Maintenance of vascular integrity is critical for homeostasis, and temporally and spatially regulated vascular leak is a central feature of inflammation. Sphingosine-1-phosphate (S1P) can regulate endothelial barrier function, but the sources of the S1P that provide this activity in vivo and its importance in modulating different inflammatory responses are unknown. We report here that mutant mice engineered to selectively lack S1P in plasma displayed increased vascular leak and impaired survival after anaphylaxis, administration of platelet-activating factor (PAF) or histamine, and exposure to related inflammatory challenges. Increased leak was associated with increased interendothelial cell gaps in venules and was reversed by transfusion with wild-type erythrocytes (which restored plasma S1P levels) and by acute treatment with an agonist for the S1P receptor 1 (S1pr1). S1pr1 agonist did not protect wild-type mice from PAF-induced leak, consistent with plasma S1P levels being sufficient for S1pr1 activation in wild-type mice. However, an agonist for another endothelial cell Gi-coupled receptor, Par2, did protect wild-type mice from PAF-induced vascular leak, and systemic treatment with pertussis toxin prevented rescue by Par2 agonist and sensitized wild-type mice to leak-inducing stimuli in a manner that resembled the loss of plasma S1P. Our results suggest that the blood communicates with blood vessels via plasma S1P to maintain vascular integrity and regulate vascular leak. This pathway prevents lethal responses to leak-inducing mediators in mouse models.
Eric Camerer, Jean B. Regard, Ivo Cornelissen, Yoga Srinivasan, Daniel N. Duong, Daniel Palmer, Trung H. Pham, Jinny S. Wong, Rajita Pappu, Shaun R. Coughlin
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K Udwan, G Brideau, M Fila, A Edwards, B Vogt, A Doucet |
The Journal of biological chemistry | 2016 |
Sphingosine-1-Phosphate (S1P) and S1P Signaling Pathway: Therapeutic Targets in Autoimmunity and Inflammation
HC Tsai, MH Han |
Drugs | 2016 |
Emerging biology of sphingosine-1-phosphate: Role in pathogenesis and therapy
Richard Proia, Timothy Hla |
Journal of Clinical Investigation | 2015 |
Decreased serum concentrations of sphingosine-1-phosphate in sepsis
MS Winkler, A Nierhaus, M Holzmann, E Mudersbach, A Bauer, L Robbe, C Zahrte, M Geffken, S Peine, E Schwedhelm, G Daum, S Kluge, C Zoellner |
Critical Care | 2015 |
Sphingosine-1-Phosphate and Its Receptors: A Mutual Link between Blood Coagulation and Inflammation
S Mahajan-Thakur, A Böhm, G Jedlitschky, K Schrör, BH Rauch |
Mediators of Inflammation | 2015 |
Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1
S Vettorazzi, C Bode, L Dejager, L Frappart, E Shelest, C Klaßen, A Tasdogan, HM Reichardt, C Libert, M Schneider, F Weih, NH Uhlenhaut, JP David, M Gräler, A Kleiman, JP Tuckermann |
Nature Communications | 2015 |
The role of sphingolipids in endothelial barrier function
PL Jernigan, AT Makley, RS Hoehn, MJ Edwards, TA Pritts |
Biological Chemistry | 2015 |
Renal Endothelial Injury and Microvascular Dysfunction in Acute Kidney Injury
SK Verma, BA Molitoris |
Seminars in Nephrology | 2015 |
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
C Nussbaum, S Bannenberg, P Keul, MH Gräler, CF Gonçalves-de-Albuquerque, H Korhonen, KW Lipinski, G Heusch, HC de Neto, I Rohwedder, JR Göthert, VP Prasad, G Haufe, B Lange-Sperandio, S Offermanns, M Sperandio, B Levkau |
Nature Communications | 2015 |
Blood cells and endothelial barrier function
SF Rodrigues, DN Granger |
Tissue Barriers | 2015 |
Contribution of pertussis toxin to the pathogenesis of pertussis disease: Graphical Abstract Figure
NH Carbonetti, D Rasko |
Pathogens and Disease | 2015 |
Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function
JM Kulinski, R Muñoz-Cano, A Olivera |
European Journal of Pharmacology | 2015 |
Platelets in Inflammation: Regulation of Leukocyte Activities and Vascular Repair
Aà Gros, Và Ollivier, Bà Ho-Tin-Noé |
Frontiers in immunology | 2015 |
Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity in human and mice
K Sun, Y Zhang, MV Bogdanov, H Wu, A Song, J Li, W Dowhan, M Idowu, HS Juneja, JG Molina, MR Blackburn, RE Kellems, Y Xia |
Blood | 2015 |
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
A Checa, N Xu, DG Sar, JZ Haeggström, M Ståhle, CE Wheelock |
Scientific Reports | 2015 |
Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure
A Cantalupo, Y Zhang, M Kothiya, S Galvani, H Obinata, M Bucci, FJ Giordano, XC Jiang, T Hla, AD Lorenzo |
Nature Medicine | 2015 |
Exit Strategies: S1P Signaling and T Cell Migration
A Baeyens, V Fang, C Chen, SR Schwab |
Trends in Immunology | 2015 |
The Lung Endothelial Barrier in Acute Inflammation
Müller-Redetzky HC, Lienau J, Witzenrath M |
2015 | |
Mapping Sphingosine-1-Phosphate Receptor 1 Activation in vivo
Mari Kono, Ana Tucker, Jennifer Tran, Jennifer Bergner, Ewa Turner, Richard Proia |
Journal of Clinical Investigation | 2014 |
Sexually dimorphic S1PR2 expression enhances susceptibility to CNS autoimmunity
Lillian Cruz-Orengo, Brian P. Daniels, Denise Dorsey, Sarah Alison Basak, Jose G. Grajales-Reyes, Erin E. McCandless, Laura Piccio, Robert E Schmidt, Anne H. Cross, Seth D. Crosby, Robyn S. Klein |
Journal of Clinical Investigation | 2014 |
Sphingosine-1-phosphate contributes to sickle cell disease by promoting sickling
Yujin Zhang, Vladimir Berka, Anren Song, Kaiqi Sun, Wei Wang, Weiru Zhang, Chen Ning, Chonghua Li, Qibo Zhang, Mikhail Bogdanov, Danny C Alexander, Michael Milburn, Mostafa H. Ahmed, Han Lin, Modupe Idowu, Jun Zhang, Gregory Kato, Osheiza Y Abdulmalik, Wenzheng Zhang, William Dowhan, Rodney E Kellems, Pumin Zhang, Jian-Ping Jin, Martin Safo, Ah-Lim Tsai, Harinder S Juneja, Yang Xia |
Journal of Clinical Investigation | 2014 |
Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production
V Hox, A Desai, G Bandara, AM Gilfillan, DD Metcalfe, A Olivera |
Journal of Allergy and Clinical Immunology | 2014 |
Lysophospholipid receptor nomenclature review: IUPHAR Review 8: Lysophospholipid receptor nomenclature
Y Kihara, M Maceyka, S Spiegel, J Chun |
British Journal of Pharmacology | 2014 |
The role of sphingosine-1-phosphate in endothelial barrier function
BA Wilkerson, KM Argraves |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
Imaging S1P1 activation in vivo
M Kono, RL Proia |
Experimental Cell Research | 2014 |
Spinster Homolog 2 (Spns2) Deficiency Causes Early Onset Progressive Hearing Loss
J Chen, N Ingham, J Kelly, S Jadeja, D Goulding, J Pass, VB Mahajan, SH Tsang, A Nijnik, IJ Jackson, JK White, A Forge, D Jagger, KP Steel, KB Avraham |
PLoS genetics | 2014 |
Individual variation of human S1P1 coding sequence leads to heterogeneity in receptor function and drug interactions
H Obinata, S Gutkind, J Stitham, T Okuno, T Yokomizo, J Hwa, T Hla |
Journal of lipid research | 2014 |
Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases
MB Oldstone, H Rosen |
2014 | |
Dynamics of pulmonary endothelial barrier function in acute inflammation: mechanisms and therapeutic perspectives
HC Müller-Redetzky, N Suttorp, M Witzenrath |
Cell and Tissue Research | 2014 |
Sphingolipid metabolites in inflammatory disease
M Maceyka, S Spiegel |
Nature | 2014 |
Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier
A Nacer, A Movila, F Sohet, NM Girgis, UM Gundra, P Loke, R Daneman, U Frevert, JW Kazura |
PLoS pathogens | 2014 |
Current Topics in Microbiology and Immunology
M Bonelli, HY Shih, K Hirahara, K Singelton, A Laurence, A Poholek, T Hand, Y Mikami, G Vahedi, Y Kanno, JJ OShea |
Current topics in microbiology and immunology | 2014 |
To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase
GK Marathe, C Pandit, CL Lakshmikanth, VH Chaithra, SP Jacob, CJ D'Souza |
Journal of lipid research | 2014 |
Detection of host-derived sphingosine by Pseudomonas aeruginosa is important for survival in the murine lung
AE LaBauve, MJ Wargo |
PLoS pathogens | 2014 |
Fingolimod for the treatment of neurological diseases—state of play and future perspectives
R Brunkhorst, R Vutukuri, W Pfeilschifter |
Frontiers in cellular neuroscience | 2014 |
Sphingosine-1-Phosphate Transporters as Targets for Cancer Therapy
M Nagahashi, K Takabe, KP Terracina, D Soma, Y Hirose, T Kobayashi, Y Matsuda, T Wakai |
BioMed Research International | 2014 |
Intravital Imaging of Mesenchymal Stem Cell Trafficking and Association With Platelets and Neutrophils: Intravital Imaging of MSC Trafficking
GS Teo, Z Yang, CV Carman, JM Karp, CP Lin |
Stem Cells | 2014 |
Granule-mediated release of sphingosine-1-phosphate by activated platelets
D Jonnalagadda, M Sunkara, AJ Morris, SW Whiteheart |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2014 |
Albumin modulates S1P delivery from red blood cells in perfused microvessels: mechanism of the protein effect
RH Adamson, JF Clark, M Radeva, A Kheirolomoom, KW Ferrara, FE Curry |
American journal of physiology. Heart and circulatory physiology | 2014 |
Exercise increases sphingoid base-1-phosphate levels in human blood and skeletal muscle in a time- and intensity-dependent manner
M Baranowski, AU Błachnio-Zabielska, M Charmas, JW Helge, F Dela, M Książek, B Długołęcka, A Klusiewicz, A Chabowski, J Górski |
European Journal of Applied Physiology | 2014 |
Mechanosensing at the Vascular Interface
JM Tarbell, SI Simon, FR Curry |
Annual Review of Biomedical Engineering | 2014 |
Differential Modulation of S1PR(1–5) and Specific Activities of SphK and nSMase in Pulmonary and Cerebral Tissues of Rats Exposed to Hypobaric Hypoxia
S Chawla, S Saxena |
Lipids | 2014 |
Thrombospondin-1 triggers macrophage IL-10 production and promotes resolution of experimental lung injury
Y Zhao, Z Xiong, EJ Lechner, PA Klenotic, BJ Hamburg, M Hulver, A Khare, T Oriss, N Mangalmurti, Y Chan, Y Zhang, MA Ross, DB Stolz, MR Rosengart, J Pilewski, P Ray, A Ray, RL Silverstein, JS Lee |
Mucosal Immunology | 2013 |
Emerging therapeutic strategies to prevent infection-related microvascular endothelial activation and dysfunction
I Darwish, WC Liles |
Virulence | 2013 |
Vascular permeability and drug delivery in cancers
S Azzi, JK Hebda, J Gavard |
Frontiers in Oncology | 2013 |
Microvascular permeability to water is independent of shear stress, but dependent on flow direction
RH Adamson, RK Sarai, A Altangerel, JF Clark, S Weinbaum, FE Curry |
American journal of physiology. Heart and circulatory physiology | 2013 |
Tonic regulation of vascular permeability
FR Curry, RH Adamson |
Acta physiologica (Oxford, England) | 2013 |
Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2
BH Herzog, J Fu, SJ Wilson, PR Hess, A Sen, JM McDaniel, Y Pan, M Sheng, T Yago, R Silasi-Mansat, S McGee, F May, B Nieswandt, AJ Morris, F Lupu, SR Coughlin, RP McEver, H Chen, ML Kahn, L Xia |
Nature | 2013 |
Why Targeting HDL Should Work as a Therapeutic Tool, but Hasn’t:
MG Sorci-Thomas, MJ Thomas |
Journal of Cardiovascular Pharmacology | 2013 |
G Proteins Gα i1/3 Are Critical Targets for Bordetella pertussis Toxin-Induced Vasoactive Amine Sensitization
SA Diehl, B McElvany, R Noubade, N Seeberger, B Harding, K Spach, C Teuscher, SR Blanke |
Infection and immunity | 2013 |
Usage of sphingosine kinase isoforms in mast cells is species and/or cell type determined
SE Dillahunt, JL Sargent, R Suzuki, RL Proia, A Gilfillan, J Rivera, A Olivera |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression
A Olivera, Y Kitamura, LD Wright, ML Allende, W Chen, T Kaneko-Goto, Y Yoshihara, RL Proia, J Rivera |
Journal of leukocyte biology | 2013 |
The Acute Respiratory Distress Syndrome
Michael A. Matthay, Lorraine B. Ware, Guy Zimmerman |
Journal of Clinical Investigation | 2012 |
Sphingolipid Regulation of Tissue Fibrosis
BS Shea, AM Tager |
The open rheumatology journal | 2012 |
Role of the Lysophospholipid Mediators Lysophosphatidic Acid and Sphingosine 1-Phosphate in Lung Fibrosis
BS Shea, AM Tager |
Proceedings of the American Thoracic Society | 2012 |
New roles of HDL in inflammation and hematopoiesis
X Zhu, JS Parks |
Annual Review of Nutrition | 2012 |
Lipid phosphate phosphatase (LPP3) and vascular development
HM Ren, M Panchatcharam, P Mueller, D Escalante-Alcalde, AJ Morris, SS Smyth |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 |
Platelets in lung biology
AS Weyrich, GA Zimmerman |
Annual Review of Physiology | 2012 |
Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels
FE Curry, JF Clark, RH Adamson |
American journal of physiology. Heart and circulatory physiology | 2012 |
IQGAP1 is necessary for pulmonary vascular barrier protection in murine acute lung injury and pneumonia
M Bhattacharya, G Su, X Su, JA Oses-Prieto, JT Li, X Huang, H Hernandez, A Atakilit, AL Burlingame, MA Matthay, D Sheppard |
American journal of physiology. Lung cellular and molecular physiology | 2012 |
Attenuation by sphingosine-1-phosphate of rat microvessel acute permeability response to bradykinin is rapidly reversible
RH Adamson, RK Sarai, JF Clark, A Altangerel, TL Thirkill, FE Curry |
American journal of physiology. Heart and circulatory physiology | 2012 |
Role of FAK in S1P-regulated endothelial permeability
P Belvitch, SM Dudek |
Microvascular Research | 2012 |
Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection
J Nunes, M Naymark, L Sauer, A Muhammad, H Keun, J Sturge, J Stebbing, J Waxman, D Pchejetski |
British Journal of Cancer | 2012 |
Myosin light chain kinase signaling in endothelial barrier dysfunction
RR Rigor, Q Shen, CD Pivetti, MH Wu, SY Yuan |
Medicinal Research Reviews | 2012 |
Shaping the landscape: Metabolic regulation of S1P gradients
A Olivera, ML Allende, RL Proia |
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids | 2012 |
Therapeutic Dosing of Fingolimod (FTY720) Prevents Cell Infiltration, Rapidly Suppresses Ocular Inflammation, and Maintains the Blood-Ocular Barrier
DA Copland, J Liu, LP Schewitz-Bowers, V Brinkmann, K Anderson, LB Nicholson, AD Dick |
The American Journal of Pathology | 2012 |
The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate
A Mendoza, B Bréart, WD Ramos-Perez, LA Pitt, M Gobert, M Sunkara, JJ Lafaille, AJ Morris, SR Schwab |
Cell Reports | 2012 |
Sphingosine 1-Phosphate as a Therapeutic Target in Heart Failure: More Questions Than Answers
DL Mann |
Circulation | 2012 |
Allosteric Modulation of Protease-activated Receptor Signaling
Canto I, Soh UJ, Trejo J |
Mini reviews in medicinal chemistry | 2012 |
Engagement of S1P1 receptor degradative mechanisms leads to vascular leak in mice
Myat Lin Oo, Sung-Hee Chang, Shobha Thangada, Ming-Tao Wu, M Karim Rezaul, Victoria Blaho, Sun-il Hwang, David Han, Timothy Hla |
Journal of Clinical Investigation | 2011 |
S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
KM Argraves, AA Sethi, PJ Gazzolo, BA Wilkerson, AT Remaley, A Tybjaerg-Hansen, BG Nordestgaard, SD Yeatts, KS Nicholas, JL Barth, WS Argraves |
Lipids in Health and Disease | 2011 |
Role of reactive oxygen and nitrogen species in the vascular responses to inflammation
PR Kvietys, DN Granger |
Free radical biology & medicine | 2011 |
Sphingosine 1-phosphate in coagulation and inflammation
H Obinata, T Hla |
Seminars in Immunopathology | 2011 |
Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
C Christoffersen, H Obinata, SB Kumaraswamy, S Galvani, J Ahnström, M Sevvana, C Egerer-Sieber, YA Muller, T Hla, LB Nielsen, B Dahlbäck |
Proceedings of the National Academy of Sciences | 2011 |
Regulation of Mammalian Physiology, Development, and Disease by the Sphingosine 1-Phosphate and Lysophosphatidic Acid Receptors
VA Blaho, T Hla |
Chemical Reviews | 2011 |
The outs and the ins of sphingosine-1-phosphate in immunity
S Spiegel, S Milstien |
Nature reviews. Immunology | 2011 |
Mast Cell Biology
AM Gilfillan, DD Metcalfe |
2011 | |
Potential Agents against Plasma Leakage
JA Pawitan |
ISRN Pharmacology | 2011 |
Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation
G Su, A Atakilit, JT Li, N Wu, M Bhattacharya, J Zhu, JE Shieh, E Li, R Chen, S Sun, CP Su, D Sheppard |
American journal of respiratory and critical care medicine | 2011 |
Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis
A Skoura, J Michaud, DS Im, S Thangada, Y Xiong, JD Smith, T Hla |
Arteriosclerosis, thrombosis, and vascular biology | 2011 |
Pericyte-Derived Sphinogosine 1-Phosphate Induces the Expression of Adhesion Proteins and Modulates the Retinal Endothelial Cell Barrier
PG McGuire, S Rangasamy, J Maestas, A Das |
Arteriosclerosis, thrombosis, and vascular biology | 2011 |
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
A Vieira-de-Abreu, RA Campbell, AS Weyrich, GA Zimmerman |
Seminars in Immunopathology | 2011 |
Free Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Reduces Retinal Vascular Permeability in Association with a Reduction of Acid Sphingomyelinase (ASMase)
JL Kielczewski, SL Calzi, LC Shaw, J Cai, X Qi, Q Ruan, L Wu, L Liu, P Hu, T Chan-Ling, RN Mames, S Firth, RC Baxter, P Turowski, JV Busik, ME Boulton, MB Grant |
Investigative ophthalmology & visual science | 2011 |
Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration
RA Sabbadini |
British Journal of Pharmacology | 2011 |
How platelets safeguard vascular integrity
B Ho-Tin-Noé, M Demers, DD Wagner |
Journal of Thrombosis and Haemostasis | 2011 |
Sphingosine-1-phosphate signaling and its role in disease
M Maceyka, KB Harikumar, S Milstien, S Spiegel |
Trends in Cell Biology | 2011 |
Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through β-arrestin and dishevelled-2 scaffolds
UJ Soh, JA Trejo |
Proceedings of the National Academy of Sciences | 2011 |
Plasma levels of sphingosine 1-phosphate are strongly correlated with haematocrit, but variably restored by red blood cell transfusions
S Selim, M Sunkara, AK Salous, SW Leung, EV Berdyshev, A Bailey, CL Campbell, R Charnigo, AJ Morris, SS Smyth |
Clinical science (London, England : 1979) | 2011 |
Lipid phosphate phosphatase 3 enables efficient thymic egress
B Bréart, WD Ramos-Perez, A Mendoza, AK Salous, M Gobert, Y Huang, RH Adams, JJ Lafaille, D Escalante-Alcalde, AJ Morris, SR Schwab |
Journal of Experimental Medicine | 2011 |
Sphingosine-1-Phosphate-Specific G Protein-Coupled Receptors as Novel Therapeutic Targets for Atherosclerosis
Okamoto Y, Wang F, Yoshioka K, Takuwa N, Takuwa Y |
Pharmaceuticals | 2011 |
Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock
Ana Olivera, Christoph Eisner, Yoshiaki Kitamura, Sandra Dillahunt, Laura Allende, Galina Tuymetova, Wendy Watford, Francoise Meylan, Susanne Diesner, Lingli Li, Jurgen Schnermann, Richard Proia, Juan Rivera |
Journal of Clinical Investigation | 2010 |
The Efficacy of Activated Protein C in Murine Endotoxemia Is Dependent on Integrin CD11b
Chunzhang Cao, Yamei Gao, Yang Li, Toni Antalis, Francis Castellino, Li Zhang |
Journal of Clinical Investigation | 2010 |
Prolonged Exposure to Sphingosine 1–Phosphate Receptor-1 Agonists Exacerbates Vascular Leak, Fibrosis, and Mortality after Lung Injury
BS Shea, SF Brooks, BA Fontaine, J Chun, AD Luster, AM Tager |
American journal of respiratory cell and molecular biology | 2010 |
Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation
AJ Snider, KA Gandy, LM Obeid |
Biochimie | 2010 |
Functional variants of the sphingosine-1-phosphate receptor 1 gene associate with asthma susceptibility
X Sun, SF Ma, MS Wade, C Flores, M Pino-Yanes, J Moitra, C Ober, R Kittles, AN Husain, JG Ford, JG Garcia |
Journal of Allergy and Clinical Immunology | 2010 |
Essential roles of sphingosine-1-phosphate receptor 2 in human mast cell activation, anaphylaxis, and pulmonary edema
CA Oskeritzian, MM Price, NC Hait, D Kapitonov, YT Falanga, JK Morales, JJ Ryan, S Milstien, S Spiegel |
Journal of Experimental Medicine | 2010 |
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
TH Pham, P Baluk, Y Xu, I Grigorova, AJ Bankovich, R Pappu, SR Coughlin, DM McDonald, SR Schwab, JG Cyster |
Journal of Experimental Medicine | 2010 |
Interface between hemostasis and adaptive immunity
Z Qu, EL Chaikof |
Current Opinion in Immunology | 2010 |
The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses
CC Yost, AS Weyrich, GA Zimmerman |
Biochimie | 2010 |
A novel function of sphingosine kinase 1 suppression of JNK activity in preventing inflammation and injury
A Di, T Kawamura, XP Gao, H Tang, E Berdyshev, SM Vogel, YY Zhao, T Sharma, K Bachmaier, J Xu, AB Malik |
The Journal of biological chemistry | 2010 |
Vascular permeability to plasma, plasma proteins, and cells: an update
HF Dvorak |
Current Opinion in Hematology | 2010 |
Sphingosine 1-phosphate and immune regulation: trafficking and beyond
H Chi |
Trends in Pharmacological Sciences | 2010 |
Blood sphingolipidomics in healthy humans: impact of sample collection methodology
SM Hammad, JS Pierce, F Soodavar, KJ Smith, MM Gadban, B Rembiesa, RL Klein, YA Hannun, J Bielawski, A Bielawska |
Journal of lipid research | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells
T Hla |
Circulation research | 2009 |
Coughing Precipitated by Bordetella pertussis Infection
M Hewitt, BJ Canning |
Lung | 2009 |