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Brian M. Greenwood, … , Frank H. Collins, Patrick E. Duffy
Published April 1, 2008
Citation Information: J Clin Invest. 2008;118(4):1266-1276. https://doi.org/10.1172/JCI33996.
Citation Information: J Clin Invest. 2008;118(4):1266-1276. https://doi.org/10.1172/JCI33996.
Abstract
There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of anti-mosquito measures and new artemisinin-containing treatments, prompting renewed calls for global eradication. However, treatment and mosquito control currently depend on too few compounds and thus are vulnerable to the emergence of compound-resistant parasites and mosquitoes. As discussed in this Review, new drugs, vaccines, and insecticides, as well as improved surveillance methods, are research priorities. Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions.
Authors
Brian M. Greenwood, David A. Fidock, Dennis E. Kyle, Stefan H.I. Kappe, Pedro L. Alonso, Frank H. Collins, Patrick E. Duffy
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Citation information
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Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2 R ,3 S )- N -Benzoyl-3-phenylisoserine
PM Njogu, J Gut, PJ Rosenthal, K Chibale |
ACS Medicinal Chemistry Letters | 2013 |
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Modelling the spatial spread of a homing endonuclease gene in a mosquito population
A North, A Burt, HC Godfray, Y Buckley |
Journal of Applied Ecology | 2013 |
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Using genetic methods to define the targets of compounds with antimalarial activity
EL Flannery, DA Fidock, EA Winzeler |
Journal of Medicinal Chemistry | 2013 |
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Changes in the transcriptome of the malaria parasite Plasmodium falciparum during the initial phase of transmission from the human to the mosquito
CJ Ngwa, M Scheuermayer, GR Mair, S Kern, T Brügl, CC Wirth, MN Aminake, J Wiesner, R Fischer, A Vilcinskas, G Pradel |
BMC Genomics | 2013 |
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Novel anti-Plasmodial hits identified by virtual screening of the ZINC database
G Mugumbate, AS Newton, PJ Rosenthal, J Gut, R Moreira, K Chibale, RC Guedes |
Journal of Computer-Aided Molecular Design | 2013 |
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In silico analysis of Plasmodium species specific UvrD helicase
R Tuteja |
Communicative & integrative biology | 2013 |
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High prevalence of malaria parasitemia and anemia among hospitalized children in Rakai, Uganda
VL Kiggundu, WP O'Meara, R Musoke, FK Nalugoda, G Kigozi, E Baghendaghe, T Lutalo, MK Achienge, SJ Reynolds, F Makumbi, D Serwadda, RH Gray, KK Wools-Kaloustian |
PloS one | 2013 |
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No asymptomatic malaria parasitaemia found among 108 young children at one health facility in Dar es Salaam, Tanzania
GE Strøm, MG Tellevik, M Fataki, N Langeland, B Blomberg |
Malaria Journal | 2013 |
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Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination
CJ Chaccour, KC Kobylinski, Q Bassat, T Bousema, C Drakeley, P Alonso, BD Foy |
Malaria Journal | 2013 |
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Biosynthesis of GDP-fucose and other sugar nucleotides in the blood stages of Plasmodium falciparum
S Sanz, G Bandini, D Ospina, M Bernabeu, K Mariño, C Fernández-Becerra, L Izquierdo |
The Journal of biological chemistry | 2013 |
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A member of the CPW-WPC protein family is expressed in and localized to the surface of developing ookinetes
N Kangwanrangsan, M Tachibana, R Jenwithisuk, T Tsuboi, S Riengrojpitak, M Torii, T Ishino |
Malaria Journal | 2013 |
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Discourse on malaria elimination: where do forcibly displaced persons fit in these discussions?
HA Williams, H Hering, P Spiegel |
Malaria Journal | 2013 |
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Targeting Plasmodium phosphatidylinositol 4-kinase to eliminate malaria
CW McNamara, MC Lee, CS Lim, SH Lim, J Roland, O Simon, BK Yeung, AK Chatterjee, SL McCormack, MJ Manary, AM Zeeman, KJ Dechering, TR Kumar, PP Henrich, K Gagaring, M Ibanez, N Kato, KL Kuhen, C Fischli, A Nagle, M Rottmann, DM Plouffe, B Bursulaya, S Meister, L Rameh, J Trappe, D Haasen, M Timmerman, RW Sauerwein, R Suwanarusk, B Russell, L Renia, F Nosten, DC Tully, CH Kocken, RJ Glynne, C Bodenreider, DA Fidock, TT Diagana, EA Winzeler |
Nature | 2013 |
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Mefloquine use, psychosis, and violence: A retinoid toxicity hypothesis
AR Mawson |
Medical science monitor : international medical journal of experimental and clinical research | 2013 |
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The pathogenesis of malaria: a new perspective
AR Mawson |
Pathogens and Global Health | 2013 |
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Ongoing Surveillance for Lymphatic Filariasis in Togo: Assessment of Alternatives and Nationwide Reassessment of Transmission Status
PJ Budge, AM Dorkenoo, YK Sodahlon, OB Fasuyi, E Mathieu |
The American journal of tropical medicine and hygiene | 2013 |
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Pharmacogenomics and Personalized Medicine for Infectious Diseases
Ganguly NK, Saha GK |
2013 | |
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Cerebral malaria
L Rénia, SW Howland, C Claser, AC Gruner, R Suwanarusk, TH Teo, B Russell, LF Ng |
Virulence | 2012 |
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Therapeutic Efficacy of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Northern Ethiopia
G Kinfu, S Gebre-Selassie, N Fikrie |
Malaria Research and Treatment | 2012 |
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Development of humanized mouse models to study human malaria parasite infection
AM Vaughan, SH Kappe, A Ploss, SA Mikolajczak |
Future Microbiology | 2012 |
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Vaccination with Lipid Core Peptides Fails to Induce Epitope-Specific T Cell Responses but Confers Non-Specific Protective Immunity in a Malaria Model
SH Apte, PL Groves, M Skwarczynski, Y Fujita, C Chang, I Toth, DL Doolan |
PloS one | 2012 |
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Overview of Plant-Made Vaccine Antigens against Malaria
M Clemente, MG Corigliano |
Journal of Biomedicine and Biotechnology | 2012 |
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The Activities of Current Antimalarial Drugs on the Life Cycle Stages of Plasmodium: A Comparative Study with Human and Rodent Parasites
M Delves, D Plouffe, C Scheurer, S Meister, S Wittlin, EA Winzeler, RE Sinden, D Leroy |
PLoS Medicine | 2012 |
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Transport and pharmacodynamics of albitiazolium, an antimalarial drug candidate
S Wein, M Maynadier, Y Bordat, J Perez, S Maheshwari, P Bette-Bobillo, CT van Ba, D Penarete-Vargas, L Fraisse, R Cerdan, H Vial |
British Journal of Pharmacology | 2012 |
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Enhanced Transmission of Drug-Resistant Parasites to Mosquitoes following Drug Treatment in Rodent Malaria
AS Bell, S Huijben, KP Paaijmans, DG Sim, BH Chan, WA Nelson, AF Read |
PloS one | 2012 |
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Simulated Impact of RTS,S/AS01 Vaccination Programs in the Context of Changing Malaria Transmission
A Brooks, OJ Briët, D Hardy, R Steketee, TA Smith |
PloS one | 2012 |
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A “Genome-to-Lead” Approach for Insecticide Discovery: Pharmacological Characterization and Screening of Aedes aegypti D1-like Dopamine Receptors
JM Meyer, KF Ejendal, LV Avramova, EE Garland-Kuntz, GI Giraldo-Calderón, TF Brust, VJ Watts, CA Hill |
PLoS neglected tropical diseases | 2012 |
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Fighting malaria with engineered symbiotic bacteria from vector mosquitoes
S Wang, AK Ghosh, N Bongio, KA Stebbings, DJ Lampe, M Jacobs-Lorena |
Proceedings of the National Academy of Sciences | 2012 |
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Bioisosteric Transformations and Permutations in the Triazolopyrimidine Scaffold To Identify the Minimum Pharmacophore Required for Inhibitory Activity against Plasmodium falciparum Dihydroorotate Dehydrogenase
A Marwaha, J White, F El_Mazouni, SA Creason, S Kokkonda, FS Buckner, SA Charman, MA Phillips, PK Rathod |
Journal of Medicinal Chemistry | 2012 |
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Malaria burden in human population of Quetta, Pakistan
AM Tareen, M Rafique, A Wadood, M Qasim, H Rahman, SH Shah, K Khan, GS Pirkani |
European Journal of Microbiology and Immunology | 2012 |
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Identification and In-Vitro ADME Assessment of a Series of Novel Anti-Malarial Agents Suitable for Hit-to-Lead Chemistry
CD Edlin, G Morgans, S Winks, S Duffy, VM Avery, S Wittlin, D Waterson, J Burrows, J Bryans |
ACS Medicinal Chemistry Letters | 2012 |
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Malaria and human red blood cells
N Mohandas, X An |
Medical Microbiology and Immunology | 2012 |
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Plasmodium falciparum UvrD helicase translocates in 3' to 5' direction, colocalizes with MLH and modulates its activity through physical interaction
M Ahmad, A Ansari, M Tarique, AT Satsangi, R Tuteja |
PloS one | 2012 |
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The dynamics of naturally acquired immunity to Plasmodium falciparum infection
M Pinkevych, J Petravic, K Chelimo, JW Kazura, AM Moormann, MP Davenport |
PLoS computational biology | 2012 |
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Seasonal prevalence of malaria vectors and entomological inoculation rates in the rubber cultivated area of Niete, South Region of Cameroon
JD Bigoga, FM Nanfack, PH Awono-Ambene, S Patchoké, J Atangana, VS Otia, E Fondjo, RS Moyou, RG Leke |
Parasites & vectors | 2012 |
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An affordable, quality-assured community-based system for high-resolution entomological surveillance of vector mosquitoes that reflects human malaria infection risk patterns
PP Chaki, Y Mlacha, D Msellemu, A Muhili, AD Malishee, ZJ Mtema, SS Kiware, Y Zhou, NF Lobo, TL Russell, S Dongus, NJ Govella, GF Killeen |
Malaria Journal | 2012 |
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The changing limits and incidence of malaria in Africa: 1939-2009
RW Snow, P Amratia, CW Kabaria, AM Noor, K Marsh |
Advances in Parasitology | 2012 |
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Design and in vitro haemolytic evaluation of cryptolepine hydrochloride-loaded gelatine nanoparticles as a novel approach for the treatment of malaria
N Kuntworbe, R Al-Kassas |
AAPS PharmSciTech | 2012 |
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Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria
M Lanaspa, C Moraleda, S Machevo, R González, B Serrano, E Macete, P Cisteró, A Mayor, D Hutchinson, PG Kremsner, P Alonso, C Menéndez, Q Bassat |
Antimicrobial agents and chemotherapy | 2012 |
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In vitro and in vivo antimalarial activities of T-2307, a novel arylamidine
A Kimura, H Nishikawa, N Nomura, J Mitsuyama, S Fukumoto, N Inoue, SI Kawazu |
Antimicrobial agents and chemotherapy | 2012 |
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A Class of Tricyclic Compounds Blocking Malaria Parasite Oocyst Development and Transmission
RT Eastman, S Pattaradilokrat, DK Raj, S Dixit, B Deng, K Miura, J Yuan, TQ Tanaka, RL Johnson, H Jiang, R Huang, KC Williamson, LE Lambert, C Long, CP Austin, Y Wu, X Su |
Antimicrobial agents and chemotherapy | 2012 |
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Novel 4-Aminoquinoline Analogs Highly Active against the Blood and Sexual Stages of Plasmodium In Vivo and In Vitro
FE Sáenz, T Mutka, K Udenze, AM Oduola, DE Kyle |
Antimicrobial agents and chemotherapy | 2012 |
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Infectious Diseases Causing Diffuse Alveolar Hemorrhage in Immunocompetent Patients: A State-of-the-Art Review
FM von Ranke, G Zanetti, B Hochhegger, E Marchiori |
Lung | 2012 |
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Vector control: The last bite
L Gravitz |
Nature | 2012 |
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From branch to bedside: Youyou Tu is awarded the 2011 Lasker~DeBakey Clinical Medical Research Award for discovering artemisinin as a treatment for malaria
Ushma S. Neill |
Journal of Clinical Investigation | 2011 |
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Genetic analysis in mice identifies cysteamine as a novel partner for artemisinin in the treatment of malaria
G Min-Oo, P Gros |
Mammalian Genome | 2011 |
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Discovery of GAMA, a Plasmodium falciparum Merozoite Micronemal Protein, as a Novel Blood-Stage Vaccine Candidate Antigen
TU Arumugam, S Takeo, T Yamasaki, A Thonkukiatkul, K Miura, H Otsuki, H Zhou, CA Long, J Sattabongkot, J Thompson, DW Wilson, JG Beeson, J Healer, BS Crabb, AF Cowman, M Torii, T Tsuboi, JH Adams |
Infection and immunity | 2011 |
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Use of remote sensing to identify spatial risk factors for malaria in a region of declining transmission: a cross-sectional and longitudinal community survey
WJ Moss, H Hamapumbu, T Kobayashi, T Shields, A Kamanga, J Clennon, S Mharakurwa, PE Thuma, G Glass |
Malaria Journal | 2011 |
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Expanding the Antimalarial Drug Arsenal-Now, But How?
BT Grimberg, RK Mehlotra |
Pharmaceuticals (Basel, Switzerland) | 2011 |
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Differential induction of functional IgG using the Plasmodium falciparum placental malaria vaccine candidate VAR2CSA
VV Pinto, SB Ditlev, KE Jensen, M Resende, M Dahlbäck, G Andersen, P Andersen, TG Theander, A Salanti, MA Nielsen |
PloS one | 2011 |
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PvRON2, a new Plasmodium vivax rhoptry neck antigen
G Arévalo-Pinzón, H Curtidor, LC Patiño, MA Patarroyo |
Malaria Journal | 2011 |
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Plasmodium ovale curtisi and Plasmodium ovale wallikeri circulate simultaneously in African communities
MC Oguike, M Betson, M Burke, D Nolder, JR Stothard, I Kleinschmidt, C Proietti, T Bousema, M Ndounga, K Tanabe, E Ntege, R Culleton, CJ Sutherland |
International Journal for Parasitology | 2011 |
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A research agenda to underpin malaria eradication
PL Alonso, G Brown, M Arevalo-Herrera, F Binka, C Chitnis, F Collins, OK Doumbo, B Greenwood, BF Hall, MM Levine, K Mendis, RD Newman, CV Plowe, MH Rodríguez, R Sinden, L Slutsker, M Tanner |
PLoS Medicine | 2011 |
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Malaria infection by sporozoite challenge induces high functional antibody titres against blood stage antigens after a DNA prime, poxvirus boost vaccination strategy in Rhesus macaques
MM Hamid, EJ Remarque, IM el Hassan, AA Hussain, DL Narum, AW Thomas, CH Kocken, WR Weiss, BW Faber |
Malaria Journal | 2011 |
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Global response of Plasmodium falciparum to hyperoxia: a combined transcriptomic and proteomic approach
M Torrentino-Madamet, L Alméras, J Desplans, YL Priol, M Belghazi, M Pophillat, P Fourquet, Y Jammes, D Parzy |
Malaria Journal | 2011 |
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Human immune responses that reduce the transmission of Plasmodium falciparum in African populations
T Bousema, CJ Sutherland, TS Churcher, B Mulder, LC Gouagna, EM Riley, GA Targett, CJ Drakeley |
International Journal for Parasitology | 2011 |
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An Invitation to Open Innovation in Malaria Drug Discovery: 47 Quality Starting Points from the TCAMS
F Calderón, D Barros, JM Bueno, JM Coterón, E Fernández, FJ Gamo, JL Lavandera, ML León, SJ Macdonald, A Mallo, P Manzano, E Porras, JM Fiandor, J Castro |
ACS Medicinal Chemistry Letters | 2011 |
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Chemical composition and larvicidal activity of Blumea densiflora essential oils against Anopheles anthropophagus: a malarial vector mosquito
L Zhu, Y Tian |
Parasitology Research | 2011 |
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Antimalarial Activity of Natural and Synthetic Prodiginines
Kancharla Papireddy, Martin Smilkstein, Jane Xu Kelly, Shweta, Shaimaa M. Salem, Mamoun Alhamadsheh, Stuart W. Haynes, Gregory L. Challis, Kevin A. Reynolds |
Journal of Medicinal Chemistry | 2011 |
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Screening of antiplasmodial efficacy of Ajuga bracteosa Wall ex. Benth
S Chandel, U Bagai |
Parasitology Research | 2011 |
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Preventing and detecting malaria infections
LB Hartjes |
The Nurse Practitioner | 2011 |
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Malaria elimination in Isabel Province, Solomon Islands: establishing a surveillance-response system to prevent introduction and reintroduction of malaria
M O'Sullivan, G Kenilorea, Y Yamaguchi, A Bobogare, L Losi, JA Atkinson, A Vallely, M Whittaker, M Tanner, R Wijesinghe |
Malaria Journal | 2011 |
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Genetic control of susceptibility to infection with Plasmodium chabaudi chabaudi AS in inbred mouse strains
A Laroque, G Min-Oo, M Tam, I Radovanovic, MM Stevenson, P Gros |
Genes and Immunity | 2011 |
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A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development
B Malleret, C Claser, AS Ong, R Suwanarusk, K Sriprawat, SW Howland, B Russell, F Nosten, L Rénia |
Scientific Reports | 2011 |
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Emerging Functions of Transcription Factors in Malaria Parasite
R Tuteja, A Ansari, VS Chauhan |
Journal of Biomedicine and Biotechnology | 2011 |
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A mass spectrometric strategy for absolute quantification of Plasmodium falciparum proteins of low abundance
PM Southworth, JE Hyde, PF Sims |
Malaria Journal | 2011 |
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Structure-guided lead optimization of triazolopyrimidine-ring substituents identifies potent Plasmodium falciparum dihydroorotate dehydrogenase inhibitors with clinical candidate potential
JM Coteron, M Marco, J Esquivias, X Deng, KL White, J White, M Koltun, FE Mazouni, S Kokkonda, K Katneni, R Bhamidipati, DM Shackleford, I Angulo-Barturen, SB Ferrer, MB Jiménez-Díaz, FJ Gamo, EJ Goldsmith, WN Charman, I Bathurst, D Floyd, D Matthews, JN Burrows, PK Rathod, SA Charman, MA Phillips |
Journal of Medicinal Chemistry | 2011 |
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Lead-optimization of aryl and aralkyl amine based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice
R Gujjar, FE Mazouni, KL White, J White, S Creason, DM Shackleford, X Deng, WN Charman, I Bathurst, J Burrows, DM Floyd, D Matthews, FS Buckner, SA Charman, MA Phillips, PK Rathod |
Journal of Medicinal Chemistry | 2011 |
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The pathogenesis of Plasmodium falciparum malaria in humans: insights from splenic physiology
PA Buffet, I Safeukui, G Deplaine, V Brousse, V Prendki, M Thellier, GD Turner, O Mercereau-Puijalon |
Blood | 2011 |
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Drugs for malaria: something old, something new, something borrowed
C Hobbs, P Duffy |
F1000 biology reports | 2011 |
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Plasmodium Protease ROM1 Is Important for Proper Formation of the Parasitophorous Vacuole
IM Vera, WL Beatty, P Sinnis, K Kim |
PLoS pathogens | 2011 |
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Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria
RW Heidebrecht, C Mulrooney, CP Austin, RH Barker, JA Beaudoin, KC Cheng, E Comer, S Dandapani, J Dick, JR Duvall, EH Ekland, DA Fidock, ME Fitzgerald, M Foley, R Guha, P Hinkson, M Kramer, AK Lukens, D Masi, LA Marcaurelle, XZ Su, CJ Thomas, M Weïwer, RC Wiegand, D Wirth, M Xia, J Yuan, J Zhao, M Palmer, B Munoz, S Schreiber |
ACS Medicinal Chemistry Letters | 2011 |
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Health Centre Surveys as a Potential Tool for Monitoring Malaria Epidemiology by Area and over Time
AR Oduro, KA Bojang, DJ Conway, T Corrah, BM Greenwood, D Schellenberg |
PloS one | 2011 |
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Hostile Takeover by Plasmodium: Reorganization of Parasite and Host Cell Membranes during Liver Stage Egress
S Graewe, KE Rankin, C Lehmann, C Deschermeier, L Hecht, U Froehlke, RR Stanway, V Heussler |
PLoS pathogens | 2011 |
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Optimization of Potent Inhibitors of P. falciparum Dihydroorotate Dehydrogenase for the Treatment of Malaria
RT Skerlj, CM Bastos, ML Booker, ML Kramer, RH Barker, CA Celatka, TJ O'Shea, B Munoz, AB Sidhu, JF Cortese, S Wittlin, P Papastogiannidis, I Angulo-Barturen, MB Jimenez-Diaz, E Sybertz |
ACS Medicinal Chemistry Letters | 2011 |
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Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches
EH Ekland, J Schneider, DA Fidock |
The FASEB Journal | 2011 |
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N-Terminal Prodomain of Pfs230 Synthesized Using a Cell-Free System Is Sufficient To Induce Complement-Dependent Malaria Transmission-Blocking Activity
M Tachibana, Y Wu, H Iriko, O Muratova, NJ MacDonald, J Sattabongkot, S Takeo, H Otsuki, M Torii, T Tsuboi |
Clinical and vaccine immunology : CVI | 2011 |
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Antiplasmodial Properties of Acyl-Lysyl Oligomers in Culture and Animal Models of Malaria
F Zaknoon, S Wein, M Krugliak, O Meir, S Rotem, H Ginsburg, H Vial, A Mor |
Antimicrobial agents and chemotherapy | 2011 |
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Aminoindoles, a Novel Scaffold with Potent Activity against Plasmodium falciparum
RH Barker, S Urgaonkar, R Mazitschek, C Celatka, R Skerlj, JF Cortese, E Tyndall, H Liu, M Cromwell, AB Sidhu, JE Guerrero-Bravo, KN Crespo-Llado, AE Serrano, J Lin, CJ Janse, SM Khan, M Duraisingh, BI Coleman, I Angulo-Barturen, MB Jiménez-Díaz, N Magán, V Gomez, S Ferrer, MS Martínez, S Wittlin, P Papastogiannidis, T O'Shea, JD Klinger, M Bree, E Lee, M Levine, RC Wiegand, B Munoz, DF Wirth, J Clardy, I Bathurst, E Sybertz |
Antimicrobial agents and chemotherapy | 2011 |
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Malaria transmission blocking immunity and sexual stage vaccines for interrupting malaria transmission in Latin America
Arévalo-Herrera M, Solarte Y, Marin C, Santos M, Castellanos J, Beier JC, Valencia SH |
2011 | |
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Why functional pre-erythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model
DL Guilbride, P Gawlinski, PD Guilbride |
PloS one | 2010 |
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Promiscuous expression of α-tubulin II in maturing male and female Plasmodium falciparum gametocytes
S Schwank, CJ Sutherland, CJ Drakeley |
PloS one | 2010 |
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The humoral response to Plasmodium falciparum VarO rosetting variant and its association with protection against malaria in Beninese children
I Vigan-Womas, A Lokossou, M Guillotte, A Juillerat, G Bentley, A Garcia, O Mercereau-Puijalon, F Migot-Nabias |
Malaria Journal | 2010 |
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A cohort study of Plasmodium falciparum infection dynamics in Western Kenya Highlands
FN Baliraine, YA Afrane, DA Amenya, M Bonizzoni, AM Vardo-Zalik, DM Menge, AK Githeko, G Yan |
BMC Infectious Diseases | 2010 |
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Elevated levels of the Plasmodium yoelii homologue of macrophage migration inhibitory factor attenuate blood-stage malaria
S Thorat, TM Daly, LW Bergman, JM Burns |
Infection and immunity | 2010 |
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Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites
NV Dharia, D Plouffe, SE Bopp, GE González-Páez, C Lucas, C Salas, V Soberon, B Bursulaya, TJ Kochel, DJ Bacon, EA Winzeler |
Genome research | 2010 |
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Malaria incidence and prevalence among children living in a peri-urban area on the coast of benin, west Africa: a longitudinal study
A Nahum, A Erhart, A Mayé, D Ahounou, C Overmeir, J Menten, H Loen, M Akogbeto, M Coosemans, A Massougbodji, U D'Alessandro |
The American journal of tropical medicine and hygiene | 2010 |
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Ecology of malaria parasites infecting Southeast Asian macaques: evidence from cytochrome b sequences
C Putaporntip, S Jongwutiwes, S Thongaree, S Seethamchai, P Grynberg, AL Hughes |
Molecular ecology | 2010 |
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Plasmodium vivax ookinete surface protein Pvs25 linked to cholera toxin B subunit induces potent transmission-blocking immunity by intranasal as well as subcutaneous immunization
T Miyata, T Harakuni, T Tsuboi, J Sattabongkot, H Kohama, M Tachibana, G Matsuzaki, M Torii, T Arakawa |
Infection and immunity | 2010 |
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Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites
S Huijben, WA Nelson, AR Wargo, DG Sim, DR Drew, AF Read |
Evolution; international journal of organic evolution | 2010 |
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Crystal structure of arginase from Plasmodium falciparum and implications for L-arginine depletion in malarial infection
DP Dowling, M Ilies, KL Olszewski, S Portugal, MM Mota, M Llinás, DW Christianson |
Biochemistry | 2010 |
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Plasmodium falciparum proteome changes in response to doxycycline treatment
S Briolant, L Almeras, M Belghazi, E Boucomont-Chapeaublanc, N Wurtz, A Fontaine, S Granjeaud, T Fusaï, C Rogier, B Pradines |
Malaria Journal | 2010 |
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Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages
EC Barker, TN Gatbonton-Schwager, Y Han, JE Clay, JJ Letterio, GP Tochtrop |
Journal of Natural Products | 2010 |
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Genetic structure of Plasmodium vivax and Plasmodium falciparum in the Bannu district of Pakistan
L Khatoon, FN Baliraine, M Bonizzoni, SA Malik, G Yan |
Malaria Journal | 2010 |
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Production of recombinant proteins from protozoan parasites
JA Fernández-Robledo, GR Vasta |
Trends in Parasitology | 2010 |
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Assessing functional annotation transfers with inter-species conserved coexpression: application to Plasmodium falciparum
L Bréhélin, I Florent, O Gascuel, E Maréchal |
BMC Genomics | 2010 |
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Chloroplast-derived vaccine antigens confer dual immunity against cholera and malaria by oral or injectable delivery
A Davoodi-Semiromi, M Schreiber, S Nalapalli, D Verma, ND Singh, RK Banks, D Chakrabarti, H Daniell |
Plant Biotechnology Journal | 2010 |
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Control of malaria
S Kar, S Kar |
Nature Reviews Drug Discovery | 2010 |
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Spiroindolones, a new and potent chemotype for the treatment of malaria
M Rottmann, C McNamara, BK Yeung, MC Lee, B Zou, B Russell, P Seitz, DM Plouffe, NV Dharia, J Tan, SB Cohen, KR Spencer, GE González-Páez, SB Lakshminarayana, A Goh, R Suwanarusk, T Jegla, EK Schmitt, HP Beck, R Brun, F Nosten, L Renia, V Dartois, TH Keller, DA Fidock, EA Winzeler, TT Diagana |
Science (New York, N.Y.) | 2010 |
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2-Hexadecynoic Acid Inhibits Plasmodial FAS-II Enzymes and Arrest Erythrocytic and Liver Stage Plasmodium Infections
D Tasdemir, D Sanabria, IL Lauinger, A Tarun, R Herman, R Perozzo, M Zloh, SH Kappe, R Brun, NM Carballeira |
Bioorganic & Medicinal Chemistry | 2010 |
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Identification of key residues involved in fibril formation by the conserved N-terminal region of Plasmodium falciparum merozoite surface protein 2 (MSP2)
X Yang, CG Adda, CA MacRaild, A Low, X Zhang, W Zeng, DC Jackson, RF Anders, RS Norton |
Biochimie | 2010 |
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Is vaccine the magic bullet for malaria elimination? A reality check
R Chilengi, J Gitaka |
Malaria Journal | 2010 |
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Reliability of Antimalarial Sensitivity Tests Depends on Drug Mechanisms of Action
S Wein, M Maynadier, CT Ba, R Cerdan, S Peyrottes, L Fraisse, H Vial |
Journal of clinical microbiology | 2010 |
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Pre-elimination of malaria on the island of Príncipe
PW Lee, CT Liu, HS Rampao, VE do Rosario, MF Shaio |
Malaria Journal | 2010 |
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γδ T Cells but Not NK Cells Are Essential for Cell-Mediated Immunity against Plasmodium chabaudi Malaria
WP Weidanz, GL LaFleur, A Brown, JM Burns, I Gramaglia, HC van der Heyde |
Infection and immunity | 2010 |
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Cysteamine, the Molecule Used To Treat Cystinosis, Potentiates the Antimalarial Efficacy of Artemisinin
G Min-Oo, A Fortin, JF Poulin, P Gros |
Antimicrobial agents and chemotherapy | 2010 |
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Developing vaccines to combat hookworm infection and intestinal schistosomiasis
PJ Hotez, JM Bethony, DJ Diemert, M Pearson, A Loukas |
Nature Reviews Microbiology | 2010 |
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Artemisinin resistance: current status and scenarios for containment
AM Dondorp, S Yeung, L White, C Nguon, NP Day, D Socheat, L von Seidlein |
Nature Reviews Microbiology | 2010 |
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Plasmodium dihydroorotate dehydrogenase: a promising target for novel anti-malarial chemotherapy.
Phillips MA, Rathod PK |
Infectious disorders drug targets | 2010 |
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Bioorganometallic Chemistry and Malaria
Biot C, Dive D |
2010 | |
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Anti-malarial market and policy surveys in sub-Saharan Africa.
Diap G, Amuasi J, Boakye I, Sevcsik AM, Pecoul B |
Malaria Journal | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Cooperativity betweenPlasmodium falciparumadhesive proteins for invasion into erythrocytes
TM DeSimone, CV Jennings, AK Bei, C Comeaux, BI Coleman, P Refour, T Triglia, J Stubbs, AF Cowman, MT Duraisingh |
Molecular Microbiology | 2009 |
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Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds
X Deng, R Gujjar, FE Mazouni, W Kaminsky, NA Malmquist, EJ Goldsmith, PK Rathod, MA Phillips |
The Journal of biological chemistry | 2009 |
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Global status of DDT and its alternatives for use in vector control to prevent disease
H Berg |
Environmental Health Perspectives | 2009 |
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Possible interruption of malaria transmission, highland Kenya, 2007-2008
CC John, MA Riedesel, NG Magak, KA Lindblade, DM Menge, JS Hodges, JM Vulule, W Akhwale |
Emerging infectious diseases | 2009 |
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The risks of malaria infection in Kenya in 2009
AM Noor, PW Gething, VA Alegana, AP Patil, SI Hay, E Muchiri, E Juma, RW Snow |
BMC Infectious Diseases | 2009 |
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Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging
IH Ploemen, M Prudêncio, BG Douradinha, J Ramesar, J Fonager, GJ Gemert, AJ Luty, CC Hermsen, RW Sauerwein, FG Baptista, MM Mota, AP Waters, I Que, CW Lowik, SM Khan, CJ Janse, BM Franke-Fayard |
PloS one | 2009 |
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Parasite threshold associated with clinical malaria in areas of different transmission intensities in north eastern Tanzania
BP Mmbando, JP Lusingu, LS Vestergaard, MM Lemnge, TG Theander, TH Scheike |
BMC medical research methodology | 2009 |
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Spatial risk profiling of Plasmodium falciparum parasitaemia in a high endemicity area in Côte d'Ivoire
G Raso, KD Silué, P Vounatsou, BH Singer, A Yapi, M Tanner, J Utzinger, EK N'Goran |
Malaria Journal | 2009 |
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Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda
J Mwesigwa, S Parikh, B McGee, P German, T Drysdale, JN Kalyango, TD Clark, G Dorsey, N Lindegardh, A Annerberg, PJ Rosenthal, MR Kamya, F Aweeka |
Antimicrobial agents and chemotherapy | 2009 |
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Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility
MK Johnson, TD Clark, D Njama-Meya, PJ Rosenthal, S Parikh |
PloS one | 2009 |
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Predicting changing malaria risk after expanded insecticide-treated net coverage in Africa
DL Smith, SI Hay, AM Noor, RW Snow |
Trends in Parasitology | 2009 |
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Advancing drug innovation for neglected diseases-criteria for lead progression
S Nwaka, B Ramirez, R Brun, L Maes, F Douglas, R Ridley |
PLoS neglected tropical diseases | 2009 |
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Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target
P Gratraud, E Huws, B Falkard, S Adjalley, DA Fidock, L Berry, WR Jacobs, MS Baird, H Vial, L Kremer |
PloS one | 2009 |
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Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain
DP Iwaniuk, ED Whetmore, N Rosa, K Ekoue-Kovi, J Alumasa, AC de Dios, PD Roepe, C Wolf |
Bioorganic & Medicinal Chemistry | 2009 |
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How might infant and paediatric immune responses influence malaria vaccine efficacy?
AM Moormann |
Parasite Immunology | 2009 |
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Co-authorship network analysis: a powerful tool for strategic planning of research, development and capacity building programs on neglected diseases
CM Morel, SJ Serruya, GO Penna, R Guimarães |
PLoS neglected tropical diseases | 2009 |
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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design
KM VanBuskirk, MT O'Neill, PD la Vega, AG Maier, U Krzych, J Williams, MG Dowler, JB Sacci, N Kangwanrangsan, T Tsuboi, NM Kneteman, DG Heppner, BA Murdock, SA Mikolajczak, AS Aly, AF Cowman, SH Kappe |
Proceedings of the National Academy of Sciences | 2009 |
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A potent malaria transmission blocking vaccine based on codon harmonized full length Pfs48/45 expressed in Escherichia coli
DR Chowdhury, E Angov, T Kariuki, N Kumar |
PloS one | 2009 |
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Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes
MB Jiménez-Díaz, T Mulet, S Viera, V Gómez, H Garuti, J Ibáñez, A Alvarez-Doval, LD Shultz, A Martínez, D Gargallo-Viola, I Angulo-Barturen |
Antimicrobial agents and chemotherapy | 2009 |
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Enhancement of artemisinin concentration and yield in response to optimization of nitrogen and potassium supply to Artemisia annua
MJ Davies, CJ Atkinson, C Burns, JG Woolley, NA Hipps, RR Arroo, N Dungey, T Robinson, P Brown, I Flockart, C Hill, L Smith, S Bentley |
Annals of Botany | 2009 |
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A Plasmodium falciparum FcB1-schizont-EST collection providing clues to schizont specific gene structure and polymorphism
I Florent, BM Porcel, E Guillaume, CD Silva, F Artiguenave, E Maréchal, L Bréhélin, O Gascuel, S Charneau, P Wincker, P Grellier |
BMC Genomics | 2009 |
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Endemicity response timelines for Plasmodium falciparum elimination
DL Smith, SI Hay |
Malaria Journal | 2009 |
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Single amino acid substitution in Plasmodium yoelii erythrocyte ligand determines its localization and controls parasite virulence
H Otsuki, O Kaneko, A Thongkukiatkul, M Tachibana, H Iriko, S Takeo, T Tsuboi, M Torii |
Proceedings of the National Academy of Sciences | 2009 |
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A world malaria map: Plasmodium falciparum endemicity in 2007
SI Hay, CA Guerra, PW Gething, AP Patil, AJ Tatem, AM Noor, CW Kabaria, BH Manh, IR Elyazar, S Brooker, DL Smith, RA Moyeed, RW Snow |
PLoS Medicine | 2009 |
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Application of pharmacogenomics to malaria: a holistic approach for successful chemotherapy
RK Mehlotra, CN Henry-Halldin, PA Zimmerman |
Pharmacogenomics | 2009 |
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Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80
MH Huynh, VB Carruthers |
Eukaryotic cell | 2009 |
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Recombinant viral vaccines expressing merozoite surface protein-1 induce antibody- and T cell-mediated multistage protection against malaria
SJ Draper, AL Goodman, S Biswas, EK Forbes, AC Moore, SC Gilbert, AV Hill |
Cell Host & Microbe | 2009 |
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Seventy-five years of Resochin® in the fight against malaria
M Jensen, H Mehlhorn |
Parasitology Research | 2009 |
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Alkylating ability of artemisinin after Cu(I)-induced activation
FB Garah, M Pitié, L Vendier, B Meunier, A Robert |
JBIC Journal of Biological Inorganic Chemistry | 2009 |
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Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues
K Vaughan, M Blythe, J Greenbaum, Q Zhang, B Peters, DL Doolan, A Sette |
Parasite Immunology | 2009 |
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Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data
VS Moorthy, WR Ballou |
Malaria Journal | 2009 |
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Identification of a Metabolically Stable Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Antimalarial Activity in Mice
R Gujjar, A Marwaha, FE Mazouni, J White, KL White, S Creason, DM Shackleford, J Baldwin, WN Charman, FS Buckner, S Charman, PK Rathod, MA Phillips |
Journal of Medicinal Chemistry | 2009 |
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Malaria Ookinete Surface Protein-Based Vaccination via the Intranasal Route Completely Blocks Parasite Transmission in both Passive and Active Vaccination Regimens in a Rodent Model of Malaria Infection
T Arakawa, M Tachibana, T Miyata, T Harakuni, H Kohama, Y Matsumoto, N Tsuji, H Hisaeda, A Stowers, M Torii, T Tsuboi |
Infection and immunity | 2009 |
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Global health inequity: scientific challenges remain but can be solved
Carol A. Dahl, Tadataka Yamada |
Journal of Clinical Investigation | 2008 |
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Cell therapy for the diseased liver: from stem cell biology to novel models for hepatotropic human pathogens
N Brezillon, D Kremsdorf, MC Weiss |
Disease models & mechanisms | 2008 |
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Large-scale differential proteome analysis in Plasmodium falciparum under drug treatment
JH Prieto, S Koncarevic, SK Park, JY 3rd, K Becker |
PloS one | 2008 |
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Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
P Bejon, J Lusingu, A Olotu, A Leach, M Lievens, J Vekemans, S Mshamu, T Lang, J Gould, MC Dubois, MA Demoitié, JF Stallaert, P Vansadia, T Carter, P Njuguna, KO Awuondo, A Malabeja, O Abdul, S Gesase, N Mturi, CJ Drakeley, B Savarese, T Villafana, WR Ballou, J Cohen, EM Riley, MM Lemnge, K Marsh, L Seidlein |
The New England journal of medicine | 2008 |
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The fatty acid biosynthesis enzyme FabI plays a key role in the development of liver-stage malarial parasites
M Yu, TR Kumar, LJ Nkrumah, A Coppi, S Retzlaff, CD Li, BJ Kelly, PA Moura, V Lakshmanan, JS Freundlich, JC Valderramos, C Vilcheze, M Siedner, JH Tsai, B Falkard, AB Sidhu, LA Purcell, P Gratraud, L Kremer, AP Waters, G Schiehser, DP Jacobus, CJ Janse, A Ager, WR Jacobs, JC Sacchettini, V Heussler, P Sinnis, DA Fidock |
Cell Host & Microbe | 2008 |
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Tropical anemia: one of Africa's great killers and a rationale for linking malaria and neglected tropical disease control to achieve a common goal
PJ Hotez, DH Molyneux |
PLoS neglected tropical diseases | 2008 |
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Malaria vaccines and their potential role in the elimination of malaria
GA Targett, BM Greenwood |
Malaria Journal | 2008 |
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