Citations to this article

Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration
Jing Chen, … , Kip M. Connor, Lois E.H. Smith
Jing Chen, … , Kip M. Connor, Lois E.H. Smith
Published October 1, 2007
Citation Information: J Clin Invest. 2007;117(10):2758-2762. https://doi.org/10.1172/JCI33513.
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Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration

Abstract

Age-related macular degeneration (AMD), the most common cause of blindness in the elderly, is characterized by degeneration of the macula and can lead to loss of fine color vision. Alterations in inflammatory and immune system pathways, which arise from genetic differences, predispose individuals to AMD. Yet the mechanism of disease progression with respect to inflammation is not fully understood. In this issue of the JCI, the study by Combadière and colleagues shows that CX3C chemokine receptor 1–deficient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD (see the related article beginning on page 2920).

Authors

Jing Chen, Kip M. Connor, Lois E.H. Smith

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Year: 2023 2018 2015 2014 2013 2012 2010 2008 Total
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Citations to this article (11)

Title and authors Publication Year
Sub-Retinal Injection of Human Lipofuscin in the Mouse - A Model of “Dry” Age-Related Macular Degeneration?
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The Role of the Microglial Cx3cr1 Pathway in the Postnatal Maturation of Retinal Photoreceptors
AI Jobling, M Waugh, KA Vessey, JA Phipps, L Trogrlic, U Greferath, SA Mills, ZL Tan, MM Ward, EL Fletcher 		The Journal of neuroscience : the official journal of the Society for Neuroscience 2018
The association between statin use and risk of age-related macular degeneration
L Ma, Y Wang, J Du, M Wang, R Zhang, Y Fu 		Scientific Reports 2015
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The role of CRP and inflammation in the pathogenesis of age-related macular degeneration
Colak E, Majkic-Singh N, Zoric L, Radosavljevic A, Kosanovic-Jakovic N 		Biochemia Medica 2012
Napoleone Ferrara receives the 2010 Lasker~DeBakey Clinical Award for breakthroughs in angiogenesis research
Neill US 		Journal of Clinical Investigation 2010
Immunopathological aspects of age-related macular degeneration
M Patel, CC Chan 		Seminars in Immunopathology 2008
Expression, localization, and function of junctional adhesion molecule-C (JAM-C) in human retinal pigment epithelium
M Economopoulou, J Hammer, F Wang, R Fariss, A Maminishkis, SS Miller 		Investigative ophthalmology & visual science 2008
Age-related macular degeneration
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