Targeted electrode-based modulation of neural circuits for depression
Helen S. Mayberg
Helen S. Mayberg
Published April 1, 2009
Citation Information: J Clin Invest. 2009;119(4):717-725. https://doi.org/10.1172/JCI38454.
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Targeted electrode-based modulation of neural circuits for depression

Abstract

During the last 20 years of neuroscience research, we have witnessed a fundamental shift in the conceptualization of psychiatric disorders, with the dominant psychological and neurochemical theories of the past now complemented by a growing emphasis on developmental, genetic, molecular, and brain circuit models. Facilitating this evolving paradigm shift has been the growing contribution of functional neuroimaging, which provides a versatile platform to characterize brain circuit dysfunction underlying specific syndromes as well as changes associated with their successful treatment. Discussed here are converging imaging findings that established a rationale for testing a targeted neuromodulation strategy, deep brain stimulation, for treatment-resistant major depression.

Authors

Helen S. Mayberg

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Figure 1

Anatomical locations of key brain regions implicated in MDD.

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Anatomical locations of key brain regions implicated in MDD. Midline, sa...
Midline, sagittal view of the brain, with subsections of the anterior cingulate cortex highlighted by coloring. A-Hc, amygdala hippocampus; BS, brainstem; C. callosum, corpus callosum; dMF9, dorso-medial frontal cortex BA9; MCC24, mid-cingulate cortex BA24 (blue); OF11, orbital frontal cortex BA11; pACC24, pregenual anterior cingulate cortex BA24 (yellow); PCC23, posterior cingulate cortex BA23; SCC24/25, SCC BA24 and BA25 (red); vMF10, ventro-medial frontal cortex BA10.