mahajan, SH Tsang, A Nijnik, IJ Jackson, JK White, A Forge, D Jagger, KP Steel, KB Avraham
PLoS genetics 2014
Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions
H Obinata, S Gutkind, J Stitham, T Okuno, T Yokomizo, J Hwa, T Hla
Journal of lipid research 2014
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
MB Oldstone, H Rosen
2014
Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives
HC Müller-Redetzky, N Suttorp, M Witzenrath
Cell and Tissue Research 2014
Sphingolipid metabolites in inflammatory disease
M Maceyka, S Spiegel
Nature 2014
Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier
A Nacer, A Movila, F Sohet, NM Girgis, UM Gundra, P Loke, R Daneman, U Frevert, JW Kazura
PLoS pathogens 2014
Current Topics in Microbiology and Immunology
M Bonelli, HY Shih, K Hirahara, K Singelton, A Laurence, A Poholek, T Hand, Y Mikami, G Vahedi, Y Kanno, JJ OShea
Current topics in microbiology and immunology 2014
To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase
GK Marathe, C Pandit, CL Lakshmikanth, VH Chaithra, SP Jacob, CJ D'Souza
Journal of lipid research 2014
Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung
AE LaBauve, MJ Wargo
PLoS pathogens 2014
Fingolimod for the treatment of neurological diseases—state of play and future perspectives
R Brunkhorst, R Vutukuri, W Pfeilschifter
Frontiers in cellular neuroscience 2014
Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
M Nagahashi, K Takabe, KP Terracina, D Soma, Y Hirose, T Kobayashi, Y Matsuda, T Wakai
BioMed Research International 2014
Intravital Imaging of Mesenchymal Stem Cell Trafficking and Association With Platelets and Neutrophils: Intravital Imaging of MSC Trafficking
GS Teo, Z Yang, CV Carman, JM Karp, CP Lin
Stem Cells 2014
Granule-mediated release of sphingosine-1-phosphate by activated platelets
D Jonnalagadda, M Sunkara, AJ Morris, SW Whiteheart
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2014
Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect
RH Adamson, JF Clark, M Radeva, A Kheirolomoom, KW Ferrara, FE Curry
American journal of physiology. Heart and circulatory physiology 2014
Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner
M Baranowski, AU Błachnio-Zabielska, M Charmas, JW Helge, F Dela, M Książek, B Długołęcka, A Klusiewicz, A Chabowski, J Górski
European Journal of Applied Physiology 2014
Mechanosensing at the Vascular Interface
JM Tarbell, SI Simon, FR Curry
Annual Review of Biomedical Engineering 2014
Differential Modulation of S1PR(1–5) and Specific Activities of SphK and nSMase in Pulmonary and Cerebral Tissues of Rats Exposed to Hypobaric Hypoxia
S Chawla, S Saxena
Lipids 2014
Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury
Y Zhao, Z Xiong, EJ Lechner, PA Klenotic, BJ Hamburg, M Hulver, A Khare, T Oriss, N Mangalmurti, Y Chan, Y Zhang, MA Ross, DB Stolz, MR Rosengart, J Pilewski, P Ray, A Ray, RL Silverstein, JS Lee
Mucosal Immunology 2013
Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction
I Darwish, WC Liles
Virulence 2013
Vascular permeability and drug delivery in cancers
S Azzi, JK Hebda, J Gavard
Frontiers in Oncology 2013
Microvascular permeability to water is independent of shear stress, but dependent on flow direction
RH Adamson, RK Sarai, A Altangerel, JF Clark, S Weinbaum, FE Curry
American journal of physiology. Heart and circulatory physiology 2013
Tonic regulation of vascular permeability
FR Curry, RH Adamson
Acta physiologica (Oxford, England) 2013
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2
BH Herzog, J Fu, SJ Wilson, PR Hess, A Sen, JM McDaniel, Y Pan, M Sheng, T Yago, R Silasi-Mansat, S McGee, F May, B Nieswandt, AJ Morris, F Lupu, SR Coughlin, RP McEver, H Chen, ML Kahn, L Xia
Nature 2013
Why Targeting HDL Should Work as a Therapeutic Tool, but Hasn’t:
MG Sorci-Thomas, MJ Thomas
Journal of Cardiovascular Pharmacology 2013
G Proteins Gα i1/3 Are Critical Targets for Bordetella pertussis Toxin-Induced Vasoactive Amine Sensitization
SA Diehl, B McElvany, R Noubade, N Seeberger, B Harding, K Spach, C Teuscher, SR Blanke
Infection and immunity 2013
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined
SE Dillahunt, JL Sargent, R Suzuki, RL Proia, A Gilfillan, J Rivera, A Olivera
Journal of immunology (Baltimore, Md. : 1950) 2013
Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression
A Olivera, Y Kitamura, LD Wright, ML Allende, W Chen, T Kaneko-Goto, Y Yoshihara, RL Proia, J Rivera
Journal of leukocyte biology 2013
The Acute Respiratory Distress Syndrome
Michael A. Matthay, Lorraine B. Ware, Guy Zimmerman
Journal of Clinical Investigation 2012
Sphingolipid Regulation of Tissue Fibrosis
BS Shea, AM Tager
The open rheumatology journal 2012
Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis
BS Shea, AM Tager
Proceedings of the American Thoracic Society 2012
New roles of HDL in inflammation and hematopoiesis
X Zhu, JS Parks
Annual Review of Nutrition 2012
Lipid phosphate phosphatase (LPP3) and vascular development
HM Ren, M Panchatcharam, P Mueller, D Escalante-Alcalde, AJ Morris, SS Smyth
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2012
Platelets in lung biology
AS Weyrich, GA Zimmerman
Annual Review of Physiology 2012
Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels
FE Curry, JF Clark, RH Adamson
American journal of physiology. Heart and circulatory physiology 2012
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia
M Bhattacharya, G Su, X Su, JA Oses-Prieto, JT Li, X Huang, H Hernandez, A Atakilit, AL Burlingame, MA Matthay, D Sheppard
American journal of physiology. Lung cellular and molecular physiology 2012
Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible
RH Adamson, RK Sarai, JF Clark, A Altangerel, TL Thirkill, FE Curry
American journal of physiology. Heart and circulatory physiology 2012
Role of FAK in S1P-regulated endothelial permeability
P Belvitch, SM Dudek
Microvascular Research 2012
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection
J Nunes, M Naymark, L Sauer, A Muhammad, H Keun, J Sturge, J Stebbing, J Waxman, D Pchejetski
British Journal of Cancer 2012
Myosin light chain kinase signaling in endothelial barrier dysfunction
RR Rigor, Q Shen, CD Pivetti, MH Wu, SY Yuan
Medicinal Research Reviews 2012
Shaping the landscape: Metabolic regulation of S1P gradients
A Olivera, ML Allende, RL Proia
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 2012
Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-Ocular Barrier
DA Copland, J Liu, LP Schewitz-Bowers, V Brinkmann, K Anderson, LB Nicholson, AD Dick
The American Journal of Pathology 2012
The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate
A Mendoza, B Bréart, WD Ramos-Perez, LA Pitt, M Gobert, M Sunkara, JJ Lafaille, AJ Morris, SR Schwab
Cell Reports 2012
Sphingosine 1-Phosphate as a Therapeutic Target in Heart Failure: More Questions Than Answers
DL Mann
Circulation 2012
Allosteric Modulation of Protease-activated Receptor Signaling
Canto I, Soh UJ, Trejo J
Mini reviews in medicinal chemistry 2012
Engagement of S1P1 receptor degradative mechanisms leads to vascular leak in mice
Myat Lin Oo, Sung-Hee Chang, Shobha Thangada, Ming-Tao Wu, M Karim Rezaul, Victoria Blaho, Sun-il Hwang, David Han, Timothy Hla
Journal of Clinical Investigation 2011
S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
KM Argraves, AA Sethi, PJ Gazzolo, BA Wilkerson, AT Remaley, A Tybjaerg-Hansen, BG Nordestgaard, SD Yeatts, KS Nicholas, JL Barth, WS Argraves
Lipids in Health and Disease 2011
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
PR Kvietys, DN Granger
Free radical biology & medicine 2011
Sphingosine 1-phosphate in coagulation and inflammation
H Obinata, T Hla
Seminars in Immunopathology 2011
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
C Christoffersen, H Obinata, SB Kumaraswamy, S Galvani, J Ahnström, M Sevvana, C Egerer-Sieber, YA Muller, T Hla, LB Nielsen, B Dahlbäck
Proceedings of the National Academy of Sciences 2011
Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors
VA Blaho, T Hla
Chemical Reviews 2011
The outs and the ins of sphingosine-1-phosphate in immunity
S Spiegel, S Milstien
Nature reviews. Immunology 2011
Mast Cell Biology
AM Gilfillan, DD Metcalfe
2011
Potential Agents against Plasma Leakage
JA Pawitan
ISRN Pharmacology 2011
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation
G Su, A Atakilit, JT Li, N Wu, M Bhattacharya, J Zhu, JE Shieh, E Li, R Chen, S Sun, CP Su, D Sheppard
American journal of respiratory and critical care medicine 2011
Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis
A Skoura, J Michaud, DS Im, S Thangada, Y Xiong, JD Smith, T Hla
Arteriosclerosis, thrombosis, and vascular biology 2011
Pericyte-Derived Sphinogosine 1-Phosphate Induces the Expression of Adhesion Proteins and Modulates the Retinal Endothelial Cell Barrier
PG McGuire, S Rangasamy, J Maestas, A Das
Arteriosclerosis, thrombosis, and vascular biology 2011
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
A Vieira-de-Abreu, RA Campbell, AS Weyrich, GA Zimmerman
Seminars in Immunopathology 2011
Free Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Reduces Retinal Vascular Permeability in Association with a Reduction of Acid Sphingomyelinase (ASMase)
JL Kielczewski, SL Calzi, LC Shaw, J Cai, X Qi, Q Ruan, L Wu, L Liu, P Hu, T Chan-Ling, RN Mames, S Firth, RC Baxter, P Turowski, JV Busik, ME Boulton, MB Grant
Investigative ophthalmology & visual science 2011
Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration
RA Sabbadini
British Journal of Pharmacology 2011
How platelets safeguard vascular integrity
B Ho-Tin-Noé, M Demers, DD Wagner
Journal of Thrombosis and Haemostasis 2011
Sphingosine-1-phosphate signaling and its role in disease
M Maceyka, KB Harikumar, S Milstien, S Spiegel
Trends in Cell Biology 2011
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds
UJ Soh, JA Trejo
Proceedings of the National Academy of Sciences 2011
Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions
S Selim, M Sunkara, AK Salous, SW Leung, EV Berdyshev, A Bailey, CL Campbell, R Charnigo, AJ Morris, SS Smyth
Clinical science (London, England : 1979) 2011
Lipid phosphate phosphatase 3 enables efficient thymic egress
B Bréart, WD Ramos-Perez, A Mendoza, AK Salous, M Gobert, Y Huang, RH Adams, JJ Lafaille, D Escalante-Alcalde, AJ Morris, SR Schwab
Journal of Experimental Medicine 2011
Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis
Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y
Pharmaceuticals 2011
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock
Ana Olivera, Christoph Eisner, Yoshiaki Kitamura, Sandra Dillahunt, Laura Allende, Galina Tuymetova, Wendy Watford, Francoise Meylan, Susanne Diesner, Lingli Li, Jurgen Schnermann, Richard Proia, Juan Rivera
Journal of Clinical Investigation 2010
The Efficacy of Activated Protein C in Murine Endotoxemia Is Dependent on Integrin CD11b
Chunzhang Cao, Yamei Gao, Yang Li, Toni Antalis, Francis Castellino, Li Zhang
Journal of Clinical Investigation 2010
Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury
BS Shea, SF Brooks, BA Fontaine, J Chun, AD Luster, AM Tager
American journal of respiratory cell and molecular biology 2010
Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation
AJ Snider, KA Gandy, LM Obeid
Biochimie 2010
Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
X Sun, SF Ma, MS Wade, C Flores, M Pino-Yanes, J Moitra, C Ober, R Kittles, AN Husain, JG Ford, JG Garcia
Journal of Allergy and Clinical Immunology 2010
Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
CA Oskeritzian, MM Price, NC Hait, D Kapitonov, YT Falanga, JK Morales, JJ Ryan, S Milstien, S Spiegel
Journal of Experimental Medicine 2010
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
TH Pham, P Baluk, Y Xu, I Grigorova, AJ Bankovich, R Pappu, SR Coughlin, DM McDonald, SR Schwab, JG Cyster
Journal of Experimental Medicine 2010
Interface between hemostasis and adaptive immunity
Z Qu, EL Chaikof
Current Opinion in Immunology 2010
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses
CC Yost, AS Weyrich, GA Zimmerman
Biochimie 2010
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury
A Di, T Kawamura, XP Gao, H Tang, E Berdyshev, SM Vogel, YY Zhao, T Sharma, K Bachmaier, J Xu, AB Malik
The Journal of biological chemistry 2010
Vascular permeability to plasma, plasma proteins, and cells: an update
HF Dvorak
Current Opinion in Hematology 2010
Sphingosine 1-phosphate and immune regulation: trafficking and beyond
H Chi
Trends in Pharmacological Sciences 2010
Blood sphingolipidomics in healthy humans: impact of sample collection methodology
SM Hammad, JS Pierce, F Soodavar, KJ Smith, MM Gadban, B Rembiesa, RL Klein, YA Hannun, J Bielawski, A Bielawska
Journal of lipid research 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells
T Hla
Circulation research 2009
Coughing Precipitated by Bordetella pertussis Infection
M Hewitt, BJ Canning
Lung 2009

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