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Citations to this article

The TEL-AML1 leukemia fusion gene dysregulates the TGF-β pathway in early B lineage progenitor cells
Anthony M. Ford, … , Tariq Enver, Mel Greaves
Anthony M. Ford, … , Tariq Enver, Mel Greaves
Published March 16, 2009
Citation Information: J Clin Invest. 2009;119(4):826-836. https://doi.org/10.1172/JCI36428.
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Research Article Oncology Article has an altmetric score of 1

The TEL-AML1 leukemia fusion gene dysregulates the TGF-β pathway in early B lineage progenitor cells

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Abstract

Chromosome translocation to generate the TEL-AML1 (also known as ETV6-RUNX1) chimeric fusion gene is a frequent and early or initiating event in childhood acute lymphoblastic leukemia (ALL). Our starting hypothesis was that the TEL-AML1 protein generates and maintains preleukemic clones and that conversion to overt disease requires secondary genetic changes, possibly in the context of abnormal immune responses. Here, we show that a murine B cell progenitor cell line expressing inducible TEL-AML1 proliferates at a slower rate than parent cells but is more resistant to further inhibition of proliferation by TGF-β. This facilitates the competitive expansion of TEL-AML1–expressing cells in the presence of TGF-β. Further analysis indicated that TEL-AML1 binds to a principal TGF-β signaling target, Smad3, and compromises its ability to activate target promoters. In mice expressing a TEL-AML1 transgene, early, pre-pro-B cells were increased in number and also showed reduced sensitivity to TGF-β–mediated inhibition of proliferation. Moreover, expression of TEL-AML1 in human cord blood progenitor cells led to the expansion of a candidate preleukemic stem cell population that had an early B lineage phenotype (CD34+CD38–CD19+) and a marked growth advantage in the presence of TGF-β. Collectively, these data suggest a plausible mechanism by which dysregulated immune responses to infection might promote the malignant evolution of TEL-AML1–expressing preleukemic clones.

Authors

Anthony M. Ford, Chiara Palmi, Clara Bueno, Dengli Hong, Penny Cardus, Deborah Knight, Giovanni Cazzaniga, Tariq Enver, Mel Greaves

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 Total
Citations: 2 4 7 3 6 3 3 3 3 1 9 5 3 1 4 4 2 63
Citation information
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Citations to this article in year 2014 (5)

Title and authors Publication Year
Murine Models of Acute Leukemia: Important Tools in Current Pediatric Leukemia Research
E Jacoby, CD Chien, TJ Fry
Frontiers in Oncology 2014
Incidence of common preleukemic gene fusions in umbilical cord blood in Slovak population
M Škorvaga, E Nikitina, M Kubeš, P Košík, B Gajdošechová, M Leitnerová, L Copáková, I Belyaev
PloS one 2014
The prenatal origins of cancer
GM Marshall, DR Carter, BB Cheung, T Liu, MK Mateos, JG Meyerowitz, WA Weiss
Nature Reviews Cancer 2014
Genetically engineered mouse models of human B-cell precursor leukemias
J Hauer, A Borkhardt, I Sánchez-García, C Cobaleda
Cell cycle (Georgetown, Tex.) 2014
Identification of TEL-AML1 (ETV6-RUNX1) associated DNA and its impact on mRNA and protein output using ChIP, mRNA expression arrays and SILAC
Y Linka, S Ginzel, A Borkhardt, P Landgraf
Genomics Data 2014

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