Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been defined. We developed what we believe to be a novel microinjection-based local gene-delivery system that is capable of targeting the inflamed intestine. Using this approach, we demonstrated a therapeutic potency for IL-22–mediated activation of the innate immune pathway in a mouse model of Th2-mediated colitis that induces disease with characteristics similar to that of IBD ulcerative colitis (UC). IL-22 gene delivery enhanced STAT3 activation specifically within colonic epithelial cells and induced both STAT3-dependent expression of mucus-associated molecules and restitution of mucus-producing goblet cells. Importantly, IL-22 gene delivery led to rapid amelioration of local intestinal inflammation. The amelioration of disease by IL-22 was mediated by enhanced mucus production. In addition, local gene delivery was used to inhibit IL-22 activity through overexpression of IL-22–binding protein. Treatment with IL-22–binding protein suppressed goblet cell restitution during the recovery phase of a dextran sulfate sodium–induced model of acute colitis. These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene–delivery system for treating UC.
Ken Sugimoto, Atsuhiro Ogawa, Emiko Mizoguchi, Yasuyo Shimomura, Akira Andoh, Atul K. Bhan, Richard S. Blumberg, Ramnik J. Xavier, Atsushi Mizoguchi
Title and authors | Publication | Year |
---|---|---|
Ubiquitin-specific protease 25 ameliorates ulcerative colitis by regulating the degradation of phosphor-STAT3
Liu Z, Liu J, Wei Y, Li J, Zhang J, Yu R, Yang Q, Miao Y, Dong W |
Cell Death & Disease | 2025 |
Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease
Abdelhamid M, Counts SE, Zhou C, Hida H, Kim JI, Michikawa M, Jung CG |
Nutrients | 2025 |
Biological functions and therapeutic applications of human mucosal-associated invariant T cells
Fang Y, Chen Y, Niu S, Lyu Z, Tian Y, Shen X, Li YR, Yang L |
Journal of Biomedical Science | 2025 |
Targeting CD4+ T cells through gut microbiota: therapeutic potential of traditional Chinese medicine in inflammatory bowel disease
Lu X, Xv Y, Hu W, Sun B, Hu H |
Frontiers in Cellular and Infection Microbiology | 2025 |
Lipidated IL-22 Alone or Combined with Immunomodulatory Agents Improves Disease Endpoints and Promotes Mucosal Healing in a Mouse Model of Chronic Dextran Sodium Sulfate-Induced Colitis.
Støy S, D'Alessio S, Sandahl TD, Dige A, Kjølbye AL, Jorgensen R, Danese S, van de Bunt M |
Digestive diseases and sciences | 2025 |
Therapeutic activation of IL-22-producing innate lymphoid cells enhances host defenses to Clostridioides difficile infection
Mears KS, Denny JE, Maslanka JR, Mdluli NV, Hulit EN, Matsuda R, Furth EE, Buffie CG, Abt MC |
Cell reports | 2025 |
Innate Lymphoid Cells in Inflammatory Bowel Disease
Yao X, Ma K, Zhu Y, Cao S |
Cells | 2025 |
Application of single-cell sequencing in the study of immune cell infiltration in inflammatory bowel disease and colorectal cancer
Zhang Z, Wang HM, Xu ZX, Luan WY, Lin SX, Miao YD |
World Journal of Gastrointestinal Oncology | 2025 |
Dietary lipids induce PPARd and BCL6 to repress macrophage IL-23 induction after intestinal injury and LPS exposure
Gil AM, Zegarra-Ruiz DF, Wu WJ, Norwood K, Assie A, Samuel BS, Major AM, Diehl GE, McAlester AA |
Research Square | 2025 |
Adding Fat to the Fire: Does Lipidated IL-22 Promote Mucosal Healing in Patients with Inflammatory Bowel Disease Treated with Immunomodulators?
Söderholm JD |
Digestive diseases and sciences | 2025 |
HIF-1α-activated IL-22/IL-22R1/Bmi1 signaling pathway modulates the self-renewal of cardiac progenitor cells in acute myocardial ischemia
Wei Lee, Syuan-Ling Lin, Chih-Sheng Chiang, Jui-Yu Chen, Wee-Wei Chieng, Shu-Rou Huang, B. Linju Yen, Mien-Chie Hung, Hsu-Tung Lee, Long-Bin Jeng, Woei-Cherng Shyu |
Stem cell reviews and reports | 2024 |
Aryl hydrocarbon receptor regulates Muc2 independent of goblet cell development or interleukin-22 signaling during colitis
Archana Saxena, Chandani Mitchell, Raymond Bogdon, Kasie Roark, Kiesha Wilson, Shanieka Staley, Michelle Hailey, Michal Williams, Alex Rutkovsky, Prakash Nagarkatti, Mitzi Nagarkatti, Philip Busbee |
International journal of molecular sciences | 2024 |
Characteristics of mucin hypersecretion in different inflammatory patterns based on endotypes of chronic rhinosinusitis
Zhai Z, Shao L, Lu Z, Yang Y, Wang J, Liu Z, Wang H, Zheng Y, Lu H, Song X, Zhang Y |
Clinical and Translational Allergy | 2024 |
A non-human primate model for human norovirus infection.
Rimkute I, Chaimongkol N, Woods KD, Nagata BM, Darko S, Gudbole S, Henry AR, Sosnovtsev SV, Olia AS, Verardi R, Bok K, Todd JP, Woodward R, Kwong PD, Douek DC, Alves DA, Green KY, Roederer M |
Nature Microbiology | 2024 |
TH17 cell: a double-edged sword in the development of inflammatory bowel disease
Wen Y, Wang H, Tian D, Wang G |
Therapeutic advances in gastroenterology | 2024 |
Intestinal IL-22RA1 signaling regulates intrinsic and systemic lipid and glucose metabolism to alleviate obesity-associated disorders.
Gaudino SJ, Singh A, Huang H, Padiadpu J, Jean-Pierre M, Kempen C, Bahadur T, Shiomitsu K, Blumberg R, Shroyer KR, Beyaz S, Shulzhenko N, Morgun A, Kumar P |
Nature Communications | 2024 |
Group 3 innate lymphoid cells in intestinal health and disease.
Horn V, Sonnenberg GF |
Nature reviews. Gastroenterology & hepatology | 2024 |
The Peptide LLTRAGL Derived from Rapana venosa Exerts Protective Effect against Inflammatory Bowel Disease in Zebrafish Model by Regulating Multi-Pathways
Cao Y, Xu F, Xia Q, Liu K, Lin H, Zhang S, Zhang Y |
Marine drugs | 2024 |
Fructooligosaccharides act on the gut-bone axis to improve bone independent of Tregs and alter osteocytes in young adult C57BL/6 female mice.
Islam P, Ice JA, Alake SE, Adedigba P, Hatter B, Robinson K, Clarke SL, Ford Versypt AN, Ritchey J, Lucas EA, Smith BJ |
JBMR Plus | 2024 |
Tissue adaptation of CD4 T lymphocytes in homeostasis and cancer
Pereira MV, Galvani RG, Gonçalves-Silva T, de Vasconcelo ZF, Bonomo A |
Frontiers in immunology | 2024 |
Deficiency of IL-22-binding protein enhances the ability of the gut microbiota to protect against enteric pathogens.
Fachi JL, Di Luccia B, Gilfillan S, Chang HW, Song C, Cheng J, Cella M, Vinolo MA, Gordon JI, Colonna M |
Proceedings of the National Academy of Sciences | 2024 |
IL-22-dependent responses and their role during Citrobacter rodentium infection.
Melchior K, Gerner RR, Hossain S, Nuccio S-P, Moreira CG, Raffatellu M |
Infection and immunity | 2024 |
Epigenetic Insights Into Necrotizing Enterocolitis: Unraveling Methylation-Regulated Biomarkers.
Tian B, Xu X, Li L, Tian Y, Liu Y, Mu Y, Lu J, Song K, Lv J, He Q, Zhong W, Xia H, Lan C |
Inflammation | 2024 |
Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity
Pan P, Wang Y, Nyirenda MH, Saiyed Z, Karimian Azari E, Sunderman A, Milling S, Harnett MM, Pineda M |
Communications biology | 2024 |
MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis
El Morr Y, Fürstenheim M, Mestdagh M, Franciszkiewicz K, Salou M, Morvan C, Dupré T, Vorobev A, Jneid B, Premel V, Darbois A, Perrin L, Mondot S, Colombeau L, Bugaut H, du Halgouet A, Richon S, Procopio E, Maurin M, Philippe C, Rodriguez R, Lantz O, Legoux F |
Science Immunology | 2024 |
Precision therapy for ulcerative colitis: insights from mitochondrial dysfunction interacting with the immune microenvironment
Zhang YF, Fan MY, Bai QR, Zhao R, Song S, Wu L, Lu JH, Liu JW, Wang Q, Li Y, Chen X |
Frontiers in immunology | 2024 |
Insights into the tissue repair features of MAIT cells
Gao M, Zhao X |
Frontiers in immunology | 2024 |
OLFM4 modulates intestinal inflammation by promoting IL-22+ILC3 in the gut
Xing Z, Li X, He J, Chen Y, Zhu L, Zhang X, Huang Z, Tang J, Guo Y, He Y |
Communications biology | 2024 |
IL-22 promotes mucin-type O-glycosylation and MATH1(+) cell-mediated amelioration of intestinal inflammation.
Singh A, Beaupre M, Villegas-Novoa C, Shiomitsu K, Gaudino SJ, Tawch S, Damle R, Kempen C, Choudhury B, McAleer JP, Sheridan BS, Denoya P, Blumberg RS, Hearing P, Allbritton NL, Kumar P |
Cell Reports | 2024 |
The role of IL-22 in cancer.
Hunzeker ZE, Zhao L, Kim AM, Parker JM, Zhu Z, Xiao H, Bai Q, Wakefield MR, Fang Y |
Medical oncology (Northwood, London, England) | 2024 |
Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance
Wang Y, Li C, Li J, Zhang S, Zhang Q, Duan J, Guo J |
Acta Pharmaceutica Sinica. B | 2024 |
Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells.
Ohara D, Takeuchi Y, Hirota K |
Cellular & molecular immunology | 2024 |
Clostridium sporogenes-derived metabolites protect mice against colonic inflammation.
Krause FF, Mangold KI, Ruppert AL, Leister H, Hellhund-Zingel A, Lopez Krol A, Pesek J, Watzer B, Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, Nockher WA, Taudte RV, Bertrams W, Schmeck B, Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A |
Gut microbes | 2024 |
Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release
Han X, Allaire JM, Crowley SM, Chan JJ, Lau K, Zhang C, Hirota SA, Bergstrom K, Knodler LA, Vallance BA |
Gut Microbes | 2024 |
IL-22, a vital cytokine in autoimmune diseases.
Li J, Wu Z, Wu Y, Hu X, Yang J, Zhu D, Wu M, Li X, Bentum-Ennin L, Wanglai H |
Clinical and experimental immunology | 2024 |
The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation
Okumura R, Takeda K |
Seminars in Immunopathology | 2024 |
Impact of gut microbiota and its metabolites on immunometabolism in colorectal cancer
Flory M, Bravo P, Alam A |
Immunometabolism (Cobham, Surrey) | 2024 |
Therapeutic Potential of Nutritional Aryl Hydrocarbon Receptor Ligands in Gut-Related Inflammation and Diseases
Huang FC |
Biomedicines | 2024 |
IL-22 regulates MASTL expression in intestinal epithelial cells
Pravoverov K, Fatima I, Barman S, Jühling F, Primeaux M, Baumert TF, Singh AB, Dhawan P |
American Journal of Physiology - Gastrointestinal and Liver Physiology | 2024 |
The Pivotal Role of Aryl Hydrocarbon Receptor-Regulated Tight Junction Proteins and Innate Immunity on the Synergistic Effects of Postbiotic Butyrate and Active Vitamin D3 to Defense against Microbial Invasion in Salmonella Colitis
Huang FC, Huang SC |
Nutrients | 2023 |
CD4 T-Cell Subsets and the Pathophysiology of Inflammatory Bowel Disease
Gomez-Bris R, Saez A, Herrero-Fernandez B, Rius C, Sanchez-Martinez H, Gonzalez-Granado JM |
International journal of molecular sciences | 2023 |
BTNL2 promotes colitis‐associated tumorigenesis in mice by regulating IL‐22 production
Peng Q, Pan T, He R, Yi M, Feng L, Cui Z, Gao R, Wang H, Feng X, Li H, Wang Y, Zhang C, Cheng D, Du Y, Wang C |
EMBO reports | 2023 |
Mucosal healing and inflammatory bowel disease: Therapeutic implications and new targets
Otte ML, Lama Tamang R, Papapanagiotou J, Ahmad R, Dhawan P, Singh AB |
World Journal of Gastroenterology | 2023 |
Preparation and Characterization of IL-22 mRNA-loaded Lipid Nanoparticles
Alghoul Z, Sung J, Wu K, Alpini G, Glaser S, Yang C, Merlin D |
Bio-protocol | 2023 |
The role of group 3 innate lymphoid cell in intestinal disease
Li M, Wang Z, Jiang W, Lu Y, Zhang J |
Frontiers in immunology | 2023 |
Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation
Chen Y, Wang Y, Fu Y, Yin Y, Xu K |
Cell & Bioscience | 2023 |
FGF21 Depletion Attenuates Colitis through Intestinal Epithelial IL-22-STAT3 Activation in Mice
Liu L, Li F, Shao T, Zhang L, Lee J, Dryden G, McClain CJ, Zhao C, Feng W |
Nutrients | 2023 |
Delayed and limited administration of the JAKinib tofacitinib mitigates chronic DSS-induced colitis
Seal R, Schwab LS, Chiarolla CM, Hundhausen N, Klose GH, Reu-Hofer S, Rosenwald A, Wiest J, Berberich-Siebelt F |
Frontiers in immunology | 2023 |
A Compendium of Mucosal Molecular Characteristics Provides Novel Perspectives on the Treatment of Ulcerative Colitis.
Chang MJ, Hao JW, Qiao J, Chen MR, Wang Q, Wang Q, Zhang SX, Yu Q, He PF |
Journal of Crohn's & colitis | 2023 |
IL-22BP controls the progression of liver metastasis in colorectal cancer.
Giannou AD, Kempski J, Zhang T, Lücke J, Shiri AM, Zazara DE, Belios I, Machicote A, Seeger P, Agalioti T, Tintelnot J, Sagebiel A, Tomczak M, Bauditz L, Bedke T, Kocheise L, Mercanoglu B, Fard-Aghaie M, Giorgakis E, Lykoudis PM, Pikouli A, Grass JK, Wahib R, Bardenhagen J, Brunswig B, Heumann A, Ghadban T, Duprée A, Tachezy M, Melling N, Arck PC, Stringa P, Gentilini MV, Gondolesi GE, Nakano R, Thomson AW, Perez D, Li J, Mann O, Izbicki JR, Gagliani N, Maroulis IC, Huber S |
Frontiers in Oncology | 2023 |
Recent Advances in Site-Specific Lipid Nanoparticles for mRNA Delivery
Xu X, Xia T |
2023 | |
The Effects of a High-Fat Diet on Inflammatory Bowel Disease
Dang Y, Ma C, Chen K, Chen Y, Jiang M, Hu K, Li L, Zeng Z, Zhang H |
Biomolecules | 2023 |
IL-22 promotes occludin expression by activating autophagy and treats ulcerative colitis.
Nong H, Yuan H, Lin Y, Chen S, Li Y, Luo Z, Yang W, Zhang T, Chen Y |
Molecular and Cellular Biochemistry | 2023 |
Dose escalation randomised study of efmarodocokin alfa in healthy volunteers and patients with ulcerative colitis
Wagner F, Mansfield JC, Lekkerkerker AN, Wang Y, Keir M, Dash A, Butcher B, Harder B, Orozco LD, Mar JS, Chen H, Rothenberg ME |
Gut | 2023 |
The interplay between innate lymphoid cells and microbiota
Wang R, Cui W, Yang H |
mBio | 2023 |
Therapeutic potential of gene therapy for gastrointestinal diseases: Advancements and future perspectives
Yue NN, Xu HM, Xu J, Zhu MZ, Zhang Y, Tian CM, Nie YQ, Yao J, Liang YJ, Li DF, Wang LS |
2023 | |
Versatile roles of innate lymphoid cells at the mucosal barrier: from homeostasis to pathological inflammation.
Ryu S, Lim M, Kim J, Kim HY |
Experimental & molecular medicine | 2023 |
NOD-like receptors mediate homeostatic intestinal epithelial barrier function: promising therapeutic targets for inflammatory bowel disease
Zhou F, Zhang GD, Tan Y, Hu SA, Tang Q, Pei G |
Therapeutic advances in gastroenterology | 2023 |
Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
Moniruzzaman M, Rahman MA, Wang R, Wong KY, Chen AC, Mueller A, Taylor S, Harding A, Illankoon T, Wiid P, Sajiir H, Schreiber V, Burr LD, McGuckin MA, Phipps S, Hasnain SZ |
Journal of Experimental Medicine | 2023 |
Antimicrobial overproduction sustains intestinal inflammation by inhibiting Enterococcus colonization
Jang KK, Heaney T, London M, Ding Y, Putzel G, Yeung F, Ercelen D, Chen YH, Axelrad J, Gurunathan S, Zhou C, Podkowik M, Arguelles N, Srivastava A, Shopsin B, Torres VJ, Keestra-Gounder AM, Pironti A, Griffin ME, Hang HC, Cadwell K |
Cell Host & Microbe | 2023 |
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Bonetti L, Horkova V, Longworth J, Guerra L, Kurniawan H, Franchina DG, Soriano-Baguet L, Grusdat M, Spath S, Koncina E, Ewen A, Binsfeld C, Verschueren C, Gérardy JJ, Kobayashi T, Dostert C, Farinelle S, Härm J, Chen Y, Harris IS, Lang PA, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D |
2023 | |
Elevated Fecal Calprotectin Accompanied by Intestinal Neutrophil Infiltration and Goblet Cell Hyperplasia in a Murine Model of Multiple Sclerosis
Nouri M, Weström B, Lavasani S |
International journal of molecular sciences | 2023 |
Intestinal Barrier Dysfunction in Inflammatory Bowel Disease: Underpinning Pathogenesis and Therapeutics.
Dunleavy KA, Raffals LE, Camilleri M |
Digestive Diseases and Sciences | 2023 |
Supplementation with the Probiotic Strains Bifidobacterium longum and Lactiplantibacillus rhamnosus Alleviates Glucose Intolerance by Restoring the IL-22 Response and Pancreatic Beta Cell Dysfunction in Type 2 Diabetic Mice.
Kim WJ, Ryu R, Doo EH, Choi Y, Kim K, Kim BK, Kim H, Kim M, Huh CS |
Probiotics and Antimicrobial Proteins | 2023 |
Activation of the aryl hydrocarbon receptor in inflammatory bowel disease: insights from gut microbiota
Hou JJ, Ma AH, Qin YH |
Frontiers in Cellular and Infection Microbiology | 2023 |
Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food
Kemter AM, Patry RT, Arnold J, Hesser LA, Campbell E, Ionescu E, Mimee M, Wang S, Nagler CR |
Cell Reports | 2023 |
Epithelial dysfunction is prevented by IL-22 treatment in a Citrobacter rodentium-induced colitis model that shares similarities with Inflammatory Bowel Disease
Qifan Zhu, Daniel Korenfeld, Abel Suarez-Fueyo, Sean Graham, Liang Jin, Rachael Duffy, Andrew Caruso, Chenqi Hu, Yu Tian, Bradford McRae, Raj Kamath, Lucy Phillips, Annette Schwartz-Sterman, Susan Westmorel, Xiaohong Cao, Marc Levesque, Yingtao Bi, Jesus Paez-Cortez, Radhika Goenka |
Mucosal Immunology | 2022 |
Immune translational control by CPEB4 regulates intestinal inflammation resolution and colorectal cancer development
A Sibilio, C Suñer, M Fernández-Alfara, J Martín, A Berenguer, A Calon, V Chanes, A Millanes-Romero, G Fernández-Miranda, E Batlle, M Fernández, R Méndez |
iScience | 2022 |
Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine
N Walker, J Liu, S Young, R Woode, L Clarke |
AJP Gastrointestinal and Liver Physiology | 2022 |
Intestinal Epithelial AMPK Deficiency Causes Delayed Colonic Epithelial Repair in DSS-Induced Colitis
S Olivier, H Diounou, C Pochard, L Frechin, E Durieu, M Foretz, M Neunlist, M Rolli-Derkinderen, B Viollet |
Cells | 2022 |
Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation
Ghimire S, Ederer KU, Meedt E, Weber D, Matos C, Hiergeist A, Zeman F, Wolff D, Edinger M, Poeck H, Herr W, Gessner A, Holler E, Bülow S |
Frontiers in immunology | 2022 |
A Review on the Immunomodulatory Mechanism of Acupuncture in the Treatment of Inflammatory Bowel Disease.
Liu Z, Jiao Y, Yu T, Wang H, Zhang Y, Liu D, Xu Y, Guan Q, Lu M |
Evidence-based complementary and alternative medicine : eCAM | 2022 |
Regulatory role of short-chain fatty acids in inflammatory bowel disease.
Zhang Z, Zhang H, Chen T, Shi L, Wang D, Tang D |
Cell communication and signaling : CCS | 2022 |
Interleukin-1β secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair
Wu WJ, Kim M, Chang LC, Assie A, Saldana-Morales FB, Zegarra-Ruiz DF, Norwood K, Samuel BS, Diehl GE |
Gut microbes | 2022 |
Differential colitis susceptibility of Th1- and Th2-biased mice: A multi-omics approach
Mukhopadhyay S, Saha S, Chakraborty S, Prasad P, Ghosh A, Aich P |
PloS one | 2022 |
Diffuse invasive signet ring cell carcinoma in total colorectum caused by ulcerative colitis: A case report and review of literature.
Zhang Z, Yu PF, Gu GL, Zhang YH, Wang YM, Dong ZW, Yang HR |
World journal of clinical cases | 2022 |
Rewiring host–microbe interactions and barrier function during gastrointestinal inflammation
Jensen SK, Pærregaard SI, Brandum EP, Jørgensen AS, Hjortø GM, Jensen BA |
Gastroenterology Report | 2022 |
Gut homeostasis, injury, and healing: New therapeutic targets
Oncel S, Basson MD |
World Journal of Gastroenterology | 2022 |
Clostridioides difficile Toxin B Activates Group 3 Innate Lymphocytes.
Pope RL, Chitrakar A, Sah P, Shadid T, Ballard JD, Zenewicz LA |
Infection and immunity | 2022 |
TNF hampers intestinal tissue repair in colitis by restricting IL-22 bioavailability.
Ninnemann J, Winsauer C, Bondareva M, Kühl AA, Lozza L, Durek P, Lissner D, Siegmund B, Kaufmann SHE, Mashreghi MF, Nedospasov SA, Kruglov AA |
Mucosal Immunology | 2022 |
LRBA Deficiency Can Lead to Lethal Colitis That Is Diminished by SHIP1 Agonism
Sudan R, Fernandes S, Srivastava N, Pedicone C, Meyer ST, Chisholm JD, Engelman RW, Kerr WG |
Frontiers in immunology | 2022 |
A Non-redundant Role for T cell-derived Interleukin 22 in Antibacterial Defense of Colonic Crypts
Zindl CL, Witte SJ, Laufer VA, Gao M, Yue Z, Janowski KM, Cai B, Frey BF, Silberger DJ, Harbour SN, Singer JR, Turner H, Lund FE, Vallance BA, Rosenberg AF, Schoeb TR, Chen JY, Hatton RD, Weaver CT |
Immunity | 2022 |
Amelioration of DSS-Induced Acute Colitis in Mice by Recombinant Monomeric Human Interleukin-22
Kim S, Hong EH, Lee CK, Ryu Y, Jeong H, Heo S, Lee JJ, Ko HJ |
Immune Network | 2022 |
PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation.
Wu D, Hu L, Han M, Deng Y, Zhang Y, Ren G, Zhao X, Li Z, Li P, Zhang Y, Chen S, Li J, Shi Y, Xue J, Wang P, Zhong C |
Nature metabolism | 2022 |
Interaction between microbiota and immunity and its implication in colorectal cancer.
Xing C, Du Y, Duan T, Nim K, Chu J, Wang HY, Wang RF |
Frontiers in immunology | 2022 |
Identification of genetic variants of the IL‐22 gene in association with an altered risk of COPD susceptibility
Wang Y, Zhou Q, Chen L, Dong L, Xiong M, Xie X, Zhao L, Xu J, Zheng Z, Wang J, Lu W |
The Clinical Respiratory Journal | 2022 |
Inflammation triggers ILC3 patrolling of the intestinal barrier.
Jarade A, Garcia Z, Marie S, Demera A, Prinz I, Bousso P, Di Santo JP, Serafini N |
Nature Immunology | 2022 |
Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease
Katsandegwaza B, Horsnell W, Smith K |
International journal of molecular sciences | 2022 |
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, Tans S, Lopez-Iglesias C, Peters PJ, Wu W, Kotlarz D, Klein C, Margaritis T, Holstege F, Clevers H |
Cell Stem Cell | 2022 |
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases.
Mutalub YB, Abdulwahab M, Mohammed A, Yahkub AM, Al-Mhanna SB, Yusof W, Tang SP, Rasool AHG, Mokhtar SS |
2022 | |
Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism.
Bachmann R, Van Hul M, Baldin P, Léonard D, Delzenne NM, Belzer C, Ouwerkerk JP, Repsilber D, Rangel I, Kartheuser A, Brummer RJ, De Vos WM, Cani PD |
Cells | 2022 |
Interleukin-22 Ameliorates Dextran Sulfate Sodium-Induced Colitis through the Upregulation of lncRNA-UCL to Accelerate Claudin-1 Expression via Sequestering miR-568 in Mice.
He C, Chen Z, Huang J, Gan R, Wang J, Wang L, Li D, Yao J |
Oxidative medicine and cellular longevity | 2022 |
Preventive Effect of Vitamin C on Dextran Sulfate Sodium (DSS)-Induced Colitis via the Regulation of IL-22 and IL-6 Production in Gulo(−/−) Mice
Jo H, Lee D, Go C, Jang Y, Chu N, Bae S, Kang D, Im JP, Kim Y, Kang JS |
International journal of molecular sciences | 2022 |
Role of IL-22 in intestinal microenvironment and potential targeted therapy through diet.
Wang P, Chan WK, Wang J, Yang Z, Wang Y |
Immunologic research | 2022 |
Utilizing mast cells in a positive manner to overcome inflammatory and allergic diseases
Zhang Z, Ernst PB, Kiyono H, Kurashima Y |
Frontiers in immunology | 2022 |
Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.
Swedik SM, Madola A, Cruz MA, Llorens-Bonilla BJ, Levine AD |
Journal of immunology (Baltimore, Md. : 1950) | 2022 |
IL-22BP production is heterogeneously distributed in Crohn's disease.
Fantou A, Lagrue E, Laurent T, Delbos L, Blandin S, Jarry A, Beriou G, Braudeau C, Salabert N, Marin E, Moreau A, Podevin J, Bourreille A, Josien R, Martin JC |
Frontiers in immunology | 2022 |
Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)
Ogbechi J, Huang YS, Clanchy FI, Pantazi E, Topping LM, Darlington LG, Williams RO, Stone TW |
Frontiers in immunology | 2022 |
Mechanistic studies of MALAT1 in respiratory diseases
Wu W, Wang S, Zhang L, Mao B, Wang B, Wang X, Zhao D, Zhao P, Mou Y, Yan P |
Frontiers in Molecular Biosciences | 2022 |
Intelectin-1 binds and alters the localization of the mucus barrier–modifying bacterium Akkermansia muciniphila
Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS |
Journal of Experimental Medicine | 2022 |
IL-22 and Lactobacillus delbrueckii Mitigate Alcohol Induced Exacerbation of DSS-Induced Colitis
Cannon AR, Shim EH, Kuprys PV, Choudhry MA |
Journal of leukocyte biology | 2022 |
Porcine Interleukin-17 and 22 Co-Expressed by Yarrowia lipolytica Enhance Immunity and Increase Protection against Bacterial Challenge in Mice and Piglets.
Peng J, Yang F, Chen J, Guo S, Zhang L, Deng D, Li J, Lv X, Gao R |
Biology | 2022 |
BMP-signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Lindholm HT, Parmar N, Drurey C, Poveda MC, Vornewald P, Ostrop J, Díez-Sanchez A, Maizels RM, Oudhoff MJ |
Science Immunology | 2022 |
Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL‐22‐mediated intestinal epithelial repair
Chen J, Huang J, Shi J, Li M, Zhao E, Li G, Chen X, Wang T, Li Q, Li W, Ma J, Mao W, Fang R, Hao J, Huang W, Xiang AP, Zhang X |
Cell Proliferation | 2022 |
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor
Alvik K, Shao P, Hutin D, Baglole C, Grant DM, Matthews J |
Toxicological Sciences | 2022 |
A phase 2 study of interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract
Ponce DM, Alousi AM, Nakamura R, Slingerland J, Calafiore M, Sandhu KS, Barker JN, Devlin S, Shia J, Giralt S, Perales MA, Moore G, Fatmi S, Soto C, Gomes A, Giardina P, Marcello L, Yan X, Tang T, Dreyer K, Chen J, Daley WL, Peled JU, van den Brink MR, Hanash AM |
Blood | 2022 |
USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network
An R, Wang P, Guo H, Liuyu T, Zhong B, Zhang ZD |
2022 | |
Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease
M Stürzl, M Kunz, SM Krug, E Naschberger |
Frontiers in Medicine | 2021 |
MAIT cells, guardians of skin and mucosa?
I Nel, L Bertrand, A Toubal, A Lehuen |
Mucosal Immunology | 2021 |
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier
CY Liu, CM Cham, EB Chang |
Translational research : the journal of laboratory and clinical medicine | 2021 |
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation
AM Tsou, JA Goettel, B Bao, A Biswas, YH Kang, NS Redhu, K Peng, GG Putzel, J Saltzman, R Kelly, J Gringauz, J Barends, M Hatazaki, SM Frei, R Emani, Y Huang, Z Shen, JG Fox, JN Glickman, BH Horwitz, SB Snapper |
Microbiome | 2021 |
Immunological Networks Defining the Heterogeneity of Inflammatory Bowel Diseases
KA Selin, CR Hedin, EJ Villablanca |
Journal of Crohn's & colitis | 2021 |
Intestinal Stem Cells and Immune Cell Relationships: Potential Therapeutic Targets for Inflammatory Bowel Diseases
Q Hou, J Huang, H Ayansola, H Masatoshi, B Zhang |
Frontiers in immunology | 2021 |
Intestinal Mucosal Wound Healing and Barrier Integrity in IBD–Crosstalk and Trafficking of Cellular Players
K Sommer, M Wiendl, TM Müller, K Heidbreder, C Voskens, MF Neurath, S Zundler |
Frontiers in Medicine | 2021 |
Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease
A Drobny, PA Ngo, MF Neurath, F Zunke, R López-Posadas |
Frontiers in Medicine | 2021 |
miR‑452‑5p regulates the responsiveness of intestinal epithelial cells in inflammatory bowel disease through Mcl‑1
M Deng, J Hu, R Tong, H Guo, Y Liu |
Experimental and therapeutic medicine | 2021 |
A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability
A Apostolou, RA Panchakshari, A Banerjee, DV Manatakis, MD Paraskevopoulou, R Luc, G Abu-Ali, A Dimitriou, C Lucchesi, G Kulkarni, TI Maulana, M Kasendra, JS Kerns, B Bleck, L Ewart, ES Manolakos, GA Hamilton, C Giallourakis, K Karalis |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2021 |
Aucuboside Inhibits the Generation of Th17 Cells in Mice Colitis
C Mei, X Wang, F Meng, X Zhang, L Chen, S Yan, J Xue, X Sun, Y Wang |
Frontiers in pharmacology | 2021 |
Identification of an IL-22-Dependent Gene Signature as a Pharmacodynamic Biomarker
J Rae, J Hackney, K Huang, M Keir, A Herman |
International journal of molecular sciences | 2021 |
Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance
R Kawano, T Okamura, Y Hashimoto, S Majima, T Senmaru, E Ushigome, M Asano, M Yamazaki, H Takakuwa, R Sasano, N Nakanishi, M Hamaguchi, M Fukui |
International journal of molecular sciences | 2021 |
Interleukin-22 Attenuates Acute Pancreatitis-Associated Intestinal Mucosa Injury in Mice via STAT3 Activation
J Bai, J Bai, M Yang |
Gut and Liver | 2021 |
Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
HM Grifka-Walk, BR Jenkins, DJ Kominsky |
Frontiers in immunology | 2021 |
Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
SY Moon, KD Kim, J Yoo, JH Lee, C Hwangbo |
Molecules (Basel, Switzerland) | 2021 |
Colonizing Microbes, IL-10 and IL-22: Keeping the Peace at the Mucosal Surface
E Kidess, M Kleerebezem, S Brugman |
Frontiers in microbiology | 2021 |
Gardenia Jasminoides Ameliorates Antibiotic-Associated Aggravation of DNCB-Induced Atopic Dermatitis by Restoring the Intestinal Microbiome Profile
HI Kim, SH Hong, SY Lee, JM Ku, MJ Kim, SG Ko |
Nutrients | 2021 |
Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases
A Schulz-Kuhnt, MF Neurath, S Wirtz, I Atreya |
Frontiers in Medicine | 2021 |
Act Locally, Act Globally—Microbiota, Barriers, and Cytokines in Atherosclerosis
N Kurilenko, AR Fatkhullina, A Mazitova, EK Koltsova |
Cells | 2021 |
Interleukin-22 Deficiency Contributes to Dextran Sulfate Sodium-Induced Inflammation in Japanese Medaka, Oryzias latipes
Y Takahashi, Y Okamura, N Harada, M Watanabe, H Miyanishi, T Kono, M Sakai, J Hikima |
Frontiers in immunology | 2021 |
The Role of the IL-23/IL-17 Axis in Disease Initiation in Spondyloarthritis: Lessons Learned From Animal Models
M Mandour, S Chen, MG van de Sande |
Frontiers in immunology | 2021 |
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)
H Choe, JL Ferrara |
Expert Opinion on Therapeutic Targets | 2021 |
Bacterial Translocation as Inflammatory Driver in Crohn’s Disease
R Linares, R Francés, A Gutiérrez, O Juanola |
Frontiers in Cell and Developmental Biology | 2021 |
Innate Lymphoid Cells and Celiac Disease: Current Perspective
X Yu, J Vargas, PH Green, G Bhagat |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2021 |
Non‐zero‐sum microbiome immune system interactions
T Tuganbaev, K Honda |
European Journal of Immunology | 2021 |
Critical role of interferons in gastrointestinal injury repair
C McElrath, V Espinosa, JD Lin, J Peng, R Sridhar, O Dutta, HC Tseng, SV Smirnov, H Risman, MJ Sandoval, V Davra, YJ Chang, BP Pollack, RB Birge, M Galan, A Rivera, JE Durbin, SV Kotenko |
Nature Communications | 2021 |
Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
E Filidou, G Kolios |
Pharmaceuticals (Basel, Switzerland) | 2021 |
Alcohol Use and Abuse Conspires With HIV Infection to Aggravate Intestinal Dysbiosis and Increase Microbial Translocation in People Living With HIV: A Review
J Yan, J Ouyang, S Isnard, X Zhou, V Harypursat, JP Routy, Y Chen |
Frontiers in immunology | 2021 |
LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia
Y Li, Q Zhang, L Li, D Hao, P Cheng, K Li, X Li, J Wang, Q Wang, Z Du, H Ji, H Chen |
Cellular and Molecular Life Sciences | 2021 |
Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
JP ten Klooster, M Bol-Schoenmakers, K van Summeren, AL van Vliet, CA de Haan, FJ van Kuppeveld, S Verkoeijen, R Pieters |
2021 | |
Diet–Host–Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis
H Han, S Safe, A Jayaraman, RS Chapkin |
Annual Review of Nutrition | 2021 |
Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid–Driven Colonic Inflammation
FD Ihekweazu, MA Engevik, W Ruan, Z Shi, R Fultz, KA Engevik, AL Chang-Graham, J Freeborn, ES Park, S Venable, TD Horvath, SJ Haidacher, AM Haag, A Goodwin, DA Schady, JM Hyser, JK Spinler, Y Liu, J Versalovic |
The American Journal of Pathology | 2021 |
Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD
MV Fernandez-Cantos, D Garcia-Morena, V Iannone, H El-Nezami, M Kolehmainen, OP Kuipers |
Tissue Barriers | 2021 |
IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
Droeser RA, Iezzi G |
Journal of cellular immunology | 2021 |
Cytokine therapy in necrotizing enterocolitis: A promising treatment for preterm infants
Wang B, Koch MA |
Cell reports. Medicine | 2021 |
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Yang S, Yu M |
Journal of inflammation research | 2021 |
The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions.
Spalinger MR, Sayoc-Becerra A, Ordookhanian C, Canale V, Santos AN, King SJ, Krishnan M, Nair MG, Scharl M, McCole DF |
Journal of Crohn's & colitis | 2021 |
Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis.
Neyazi M, Bharadwaj SS, Bullers S, Varenyiova Z, Travis S, Arancibia-Cárcamo CV, Powrie F, Geremia A |
Inflammatory Bowel Diseases | 2021 |
Disease Tolerance during Viral-Bacterial Co-Infections.
Barman TK, Metzger DW |
Viruses | 2021 |
Microbiota regulate innate immune signaling and protective immunity against cancer.
Xing C, Wang M, Ajibade AA, Tan P, Fu C, Chen L, Zhu M, Hao ZZ, Chu J, Yu X, Yin B, Zhu J, Shen WJ, Duan T, Wang HY, Wang RF |
Cell Host & Microbe | 2021 |
Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut.
Laursen MF, Sakanaka M, von Burg N, Mörbe U, Andersen D, Moll JM, Pekmez CT, Rivollier A, Michaelsen KF, Mølgaard C, Lind MV, Dragsted LO, Katayama T, Frandsen HL, Vinggaard AM, Bahl MI, Brix S, Agace W, Licht TR, Roager HM |
Nature Microbiology | 2021 |
Natural Food Polysaccharides Ameliorate Inflammatory Bowel Disease and Its Mechanisms
Wang Y, Zhu H, Wang X, Yu Y, Xie J |
Foods | 2021 |
IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
Zenewicz LA |
Frontiers in immunology | 2021 |
The Tissue Protective Functions of Interleukin-22 can be Decoupled from Pro-Inflammatory Actions Through Structure-Based Design
Saxton RA, Henneberg LT, Calafiore M, Su L, Jude KM, Hanash AM, Garcia KC |
Immunity | 2021 |
Mucins Dynamics in Physiological and Pathological Conditions
Melhem H, Regan-Komito D, Niess JH |
International journal of molecular sciences | 2021 |
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions
Pral LP, Fachi JL, Corrêa RO, Colonna M, Vinolo MA |
Trends in Immunology | 2021 |
Neuronal regulation of the gut immune system and neuromodulation for treating inflammatory bowel disease
Populin L, Stebbing MJ, Furness JB |
FASEB bioAdvances | 2021 |
Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model
Smyth DJ, Ren B, White MP, McManus C, Webster H, Shek V, Evans C, Pandhal J, Fields F, Maizels RM, Mayfield S |
Journal of Biotechnology | 2021 |
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice
Renaud V, Houde VP, Pilon G, Varin TV, Roblet C, Marette A, Boutin Y, Bazinet L |
International journal of molecular sciences | 2021 |
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3
Han H, Davidson LA, Fan YY, Landrock KK, Jayaraman A, Safe SH, Chapkin RS |
AJP Gastrointestinal and Liver Physiology | 2021 |
The Pathogenic Roles of IL-22 in Colitis: Its Transcription Regulation by Musculin in T Helper Subsets and Innate Lymphoid Cells.
Yan J, Yu J, Liu K, Liu Y, Mao C, Gao W |
Frontiers in immunology | 2021 |
Regulatory Roles of MicroRNA in Shaping T Cell Function, Differentiation and Polarization
Naqvi RA, Manali M, Khan SH, Naqvi AR |
Seminars in cell & developmental biology | 2021 |
Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities
G Pastor-Fernández, IR Mariblanca, MN Navarro |
Cells | 2020 |
Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing
G Ho, JA Cartwright, EJ Thompson, CC Bain, AG Rossi |
Inflammatory Bowel Diseases | 2020 |
Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis
CF Yeh, YH Chen, SF Liu, HL Kao, MS Wu, KC Yang, WK Wu |
International journal of molecular sciences | 2020 |
The development of colitis in Il10−/− mice is dependent on IL-22
DC Gunasekera, J Ma, V Vacharathit, P Shah, A Ramakrishnan, P Uprety, Z Shen, A Sheh, CF Brayton, MT Whary, JG Fox, JH Bream |
Mucosal Immunology | 2020 |
Interleukin 23 and autoimmune diseases: current and possible future therapies
AI Abdo, GJ Tye |
Inflammation Research | 2020 |
Immune Cell Circuits in Mucosal Wound Healing: Clinical Implications
S Zundler, V Tauschek, MF Neurath |
Viszeralmedizin | 2020 |
Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier
F Puértolas-Balint, BO Schroeder |
Frontiers in immunology | 2020 |
Membrane mucins of the intestine at a glance
T Pelaseyed, GC Hansson |
Journal of cell science | 2020 |
The relationship between intestinal goblet cells and the immune response
M Zhang, C Wu |
Bioscience Reports | 2020 |
How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology
A Rannug |
International journal of molecular sciences | 2020 |
Immunological Mechanisms in Inflammation-Associated Colon Carcinogenesis
T Hirano, D Hirayama, K Wagatsuma, T Yamakawa, Y Yokoyama, H Nakase |
International journal of molecular sciences | 2020 |
Role of regenerating islet-derived proteins in inflammatory bowel disease
JA Edwards, N Tan, N Toussaint, P Ou, C Mueller, A Stanek, V Zinsou, S Roudnitsky, M Sagal, L Dresner, A Schwartzman, C Huan |
World journal of gastroenterology : WJG | 2020 |
Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier
D Ahn, A Prince |
Frontiers in Cellular and Infection Microbiology | 2020 |
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
T Arshad, F Mansur, R Palek, S Manzoor, V Liska |
Frontiers in immunology | 2020 |
Soil-Transmitted Helminth Vaccines: Are We Getting Closer?
A Zawawi, KJ Else |
Frontiers in immunology | 2020 |
Microbiota-Dependent Effects of IL-22
M Sabihi, M Böttcher, P Pelczar, S Huber |
Cells | 2020 |
The Regulatory Function of CCR9+ Dendritic Cells in Inflammation and Autoimmunity
M Pathak, G Lal |
Frontiers in immunology | 2020 |
Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases
M Ghiboub, CM Verburgt, B Sovran, MA Benninga, WJ de Jonge, JE Limbergen |
Nutrients | 2020 |
Microbiota Changes Due to Grape Seed Extract Diet Improved Intestinal Homeostasis and Decreased Fatness in Parental Broiler Hens
J Grandhaye, V Douard, A Rodriguez-Mateos, Y Xu, A Cheok, A Riva, R Guabiraba, O Zemb, C Philippe, M Monnoye, C Staub, E Venturi, A Barbe, C Ramé, J Dupont, P Froment |
Microorganisms | 2020 |
Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models
L Zhang, CD Wallace, JE Erickson, CM Nelson, SM Gaudette, CS Pohl, SD Karsen, GH Simler, R Peng, CA Stedman, FS Laroux, MA Wurbel, RV Kamath, BL McRae, AJ Sterman, S Mitra |
Scientific Reports | 2020 |
Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella
Y Yang, J Wang, J Xu, Q Liu, Z Wang, X Zhu, X Ai, Q Gao, X Chen, J Zou |
Frontiers in immunology | 2020 |
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
HX Wei, B Wang, B Li |
Frontiers in immunology | 2020 |
From intestinal dysbiosis to alcohol-associated liver disease
BG Mendes, B Schnabl |
Clinical and Molecular Hepatology | 2020 |
CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes
M Kunkl, C Amormino, S Frascolla, M Sambucci, MD Bardi, S Caristi, S Arcieri, L Battistini, L Tuosto |
Frontiers in immunology | 2020 |
Decrease in Mucosal IL17A, IFNγ and IL10 Expressions in Active Crohn’s Disease Patients Treated with High-Dose Vitamin D Alone or Combined with Infliximab
M Bendix, A Dige, SP Jørgensen, JF Dahlerup, BM Bibby, B Deleuran, J Agnholt |
Nutrients | 2020 |
CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation
S Cui, C Wang, W Bai, J Li, Y Pan, X Huang, H Yang, Z Feng, Q Xiang, L Fei, L Zheng, J Huang, Q Zhang, Y Wu, Y Chen |
Science Advances | 2020 |
Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems
SH Kim, YS Jang |
Immune Network | 2020 |
Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy
S Das, CS Croix, M Good, J Chen, J Zhao, S Hu, M Ross, MM Myerburg, JM Pilewski, J Williams, SE Wenzel, JK Kolls, A Ray, P Ray |
iScience | 2020 |
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
J Kempski, AD Giannou, K Riecken, L Zhao, B Steglich, J Lücke, L Garcia-Perez, KF Karstens, A Wöstemeier, M Nawrocki, P Pelczar, M Witkowski, S Nilsson, L Konczalla, AM Shiri, J Kempska, R Wahib, L Brockmann, P Huber, AC Gnirck, JE Turner, DE Zazara, PC Arck, A Stein, R Simon, A Daubmann, J Meiners, D Perez, T Strowig, P Koni, AA Kruglov, G Sauter, JR Izbicki, AH Guse, T Roesch, AW Lohse, RA Flavell, N Gagliani, S Huber |
Gastroenterology | 2020 |
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity
SJ Gaudino, M Beaupre, X Lin, P Joshi, S Rathi, PA McLaughlin, C Kempen, N Mehta, O Eskiocak, B Yueh, RS Blumberg, AW van der Velden, KR Shroyer, AB Bialkowska, S Beyaz, P Kumar |
Mucosal Immunology | 2020 |
Gut microbiota and cardiovascular disease: opportunities and challenges
N Kazemian, M Mahmoudi, F Halperin, JC Wu, S Pakpour |
Microbiome | 2020 |
The role of IL-22 in intestinal health and disease
ME Keir, T Yi, TT Lu, N Ghilardi |
Journal of Experimental Medicine | 2020 |
Commentary on: The potency of lncRNA MALAT1/miR-155 in altering asthmatic Th1/Th2 balance by modulation of CTLA4
R Foronjy |
Bioscience Reports | 2020 |
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N |
Nature reviews. Gastroenterology & hepatology | 2020 |
A Central Role for Lipocalin-2 in the Adaptation to Short-Bowel Syndrome Through Down-Regulation of IL22 in Mice.
Zhang A, Sodhi CP, Wang M, Shores DR, Fulton W, Prindle T, Brosten S, O'Hare E, Lau A, Ding H, Jia H, Lu P, White JR, Hui J, Sears CL, Hackam DJ, Alaish SM |
Cellular and Molecular Gastroenterology and Hepatology | 2020 |
Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
van Tilburg Bernardes E, Pettersen VK, Gutierrez MW, Laforest-Lapointe I, Jendzjowsky NG, Cavin JB, Vicentini FA, Keenan CM, Ramay HR, Samara J, MacNaughton WK, Wilson RJ, Kelly MM, McCoy KD, Sharkey KA, Arrieta MC |
Nature Communications | 2020 |
Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice
Aarts J, Roeleveld DM, Helsen MM, Walgreen B, Vitters EL, Kolls J, van de Loo FA, van Lent PL, van der Kraan PM, Koenders MI |
Rheumatology (Oxford, England) | 2020 |
Gingival crevicular fluid levels of Interleukin-22 (IL-22) and human β Defensin-2 (hBD-2) in periodontal health and disease : A correlative study.
Sidharthan S, Dharmarajan G, Kulloli A |
Journal of Oral Biology and Craniofacial Research | 2020 |
A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis
Ozkul C, Ruiz VE, Battaglia T, Xu J, Roubaud-Baudron C, Cadwell K, Perez-Perez GI, Blaser MJ |
Genome Medicine | 2020 |
IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice
Liang Y, Yi P, Ru W, Jie Z, Wang H, Ghanayem T, Wang X, Alamer E, Liu J, Hu H, Soong L, Cai J, Sun J |
Journal of Neuroinflammation | 2020 |
Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium
Heppert JK, Davison JM, Kelly C, Mercado GP, Lickwar CR, Rawls JF |
Nature reviews. Gastroenterology & hepatology | 2020 |
Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility.
Cromarty R, Archary D |
AIDS Research and Treatment | 2020 |
Effects of novel probiotic strains of Bacillus pumilus and Bacillus subtilis on production, gut health, and immunity of broiler chickens raised under suboptimal conditions.
Bilal M, Si W, Barbe F, Chevaux E, Sienkiewicz O, Zhao X |
Poultry science | 2020 |
6-Formylindolo (3, 2-b) Carbazole (FICZ)–mediated protection of gut barrier is dependent on T cells in a mouse model of alcohol combined with burn injury
Li X, Luck ME, Hammer AM, Cannon AR, Choudhry MA |
2020 | |
The role of innate lymphoid cells in response to microbes at mucosal surfaces.
Seo GY, Giles DA, Kronenberg M |
Mucosal Immunology | 2020 |
Reparative T lymphocytes in organ injury
Franco D'Alessio, Johanna Kurzhagen, Hamid Rabb |
Journal of Clinical Investigation | 2019 |
Innate Lymphoid Cells: Their Contributions to Gastrointestinal Tissue Homeostasis and HIV/SIV Disease Pathology
JC Mudd, JM Brenchley |
Current HIV/AIDS Reports | 2019 |
Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection
K Burge, A Gunasekaran, J Eckert, H Chaaban |
International journal of molecular sciences | 2019 |
TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer
G Cui |
Frontiers in Oncology | 2019 |
Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease—Focusing on Intestinal Barrier Function
I Schoultz, Å Keita |
Cells | 2019 |
The Role of Immune Cells and Cytokines in Intestinal Wound Healing
X Xue, DM Falcon |
International journal of molecular sciences | 2019 |
Impact of the Microbiome on the Immune System
CB Lambring, S Siraj, K Patel, UT Sankpal, S Mathew, R Basha |
Critical reviews in immunology | 2019 |
Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains
A Steimle, S Menz, A Bender, B Ball, AN Weber, T Hagemann, A Lange, JK Maerz, R Parusel, L Michaelis, A Schäfer, H Yao, HC Löw, S Beier, MT Mebrhatu, K Gronbach, S Wagner, D Voehringer, M Schaller, B Fehrenbacher, IB Autenrieth, TA Oelschlaeger, JS Frick, L Teixeira |
PLoS Biology | 2019 |
IL-23–producing IL-10Rα–deficient gut macrophages elicit an IL-22–driven proinflammatory epithelial cell response
B Bernshtein, C Curato, M Ioannou, CA Thaiss, M Gross-Vered, M Kolesnikov, Q Wang, E David, L Chappell-Maor, A Harmelin, E Elinav, P Thakker, V Papayannopoulos, S Jung |
Science Immunology | 2019 |
Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity
E Gianchecchi, A Fierabracci |
International journal of molecular sciences | 2019 |
Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity
AT Soderholm, VA Pedicord |
Immunology | 2019 |
Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species
JW Bostick, Y Wang, Z Shen, Y Ge, J Brown, ZE Chen, M Mohamadzadeh, JG Fox, L Zhou |
Proceedings of the National Academy of Sciences | 2019 |
TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells
FC Yang, PY Chiu, Y Chen, TW Mak, NJ Chen |
Journal of Biomedical Science | 2019 |
Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD
N Köhler, R Zeiser |
Frontiers in immunology | 2019 |
Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis
B Wang, JH Lim, T Kajikawa, X Li, BA Vallance, NM Moutsopoulos, T Chavakis, G Hajishengallis |
Cell Reports | 2019 |
Interleukin‑22 regulates the homeostasis of the intestinal epithelium during inflammation
X Zhang, S Liu, Y Wang, H Hu, L Li, Y Wu, D Cao, Y Cai, J Zhang, X Zhang |
International journal of molecular medicine | 2019 |
Human Gut-Associated Natural Killer Cells in Health and Disease
A Poggi, R Benelli, R Venè, D Costa, N Ferrari, F Tosetti, MR Zocchi |
Frontiers in immunology | 2019 |
Innate Lymphoid Cells in Mucosal Immunity
SK Panda, M Colonna |
Frontiers in immunology | 2019 |
Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-Based Therapies for Inflammatory Bowel Diseases
LJ Cohen, JH Cho, D Gevers, H Chu |
Gastroenterology | 2019 |
IL-22-binding protein exacerbates influenza, bacterial super-infection
RN Abood, KJ McHugh, HE Rich, MA Ortiz, JM Tobin, K Ramanan, KM Robinson, JM Bomberger, JK Kolls, ML Manni, DA Pociask, JF Alcorn |
Mucosal Immunology | 2019 |
Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways
MA Engevik, B Luk, AL Chang-Graham, A Hall, B Herrmann, W Ruan, BT Endres, Z Shi, KW Garey, JM Hyser, J Versalovic, S Gorska, N Pujol |
mBio | 2019 |
Vitamin D/Vitamin D Receptor Signaling Is Required for Normal Development and Function of Group 3 Innate Lymphoid Cells in the Gut
L He, M Zhou, YC Li |
iScience | 2019 |
Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells
Z Pu, Y Che, W Zhang, H Sun, T Meng, H Xie, L Cao, H Hao |
International journal of molecular medicine | 2019 |
Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation
S Fan, CM Weight, AC Luissint, RS Hilgarth, JC Brazil, M Ettel, A Nusrat, CA Parkos, A Yap |
Molecular biology of the cell | 2019 |
Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway
Moniruzzaman, R Wang, V Jeet, MA McGuckin, SZ Hasnain |
International journal of molecular sciences | 2019 |
Gut IgA abundance in adult life is a major determinant of resistance to dextran sodium sulfate‐colitis and can compensate for the effects of inadequate maternal IgA received by neonates
S Gupta, S Basu, V Bal, S Rath, A George |
Immunology | 2019 |
Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis
M Fangxiao, K Yifan, Z Jihong, S Yan, L Yingchao |
Evidence-Based Complementary and Alternative Medicine | 2019 |
Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model
FD Ihekweazu, TY Fofanova, K Queliza, D Nagy-Szakal, CJ Stewart, MA Engevik, KG Hulten, N Tatevian, DY Graham, J Versalovic, JF Petrosino, R Kellermayer |
Gut microbes | 2019 |
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis
CH Poholek, SJ Dulson, AJ Zajac, LE Harrington |
ImmunoHorizons | 2019 |
High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential
Q Mo, A Fu, L Deng, M Zhao, Y Li, H Zhang, F Feng |
Nutrients | 2019 |
Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes
Q Cao, X Gao, Y Lin, C Yue, Y Wang, F Quan, Z Zhang, X Liu, Y Lu, Y Zhan, H Yang, X Li, D Qin, L Birnbaumer, K Hao, Y Yang |
Theranostics | 2019 |
lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells
G Ding, Y Ming, Y Zhang |
Gastroenterology Research and Practice | 2019 |
Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality
TS Hinks, E Marchi, M Jabeen, M Olshansky, A Kurioka, TJ Pediongco, BS Meehan, L Kostenko, SJ Turner, AJ Corbett, Z Chen, P Klenerman, J McCluskey |
Cell Reports | 2019 |
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells
N Powell, E Pantazi, P Pavlidis, A Tsakmaki, K Li, F Yang, A Parker, C Pin, D Cozzetto, D Minns, E Stolarczyk, S Saveljeva, R Mohamed, P Lavender, B Afzali, J Digby-Bell, T Tjir-Li, A Kaser, J Friedman, TT MacDonald, GA Bewick, G M |
Gut | 2019 |
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells
EM Walker, N Slisarenko, GL Gerrets, PJ Kissinger, ES Didier, MJ Kuroda, RS Veazey, SM Jazwinski, N Rout |
GeroScience | 2019 |
miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally?
AK Hossian, GG Mackenzie, G Mattheolabakis |
Nanomedicine | 2019 |
MUC1 as a target for CAR‐T therapy in head and neck squamous cell carinoma
Mei Z, Zhang K, Lam AK, Huang J, Qiu F, Qiao B, Zhang Y |
Cancer Medicine | 2019 |
Protecting intestinal epithelial cells against deoxynivalenol and E. coli damage by recombinant porcine IL-22.
Li Y, Wang J, Li Y, Wu H, Zhao S, Yu Q |
Veterinary Microbiology | 2019 |
Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study.
Naganuma M, Sugimoto S, Fukuda T, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Abe T, Suzuki Y, Kanai T |
Journal of Gastroenterology | 2019 |
Function of innate lymphoid cells in the immune-related disorders.
Dzopalić T, Božić-Nedeljković B, Jurišić V |
Human Cell | 2019 |
siRNA Targeting and Treatment of Gastrointestinal Diseases.
Chevalier R |
Clinical and Translational Science | 2019 |
Dual TLR2 and TLR7 agonists as HIV latency reversing agents
Amanda B Macedo, Camille Novis, Caroline De Assis, Eric, S Sorensen, Paula Moszczynski, Szu-han Huang, Yanqin Ren, Adam Spivak, Brad Jones, Vicente Planelles, Alberto Bosque |
JCI Insight | 2018 |
Purine metabolism controls innate lymphoid cell function and protects against intestinal injury
S Crittenden, A Cheyne, A Adams, T Forster, CT Robb, J Felton, GT Ho, D Ruckerl, AG Rossi, SM Anderton, P Ghazal, J Satsangi, SE Howie, C Yao |
Immunology and Cell Biology | 2018 |
Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells
HA Penny, SH Hodge, MR Hepworth |
Seminars in Immunopathology | 2018 |
Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation
B Bhatt, P Zeng, H Zhu, S Sivaprakasam, S Li, H Xiao, L Dong, P Shiao, R Kolhe, N Patel, H Li, D Levy-Bercowski, V Ganapathy, N Singh |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
T Imam, S Park, MH Kaplan, MR Olson |
Frontiers in immunology | 2018 |
miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis
L Wang, E Wang, Y Wang, R Mines, K Xiang, Z Sun, G Zhou, KY Chen, N Rakhilin, S Chao, G Ye, Z Wu, H Yan, H Shen, J Everitt, P Bu, X Shen |
eLife | 2018 |
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
M Kasembeli, U Bharadwaj, P Robinson, D Tweardy |
International journal of molecular sciences | 2018 |
The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It
H Armstrong, M Bording-Jorgensen, S Dijk, E Wine |
Cancers | 2018 |
Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health
J Zou, B Chassaing, V Singh, M Pellizzon, M Ricci, MD Fythe, MV Kumar, AT Gewirtz |
Cell Host & Microbe | 2018 |
In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration
H Geng, HF Bu, F Liu, L Wu, K Pfeifer, PM Chou, X Wang, J Sun, L Lu, A Pandey, MS Bartolomei, IG de Plaen, P Wang, J Yu, J Qian, XD Tan |
Gastroenterology | 2018 |
A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage
VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Contreras, D Merlin, AT Gewirtz, A Nusrat, TL Denning |
Proceedings of the National Academy of Sciences | 2018 |
Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis
G Zhang, J Liu, L Wu, Y Fan, L Sun, F Qian, D Chen, RD Ye |
Frontiers in immunology | 2018 |
Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion
A Barthelemy, V Sencio, D Soulard, L Deruyter, C Faveeuw, RL Goffic, F Trottein, AJ Bäumler |
Infection and immunity | 2018 |
Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production
S Seshadri, RL Pope, LA Zenewicz |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
The Interleukin-20 Cytokines in Intestinal Diseases
JH Niess, P Hruz, T Kaymak |
Frontiers in immunology | 2018 |
Canonical Wnt Signaling in CD11c + APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon
D Swafford, A Shanmugam, P Ranganathan, MS Hussein, PA Koni, PD Prasad, M Thangaraju, S Manicassamy |
Journal of immunology (Baltimore, Md. : 1950) | 2018 |
Regulation of IL-22BP in psoriasis
S Voglis, S Moos, L Kloos, F Wanke, M Zayoud, P Pelczar, AD Giannou, S Pezer, M Albers, F Luessi, S Huber, K Schäkel, FC Kurschus |
Scientific Reports | 2018 |
Role of the Microbiome in Food Allergy
H Ho, S Bunyavanich |
Current Allergy and Asthma Reports | 2018 |
Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
JA Mullaney, JE Stephens, ME Costello, C Fong, BE Geeling, PG Gavin, CM Wright, TD Spector, MA Brown, EE Hamilton-Williams |
Microbiome | 2018 |
Interleukin-22 levels are increased in gastrointestinal graft- versus -host disease in children
DT Lounder, P Khandelwal, NJ Gloude, CE Dandoy, S Jodele, M Medvedovic, LA Denson, A Lane, K Lake, B Litts, A Wilkey, SM Davies |
Haematologica | 2018 |
Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling
JM Zha, HS Li, Q Lin, WT Kuo, ZH Jiang, PY Tsai, N Ding, J Wu, SF Xu, YT Wang, J Pan, XM Zhou, K Chen, M Tao, MA Odenwald, A Tamura, S Tsukita, JR Turner, WQ He |
CMGH Cellular and Molecular Gastroenterology and Hepatology | 2018 |
An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis
AR Fatkhullina, IO Peshkova, A Dzutsev, T Aghayev, JA McCulloch, V Thovarai, JH Badger, R Vats, P Sundd, HY Tang, AV Kossenkov, SL Hazen, G Trinchieri, SI Grivennikov, EK Koltsova |
Immunity | 2018 |
Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons
Z He, J Song, J Hua, M Yang, Y Ma, T Yu, J Feng, B Liu, X Wang, Y Li, J Li |
Cell Death and Disease | 2018 |
Nonclinical safety assessment of a human interleukin‐22 FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability
DW Lee, S Zhong, R Pai, J Rae, S Sukumaran, EG Stefanich, J Lutman, E Doudement, X Wang, B Harder, A Lekkerkerker, A Herman, W Ouyang, DM Danilenko |
Pharmacology Research & Perspectives | 2018 |
TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis
B Xiao, Q Chen, Z Zhang, L Wang, Y Kang, T Denning, D Merlin |
Journal of Controlled Release | 2018 |
Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis
AR Cannon, PV Kuprys, AN Cobb, X Ding, AN Kothari, PC Kuo, JM Eberhardt, AM Hammer, NL Morris, X Li, MA Choudhry |
Journal of leukocyte biology | 2018 |
Delivery of interleukin-22 binding protein (IL-22BP) gene by cationic micelle for colon cancer gene therapy
Men K, Huang R, Zhang X, Zhang R, Zhang Y, Peng Y, Tong R, Yang L, Wei Y, Duan X |
RSC Advances | 2018 |
Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism.
Takasawa S, Tsuchida C, Sakuramoto-Tsuchida S, Takeda M, Itaya-Hironaka A, Yamauchi A, Misu M, Shobatake R, Uchiyama T, Makino M, Ohbayashi C |
Immunologic research | 2018 |
IL-22: There is a gap in our knowledge
Zenewicz LA |
ImmunoHorizons | 2018 |
IL-22 deficiency increases CD4 T cell responses to mucosal immunization.
Budda SA, Zenewicz LA |
Vaccine | 2018 |
Th17 Cell Regulation by P. UF1 Bacterium During Intestinal Inflammation
Natacha Colliou, Yong Ge, Bikash Sahay, Minghao Gong, Mojgan Zadeh, Jennifer Owen, j Neu, William Farmerie, Francis Alonzo, Ken Liu, Dean P. Jones, Shuzhao Li, Mansour Mohamadzadeh |
Journal of Clinical Investigation | 2017 |
The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages
K Chebli, L Papon, C Paul, A Garcel, N Campos, D Scherrer, HJ Ehrlich, M Hahne, J Tazi |
Scientific Reports | 2017 |
Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation
R López-Posadas, M Stürzl, I Atreya, MF Neurath, N Britzen-Laurent |
Frontiers in immunology | 2017 |
Innate Lymphoid Cells in HIV/SIV Infections
SV Shah, C Manickam, DR Ram, RK Reeves |
Frontiers in immunology | 2017 |
Regulation of Gastric Carcinogenesis by Inflammatory Cytokines
KA Bockerstett, RJ DiPaolo |
Cellular and Molecular Gastroenterology and Hepatology | 2017 |
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases
C Abraham, PS Dulai, S Vermeire, WJ Sandborn |
Gastroenterology | 2017 |
HIV as a Cause of Immune Activation and Immunosenescence
T Sokoya, HC Steel, M Nieuwoudt, TM Rossouw |
Mediators of Inflammation | 2017 |
Eosinophils in Autoimmune Diseases
D Čiháková, NL Diny, NR Rose |
Frontiers in immunology | 2017 |
Targeting IL-10 Family Cytokines for the Treatment of Human Diseases
X Wang, K Wong, W Ouyang, S Rutz |
Cold Spring Harbor perspectives in biology | 2017 |
Helminths in the gastrointestinal tract as modulators of immunity and pathology
F Varyani, JO Fleming, RM Maizels |
AJP Gastrointestinal and Liver Physiology | 2017 |
IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis
V Jeffery, AJ Goldson, JR Dainty, M Chieppa, A Sobolewski |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut
BB Yoo, SK Mazmanian |
Immunity | 2017 |
Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis
L Brockmann, A Giannou, N Gagliani, S Huber |
International journal of molecular sciences | 2017 |
TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis
J Kempski, L Brockmann, N Gagliani, S Huber |
Frontiers in immunology | 2017 |
Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats
B Wang, P Zhao, Y Zhou, L Meng, W Zhu, C Jiang, L Wang, Y Cai, S Lu, W Hou, HM Ashour |
PloS one | 2017 |
Role of Regulatory Cells in Oral Tolerance
M Wawrzyniak, L O'Mahony, M Akdis |
Allergy, asthma & immunology research | 2017 |
Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
D Bauché, JC Marie |
IBMS BoneKEy | 2017 |
Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells
Z Wu, Z Hu, X Cai, W Ren, F Dai, H Liu, J Chang, B Li |
Scientific Reports | 2017 |
IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake
T Jinnohara, T Kanaya, K Hase, S Sakakibara, T Kato, N Tachibana, T Sasaki, Y Hashimoto, T Sato, H Watarai, J Kunisawa, N Shibata, IR Williams, H Kiyono, H Ohno |
Journal of Experimental Medicine | 2017 |
Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity
E Chichelnitskiy, B Himmelseher, M Bachmann, J Pfeilschifter, H Mühl |
Frontiers in immunology | 2017 |
Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses
LX Sang, B Chang, JF Zhu, FL Yang, Y Li, XF Jiang, DN Wang, CL Lu, X Sun |
World journal of gastroenterology : WJG | 2017 |
Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer
H Bergmann, S Roth, K Pechloff, EA Kiss, S Kuhn, M Heikenwälder, A Diefenbach, FR Greten, J Ruland |
European Journal of Immunology | 2017 |
The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
V Wacleche, A Landay, JP Routy, P Ancuta |
Viruses | 2017 |
Lactobacillus delivery of bioactive interleukin-22
Y Lin, K Krogh-Andersen, L Hammarström, H Marcotte |
Microbial cell factories | 2017 |
The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine
AK Savage, HE Liang, RM Locksley |
Journal of immunology (Baltimore, Md. : 1950) | 2017 |
A Nationwide Study of Severe and Protracted Diarrhoea in Patients with Primary Immunodeficiency Diseases
WI Lee, CC Chen, TH Jaing, LS Ou, C Hsueh, JL Huang |
Scientific Reports | 2017 |
Neutrophil Elastase and Interleukin 17 Expressed in the Pig Colon during Brachyspira hyodysenteriae Infection Synergistically with the Pathogen Induce Increased Mucus Transport Speed and Production via Mitogen-Activated Protein Kinase 3
MP Quintana-Hayashi, N Navabi, M Mahu, V Venkatakrishnan, HR Fernandez, F Haesebrouck, F Pasmans, SK Lindén, GH Palmer |
Infection and immunity | 2017 |
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium
C Friedrich, P Mamareli, S Thiemann, F Kruse, Z Wang, B Holzmann, T Strowig, T Sparwasser, M Lochner, DS Zamboni |
PLoS pathogens | 2017 |
CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22
A Ezeonyeji, H Baldwin, M Vukmanovic-Stejic, MR Ehrenstein |
Frontiers in immunology | 2017 |
Expression of REG family genes in human inflammatory bowel diseases and its regulation
C Tsuchida, S Sakuramoto-Tsuchida, M Taked, A Itaya-Hironaka, A Yamauchi, M Misu, R Shobatake, T Uchiyama, M Makino, I Pujol-Autonell, M Vives-Pi, C Ohbayashi, S Takasawa |
Biochemistry and Biophysics Reports | 2017 |
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling
S Seshadri, DS Allan, JR Carlyle, LA Zenewicz, SR Blanke |
PLoS pathogens | 2017 |
Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity
KA Kuhn, HM Schulz, EH Regner, EL Severs, JD Hendrickson, G Mehta, AK Whitney, D Ir, N Ohri, CE Robertson, DN Frank, EL Campbell, SP Colgan |
Mucosal Immunology | 2017 |
Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice
JM Allen, LJ Mailing, J Cohrs, C Salmonson, JD Fryer, V Nehra, VL Hale, P Kashyap, BA White, JA Woods |
Gut microbes | 2017 |
Clinical importance of IL-22 cascade in IBD
A Mizoguchi, A Yano, H Himuro, Y Ezaki, T Sadanaga, E Mizoguchi |
Journal of Gastroenterology | 2017 |
Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis.
Wittig BM, Sabat R, Holzlöhner P, Witte-Händel E, Heilmann K, Witte K, Triebus J, Tzankov A, Laman JD, Bokemeyer B, Terracciano L, Schwärzler C, Kohler H, Volkmer R, Loddenkemper C, Wolk K, Hoffmann U, Günthert U |
Mucosal Immunology | 2017 |
Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders
A Liñán-Rico, F Turco, F Ochoa-Cortes, A Harzman, BJ Needleman, R Arsenescu, M Abdel-Rasoul, P Fadda, I Grants, E Whitaker, R Cuomo, FL Christofi |
Inflammatory Bowel Diseases | 2016 |
Microbiota-specific Th17 Cells: Yin and Yang in Regulation of Inflammatory Bowel Disease
W Wu, F Chen, Z Liu, Y Cong |
Inflammatory Bowel Diseases | 2016 |
Cytokine-Induced Modulation of Colorectal Cancer
LF Mager, MH Wasmer, TT Rau, P Krebs |
Frontiers in Oncology | 2016 |
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity
HS Ranhotra, KL Flannigan, M Brave, S Mukherjee, DJ Lukin, SA Hirota, S Mani |
Nuclear Receptor Research | 2016 |
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus
L Drujont, A Lemoine, A Moreau, G Bienvenu, M Lancien, T Cens, F Guillot, G Bériou, L Bouchet-Delbos, HJ Fehling, E Chiffoleau, AB Nicot, P Charnet, JC Martin, R Josien, MC Cuturi, C Louvet |
Scientific Reports | 2016 |
Gut Mucosal Barrier Dysfunction, Microbial Dysbiosis, and Their Role in HIV-1 Disease Progression
JC Mudd, JM Brenchley |
The Journal of Infectious Diseases | 2016 |
Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection
C Tincati, DC Douek, G Marchetti |
AIDS Research and Therapy | 2016 |
Molecular pathways driving disease-specific alterations of intestinal epithelial cells
R López-Posadas, MF Neurath, I Atreya |
Cellular and Molecular Life Sciences | 2016 |
Emerging roles for antigen presentation in establishing host-microbiome symbiosis
NJ Bessman, GF Sonnenberg |
Immunological Reviews | 2016 |
Functional role of mucosal-associated invariant T cells in HIV infection
A Saeidi, R Ellegård, YK Yong, HY Tan, V Velu, JE Ussher, M Larsson, EM Shankar |
Journal of leukocyte biology | 2016 |
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich |
Cytokine & Growth Factor Reviews | 2016 |
Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases
I Soufli, R Toumi, H Rafa, C Touil-Boukoffa |
World journal of gastrointestinal pharmacology and therapeutics | 2016 |
How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
MB Khawar, F Azam, N Sheikh, KA Mujeeb |
Journal of Immunology Research | 2016 |
Intestinal inflammation without weight loss decreases bone density and growth
R Irwin, S Raehtz, N Parameswaran, LR McCabe |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2016 |
Mechanisms of interleukin-22’s beneficial effects in acute pancreatitis
C Huan |
World journal of gastrointestinal pathophysiology | 2016 |
Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur?
EN McNamee, J Rivera-Nieves |
Frontiers in immunology | 2016 |
High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22
M Gulhane, L Murray, R Lourie, H Tong, YH Sheng, R Wang, A Kang, V Schreiber, KY Wong, G Magor, S Denman, J Begun, TH Florin, A Perkins, PÓ Cuív, MA McGuckin, SZ Hasnain |
Scientific Reports | 2016 |
Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice
Y Luo, X Wu, Z Ma, W Tan, L Wang, D Na, G Zhang, A Yin, H Huang, D Xia, Y Zhang, X Shi, L Wang |
Cellular and Molecular Immunology | 2016 |
Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
AC Luissint, CA Parkos, A Nusrat |
Gastroenterology | 2016 |
Cytokine responses and epithelial function in the intestinal mucosa
JC Onyiah, SP Colgan |
Cellular and Molecular Life Sciences | 2016 |
Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation
K Aden, A Rehman, M Falk-Paulsen, T Secher, J Kuiper, F Tran, S Pfeuffer, R Sheibani-Tezerji, A Breuer, A Luzius, M Jentzsch, R Häsler, S Billmann-Born, O Will, S Lipinski, R Bharti, T Adolph, JL Iovanna, SL Kempster, RS Blumberg, S Schreiber, B Becher, M Chamaillard, A Kaser, P Rosenstiel |
Cell Reports | 2016 |
Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer
S Zundler, M Neurath |
Human vaccines | 2016 |
Interleukin-22 in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation
B Lamarthée, F Malard, P Saas, M Mohty, B Gaugler |
Frontiers in immunology | 2016 |
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease
J Sun, X Shen, Y Li, Z Guo, W Zhu, L Zuo, J Zhao, L Gu, J Gong, J Li |
Nutrients | 2016 |
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
OB Parks, DA Pociask, Z Hodzic, JK Kolls, M Good |
Frontiers in Cell and Developmental Biology | 2016 |
The Role of IL-22 in Viral Infections: Paradigms and Paradoxes
SG Brias, G Stack, MA Stacey, AJ Redwood, IR Humphreys |
Frontiers in immunology | 2016 |
During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection
H Erdmann, J Behrends, C Hölscher |
Scientific Reports | 2016 |
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway
S Li, JJ Heller, JW Bostick, A Lee, H Schjerven, P Kastner, S Chan, ZE Chen, L Zhou |
Immunity | 2016 |
The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection
MM Heimesaat, U Grundmann, ME Alutis, A Fischer, UB Göbel, S Bereswill |
Gut pathogens | 2016 |
IL-22 dampens the T cell response in experimental malaria
J Sellau, CF Alvarado, S Hoenow, MS Mackroth, D Kleinschmidt, S Huber, T Jacobs |
Scientific Reports | 2016 |
Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice
YY Qiao, XQ Liu, CQ Xu, Z Zhang, HW Xu |
World journal of gastroenterology : WJG | 2016 |
Homeostatic PPAR Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine
I Manoharan, A Suryawanshi, Y Hong, P Ranganathan, A Shanmugam, S Ahmad, D Swafford, B Manicassamy, G Ramesh, PA Koni, M Thangaraju, S Manicassamy |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells
I Marafini, I Monteleone, DD Fusco, S Sedda, ML Cupi, D Fina, AO Paoluzi, F Pallone, G Monteleone, RK Reeves |
PloS one | 2016 |
Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice: IL-22 against inflammatory bowel disease
GX Yang, Y Sun, K Tsuneyama, W Zhang, PS Leung, XS He, AA Ansari, C Bowlus, WM Ridgway, ME Gershwin |
Clinical & Experimental Immunology | 2016 |
IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression
JL Reyes, MR Fernando, F Lopes, G Leung, NL Mancini, CE Matisz, A Wang, DM McKay, DR Herbert |
PLoS pathogens | 2016 |
Biological and pathological activities of interleukin-22
MP Lanfranca, Y Lin, J Fang, W Zou, T Frankel |
Journal of Molecular Medicine | 2016 |
IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori
BR Dixon, JN Radin, MB Piazuelo, DC Contreras, HM Algood, PL Ho |
PloS one | 2016 |
Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques
ES Ryan, L Micci, R Fromentin, S Paganini, CS McGary, K Easley, N Chomont, M Paiardini, DC Douek |
PLoS pathogens | 2016 |
Reparative inflammation takes charge of tissue regeneration
M Karin, H Clevers |
Nature | 2016 |
EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
L Jiang, Y Shen, D Guo, D Yang, J Liu, X Fei, Y Yang, B Zhang, Z Lin, F Yang, X Wang, K Wang, J Wang, Z Cai |
Nature Communications | 2016 |
Cytokines IL-17 and IL-22 in the host response to infection
M Valeri, M Raffatellu, B Napier |
Pathogens and Disease | 2016 |
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22
R Porte, LV Maele, N Muñoz-Wolf, B Foligné, L Dumoutier, J Tabareau, D Cayet, P Gosset, N Jonckheere, IV Seuningen, JA Chabalgoity, M Simonet, M Lamkanfi, JC Renauld, JC Sirard, C Carnoy, B McCormick |
Infection and immunity | 2016 |
Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease
M Forkel, J Mjösberg |
Current Allergy and Asthma Reports | 2016 |
Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut
Park Y, Moon SJ, Lee SW |
BMB Reports | 2016 |
Role of AhR in positive regulation of cell proliferation and survival.
Yin J, Sheng B, Qiu Y, Yang K, Xiao W, Yang H |
Cell Proliferation | 2016 |
A novel intestinal organoid-based in vitro co-culture system to dissect out the initial host defense system.
Mizoguchi A |
Journal of Gastroenterology | 2016 |
Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation.
Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, Iwatani S, Shiraishi E, Mukai A, Inoue T, Hayashi Y, Tsujii M, Motooka D, Nakamura S, Iida T, Takehara T |
Journal of Gastroenterology | 2016 |
IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity
R Bahri, IS Pateras, O D’Orlando, DA Goyeneche-Patino, M Campbell, JK Polansky, H Sandig, M Papaioannou, K Evangelou, PG Foukas, VG Gorgoulis, S Bulfone-Paus |
OncoImmunology | 2015 |
Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
SC Nalle, JR Turner |
Mucosal Immunology | 2015 |
Immunopathogenesis of IBD: current state of the art
HS de Souza, C Fiocchi |
Nature Reviews Gastroenterology & Hepatology | 2015 |
The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU)
D Sun, D Liang, HJ Kaplan, H Shao |
Cytokine | 2015 |
Cytokines, IBD, and Colitis-associated Cancer:
R Francescone, V Hou, SI Grivennikov |
Inflammatory Bowel Diseases | 2015 |
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
M Buchert, CJ Burns, M Ernst |
Oncogene | 2015 |
Roles and regulation of the mucus barrier in the gut
S Cornick, A Tawiah, K Chadee |
Tissue Barriers | 2015 |
STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?
PM Nguyen, TL Putoczki, M Ernst |
Journal of Interferon & Cytokine Research | 2015 |
The role of Gr-1 + cells and tumour necrosis factor- α signalling during Clostridium difficile colitis in mice
AJ McDermott, KE Higdon, R Muraglia, JR Erb-Downward, NR Falkowski, RA McDonald, VB Young, GB Huffnagle |
Immunology | 2015 |
Interleukin-22: Immunobiology and Pathology
JA Dudakov, AM Hanash, MR van Brink |
Annual Review of Immunology | 2015 |
Role of group 3 innate lymphoid cells in antibody production
G Magri, A Cerutti |
Current Opinion in Immunology | 2015 |
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
GF Sonnenberg, D Artis |
Nature Medicine | 2015 |
Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk
R Rohmah, F Hardiyanti, F Fatchiyah |
Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : časopis Društva za medicinsku informatiku BiH | 2015 |
Group 3 innate lymphoid cells: regulating host–commensal bacteria interactions in inflammation and cancer
J Goc, MR Hepworth, GF Sonnenberg |
International Immunology | 2015 |
Th17 plasticity and its changes associated with inflammatory bowel disease
A Ueno |
World journal of gastroenterology : WJG | 2015 |
Tristetraprolin regulation of interleukin-22 production
L Härdle, M Bachmann, F Bollmann, A Pautz, T Schmid, W Eberhardt, H Kleinert, J Pfeilschifter, H Mühl |
Scientific Reports | 2015 |
Differential Requirements for IL-17A and IL-22 in Cecal versus Colonic Inflammation Induced by Helicobacter hepaticus
PJ Morrison, SJ Ballantyne, SJ Macdonald, JW Moore, D Jenkins, JF Wright, LA Fouser, MC Kullberg |
The American Journal of Pathology | 2015 |
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis
E Hainzl, S Stockinger, I Rauch, S Heider, D Berry, C Lassnig, C Schwab, F Rosebrock, G Milinovich, M Schlederer, M Wagner, C Schleper, A Loy, T Urich, L Kenner, X Han, T Decker, B Strobl, M Muller |
Journal of immunology (Baltimore, Md. : 1950) | 2015 |
Attenuated Airway Epithelial Cell Interleukin-22R1 Expression in the Infant Nonhuman Primate Lung
DT Dugger, JE Gerriets, LA Miller |
American journal of respiratory cell and molecular biology | 2015 |
Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells
L Masson, AL Salkinder, AJ Olivier, LR McKinnon, H Gamieldien, K Mlisana, TJ Scriba, DA Lewis, F Little, HB Jaspan, K Ronacher, L Denny, SS Karim, JA Passmore |
Immunology | 2015 |
IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis
JC Martin, G Bériou, M Heslan, C Bossard, A Jarry, A Abidi, P Hulin, S Ménoret, R Thinard, I Anegon, C Jacqueline, B Lardeux, F Halary, JC Renauld, A Bourreille, R Josien |
Mucosal Immunology | 2015 |
Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease
R Okamoto, M Watanabe |
Journal of Gastroenterology | 2015 |
CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis
J Brasseit, E Althaus-Steiner, M Faderl, N Dickgreber, L Saurer, V Genitsch, T Dolowschiak, H Li, D Finke, WD Hardt, KD McCoy, AJ Macpherson, N Corazza, M Noti, C Mueller |
Mucosal Immunology | 2015 |
IL-22 Up-Regulates β-Defensin-2 Expression in Human Alveolar Epithelium via STAT3 but Not NF-κB Signaling Pathway.
Li A, Gan Y, Wang R, Liu Y, Ma T, Huang M, Cui X |
Inflammation | 2015 |
Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation.
Dunn ET, Taylor ES, Stebbings S, Schultz M, Butt AG, Kemp RA |
Immunology and Cell Biology | 2015 |
[Interleukin-22 - friend or foe?].
Leipe J |
2015 | |
IL-21 induces IL-22 production in CD4+ T cells
A Yeste, ID Mascanfroni, M Nadeau, EJ Burns, AM Tukpah, A Santiago, C Wu, B Patel, D Kumar, FJ Quintana |
Nature Communications | 2014 |
PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis
MR Spalinger, S Kasper, C Chassard, T Raselli, I Frey-Wagner, C Gottier, S Lang, K Atrott, SR Vavricka, F Mair, B Becher, C Lacroix, M Fried, G Rogler, M Scharl |
Mucosal Immunology | 2014 |
Cytokines in inflammatory bowel disease
MF Neurath |
Nature Reviews Immunology | 2014 |
Stat3: Friend or Foe in Colitis and Colitis-associated Cancer?
J Han, AL Theiss |
Inflammatory Bowel Diseases | 2014 |
Interleukin 23 in Crohnʼs Disease:
A Eken, AK Singh, M Oukka |
Inflammatory Bowel Diseases | 2014 |
Interactions between the intestinal microbiota and innate lymphoid cells
VL Chen, DL Kasper |
Gut microbes | 2014 |
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production
MM Lowe, JE Mold, B Kanwar, Y Huang, A Louie, MP Pollastri, C Wang, G Patel, DG Franks, J Schlezinger, DH Sherr, AE Silverstone, ME Hahn, JM McCune |
PloS one | 2014 |
Targeting Interleukins for the Treatment of Inflammatory Bowel Disease—What Lies Beyond Anti-TNF Therapy?:
MH McLean, MF Neurath, SK Durum |
Inflammatory Bowel Diseases | 2014 |
Unexpected Targets and Triggers of Autoimmunity
Y Lee, M Collins, VK Kuchroo |
Journal of Clinical Immunology | 2014 |
Role of Th17 Cells in the Pathogenesis of Human IBD
J Gálvez |
ISRN Inflammation | 2014 |
Toll-Like Receptor 4-Induced IL-22 Accelerates Kidney Regeneration
OP Kulkarni, I Hartter, SR Mulay, J Hagemann, MN Darisipudi, SK Vr, S Romoli, D Thomasova, M Ryu, S Kobold, HJ Anders |
Journal of the American Society of Nephrology : JASN | 2014 |
Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis
JA Smith |
Current Allergy and Asthma Reports | 2014 |
Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice
J Ermann, T Staton, JN Glickman, RW Malefyt, LH Glimcher |
Proceedings of the National Academy of Sciences | 2014 |
Review: The Interleukin-23/Interleukin-17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond: IL-23/IL-17 Axis in SpA
JA Smith, RA Colbert |
Arthritis & Rheumatology | 2014 |
Recognition Strategies of Group 3 Innate Lymphoid Cells
M Killig, T Glatzer, C Romagnani |
Frontiers in immunology | 2014 |
Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-γ responses
S Justa, X Zhou, S Sarkar |
PloS one | 2014 |
Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection
Y Peng, X Gao, J Yang, S Shekhar, S Wang, Y Fan, W Zhao, X Yang |
Molecular Medicine | 2014 |
The role of commensal bacteria in the regulation of sensitization to food allergens
S Cao, TJ Feehley, CR Nagler |
FEBS Letters | 2014 |
Effects of Mycobacteria Major Secretion Protein, Ag85B, on Allergic Inflammation in the Lung
Y Tsujimura, H Inada, M Yoneda, T Fujita, K Matsuo, Y Yasutomi |
PloS one | 2014 |
Role of interleukin-22 in inflammatory bowel disease
LJ Li |
World journal of gastroenterology : WJG | 2014 |
Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation
A Schuetz, C Deleage, I Sereti, R Rerknimitr, N Phanuphak, Y Phuang-Ngern, JD Estes, NG Sandler, S Sukhumvittaya, M Marovich, S Jongrakthaitae, S Akapirat, JL Fletscher, E Kroon, R Dewar, R Trichavaroj, N Chomchey, DC Douek, RJ O′Connell, V Ngauy, ML Robb, P Phanuphak, NL Michael, JL Excler, JH Kim, MS de Souza, J Ananworanich, RC Desrosiers |
PLoS pathogens | 2014 |
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms
J Niebling, AE Rünker, S Schallenberg, K Kretschmer, G Kempermann |
F1000Research | 2014 |
Immune Modulatory Effects of IL-22 on Allergen-Induced Pulmonary Inflammation
P Fang, L Zhou, Y Zhou, JK Kolls, T Zheng, Z Zhu, B Ryffel |
PloS one | 2014 |
T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis: Th17 pathway, appendectomy and colitis
R Cheluvappa, AS Luo, MC Grimm |
Clinical & Experimental Immunology | 2014 |
Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis:
HT Tran, IA Lee, D Low, A Kamba, A Mizoguchi, HN Shi, CG Lee, JA Elias, E Mizoguchi |
Inflammatory Bowel Diseases | 2014 |
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
K Moriwaki, S Balaji, T McQuade, N Malhotra, J Kang, FK Chan |
Immunity | 2014 |
Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells
E Macho-Fernandez, EP Koroleva, CM Spencer, M Tighe, E Torrado, AM Cooper, YX Fu, AV Tumanov |
Mucosal Immunology | 2014 |
Interleukin-22: A likely target for treatment of autoimmune diseases
X Yang, SG Zheng |
Autoimmunity Reviews | 2014 |
Cytokine crowdsourcing: multicellular production of TH17-associated cytokines
KO Busman-Sahay, T Walrath, S Huber, W O'Connor |
Journal of leukocyte biology | 2014 |
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
S Rutz, X Wang, W Ouyang |
Nature Reviews Immunology | 2014 |
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
X Wang, N Ota, P Manzanillo, L Kates, J Zavala-Solorio, C Eidenschenk, J Zhang, J Lesch, WP Lee, J Ross, L Diehl, N Bruggen, G Kolumam, W Ouyang |
Nature | 2014 |
Therapeutic opportunities of the IL-22-IL-22R1 system.
Sabat R, Ouyang W, Wolk K |
Nature reviews. Drug discovery | 2014 |
STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration.
Khomenko T, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S |
Digestive Diseases and Sciences | 2014 |
Experimental appendicitis and appendectomy modulate the CCL20-CCR6 axis to limit inflammatory colitis pathology.
Cheluvappa R |
International Journal of Colorectal Disease | 2014 |
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.
Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen AC, Loudovaris T, Kay TW, Thomas HE, Whitehead JP, Forbes JM, Prins JB, McGuckin MA |
Nature Medicine | 2014 |
Essentials of Th17 cell commitment and plasticity
P Muranski, NP Restifo |
Blood | 2013 |
Over-expression of CXCR4 on mesenchymal stem cells protect against experimental colitis via immunomodulatory functions in impaired tissue
X Liu, D Zuo, H Fan, Q Tang, Z Shou, D Cao, Z Zou |
Journal Of Molecular Histology | 2013 |
Microbial translocation in the pathogenesis of HIV infection and AIDS
G Marchetti, C Tincati, G Silvestri |
Clinical microbiology reviews | 2013 |
CD4(+) T-cell subsets in intestinal inflammation
M Shale, C Schiering, F Powrie |
Immunological Reviews | 2013 |
HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes
JW Shui, M Kronenberg |
Gut microbes | 2013 |
Identification of Potential Cytokine Pathways for Therapeutic Intervention in Murine Primary Biliary Cirrhosis
K Kawata, M Tsuda, GX Yang, W Zhang, H Tanaka, K Tsuneyama, P Leung, XS He, S Knechtle, AA Ansari, RL Coppel, ME Gershwin, AS Basso |
PloS one | 2013 |
β-Arrestin-1 Deficiency Protects Mice from Experimental Colitis
T Lee, E Lee, R Irwin, PC Lucas, LR McCabe, N Parameswaran |
The American Journal of Pathology | 2013 |
Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek, SG Deeks |
Immunological Reviews | 2013 |
IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism
A Eken, AK Singh, PM Treuting, M Oukka |
Mucosal Immunology | 2013 |
High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease
L Song, R Zhou, S Huang, F Zhou, S Xu, W Wang, F Yi, X Wang, B Xia |
Mediators of Inflammation | 2013 |
Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections
J Kim, W Khan |
Pathogens | 2013 |
Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells
JL Bishop, ME Roberts, JL Beer, M Huang, MK Chehal, X Fan, LA Fouser, HL Ma, JT Bacani, KW Harder |
Mucosal Immunology | 2013 |
IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection
DA Pociask, EV Scheller, S Mandalapu, KJ McHugh, RI Enelow, CL Fattman, JK Kolls, JF Alcorn |
The American Journal of Pathology | 2013 |
Mucosal immunity in human and simian immunodeficiency lentivirus infections
JM Brenchley |
Mucosal Immunology | 2013 |
Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice
H Sokol, KL Conway, M Zhang, M Choi, B Morin, Z Cao, EJ Villablanca, C Li, C Wijmenga, SH Yun, HN Shi, RJ Xavier |
Gastroenterology | 2013 |
Carbon monoxide attenuates dextran sulfate sodium-induced colitis via inhibition of GSK-3β signaling
MJ Uddin, S Jeong, M Zheng, Y Chen, GJ Cho, HT Chung, Y Joe |
Oxidative Medicine & Cellular Longevity | 2013 |
Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?
H Mühl |
Frontiers in immunology | 2013 |
IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection
JE Turner, B Stockinger, H Helmby |
PLoS pathogens | 2013 |
Why interleukin-10 supplementation does not work in Crohn's disease patients
GJ Marlow, D Gent, LR Ferguson |
World journal of gastroenterology : WJG | 2013 |
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
CL Zindl, JF Lai, YK Lee, CL Maynard, SN Harbour, W Ouyang, DD Chaplin, CT Weaver |
Proceedings of the National Academy of Sciences | 2013 |
Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis
LZ Yu, HY Wang, SP Yang, ZP Yuan, FY Xu, C Sun, RH Shi |
World journal of gastroenterology : WJG | 2013 |
Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection
S Ivanov, J Renneson, J Fontaine, A Barthelemy, C Paget, EM Fernandez, F Blanc, CD Trez, LV Maele, L Dumoutier, MR Huerre, G Eberl, M Si-Tahar, P Gosset, JC Renauld, JC Sirard, C Faveeuw, F Trottein |
Journal of virology | 2013 |
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
S Kirchberger, DJ Royston, O Boulard, E Thornton, F Franchini, RL Szabady, O Harrison, F Powrie |
Journal of Experimental Medicine | 2013 |
IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
LA Zenewicz, X Yin, G Wang, E Elinav, L Hao, L Zhao, RA Flavell |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides
C Kozlowski, S Jeet, J Beyer, S Guerrero, J Lesch, X Wang, J Devoss, L Diehl |
Disease models & mechanisms | 2013 |
IL-22 in tissue-protective therapy
H Mühl, P Scheiermann, M Bachmann, L Härdle, A Heinrichs, J Pfeilschifter |
British Journal of Pharmacology | 2013 |
IL-22 is related to development of human colon cancer by activation of STAT3
R Jiang, H Wang, L Deng, J Hou, R Shi, M Yao, Y Gao, A Yao, X Wang, L Yu, B Sun |
BMC Cancer | 2013 |
Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10
S Sarkar, X Zhou, S Justa, SR Bommireddy |
Arthritis & Rheumatism | 2013 |
Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury
JL Rendon, X Li, S Akhtar, MA Choudhry |
Shock (Augusta, Ga.) | 2013 |
Microbial-immune cross-talk and regulation of the immune system
J Cahenzli, ML Balmer, KD McCoy |
Immunology | 2013 |
IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue
JM Leung, M Davenport, MJ Wolff, KE Wiens, WM Abidi, MA Poles, I Cho, T Ullman, L Mayer, P Loke |
Mucosal Immunology | 2013 |
IL-23 Induces IL-22 and IL-17 Production in Response to Chlamydia muridarum Genital Tract Infection, but the Absence of these Cytokines does not Influence Disease Pathogenesis
LC Frazer, AM Scurlock, MA Zurenski, MM Riley, M Mintus, DA Pociask, JE Sullivan, CW Andrews, T Darville |
American Journal of Reproductive Immunology | 2013 |
Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid
JC Martin, G Bériou, M Heslan, C Chauvin, L Utriainen, A Aumeunier, CL Scott, A Mowat, V Cerovic, SA Houston, M Leboeuf, FX Hubert, C Hémont, M Merad, S Milling, R Josien |
Mucosal Immunology | 2013 |
Deletion of Intestinal Epithelial Cell STAT3 Promotes T-Lymphocyte STAT3 Activation and Chronic Colitis Following Acute Dextran Sodium Sulfate Injury in Mice:
TA Willson, I Jurickova, M Collins, LA Denson |
Inflammatory Bowel Diseases | 2013 |
Gene–gene and gene–environment interactions in ulcerative colitis
MH Wang, C Fiocchi, X Zhu, S Ripke, MI Kamboh, N Rebert, RH Duerr, JP Achkar |
Human Genetics | 2013 |
Role of IL-22– and TNF-α–Producing Th22 Cells in Uveitis Patients with Behçet’s Disease
S Sugita, Y Kawazoe, A Imai, T Kawaguchi, S Horie, H Keino, M Takahashi, M Mochizuki |
Journal of immunology (Baltimore, Md. : 1950) | 2013 |
How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases.
Baeten DL, Kuchroo VK |
Nature Medicine | 2013 |
Aryl hydrocarbon receptor and colitis.
Monteleone I, Pallone F, Monteleone G |
Seminars in Immunopathology | 2013 |
Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells
Wang X, Ouyang W |
2013 | |
Interleukin-22 Ameliorates Cerulein-Induced Pancreatitis in Mice by Inhibiting the Autophagic Pathway
D Feng, O Park, S Radaeva, H Wang, S Yin, X Kong, M Zheng, S Zakhari, JK Kolls, B Gao |
International journal of biological sciences | 2012 |
The transition of acute to chronic bowel inflammation in spondyloarthritis
LV Praet, P Jacques, FV Bosch, D Elewaut |
Nature Reviews Rheumatology | 2012 |
TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
AK Marwaha, NJ Leung, AN McMurchy, MK Levings |
Frontiers in immunology | 2012 |
Microbial translocation across the GI tract
JM Brenchley, DC Douek |
Annual Review of Immunology | 2012 |
Helminth infection in populations undergoing epidemiological transition: a friend or foe?
AE Wiria, Y Djuardi, T Supali, E Sartono, M Yazdanbakhsh |
Seminars in Immunopathology | 2012 |
Th17 cells: critical mediators of host responses to burn injury and sepsis
JL Rendon, MA Choudhry |
Journal of leukocyte biology | 2012 |
Association of single nucleotide polymorphisms of IL23R and IL17 with ulcerative colitis risk in a Chinese Han population
P Yu, F Shen, X Zhang, R Cao, X Zhao, P Liu, H Tu, X Yang, R Shi, H Zhang |
PloS one | 2012 |
Cellular and molecular mechanisms of intestinal fibrosis
S Speca, I Giusti, F Rieder, G Latella |
World journal of gastroenterology : WJG | 2012 |
A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing
X Sun, L Chalmers, X Fu, M Zhao |
Advances in Skin & Wound Care | 2012 |
Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection
J Cowan, S Pandey, LG Filion, JB Angel, A Kumar, DW Cameron |
Clinical & Experimental Immunology | 2012 |
Healing of intestinal inflammation by IL-22
A Mizoguchi |
Inflammatory Bowel Diseases | 2012 |
Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt+ Innate Lymphoid Cells and Intraepithelial Lymphocytes
EA Kiss, A Diefenbach |
Frontiers in immunology | 2012 |
Analysis of IL12B Gene Variants in Inflammatory Bowel Disease
J Glas, J Seiderer, J Wagner, T Olszak, C Fries, C Tillack, M Friedrich, F Beigel, J Stallhofer, C Steib, M Wetzke, B Göke, T Ochsenkühn, J Diegelmann, D Czamara, S Brand |
PloS one | 2012 |
A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity
JM Leung, P Loke |
International Journal for Parasitology | 2012 |
Helminthic therapy: improving mucosal barrier function
MJ Wolff, MJ Broadhurst, P Loke |
Trends in Parasitology | 2012 |
Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection
C Cosgrove, JE Ussher, A Rauch, K Gärtner, A Kurioka, MH Hühn, K Adelmann, YH Kang, JR Fergusson, P Simmonds, P Goulder, TH Hansen, J Fox, HF Günthard, N Khanna, F Powrie, A Steel, B Gazzard, RE Phillips, J Frater, H Uhlig, P Klenerman |
Blood | 2012 |
IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration
P Kumar, K Rajasekaran, JM Palmer, MS Thakar, S Malarkannan |
Journal of Cancer | 2012 |
Th22 cells as well as Th17 cells expand differentially in patients with early-stage and late-stage myelodysplastic syndrome
L Shao, L Zhang, Y Hou, S Yu, X Liu, X Huang, Y Sun, T Tian, N He, D Ma, J Peng, M Hou |
PloS one | 2012 |
Mitigating colon cancer with a novel strain of Lactobacillus acidophilus: a (re-)balancing act
YL Lightfoot, HU Rehman, AD Myers, M Mohamadzadeh |
Immunotherapy | 2012 |
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
S Huber, N Gagliani, LA Zenewicz, FJ Huber, L Bosurgi, B Hu, M Hedl, W Zhang, W O'Connor, AJ Murphy, DM Valenzuela, GD Yancopoulos, CJ Booth, JH Cho, W Ouyang, C Abraham, RA Flavell |
Nature | 2012 |
Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22
JP Huai, XC Sun, MJ Chen, Y Jin, XH Ye, JS Wu, ZM Huang |
World journal of gastroenterology : WJG | 2012 |
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
B Kronenberger, I Rudloff, M Bachmann, F Brunner, L Kapper, N Filmann, O Waidmann, E Herrmann, J Pfeilschifter, S Zeuzem, A Piiper, H Mühl |
BMC Medicine | 2012 |
The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22
LM Lilly, MA Gessner, CW Dunaway, AE Metz, L Schwiebert, CT Weaver, GD Brown, C Steele |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
C Manta, E Heupel, K Radulovic, V Rossini, N Garbi, CU Riedel, JH Niess |
Mucosal Immunology | 2012 |
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
JW Shui, A Larange, G Kim, JL Vela, S Zahner, H Cheroutre, M Kronenberg |
Nature | 2012 |
Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection
NR Klatt, JD Estes, X Sun, AM Ortiz, JS Barber, LD Harris, B Cervasi, LK Yokomizo, L Pan, CL Vinton, B Tabb, LA Canary, Q Dang, VM Hirsch, G Alter, Y Belkaid, JD Lifson, G Silvestri, JD Milner, M Paiardini, EK Haddad, JM Brenchley |
Mucosal Immunology | 2012 |
IL-22 is expressed by the invasive trophoblast of the equine (Equus caballus) chorionic girdle
MM Brosnahan, DC Miller, M Adams, DF Antczak |
Journal of immunology (Baltimore, Md. : 1950) | 2012 |
Interleukin-22: implications for liver ischemia-reperfusion injury
PJ Chestovich, Y Uchida, W Chang, M Ajalat, C Lassman, R Sabat, RW Busuttil, JW Kupiec-Weglinski |
Transplantation | 2012 |
Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease.
Shah N, Kammermeier J, Elawad M, Glocker EO |
Current Allergy and Asthma Reports | 2012 |
Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond.
Salem M, Seidelin JB, Rogler G, Nielsen OH |
Cellular and molecular life sciences : CMLS | 2012 |
Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma
Schnyder B, Schnyder-Candrian S |
2012 | |
In vivo consequences of liver-specific interleukin-22 expression: implications for human liver disease progression
O Park, H Wang, H Weng, L Feigenbaum, H Li, S Yin, SH Ki, SH Yoo, S Dooley, FS Wang, HA Young, B Gao |
Hepatology | 2011 |
IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease
C Taube, C Tertilt, G Gyülveszi, N Dehzad, K Kreymborg, K Schneeweiss, E Michel, S Reuter, JC Renauld, D Arnold-Schild, H Schild, R Buhl, B Becher |
PloS one | 2011 |
IL-22–Induced Regulatory CD11b + APCs Suppress Experimental Autoimmune Uveitis
Y Ke, D Sun, G Jiang, HJ Kaplan, H Shao |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Th17-related cytokines: new players in the control of chronic intestinal inflammation
I Monteleone, F Pallone, G Monteleone |
BMC Medicine | 2011 |
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity
PJ Morrison, SJ Ballantyne, MC Kullberg |
Immunology | 2011 |
Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease
C Abraham, R Medzhitov |
Gastroenterology | 2011 |
Pro-Inflammatory Cytokines in the Pathogenesis of IBD
W Strober, IJ Fuss |
Gastroenterology | 2011 |
Th17 cell cytokine secretion profile in host defense and autoimmunity
KE Graeber, NJ Olsen |
Inflammation Research | 2011 |
Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression
JA Skyberg, A Robison, S Golden, MC Rollins, G Callis, E Huarte, I Kochetkova, MA Jutila, DW Pascual |
Journal of leukocyte biology | 2011 |
Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells
G Zeng, CY Chen, D Huang, S Yao, RC Wang, ZW Chen |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice
A Nishida, CW Lau, M Zhang, A Andoh, HN Shi, E Mizoguchi, A Mizoguchi |
Gastroenterology | 2011 |
Mucin dynamics and enteric pathogens
MA McGuckin, SK Lindén, P Sutton, TH Florin |
Nature Reviews Microbiology | 2011 |
Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1- and IL-23-Dependent Manner during Invasive Fungal Infection
JL Werner, MA Gessner, LM Lilly, MP Nelson, AE Metz, D Horn, CW Dunaway, J Deshane, DD Chaplin, CT Weaver, GD Brown, C Steele, GS Deepe |
Infection and immunity | 2011 |
The light and dark sides of intestinal intraepithelial lymphocytes
H Cheroutre, F Lambolez, D Mucida |
Nature reviews. Immunology | 2011 |
In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner
NC Brembilla, JM Ramirez, R Chicheportiche, O Sorg, JH Saurat, C Chizzolini |
PloS one | 2011 |
Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells
SL Sanos, C Vonarbourg, A Mortha, A Diefenbach |
Immunology | 2011 |
High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22
Z Wang, L Yang, Y Jiang, ZQ Ling, Z Li, Y Cheng, H Huang, L Wang, Y Pan, Z Wang, X Yan, Y Chen |
PloS one | 2011 |
Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology
M Kamanaka, S Huber, LA Zenewicz, N Gagliani, C Rathinam, W O'Connor, YY Wan, S Nakae, Y Iwakura, L Hao, RA Flavell |
Journal of Experimental Medicine | 2011 |
An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis
SZ Sheikh, RA Hegazi, T Kobayashi, JC Onyiah, SM Russo, K Matsuoka, AR Sepulveda, F Li, LE Otterbein, SE Plevy |
Journal of immunology (Baltimore, Md. : 1950) | 2011 |
Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge
AV Tumanov, EP Koroleva, X Guo, Y Wang, A Kruglov, S Nedospasov, YX Fu |
Cell Host & Microbe | 2011 |
The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
J Qiu, JJ Heller, X Guo, ZE Chen, K Fish, YX Fu, L Zhou |
Immunity | 2011 |
Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a
I Rudloff, M Bachmann, J Pfeilschifter, H Mühl |
The Journal of biological chemistry | 2011 |
Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus
MA Gessner, JL Werner, LM Lilly, MP Nelson, AE Metz, CW Dunaway, YR Chan, W Ouyang, GD Brown, CT Weaver, C Steele, GS Deepe |
Infection and immunity | 2011 |
The Role of Osteopontin (OPN/SPP1) Haplotypes in the Susceptibility to Crohn's Disease
J Glas, J Seiderer, C Bayrle, M Wetzke, C Fries, C Tillack, T Olszak, F Beigel, C Steib, M Friedrich, J Diegelmann, D Czamara, S Brand, JH Niess |
PloS one | 2011 |
The Pathogenicity of an Enteric Citrobacter rodentium Infection Is Enhanced by Deficiencies in the Antioxidants Selenium and Vitamin E
AD Smith, S Botero, T Shea-Donohue, JF Urban, BA McCormick |
Infection and immunity | 2011 |
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
GF Sonnenberg, LA Fouser, D Artis |
Nature Immunology | 2011 |
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium.
Ota N, Wong K, Valdez PA, Zheng Y, Crellin NK, Diehl L, Ouyang W |
Nature Immunology | 2011 |
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
Ramirez-Carrozzi V, Sambandam A, Luis E, Lin Z, Jeet S, Lesch J, Hackney J, Kim J, Zhou M, Lai J, Modrusan Z, Sai T, Lee W, Xu M, Caplazi P, Diehl L, de Voss J, Balazs M, Gonzalez L Jr, Singh H, Ouyang W, Pappu R |
Nature Immunology | 2011 |
Inflammatory bowel disease: is it a primary immunodeficiency?
Glocker E, Grimbacher B |
Cellular and molecular life sciences : CMLS | 2011 |
Averting inflammation by targeting the cytokine environment
M Kopf, MF Bachmann, BJ Marsland |
Nature Reviews Drug Discovery | 2010 |
Inflammatory Bowel Disease
A Kaser, S Zeissig, RS Blumberg |
Annual Review of Immunology | 2010 |
Infection and apoptosis as a combined inflammatory trigger
MB Torchinsky, J Garaude, JM Blander |
Current Opinion in Immunology | 2010 |
New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression
SM Steward-Tharp, Y Song, RM Siegel, JJ O'Shea |
Annals of the New York Academy of Sciences | 2010 |
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?
A Jarnicki, T Putoczki, M Ernst |
Cell division | 2010 |
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine
C Wang, SG Kang, H HogenEsch, PE Love, CH Kim |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Toll-like receptors in inflammatory bowel diseases: A decade later
E Cario |
Inflammatory Bowel Diseases | 2010 |
Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma
S Saha, X Jing, SY Park, S Wang, X Li, D Gupta, R Dziarski |
Cell Host & Microbe | 2010 |
Animal models of IBD: linkage to human disease
A Mizoguchi, E Mizoguchi |
Current Opinion in Pharmacology | 2010 |
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
NR Klatt, LD Harris, CL Vinton, H Sung, JA Briant, B Tabb, D Morcock, JW McGinty, JD Lifson, BA Lafont, MA Martin, AD Levine, JD Estes, JM Brenchley |
Mucosal Immunology | 2010 |
Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections
MS Wilson, CG Feng, DL Barber, F Yarovinsky, AW Cheever, A Sher, M Grigg, M Collins, L Fouser, TA Wynn |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections
JM Brenchley, G Silvestri, DC Douek |
Immunity | 2010 |
The role of the immune system in regulating the microbiota
BP Willing, N Gill, BB Finlay |
Gut microbes | 2010 |
Genes and Environment: How Will Our Concepts on the Pathophysiology of IBD Develop in the Future?
A Kaser, S Zeissig, RS Blumberg |
Digestive diseases (Basel, Switzerland) | 2010 |
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
JG Fox, Z Ge, MT Whary, SE Erdman, BH Horwitz |
Mucosal Immunology | 2010 |
Th17 cell dynamics in HIV infection
NR Klatt, JM Brenchley |
Current Opinion in HIV and AIDS | 2010 |
Mucosal T cells in gut homeostasis and inflammation
F Wijk, H Cheroutre |
Expert Review of Clinical Immunology | 2010 |
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
GF Sonnenberg, MG Nair, TJ Kirn, C Zaph, LA Fouser, D Artis |
Journal of Experimental Medicine | 2010 |
Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor
MS Alam, Y Maekawa, A Kitamura, K Tanigaki, T Yoshimoto, K Kishihara, K Yasutomo |
Proceedings of the National Academy of Sciences | 2010 |
Proinflammatory cytokines underlying the inflammation of Crohn's disease
W Strober, F Zhang, A Kitani, I Fuss, S Fichtner-Feigl |
Current Opinion in Gastroenterology | 2010 |
Unraveling the genetics of autoimmunity
LA Zenewicz, C Abraham, RA Flavell, JH Cho |
Cell | 2010 |
Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1
M Bachmann, K Horn, I Rudloff, I Goren, M Holdener, U Christen, N Darsow, KP Hunfeld, U Koehl, P Kind, J Pfeilschifter, P Kraiczy, H Mühl, J Coburn |
PLoS pathogens | 2010 |
The dual nature of TH17 cells: shifting the focus to function
W O'Connor, LA Zenewicz, RA Flavell |
Nature Immunology | 2010 |
T helper 17 cells: discovery, function, and physiological trigger
MB Torchinsky, JM Blander |
Cellular and Molecular Life Sciences | 2010 |
Biology of interleukin-22.
Wolk K, Witte E, Witte K, Warszawska K, Sabat R |
Seminars in Immunopathology | 2010 |
Structure and function of interleukin-22 and other members of the interleukin-10 family.
Trivella DB, Ferreira-Júnior JR, Dumoutier L, Renauld JC, Polikarpov I |
Cellular and molecular life sciences : CMLS | 2010 |
Inflammatory arthritis in caspase 1 geneâdeficient mice: Contribution of proteinase 3 to caspase 1âindependent production of bioactive interleukin-1β
LA Joosten, MG Netea, G Fantuzzi, MI Koenders, MM Helsen, H Sparrer, CT Pham, JW van der Meer, CA Dinarello, WB van Berg |
Arthritis & Rheumatism | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
M Muñoz, MM Heimesaat, K Danker, D Struck, U Lohmann, R Plickert, S Bereswill, A Fischer, IR Dunay, K Wolk, C Loddenkemper, HW Krell, C Libert, LR Lund, O Frey, C Hölscher, Y Iwakura, N Ghilardi, W Ouyang, T Kamradt, R Sabat, O Liesenfeld |
Journal of Experimental Medicine | 2009 |
Inflammatory Bowel Disease
C Abraham, JH Cho |
New England Journal of Medicine | 2009 |
Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection
U Hofer, RF Speck |
Seminars in Immunopathology | 2009 |
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
S Grivennikov, E Karin, J Terzic, D Mucida, GY Yu, S Vallabhapurapu, J Scheller, S Rose-John, H Cheroutre, L Eckmann, M Karin |
Cancer Cell | 2009 |
Synergy of IL-23 and Th17 Cytokines: New Light on Inflammatory Bowel Disease
W Shen, SK Durum |
Neurochemical Research | 2009 |
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
G Pickert, C Neufert, M Leppkes, Y Zheng, N Wittkopf, M Warntjen, HA Lehr, S Hirth, B Weigmann, S Wirtz, W Ouyang, MF Neurath, C Becker |
Journal of Experimental Medicine | 2009 |
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor
EO Glocker, D Kotlarz, K Boztug, EM Gertz, AA Schäffer, F Noyan, M Perro, J Diestelhorst, A Allroth, D Murugan, N Hätscher, D Pfeifer, KW Sykora, M Sauer, H Kreipe, M Lacher, R Nustede, C Woellner, U Baumann, U Salzer, S Koletzko, N Shah, AW Segal, A Sauerbrey, S Buderus, SB Snapper, B Grimbacher, C Klein |
The New England journal of medicine | 2009 |
Dexamethasone suppresses interleukin-22 associated with bacterial infection in vitro and in vivo
E Ziesché, P Scheiermann, M Bachmann, CD Sadik, C Hofstetter, B Zwissler, J Pfeilschifter, H Mühl |
Clinical & Experimental Immunology | 2009 |
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
CE Egwuagu |
Cytokine | 2009 |
Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity
S Sanjabi, LA Zenewicz, M Kamanaka, RA Flavell |
Current Opinion in Pharmacology | 2009 |
Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
MS Silverberg, JH Cho, JD Rioux, DP McGovern, J Wu, V Annese, JP Achkar, P Goyette, R Scott, W Xu, MM Barmada, L Klei, MJ Daly, C Abraham, TM Bayless, F Bossa, AM Griffiths, AF Ippoliti, RG Lahaie, A Latiano, P Paré, DD Proctor, MD Regueiro, AH Steinhart, SR Targan, LP Schumm, EO Kistner, AT Lee, PK Gregersen, JI Rotter, SR Brant, KD Taylor, K Roeder, RH Duerr |
Nature Genetics | 2009 |
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells.
Trifari S, Kaplan CD, Tran EH, Crellin NK, Spits H |
Nature Immunology | 2009 |
Expression, purification and characterization of recombinant human interleukin-22 in Pichia pastoris.
Cai X, Wang J, Wang Y, Yang Y, Gao J, Fu W, Wang J, Xu D |
Molecular Biology Reports | 2009 |
IL-22: a critical mediator in mucosal host defense.
Aujla SJ, Kolls JK |
Journal of Molecular Medicine | 2009 |
Tumor-specific Th17-polarized cells eradicate large established melanoma
P Muranski, A Boni, PA Antony, L Cassard, KR Irvine, A Kaiser, CM Paulos, DC Palmer, CE Touloukian, K Ptak, L Gattinoni, C Wrzesinski, CS Hinrichs, KW Kerstann, L Feigenbaum, CC Chan, NP Restifo |
Blood | 2008 |
Role of cytokines in inflammatory bowel disease
F Sanchez-Munoz, A Dominguez-Lopez, JK Yamamoto-Furusho |
World journal of gastroenterology : WJG | 2008 |
Dendritic cells in intestinal immune regulation
JL Coombes, F Powrie |
Nature reviews. Immunology | 2008 |
Role of mucosal dendritic cells in inflammatory bowel disease
JH Niess |
World journal of gastroenterology : WJG | 2008 |
Role of STAT3 in inflammatory bowel disease
K Sugimoto |
World journal of gastroenterology : WJG | 2008 |
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
W Ouyang, JK Kolls, Y Zheng |
Immunity | 2008 |
Cytokine signaling modules in inflammatory responses
JJ O'Shea, PJ Murray |
Immunity | 2008 |
Roles of galectins in inflammatory bowel disease
A Hokama, E Mizoguchi, A Mizoguchi |
World journal of gastroenterology : WJG | 2008 |
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
LA Zenewicz, GD Yancopoulos, DM Valenzuela, AJ Murphy, S Stevens, RA Flavell |
Immunity | 2008 |
A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
M Cella, A Fuchs, W Vermi, F Facchetti, K Otero, JK Lennerz, JM Doherty, JC Mills, M Colonna |
Nature | 2008 |
Gene expression profiling in autoimmune non-infectious uveitis disease
Li Z, Liu B, Arvydas M, Mahesh SP, Yeh S, Lew J, Lim WK, Sen HN, Clarke G, Buggage R, Miller SS, Nussenblatt. RB |
Journal of immunology (Baltimore, Md. : 1950) | 2008 |