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Citations to this article

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
Ken Sugimoto, … , Ramnik J. Xavier, Atsushi Mizoguchi
Ken Sugimoto, … , Ramnik J. Xavier, Atsushi Mizoguchi
Published January 2, 2008
Citation Information: J Clin Invest. 2008;118(2):534-544. https://doi.org/10.1172/JCI33194.
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Research Article Genetics Article has an altmetric score of 13

IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis

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Abstract

Expression of IL-22 is induced in several human inflammatory conditions, including inflammatory bowel disease (IBD). Expression of the IL-22 receptor is restricted to innate immune cells; however, the role of IL-22 in colitis has not yet been defined. We developed what we believe to be a novel microinjection-based local gene-delivery system that is capable of targeting the inflamed intestine. Using this approach, we demonstrated a therapeutic potency for IL-22–mediated activation of the innate immune pathway in a mouse model of Th2-mediated colitis that induces disease with characteristics similar to that of IBD ulcerative colitis (UC). IL-22 gene delivery enhanced STAT3 activation specifically within colonic epithelial cells and induced both STAT3-dependent expression of mucus-associated molecules and restitution of mucus-producing goblet cells. Importantly, IL-22 gene delivery led to rapid amelioration of local intestinal inflammation. The amelioration of disease by IL-22 was mediated by enhanced mucus production. In addition, local gene delivery was used to inhibit IL-22 activity through overexpression of IL-22–binding protein. Treatment with IL-22–binding protein suppressed goblet cell restitution during the recovery phase of a dextran sulfate sodium–induced model of acute colitis. These data demonstrate what we believe to be a novel function for IL-22 in the intestine and suggest the potency of a local IL-22 gene–delivery system for treating UC.

Authors

Ken Sugimoto, Atsuhiro Ogawa, Emiko Mizoguchi, Yasuyo Shimomura, Akira Andoh, Atul K. Bhan, Richard S. Blumberg, Ramnik J. Xavier, Atsushi Mizoguchi

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 10 29 27 41 53 45 41 30 35 47 26 35 39 31 29 26 16 11 571
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Swedik SM, Madola A, Cruz MA, Llorens-Bonilla BJ, Levine AD
Journal of immunology (Baltimore, Md. : 1950) 2022
IL-22BP production is heterogeneously distributed in Crohn's disease.
Fantou A, Lagrue E, Laurent T, Delbos L, Blandin S, Jarry A, Beriou G, Braudeau C, Salabert N, Marin E, Moreau A, Podevin J, Bourreille A, Josien R, Martin JC
Frontiers in immunology 2022
Modulation of immune cell function, IDO expression and kynurenine production by the quorum sensor 2-heptyl-3-hydroxy-4-quinolone (PQS)
Ogbechi J, Huang YS, Clanchy FI, Pantazi E, Topping LM, Darlington LG, Williams RO, Stone TW
Frontiers in immunology 2022
Mechanistic studies of MALAT1 in respiratory diseases
Wu W, Wang S, Zhang L, Mao B, Wang B, Wang X, Zhao D, Zhao P, Mou Y, Yan P
Frontiers in Molecular Biosciences 2022
Intelectin-1 binds and alters the localization of the mucus barrier–modifying bacterium Akkermansia muciniphila
Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS
Journal of Experimental Medicine 2022
IL-22 and Lactobacillus delbrueckii Mitigate Alcohol Induced Exacerbation of DSS-Induced Colitis
Cannon AR, Shim EH, Kuprys PV, Choudhry MA
Journal of leukocyte biology 2022
Porcine Interleukin-17 and 22 Co-Expressed by Yarrowia lipolytica Enhance Immunity and Increase Protection against Bacterial Challenge in Mice and Piglets.
Peng J, Yang F, Chen J, Guo S, Zhang L, Deng D, Li J, Lv X, Gao R
Biology 2022
BMP-signaling in the intestinal epithelium drives a critical feedback loop to restrain IL-13-driven tuft cell hyperplasia
Lindholm HT, Parmar N, Drurey C, Poveda MC, Vornewald P, Ostrop J, Díez-Sanchez A, Maizels RM, Oudhoff MJ
Science Immunology 2022
Nestin+ Peyer's patch resident MSCs enhance healing of inflammatory bowel disease through IL‐22‐mediated intestinal epithelial repair
Chen J, Huang J, Shi J, Li M, Zhao E, Li G, Chen X, Wang T, Li Q, Li W, Ma J, Mao W, Fang R, Hao J, Huang W, Xiang AP, Zhang X
Cell Proliferation 2022
Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor
Alvik K, Shao P, Hutin D, Baglole C, Grant DM, Matthews J
Toxicological Sciences 2022
A phase 2 study of interleukin-22 and systemic corticosteroids as initial treatment for acute GVHD of the lower GI tract
Ponce DM, Alousi AM, Nakamura R, Slingerland J, Calafiore M, Sandhu KS, Barker JN, Devlin S, Shia J, Giralt S, Perales MA, Moore G, Fatmi S, Soto C, Gomes A, Giardina P, Marcello L, Yan X, Tang T, Dreyer K, Chen J, Daley WL, Peled JU, van den Brink MR, Hanash AM
Blood 2022
USP2 promotes experimental colitis and bacterial infections by inhibiting the proliferation of myeloid cells and remodeling the extracellular matrix network
An R, Wang P, Guo H, Liuyu T, Zhong B, Zhang ZD
2022
Angiocrine Regulation of Epithelial Barrier Integrity in Inflammatory Bowel Disease
M Stürzl, M Kunz, SM Krug, E Naschberger
Frontiers in Medicine 2021
MAIT cells, guardians of skin and mucosa?
I Nel, L Bertrand, A Toubal, A Lehuen
Mucosal Immunology 2021
Epithelial wound healing in inflammatory bowel diseases: the next therapeutic frontier
CY Liu, CM Cham, EB Chang
Translational research : the journal of laboratory and clinical medicine 2021
Utilizing a reductionist model to study host-microbe interactions in intestinal inflammation
AM Tsou, JA Goettel, B Bao, A Biswas, YH Kang, NS Redhu, K Peng, GG Putzel, J Saltzman, R Kelly, J Gringauz, J Barends, M Hatazaki, SM Frei, R Emani, Y Huang, Z Shen, JG Fox, JN Glickman, BH Horwitz, SB Snapper
Microbiome 2021
Immunological Networks Defining the Heterogeneity of Inflammatory Bowel Diseases
KA Selin, CR Hedin, EJ Villablanca
Journal of Crohn's & colitis 2021
Intestinal Stem Cells and Immune Cell Relationships: Potential Therapeutic Targets for Inflammatory Bowel Diseases
Q Hou, J Huang, H Ayansola, H Masatoshi, B Zhang
Frontiers in immunology 2021
Intestinal Mucosal Wound Healing and Barrier Integrity in IBD–Crosstalk and Trafficking of Cellular Players
K Sommer, M Wiendl, TM Müller, K Heidbreder, C Voskens, MF Neurath, S Zundler
Frontiers in Medicine 2021
Molecular Communication Between Neuronal Networks and Intestinal Epithelial Cells in Gut Inflammation and Parkinson's Disease
A Drobny, PA Ngo, MF Neurath, F Zunke, R López-Posadas
Frontiers in Medicine 2021
miR‑452‑5p regulates the responsiveness of intestinal epithelial cells in inflammatory bowel disease through Mcl‑1
M Deng, J Hu, R Tong, H Guo, Y Liu
Experimental and therapeutic medicine 2021
A Novel Microphysiological Colon Platform to Decipher Mechanisms Driving Human Intestinal Permeability
A Apostolou, RA Panchakshari, A Banerjee, DV Manatakis, MD Paraskevopoulou, R Luc, G Abu-Ali, A Dimitriou, C Lucchesi, G Kulkarni, TI Maulana, M Kasendra, JS Kerns, B Bleck, L Ewart, ES Manolakos, GA Hamilton, C Giallourakis, K Karalis
CMGH Cellular and Molecular Gastroenterology and Hepatology 2021
Aucuboside Inhibits the Generation of Th17 Cells in Mice Colitis
C Mei, X Wang, F Meng, X Zhang, L Chen, S Yan, J Xue, X Sun, Y Wang
Frontiers in pharmacology 2021
Identification of an IL-22-Dependent Gene Signature as a Pharmacodynamic Biomarker
J Rae, J Hackney, K Huang, M Keir, A Herman
International journal of molecular sciences 2021
Erythritol Ameliorates Small Intestinal Inflammation Induced by High-Fat Diets and Improves Glucose Tolerance
R Kawano, T Okamura, Y Hashimoto, S Majima, T Senmaru, E Ushigome, M Asano, M Yamazaki, H Takakuwa, R Sasano, N Nakanishi, M Hamaguchi, M Fukui
International journal of molecular sciences 2021
Interleukin-22 Attenuates Acute Pancreatitis-Associated Intestinal Mucosa Injury in Mice via STAT3 Activation
J Bai, J Bai, M Yang
Gut and Liver 2021
Amino Acid Trp: The Far Out Impacts of Host and Commensal Tryptophan Metabolism
HM Grifka-Walk, BR Jenkins, DJ Kominsky
Frontiers in immunology 2021
Phytochemicals Targeting JAK–STAT Pathways in Inflammatory Bowel Disease: Insights from Animal Models
SY Moon, KD Kim, J Yoo, JH Lee, C Hwangbo
Molecules (Basel, Switzerland) 2021
Colonizing Microbes, IL-10 and IL-22: Keeping the Peace at the Mucosal Surface
E Kidess, M Kleerebezem, S Brugman
Frontiers in microbiology 2021
Gardenia Jasminoides Ameliorates Antibiotic-Associated Aggravation of DNCB-Induced Atopic Dermatitis by Restoring the Intestinal Microbiome Profile
HI Kim, SH Hong, SY Lee, JM Ku, MJ Kim, SG Ko
Nutrients 2021
Innate Lymphoid Cells as Regulators of Epithelial Integrity: Therapeutic Implications for Inflammatory Bowel Diseases
A Schulz-Kuhnt, MF Neurath, S Wirtz, I Atreya
Frontiers in Medicine 2021
Act Locally, Act Globally—Microbiota, Barriers, and Cytokines in Atherosclerosis
N Kurilenko, AR Fatkhullina, A Mazitova, EK Koltsova
Cells 2021
Interleukin-22 Deficiency Contributes to Dextran Sulfate Sodium-Induced Inflammation in Japanese Medaka, Oryzias latipes
Y Takahashi, Y Okamura, N Harada, M Watanabe, H Miyanishi, T Kono, M Sakai, J Hikima
Frontiers in immunology 2021
The Role of the IL-23/IL-17 Axis in Disease Initiation in Spondyloarthritis: Lessons Learned From Animal Models
M Mandour, S Chen, MG van de Sande
Frontiers in immunology 2021
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD)
H Choe, JL Ferrara
Expert Opinion on Therapeutic Targets 2021
Bacterial Translocation as Inflammatory Driver in Crohn’s Disease
R Linares, R Francés, A Gutiérrez, O Juanola
Frontiers in Cell and Developmental Biology 2021
Innate Lymphoid Cells and Celiac Disease: Current Perspective
X Yu, J Vargas, PH Green, G Bhagat
CMGH Cellular and Molecular Gastroenterology and Hepatology 2021
Non‐zero‐sum microbiome immune system interactions
T Tuganbaev, K Honda
European Journal of Immunology 2021
Critical role of interferons in gastrointestinal injury repair
C McElrath, V Espinosa, JD Lin, J Peng, R Sridhar, O Dutta, HC Tseng, SV Smirnov, H Risman, MJ Sandoval, V Davra, YJ Chang, BP Pollack, RB Birge, M Galan, A Rivera, JE Durbin, SV Kotenko
Nature Communications 2021
Probiotics in Intestinal Mucosal Healing: A New Therapy or an Old Friend?
E Filidou, G Kolios
Pharmaceuticals (Basel, Switzerland) 2021
Alcohol Use and Abuse Conspires With HIV Infection to Aggravate Intestinal Dysbiosis and Increase Microbial Translocation in People Living With HIV: A Review
J Yan, J Ouyang, S Isnard, X Zhou, V Harypursat, JP Routy, Y Chen
Frontiers in immunology 2021
LKB1 deficiency upregulates RELM-α to drive airway goblet cell metaplasia
Y Li, Q Zhang, L Li, D Hao, P Cheng, K Li, X Li, J Wang, Q Wang, Z Du, H Ji, H Chen
Cellular and Molecular Life Sciences 2021
Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine
JP ten Klooster, M Bol-Schoenmakers, K van Summeren, AL van Vliet, CA de Haan, FJ van Kuppeveld, S Verkoeijen, R Pieters
2021
Diet–Host–Microbiota Interactions Shape Aryl Hydrocarbon Receptor Ligand Production to Modulate Intestinal Homeostasis
H Han, S Safe, A Jayaraman, RS Chapkin
Annual Review of Nutrition 2021
Bacteroides ovatus Promotes IL-22 Production and Reduces Trinitrobenzene Sulfonic Acid–Driven Colonic Inflammation
FD Ihekweazu, MA Engevik, W Ruan, Z Shi, R Fultz, KA Engevik, AL Chang-Graham, J Freeborn, ES Park, S Venable, TD Horvath, SJ Haidacher, AM Haag, A Goodwin, DA Schady, JM Hyser, JK Spinler, Y Liu, J Versalovic
The American Journal of Pathology 2021
Role of microbiota and related metabolites in gastrointestinal tract barrier function in NAFLD
MV Fernandez-Cantos, D Garcia-Morena, V Iannone, H El-Nezami, M Kolehmainen, OP Kuipers
Tissue Barriers 2021
IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
Droeser RA, Iezzi G
Journal of cellular immunology 2021
Cytokine therapy in necrotizing enterocolitis: A promising treatment for preterm infants
Wang B, Koch MA
Cell reports. Medicine 2021
Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity
Yang S, Yu M
Journal of inflammation research 2021
The JAK Inhibitor Tofacitinib Rescues Intestinal Barrier Defects Caused by Disrupted Epithelial-macrophage Interactions.
Spalinger MR, Sayoc-Becerra A, Ordookhanian C, Canale V, Santos AN, King SJ, Krishnan M, Nair MG, Scharl M, McCole DF
Journal of Crohn's & colitis 2021
Overexpression of Cancer-Associated Stem Cell Gene OLFM4 in the Colonic Epithelium of Patients With Primary Sclerosing Cholangitis.
Neyazi M, Bharadwaj SS, Bullers S, Varenyiova Z, Travis S, Arancibia-Cárcamo CV, Powrie F, Geremia A
Inflammatory Bowel Diseases 2021
Disease Tolerance during Viral-Bacterial Co-Infections.
Barman TK, Metzger DW
Viruses 2021
Microbiota regulate innate immune signaling and protective immunity against cancer.
Xing C, Wang M, Ajibade AA, Tan P, Fu C, Chen L, Zhu M, Hao ZZ, Chu J, Yu X, Yin B, Zhu J, Shen WJ, Duan T, Wang HY, Wang RF
Cell Host & Microbe 2021
Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut.
Laursen MF, Sakanaka M, von Burg N, Mörbe U, Andersen D, Moll JM, Pekmez CT, Rivollier A, Michaelsen KF, Mølgaard C, Lind MV, Dragsted LO, Katayama T, Frandsen HL, Vinggaard AM, Bahl MI, Brix S, Agace W, Licht TR, Roager HM
Nature Microbiology 2021
Natural Food Polysaccharides Ameliorate Inflammatory Bowel Disease and Its Mechanisms
Wang Y, Zhu H, Wang X, Yu Y, Xie J
Foods 2021
IL-22 Binding Protein (IL-22BP) in the Regulation of IL-22 Biology
Zenewicz LA
Frontiers in immunology 2021
The Tissue Protective Functions of Interleukin-22 can be Decoupled from Pro-Inflammatory Actions Through Structure-Based Design
Saxton RA, Henneberg LT, Calafiore M, Su L, Jude KM, Hanash AM, Garcia KC
Immunity 2021
Mucins Dynamics in Physiological and Pathological Conditions
Melhem H, Regan-Komito D, Niess JH
International journal of molecular sciences 2021
Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions
Pral LP, Fachi JL, Corrêa RO, Colonna M, Vinolo MA
Trends in Immunology 2021
Neuronal regulation of the gut immune system and neuromodulation for treating inflammatory bowel disease
Populin L, Stebbing MJ, Furness JB
FASEB bioAdvances 2021
Oral delivery of a functional algal-expressed TGF-β mimic halts colitis in a murine DSS model
Smyth DJ, Ren B, White MP, McManus C, Webster H, Shek V, Evans C, Pandhal J, Fields F, Maizels RM, Mayfield S
Journal of Biotechnology 2021
The Concentration of Organic Acids in Cranberry Juice Modulates the Gut Microbiota in Mice
Renaud V, Houde VP, Pilon G, Varin TV, Roblet C, Marette A, Boutin Y, Bazinet L
International journal of molecular sciences 2021
Loss of aryl hydrocarbon receptor suppresses the response of colonic epithelial cells to IL22 signaling by upregulating SOCS3
Han H, Davidson LA, Fan YY, Landrock KK, Jayaraman A, Safe SH, Chapkin RS
AJP Gastrointestinal and Liver Physiology 2021
The Pathogenic Roles of IL-22 in Colitis: Its Transcription Regulation by Musculin in T Helper Subsets and Innate Lymphoid Cells.
Yan J, Yu J, Liu K, Liu Y, Mao C, Gao W
Frontiers in immunology 2021
Regulatory Roles of MicroRNA in Shaping T Cell Function, Differentiation and Polarization
Naqvi RA, Manali M, Khan SH, Naqvi AR
Seminars in cell & developmental biology 2021
Decoding IL-23 Signaling Cascade for New Therapeutic Opportunities
G Pastor-Fernández, IR Mariblanca, MN Navarro
Cells 2020
Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing
G Ho, JA Cartwright, EJ Thompson, CC Bain, AG Rossi
Inflammatory Bowel Diseases 2020
Mutual Interplay of Host Immune System and Gut Microbiota in the Immunopathology of Atherosclerosis
CF Yeh, YH Chen, SF Liu, HL Kao, MS Wu, KC Yang, WK Wu
International journal of molecular sciences 2020
The development of colitis in Il10−/− mice is dependent on IL-22
DC Gunasekera, J Ma, V Vacharathit, P Shah, A Ramakrishnan, P Uprety, Z Shen, A Sheh, CF Brayton, MT Whary, JG Fox, JH Bream
Mucosal Immunology 2020
Interleukin 23 and autoimmune diseases: current and possible future therapies
AI Abdo, GJ Tye
Inflammation Research 2020
Immune Cell Circuits in Mucosal Wound Healing: Clinical Implications
S Zundler, V Tauschek, MF Neurath
Viszeralmedizin 2020
Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier
F Puértolas-Balint, BO Schroeder
Frontiers in immunology 2020
Membrane mucins of the intestine at a glance
T Pelaseyed, GC Hansson
Journal of cell science 2020
The relationship between intestinal goblet cells and the immune response
M Zhang, C Wu
Bioscience Reports 2020
How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology
A Rannug
International journal of molecular sciences 2020
Immunological Mechanisms in Inflammation-Associated Colon Carcinogenesis
T Hirano, D Hirayama, K Wagatsuma, T Yamakawa, Y Yokoyama, H Nakase
International journal of molecular sciences 2020
Role of regenerating islet-derived proteins in inflammatory bowel disease
JA Edwards, N Tan, N Toussaint, P Ou, C Mueller, A Stanek, V Zinsou, S Roudnitsky, M Sagal, L Dresner, A Schwartzman, C Huan
World journal of gastroenterology : WJG 2020
Participation of the IL-10RB Related Cytokines, IL-22 and IFN-λ in Defense of the Airway Mucosal Barrier
D Ahn, A Prince
Frontiers in Cellular and Infection Microbiology 2020
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
T Arshad, F Mansur, R Palek, S Manzoor, V Liska
Frontiers in immunology 2020
Soil-Transmitted Helminth Vaccines: Are We Getting Closer?
A Zawawi, KJ Else
Frontiers in immunology 2020
Microbiota-Dependent Effects of IL-22
M Sabihi, M Böttcher, P Pelczar, S Huber
Cells 2020
The Regulatory Function of CCR9+ Dendritic Cells in Inflammation and Autoimmunity
M Pathak, G Lal
Frontiers in immunology 2020
Nutritional Therapy to Modulate Tryptophan Metabolism and Aryl Hydrocarbon-Receptor Signaling Activation in Human Diseases
M Ghiboub, CM Verburgt, B Sovran, MA Benninga, WJ de Jonge, JE Limbergen
Nutrients 2020
Microbiota Changes Due to Grape Seed Extract Diet Improved Intestinal Homeostasis and Decreased Fatness in Parental Broiler Hens
J Grandhaye, V Douard, A Rodriguez-Mateos, Y Xu, A Cheok, A Riva, R Guabiraba, O Zemb, C Philippe, M Monnoye, C Staub, E Venturi, A Barbe, C Ramé, J Dupont, P Froment
Microorganisms 2020
Near infrared readouts offer sensitive and rapid assessments of intestinal permeability and disease severity in inflammatory bowel disease models
L Zhang, CD Wallace, JE Erickson, CM Nelson, SM Gaudette, CS Pohl, SD Karsen, GH Simler, R Peng, CA Stedman, FS Laroux, MA Wurbel, RV Kamath, BL McRae, AJ Sterman, S Mitra
Scientific Reports 2020
Characterization of IL-22 Bioactivity and IL-22-Positive Cells in Grass Carp Ctenopharyngodon idella
Y Yang, J Wang, J Xu, Q Liu, Z Wang, X Zhu, X Ai, Q Gao, X Chen, J Zou
Frontiers in immunology 2020
IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology
HX Wei, B Wang, B Li
Frontiers in immunology 2020
From intestinal dysbiosis to alcohol-associated liver disease
BG Mendes, B Schnabl
Clinical and Molecular Hepatology 2020
CD28 Autonomous Signaling Orchestrates IL-22 Expression and IL-22-Regulated Epithelial Barrier Functions in Human T Lymphocytes
M Kunkl, C Amormino, S Frascolla, M Sambucci, MD Bardi, S Caristi, S Arcieri, L Battistini, L Tuosto
Frontiers in immunology 2020
Decrease in Mucosal IL17A, IFNγ and IL10 Expressions in Active Crohn’s Disease Patients Treated with High-Dose Vitamin D Alone or Combined with Infliximab
M Bendix, A Dige, SP Jørgensen, JF Dahlerup, BM Bibby, B Deleuran, J Agnholt
Nutrients 2020
CD1d1 intrinsic signaling in macrophages controls NLRP3 inflammasome expression during inflammation
S Cui, C Wang, W Bai, J Li, Y Pan, X Huang, H Yang, Z Feng, Q Xiang, L Fei, L Zheng, J Huang, Q Zhang, Y Wu, Y Chen
Science Advances 2020
Recent Insights into Cellular Crosstalk in Respiratory and Gastrointestinal Mucosal Immune Systems
SH Kim, YS Jang
Immune Network 2020
Interleukin-22 Inhibits Respiratory Syncytial Virus Production by Blocking Virus-Mediated Subversion of Cellular Autophagy
S Das, CS Croix, M Good, J Chen, J Zhao, S Hu, M Ross, MM Myerburg, JM Pilewski, J Williams, SE Wenzel, JK Kolls, A Ray, P Ray
iScience 2020
IL22BP Mediates the Antitumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
J Kempski, AD Giannou, K Riecken, L Zhao, B Steglich, J Lücke, L Garcia-Perez, KF Karstens, A Wöstemeier, M Nawrocki, P Pelczar, M Witkowski, S Nilsson, L Konczalla, AM Shiri, J Kempska, R Wahib, L Brockmann, P Huber, AC Gnirck, JE Turner, DE Zazara, PC Arck, A Stein, R Simon, A Daubmann, J Meiners, D Perez, T Strowig, P Koni, AA Kruglov, G Sauter, JR Izbicki, AH Guse, T Roesch, AW Lohse, RA Flavell, N Gagliani, S Huber
Gastroenterology 2020
IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity
SJ Gaudino, M Beaupre, X Lin, P Joshi, S Rathi, PA McLaughlin, C Kempen, N Mehta, O Eskiocak, B Yueh, RS Blumberg, AW van der Velden, KR Shroyer, AB Bialkowska, S Beyaz, P Kumar
Mucosal Immunology 2020
Gut microbiota and cardiovascular disease: opportunities and challenges
N Kazemian, M Mahmoudi, F Halperin, JC Wu, S Pakpour
Microbiome 2020
The role of IL-22 in intestinal health and disease
ME Keir, T Yi, TT Lu, N Ghilardi
Journal of Experimental Medicine 2020
Commentary on: The potency of lncRNA MALAT1/miR-155 in altering asthmatic Th1/Th2 balance by modulation of CTLA4
R Foronjy
Bioscience Reports 2020
JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Nature reviews. Gastroenterology & hepatology 2020
A Central Role for Lipocalin-2 in the Adaptation to Short-Bowel Syndrome Through Down-Regulation of IL22 in Mice.
Zhang A, Sodhi CP, Wang M, Shores DR, Fulton W, Prindle T, Brosten S, O'Hare E, Lau A, Ding H, Jia H, Lu P, White JR, Hui J, Sears CL, Hackam DJ, Alaish SM
Cellular and Molecular Gastroenterology and Hepatology 2020
Intestinal fungi are causally implicated in microbiome assembly and immune development in mice
van Tilburg Bernardes E, Pettersen VK, Gutierrez MW, Laforest-Lapointe I, Jendzjowsky NG, Cavin JB, Vicentini FA, Keenan CM, Ramay HR, Samara J, MacNaughton WK, Wilson RJ, Kelly MM, McCoy KD, Sharkey KA, Arrieta MC
Nature Communications 2020
Systemic overexpression of interleukin-22 induces the negative immune-regulator SOCS3 and potently reduces experimental arthritis in mice
Aarts J, Roeleveld DM, Helsen MM, Walgreen B, Vitters EL, Kolls J, van de Loo FA, van Lent PL, van der Kraan PM, Koenders MI
Rheumatology (Oxford, England) 2020
Gingival crevicular fluid levels of Interleukin-22 (IL-22) and human β Defensin-2 (hBD-2) in periodontal health and disease : A correlative study.
Sidharthan S, Dharmarajan G, Kulloli A
Journal of Oral Biology and Craniofacial Research 2020
A single early-in-life antibiotic course increases susceptibility to DSS-induced colitis
Ozkul C, Ruiz VE, Battaglia T, Xu J, Roubaud-Baudron C, Cadwell K, Perez-Perez GI, Blaser MJ
Genome Medicine 2020
IL-22 hinders antiviral T cell responses and exacerbates ZIKV encephalitis in immunocompetent neonatal mice
Liang Y, Yi P, Ru W, Jie Z, Wang H, Ghanayem T, Wang X, Alamer E, Liu J, Hu H, Soong L, Cai J, Sun J
Journal of Neuroinflammation 2020
Transcriptional programmes underlying cellular identity and microbial responsiveness in the intestinal epithelium
Heppert JK, Davison JM, Kelly C, Mercado GP, Lickwar CR, Rawls JF
Nature reviews. Gastroenterology & hepatology 2020
Inflammation, HIV, and Immune Quiescence: Leveraging on Immunomodulatory Products to Reduce HIV Susceptibility.
Cromarty R, Archary D
AIDS Research and Treatment 2020
Effects of novel probiotic strains of Bacillus pumilus and Bacillus subtilis on production, gut health, and immunity of broiler chickens raised under suboptimal conditions.
Bilal M, Si W, Barbe F, Chevaux E, Sienkiewicz O, Zhao X
Poultry science 2020
6-Formylindolo (3, 2-b) Carbazole (FICZ)–mediated protection of gut barrier is dependent on T cells in a mouse model of alcohol combined with burn injury
Li X, Luck ME, Hammer AM, Cannon AR, Choudhry MA
2020
The role of innate lymphoid cells in response to microbes at mucosal surfaces.
Seo GY, Giles DA, Kronenberg M
Mucosal Immunology 2020
Reparative T lymphocytes in organ injury
Franco D'Alessio, Johanna Kurzhagen, Hamid Rabb
Journal of Clinical Investigation 2019
Innate Lymphoid Cells: Their Contributions to Gastrointestinal Tissue Homeostasis and HIV/SIV Disease Pathology
JC Mudd, JM Brenchley
Current HIV/AIDS Reports 2019
Curcumin and Intestinal Inflammatory Diseases: Molecular Mechanisms of Protection
K Burge, A Gunasekaran, J Eckert, H Chaaban
International journal of molecular sciences 2019
TH9, TH17, and TH22 Cell Subsets and Their Main Cytokine Products in the Pathogenesis of Colorectal Cancer
G Cui
Frontiers in Oncology 2019
Cellular and Molecular Therapeutic Targets in Inflammatory Bowel Disease—Focusing on Intestinal Barrier Function
I Schoultz, Å Keita
Cells 2019
The Role of Immune Cells and Cytokines in Intestinal Wound Healing
X Xue, DM Falcon
International journal of molecular sciences 2019
Impact of the Microbiome on the Immune System
CB Lambring, S Siraj, K Patel, UT Sankpal, S Mathew, R Basha
Critical reviews in immunology 2019
Flagellin hypervariable region determines symbiotic properties of commensal Escherichia coli strains
A Steimle, S Menz, A Bender, B Ball, AN Weber, T Hagemann, A Lange, JK Maerz, R Parusel, L Michaelis, A Schäfer, H Yao, HC Löw, S Beier, MT Mebrhatu, K Gronbach, S Wagner, D Voehringer, M Schaller, B Fehrenbacher, IB Autenrieth, TA Oelschlaeger, JS Frick, L Teixeira
PLoS Biology 2019
IL-23–producing IL-10Rα–deficient gut macrophages elicit an IL-22–driven proinflammatory epithelial cell response
B Bernshtein, C Curato, M Ioannou, CA Thaiss, M Gross-Vered, M Kolesnikov, Q Wang, E David, L Chappell-Maor, A Harmelin, E Elinav, P Thakker, V Papayannopoulos, S Jung
Science Immunology 2019
Recent Advances on Microbiota Involvement in the Pathogenesis of Autoimmunity
E Gianchecchi, A Fierabracci
International journal of molecular sciences 2019
Intestinal epithelial cells: at the interface of the microbiota and mucosal immunity
AT Soderholm, VA Pedicord
Immunology 2019
Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species
JW Bostick, Y Wang, Z Shen, Y Ge, J Brown, ZE Chen, M Mohamadzadeh, JG Fox, L Zhou
Proceedings of the National Academy of Sciences 2019
TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells
FC Yang, PY Chiu, Y Chen, TW Mak, NJ Chen
Journal of Biomedical Science 2019
Intestinal Microbiota Influence Immune Tolerance Post Allogeneic Hematopoietic Cell Transplantation and Intestinal GVHD
N Köhler, R Zeiser
Frontiers in immunology 2019
Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis
B Wang, JH Lim, T Kajikawa, X Li, BA Vallance, NM Moutsopoulos, T Chavakis, G Hajishengallis
Cell Reports 2019
Interleukin‑22 regulates the homeostasis of the intestinal epithelium during inflammation
X Zhang, S Liu, Y Wang, H Hu, L Li, Y Wu, D Cao, Y Cai, J Zhang, X Zhang
International journal of molecular medicine 2019
Human Gut-Associated Natural Killer Cells in Health and Disease
A Poggi, R Benelli, R Venè, D Costa, N Ferrari, F Tosetti, MR Zocchi
Frontiers in immunology 2019
Innate Lymphoid Cells in Mucosal Immunity
SK Panda, M Colonna
Frontiers in immunology 2019
Genetic Factors and the Intestinal Microbiome Guide Development of Microbe-Based Therapies for Inflammatory Bowel Diseases
LJ Cohen, JH Cho, D Gevers, H Chu
Gastroenterology 2019
IL-22-binding protein exacerbates influenza, bacterial super-infection
RN Abood, KJ McHugh, HE Rich, MA Ortiz, JM Tobin, K Ramanan, KM Robinson, JM Bomberger, JK Kolls, ML Manni, DA Pociask, JF Alcorn
Mucosal Immunology 2019
Bifidobacterium dentium Fortifies the Intestinal Mucus Layer via Autophagy and Calcium Signaling Pathways
MA Engevik, B Luk, AL Chang-Graham, A Hall, B Herrmann, W Ruan, BT Endres, Z Shi, KW Garey, JM Hyser, J Versalovic, S Gorska, N Pujol
mBio 2019
Vitamin D/Vitamin D Receptor Signaling Is Required for Normal Development and Function of Group 3 Innate Lymphoid Cells in the Gut
L He, M Zhou, YC Li
iScience 2019
Dual roles of IL-18 in colitis through regulation of the function and quantity of goblet cells
Z Pu, Y Che, W Zhang, H Sun, T Meng, H Xie, L Cao, H Hao
International journal of molecular medicine 2019
Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation
S Fan, CM Weight, AC Luissint, RS Hilgarth, JC Brazil, M Ettel, A Nusrat, CA Parkos, A Yap
Molecular biology of the cell 2019
Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 Pathway
Moniruzzaman, R Wang, V Jeet, MA McGuckin, SZ Hasnain
International journal of molecular sciences 2019
Gut IgA abundance in adult life is a major determinant of resistance to dextran sodium sulfate‐colitis and can compensate for the effects of inadequate maternal IgA received by neonates
S Gupta, S Basu, V Bal, S Rath, A George
Immunology 2019
Effect of Tripterygium wilfordii Polycoride on the NOXs-ROS-NLRP3 Inflammasome Signaling Pathway in Mice with Ulcerative Colitis
M Fangxiao, K Yifan, Z Jihong, S Yan, L Yingchao
Evidence-Based Complementary and Alternative Medicine 2019
Bacteroides ovatus ATCC 8483 monotherapy is superior to traditional fecal transplant and multi-strain bacteriotherapy in a murine colitis model
FD Ihekweazu, TY Fofanova, K Queliza, D Nagy-Szakal, CJ Stewart, MA Engevik, KG Hulten, N Tatevian, DY Graham, J Versalovic, JF Petrosino, R Kellermayer
Gut microbes 2019
IL-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis
CH Poholek, SJ Dulson, AJ Zajac, LE Harrington
ImmunoHorizons 2019
High-dose Glycerol Monolaurate Up-Regulated Beneficial Indigenous Microbiota without Inducing Metabolic Dysfunction and Systemic Inflammation: New Insights into Its Antimicrobial Potential
Q Mo, A Fu, L Deng, M Zhao, Y Li, H Zhang, F Feng
Nutrients 2019
Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes
Q Cao, X Gao, Y Lin, C Yue, Y Wang, F Quan, Z Zhang, X Liu, Y Lu, Y Zhan, H Yang, X Li, D Qin, L Birnbaumer, K Hao, Y Yang
Theranostics 2019
lncRNA Mirt2 Is Downregulated in Ulcerative Colitis and Regulates IL-22 Expression and Apoptosis in Colonic Epithelial Cells
G Ding, Y Ming, Y Zhang
Gastroenterology Research and Practice 2019
Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality
TS Hinks, E Marchi, M Jabeen, M Olshansky, A Kurioka, TJ Pediongco, BS Meehan, L Kostenko, SJ Turner, AJ Corbett, Z Chen, P Klenerman, J McCluskey
Cell Reports 2019
Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells
N Powell, E Pantazi, P Pavlidis, A Tsakmaki, K Li, F Yang, A Parker, C Pin, D Cozzetto, D Minns, E Stolarczyk, S Saveljeva, R Mohamed, P Lavender, B Afzali, J Digby-Bell, T Tjir-Li, A Kaser, J Friedman, TT MacDonald, GA Bewick, G M
Gut 2019
Inflammaging phenotype in rhesus macaques is associated with a decline in epithelial barrier-protective functions and increased pro-inflammatory function in CD161-expressing cells
EM Walker, N Slisarenko, GL Gerrets, PJ Kissinger, ES Didier, MJ Kuroda, RS Veazey, SM Jazwinski, N Rout
GeroScience 2019
miRNAs in gastrointestinal diseases: can we effectively deliver RNA-based therapeutics orally?
AK Hossian, GG Mackenzie, G Mattheolabakis
Nanomedicine 2019
MUC1 as a target for CAR‐T therapy in head and neck squamous cell carinoma
Mei Z, Zhang K, Lam AK, Huang J, Qiu F, Qiao B, Zhang Y
Cancer Medicine 2019
Protecting intestinal epithelial cells against deoxynivalenol and E. coli damage by recombinant porcine IL-22.
Li Y, Wang J, Li Y, Wu H, Zhao S, Yu Q
Veterinary Microbiology 2019
Indigo naturalis is effective even in treatment-refractory patients with ulcerative colitis: a post hoc analysis from the INDIGO study.
Naganuma M, Sugimoto S, Fukuda T, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Abe T, Suzuki Y, Kanai T
Journal of Gastroenterology 2019
Function of innate lymphoid cells in the immune-related disorders.
Dzopalić T, Božić-Nedeljković B, Jurišić V
Human Cell 2019
siRNA Targeting and Treatment of Gastrointestinal Diseases.
Chevalier R
Clinical and Translational Science 2019
Dual TLR2 and TLR7 agonists as HIV latency reversing agents
Amanda B Macedo, Camille Novis, Caroline De Assis, Eric, S Sorensen, Paula Moszczynski, Szu-han Huang, Yanqin Ren, Adam Spivak, Brad Jones, Vicente Planelles, Alberto Bosque
JCI Insight 2018
Purine metabolism controls innate lymphoid cell function and protects against intestinal injury
S Crittenden, A Cheyne, A Adams, T Forster, CT Robb, J Felton, GT Ho, D Ruckerl, AG Rossi, SM Anderton, P Ghazal, J Satsangi, SE Howie, C Yao
Immunology and Cell Biology 2018
Orchestration of intestinal homeostasis and tolerance by group 3 innate lymphoid cells
HA Penny, SH Hodge, MR Hepworth
Seminars in Immunopathology 2018
Gpr109a Limits Microbiota-Induced IL-23 Production To Constrain ILC3-Mediated Colonic Inflammation
B Bhatt, P Zeng, H Zhu, S Sivaprakasam, S Li, H Xiao, L Dong, P Shiao, R Kolhe, N Patel, H Li, D Levy-Bercowski, V Ganapathy, N Singh
Journal of immunology (Baltimore, Md. : 1950) 2018
Effector T Helper Cell Subsets in Inflammatory Bowel Diseases
T Imam, S Park, MH Kaplan, MR Olson
Frontiers in immunology 2018
miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis
L Wang, E Wang, Y Wang, R Mines, K Xiang, Z Sun, G Zhou, KY Chen, N Rakhilin, S Chao, G Ye, Z Wu, H Yan, H Shen, J Everitt, P Bu, X Shen
eLife 2018
Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment
M Kasembeli, U Bharadwaj, P Robinson, D Tweardy
International journal of molecular sciences 2018
The Complex Interplay between Chronic Inflammation, the Microbiome, and Cancer: Understanding Disease Progression and What We Can Do to Prevent It
H Armstrong, M Bording-Jorgensen, S Dijk, E Wine
Cancers 2018
Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health
J Zou, B Chassaing, V Singh, M Pellizzon, M Ricci, MD Fythe, MV Kumar, AT Gewirtz
Cell Host & Microbe 2018
In Inflamed Intestinal Tissues and Epithelial Cells, Interleukin 22 Signaling Increases Expression of H19 Long Noncoding RNA, Which Promotes Mucosal Regeneration
H Geng, HF Bu, F Liu, L Wu, K Pfeifer, PM Chou, X Wang, J Sun, L Lu, A Pandey, MS Bartolomei, IG de Plaen, P Wang, J Yu, J Qian, XD Tan
Gastroenterology 2018
A cytokine network involving IL-36γ, IL-23, and IL-22 promotes antimicrobial defense and recovery from intestinal barrier damage
VL Ngo, H Abo, E Maxim, A Harusato, D Geem, O Medina-Contreras, D Merlin, AT Gewirtz, A Nusrat, TL Denning
Proceedings of the National Academy of Sciences 2018
Elevated Expression of Serum Amyloid A 3 Protects Colon Epithelium Against Acute Injury Through TLR2-Dependent Induction of Neutrophil IL-22 Expression in a Mouse Model of Colitis
G Zhang, J Liu, L Wu, Y Fan, L Sun, F Qian, D Chen, RD Ye
Frontiers in immunology 2018
Interleukin-22 Immunotherapy during Severe Influenza Enhances Lung Tissue Integrity and Reduces Secondary Bacterial Systemic Invasion
A Barthelemy, V Sencio, D Soulard, L Deruyter, C Faveeuw, RL Goffic, F Trottein, AJ Bäumler
Infection and immunity 2018
Glucocorticoids Inhibit Group 3 Innate Lymphocyte IL-22 Production
S Seshadri, RL Pope, LA Zenewicz
Journal of immunology (Baltimore, Md. : 1950) 2018
The Interleukin-20 Cytokines in Intestinal Diseases
JH Niess, P Hruz, T Kaymak
Frontiers in immunology 2018
Canonical Wnt Signaling in CD11c + APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon
D Swafford, A Shanmugam, P Ranganathan, MS Hussein, PA Koni, PD Prasad, M Thangaraju, S Manicassamy
Journal of immunology (Baltimore, Md. : 1950) 2018
Regulation of IL-22BP in psoriasis
S Voglis, S Moos, L Kloos, F Wanke, M Zayoud, P Pelczar, AD Giannou, S Pezer, M Albers, F Luessi, S Huber, K Schäkel, FC Kurschus
Scientific Reports 2018
Role of the Microbiome in Food Allergy
H Ho, S Bunyavanich
Current Allergy and Asthma Reports 2018
Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota
JA Mullaney, JE Stephens, ME Costello, C Fong, BE Geeling, PG Gavin, CM Wright, TD Spector, MA Brown, EE Hamilton-Williams
Microbiome 2018
Interleukin-22 levels are increased in gastrointestinal graft- versus -host disease in children
DT Lounder, P Khandelwal, NJ Gloude, CE Dandoy, S Jodele, M Medvedovic, LA Denson, A Lane, K Lake, B Litts, A Wilkey, SM Davies
Haematologica 2018
Interleukin 22 Expands Transit-Amplifying Cells While Depleting Lgr5+ Stem Cells via Inhibition of Wnt and Notch Signaling
JM Zha, HS Li, Q Lin, WT Kuo, ZH Jiang, PY Tsai, N Ding, J Wu, SF Xu, YT Wang, J Pan, XM Zhou, K Chen, M Tao, MA Odenwald, A Tamura, S Tsukita, JR Turner, WQ He
CMGH Cellular and Molecular Gastroenterology and Hepatology 2018
An Interleukin-23-Interleukin-22 Axis Regulates Intestinal Microbial Homeostasis to Protect from Diet-Induced Atherosclerosis
AR Fatkhullina, IO Peshkova, A Dzutsev, T Aghayev, JA McCulloch, V Thovarai, JH Badger, R Vats, P Sundd, HY Tang, AV Kossenkov, SL Hazen, G Trinchieri, SI Grivennikov, EK Koltsova
Immunity 2018
Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons
Z He, J Song, J Hua, M Yang, Y Ma, T Yu, J Feng, B Liu, X Wang, Y Li, J Li
Cell Death and Disease 2018
Nonclinical safety assessment of a human interleukin‐22 FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability
DW Lee, S Zhong, R Pai, J Rae, S Sukumaran, EG Stefanich, J Lutman, E Doudement, X Wang, B Harder, A Lekkerkerker, A Herman, W Ouyang, DM Danilenko
Pharmacology Research & Perspectives 2018
TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis
B Xiao, Q Chen, Z Zhang, L Wang, Y Kang, T Denning, D Merlin
Journal of Controlled Release 2018
Alcohol enhances symptoms and propensity for infection in inflammatory bowel disease patients and a murine model of DSS-induced colitis
AR Cannon, PV Kuprys, AN Cobb, X Ding, AN Kothari, PC Kuo, JM Eberhardt, AM Hammer, NL Morris, X Li, MA Choudhry
Journal of leukocyte biology 2018
Delivery of interleukin-22 binding protein (IL-22BP) gene by cationic micelle for colon cancer gene therapy
Men K, Huang R, Zhang X, Zhang R, Zhang Y, Peng Y, Tong R, Yang L, Wei Y, Duan X
RSC Advances 2018
Expression of human REG family genes in inflammatory bowel disease and their molecular mechanism.
Takasawa S, Tsuchida C, Sakuramoto-Tsuchida S, Takeda M, Itaya-Hironaka A, Yamauchi A, Misu M, Shobatake R, Uchiyama T, Makino M, Ohbayashi C
Immunologic research 2018
IL-22: There is a gap in our knowledge
Zenewicz LA
ImmunoHorizons 2018
IL-22 deficiency increases CD4 T cell responses to mucosal immunization.
Budda SA, Zenewicz LA
Vaccine 2018
Th17 Cell Regulation by P. UF1 Bacterium During Intestinal Inflammation
Natacha Colliou, Yong Ge, Bikash Sahay, Minghao Gong, Mojgan Zadeh, Jennifer Owen, j Neu, William Farmerie, Francis Alonzo, Ken Liu, Dean P. Jones, Shuzhao Li, Mansour Mohamadzadeh
Journal of Clinical Investigation 2017
The Anti-Hiv Candidate Abx464 Dampens Intestinal Inflammation by Triggering Il-22 Production in Activated Macrophages
K Chebli, L Papon, C Paul, A Garcel, N Campos, D Scherrer, HJ Ehrlich, M Hahne, J Tazi
Scientific Reports 2017
Interplay of GTPases and Cytoskeleton in Cellular Barrier Defects during Gut Inflammation
R López-Posadas, M Stürzl, I Atreya, MF Neurath, N Britzen-Laurent
Frontiers in immunology 2017
Innate Lymphoid Cells in HIV/SIV Infections
SV Shah, C Manickam, DR Ram, RK Reeves
Frontiers in immunology 2017
Regulation of Gastric Carcinogenesis by Inflammatory Cytokines
KA Bockerstett, RJ DiPaolo
Cellular and Molecular Gastroenterology and Hepatology 2017
Lessons Learned From Trials Targeting Cytokine Pathways in Patients With Inflammatory Bowel Diseases
C Abraham, PS Dulai, S Vermeire, WJ Sandborn
Gastroenterology 2017
HIV as a Cause of Immune Activation and Immunosenescence
T Sokoya, HC Steel, M Nieuwoudt, TM Rossouw
Mediators of Inflammation 2017
Eosinophils in Autoimmune Diseases
D Čiháková, NL Diny, NR Rose
Frontiers in immunology 2017
Targeting IL-10 Family Cytokines for the Treatment of Human Diseases
X Wang, K Wong, W Ouyang, S Rutz
Cold Spring Harbor perspectives in biology 2017
Helminths in the gastrointestinal tract as modulators of immunity and pathology
F Varyani, JO Fleming, RM Maizels
AJP Gastrointestinal and Liver Physiology 2017
IL-6 Signaling Regulates Small Intestinal Crypt Homeostasis
V Jeffery, AJ Goldson, JR Dainty, M Chieppa, A Sobolewski
Journal of immunology (Baltimore, Md. : 1950) 2017
The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut
BB Yoo, SK Mazmanian
Immunity 2017
Regulation of TH17 Cells and Associated Cytokines in Wound Healing, Tissue Regeneration, and Carcinogenesis
L Brockmann, A Giannou, N Gagliani, S Huber
International journal of molecular sciences 2017
TH17 Cell and Epithelial Cell Crosstalk during Inflammatory Bowel Disease and Carcinogenesis
J Kempski, L Brockmann, N Gagliani, S Huber
Frontiers in immunology 2017
Increased expression of Th17 cytokines and interleukin-22 correlates with disease activity in pristane-induced arthritis in rats
B Wang, P Zhao, Y Zhou, L Meng, W Zhu, C Jiang, L Wang, Y Cai, S Lu, W Hou, HM Ashour
PloS one 2017
Role of Regulatory Cells in Oral Tolerance
M Wawrzyniak, L O'Mahony, M Akdis
Allergy, asthma & immunology research 2017
Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions
D Bauché, JC Marie
IBMS BoneKEy 2017
Interleukin 22 attenuated angiotensin II induced acute lung injury through inhibiting the apoptosis of pulmonary microvascular endothelial cells
Z Wu, Z Hu, X Cai, W Ren, F Dai, H Liu, J Chang, B Li
Scientific Reports 2017
IL-22BP dictates characteristics of Peyer’s patch follicle-associated epithelium for antigen uptake
T Jinnohara, T Kanaya, K Hase, S Sakakibara, T Kato, N Tachibana, T Sasaki, Y Hashimoto, T Sato, H Watarai, J Kunisawa, N Shibata, IR Williams, H Kiyono, H Ohno
Journal of Experimental Medicine 2017
Hypothermia Promotes Interleukin-22 Expression and Fine-Tunes Its Biological Activity
E Chichelnitskiy, B Himmelseher, M Bachmann, J Pfeilschifter, H Mühl
Frontiers in immunology 2017
Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses
LX Sang, B Chang, JF Zhu, FL Yang, Y Li, XF Jiang, DN Wang, CL Lu, X Sun
World journal of gastroenterology : WJG 2017
Card9-dependent IL-1β regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer
H Bergmann, S Roth, K Pechloff, EA Kiss, S Kuhn, M Heikenwälder, A Diefenbach, FR Greten, J Ruland
European Journal of Immunology 2017
The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
V Wacleche, A Landay, JP Routy, P Ancuta
Viruses 2017
Lactobacillus delivery of bioactive interleukin-22
Y Lin, K Krogh-Andersen, L Hammarström, H Marcotte
Microbial cell factories 2017
The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine
AK Savage, HE Liang, RM Locksley
Journal of immunology (Baltimore, Md. : 1950) 2017
A Nationwide Study of Severe and Protracted Diarrhoea in Patients with Primary Immunodeficiency Diseases
WI Lee, CC Chen, TH Jaing, LS Ou, C Hsueh, JL Huang
Scientific Reports 2017
Neutrophil Elastase and Interleukin 17 Expressed in the Pig Colon during Brachyspira hyodysenteriae Infection Synergistically with the Pathogen Induce Increased Mucus Transport Speed and Production via Mitogen-Activated Protein Kinase 3
MP Quintana-Hayashi, N Navabi, M Mahu, V Venkatakrishnan, HR Fernandez, F Haesebrouck, F Pasmans, SK Lindén, GH Palmer
Infection and immunity 2017
MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium
C Friedrich, P Mamareli, S Thiemann, F Kruse, Z Wang, B Holzmann, T Strowig, T Sparwasser, M Lochner, DS Zamboni
PLoS pathogens 2017
CD4 T-Cell Dysregulation in Psoriatic Arthritis Reveals a Regulatory Role for IL-22
A Ezeonyeji, H Baldwin, M Vukmanovic-Stejic, MR Ehrenstein
Frontiers in immunology 2017
Expression of REG family genes in human inflammatory bowel diseases and its regulation
C Tsuchida, S Sakuramoto-Tsuchida, M Taked, A Itaya-Hironaka, A Yamauchi, M Misu, R Shobatake, T Uchiyama, M Makino, I Pujol-Autonell, M Vives-Pi, C Ohbayashi, S Takasawa
Biochemistry and Biophysics Reports 2017
Bacillus anthracis lethal toxin negatively modulates ILC3 function through perturbation of IL-23-mediated MAPK signaling
S Seshadri, DS Allan, JR Carlyle, LA Zenewicz, SR Blanke
PLoS pathogens 2017
Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity
KA Kuhn, HM Schulz, EH Regner, EL Severs, JD Hendrickson, G Mehta, AK Whitney, D Ir, N Ohri, CE Robertson, DN Frank, EL Campbell, SP Colgan
Mucosal Immunology 2017
Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice
JM Allen, LJ Mailing, J Cohrs, C Salmonson, JD Fryer, V Nehra, VL Hale, P Kashyap, BA White, JA Woods
Gut microbes 2017
Clinical importance of IL-22 cascade in IBD
A Mizoguchi, A Yano, H Himuro, Y Ezaki, T Sadanaga, E Mizoguchi
Journal of Gastroenterology 2017
Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis.
Wittig BM, Sabat R, Holzlöhner P, Witte-Händel E, Heilmann K, Witte K, Triebus J, Tzankov A, Laman JD, Bokemeyer B, Terracciano L, Schwärzler C, Kohler H, Volkmer R, Loddenkemper C, Wolk K, Hoffmann U, Günthert U
Mucosal Immunology 2017
Molecular Signaling and Dysfunction of the Human Reactive Enteric Glial Cell Phenotype: Implications for GI Infection, IBD, POI, Neurological, Motility, and GI Disorders
A Liñán-Rico, F Turco, F Ochoa-Cortes, A Harzman, BJ Needleman, R Arsenescu, M Abdel-Rasoul, P Fadda, I Grants, E Whitaker, R Cuomo, FL Christofi
Inflammatory Bowel Diseases 2016
Microbiota-specific Th17 Cells: Yin and Yang in Regulation of Inflammatory Bowel Disease
W Wu, F Chen, Z Liu, Y Cong
Inflammatory Bowel Diseases 2016
Cytokine-Induced Modulation of Colorectal Cancer
LF Mager, MH Wasmer, TT Rau, P Krebs
Frontiers in Oncology 2016
Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity
HS Ranhotra, KL Flannigan, M Brave, S Mukherjee, DJ Lukin, SA Hirota, S Mani
Nuclear Receptor Research 2016
RORγt+ cells selectively express redundant cation channels linked to the Golgi apparatus
L Drujont, A Lemoine, A Moreau, G Bienvenu, M Lancien, T Cens, F Guillot, G Bériou, L Bouchet-Delbos, HJ Fehling, E Chiffoleau, AB Nicot, P Charnet, JC Martin, R Josien, MC Cuturi, C Louvet
Scientific Reports 2016
Gut Mucosal Barrier Dysfunction, Microbial Dysbiosis, and Their Role in HIV-1 Disease Progression
JC Mudd, JM Brenchley
The Journal of Infectious Diseases 2016
Gut barrier structure, mucosal immunity and intestinal microbiota in the pathogenesis and treatment of HIV infection
C Tincati, DC Douek, G Marchetti
AIDS Research and Therapy 2016
Molecular pathways driving disease-specific alterations of intestinal epithelial cells
R López-Posadas, MF Neurath, I Atreya
Cellular and Molecular Life Sciences 2016
Emerging roles for antigen presentation in establishing host-microbiome symbiosis
NJ Bessman, GF Sonnenberg
Immunological Reviews 2016
Functional role of mucosal-associated invariant T cells in HIV infection
A Saeidi, R Ellegård, YK Yong, HY Tan, V Velu, JE Ussher, M Larsson, EM Shankar
Journal of leukocyte biology 2016
STAT3 signaling in immunity
EJ Hillmer, H Zhang, HS Li, SS Watowich
Cytokine & Growth Factor Reviews 2016
Overview of cytokines and nitric oxide involvement in immuno-pathogenesis of inflammatory bowel diseases
I Soufli, R Toumi, H Rafa, C Touil-Boukoffa
World journal of gastrointestinal pharmacology and therapeutics 2016
How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
MB Khawar, F Azam, N Sheikh, KA Mujeeb
Journal of Immunology Research 2016
Intestinal inflammation without weight loss decreases bone density and growth
R Irwin, S Raehtz, N Parameswaran, LR McCabe
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2016
Mechanisms of interleukin-22’s beneficial effects in acute pancreatitis
C Huan
World journal of gastrointestinal pathophysiology 2016
Ectopic Tertiary Lymphoid Tissue in Inflammatory Bowel Disease: Protective or Provocateur?
EN McNamee, J Rivera-Nieves
Frontiers in immunology 2016
High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22
M Gulhane, L Murray, R Lourie, H Tong, YH Sheng, R Wang, A Kang, V Schreiber, KY Wong, G Magor, S Denman, J Begun, TH Florin, A Perkins, PÓ Cuív, MA McGuckin, SZ Hasnain
Scientific Reports 2016
Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice
Y Luo, X Wu, Z Ma, W Tan, L Wang, D Na, G Zhang, A Yin, H Huang, D Xia, Y Zhang, X Shi, L Wang
Cellular and Molecular Immunology 2016
Inflammation and the Intestinal Barrier: Leukocyte–Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
AC Luissint, CA Parkos, A Nusrat
Gastroenterology 2016
Cytokine responses and epithelial function in the intestinal mucosa
JC Onyiah, SP Colgan
Cellular and Molecular Life Sciences 2016
Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation
K Aden, A Rehman, M Falk-Paulsen, T Secher, J Kuiper, F Tran, S Pfeuffer, R Sheibani-Tezerji, A Breuer, A Luzius, M Jentzsch, R Häsler, S Billmann-Born, O Will, S Lipinski, R Bharti, T Adolph, JL Iovanna, SL Kempster, RS Blumberg, S Schreiber, B Becher, M Chamaillard, A Kaser, P Rosenstiel
Cell Reports 2016
Integrating Immunologic Signaling Networks: The JAK/STAT Pathway in Colitis and Colitis-Associated Cancer
S Zundler, M Neurath
Human vaccines 2016
Interleukin-22 in Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation
B Lamarthée, F Malard, P Saas, M Mohty, B Gaugler
Frontiers in immunology 2016
Therapeutic Potential to Modify the Mucus Barrier in Inflammatory Bowel Disease
J Sun, X Shen, Y Li, Z Guo, W Zhu, L Zuo, J Zhao, L Gu, J Gong, J Li
Nutrients 2016
Interleukin-22 Signaling in the Regulation of Intestinal Health and Disease
OB Parks, DA Pociask, Z Hodzic, JK Kolls, M Good
Frontiers in Cell and Developmental Biology 2016
The Role of IL-22 in Viral Infections: Paradigms and Paradoxes
SG Brias, G Stack, MA Stacey, AJ Redwood, IR Humphreys
Frontiers in immunology 2016
During acute experimental infection with the reticulotropic Trypanosoma cruzi strain Tulahuen IL-22 is induced IL-23-dependently but is dispensable for protection
H Erdmann, J Behrends, C Hölscher
Scientific Reports 2016
Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway
S Li, JJ Heller, JW Bostick, A Lee, H Schjerven, P Kastner, S Chan, ZE Chen, L Zhou
Immunity 2016
The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection
MM Heimesaat, U Grundmann, ME Alutis, A Fischer, UB Göbel, S Bereswill
Gut pathogens 2016
IL-22 dampens the T cell response in experimental malaria
J Sellau, CF Alvarado, S Hoenow, MS Mackroth, D Kleinschmidt, S Huber, T Jacobs
Scientific Reports 2016
Interleukin-22 ameliorates acute severe pancreatitis-associated lung injury in mice
YY Qiao, XQ Liu, CQ Xu, Z Zhang, HW Xu
World journal of gastroenterology : WJG 2016
Homeostatic PPAR  Signaling Limits Inflammatory Responses to Commensal Microbiota in the Intestine
I Manoharan, A Suryawanshi, Y Hong, P Ranganathan, A Shanmugam, S Ahmad, D Swafford, B Manicassamy, G Ramesh, PA Koni, M Thangaraju, S Manicassamy
Journal of immunology (Baltimore, Md. : 1950) 2016
Celiac Disease-Related Inflammation Is Marked by Reduction of Nkp44/Nkp46-Double Positive Natural Killer Cells
I Marafini, I Monteleone, DD Fusco, S Sedda, ML Cupi, D Fina, AO Paoluzi, F Pallone, G Monteleone, RK Reeves
PloS one 2016
Endogenous interleukin-22 protects against inflammatory bowel disease but not autoimmune cholangitis in dominant negative form of transforming growth factor beta receptor type II mice: IL-22 against inflammatory bowel disease
GX Yang, Y Sun, K Tsuneyama, W Zhang, PS Leung, XS He, AA Ansari, C Bowlus, WM Ridgway, ME Gershwin
Clinical & Experimental Immunology 2016
IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression
JL Reyes, MR Fernando, F Lopes, G Leung, NL Mancini, CE Matisz, A Wang, DM McKay, DR Herbert
PLoS pathogens 2016
Biological and pathological activities of interleukin-22
MP Lanfranca, Y Lin, J Fang, W Zou, T Frankel
Journal of Molecular Medicine 2016
IL-17a and IL-22 Induce Expression of Antimicrobials in Gastrointestinal Epithelial Cells and May Contribute to Epithelial Cell Defense against Helicobacter pylori
BR Dixon, JN Radin, MB Piazuelo, DC Contreras, HM Algood, PL Ho
PloS one 2016
Loss of Function of Intestinal IL-17 and IL-22 Producing Cells Contributes to Inflammation and Viral Persistence in SIV-Infected Rhesus Macaques
ES Ryan, L Micci, R Fromentin, S Paganini, CS McGary, K Easley, N Chomont, M Paiardini, DC Douek
PLoS pathogens 2016
Reparative inflammation takes charge of tissue regeneration
M Karin, H Clevers
Nature 2016
EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance
L Jiang, Y Shen, D Guo, D Yang, J Liu, X Fei, Y Yang, B Zhang, Z Lin, F Yang, X Wang, K Wang, J Wang, Z Cai
Nature Communications 2016
Cytokines IL-17 and IL-22 in the host response to infection
M Valeri, M Raffatellu, B Napier
Pathogens and Disease 2016
Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22
R Porte, LV Maele, N Muñoz-Wolf, B Foligné, L Dumoutier, J Tabareau, D Cayet, P Gosset, N Jonckheere, IV Seuningen, JA Chabalgoity, M Simonet, M Lamkanfi, JC Renauld, JC Sirard, C Carnoy, B McCormick
Infection and immunity 2016
Dysregulation of Group 3 Innate Lymphoid Cells in the Pathogenesis of Inflammatory Bowel Disease
M Forkel, J Mjösberg
Current Allergy and Asthma Reports 2016
Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut
Park Y, Moon SJ, Lee SW
BMB Reports 2016
Role of AhR in positive regulation of cell proliferation and survival.
Yin J, Sheng B, Qiu Y, Yang K, Xiao W, Yang H
Cell Proliferation 2016
A novel intestinal organoid-based in vitro co-culture system to dissect out the initial host defense system.
Mizoguchi A
Journal of Gastroenterology 2016
Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation.
Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, Iwatani S, Shiraishi E, Mukai A, Inoue T, Hayashi Y, Tsujii M, Motooka D, Nakamura S, Iida T, Takehara T
Journal of Gastroenterology 2016
IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity
R Bahri, IS Pateras, O D’Orlando, DA Goyeneche-Patino, M Campbell, JK Polansky, H Sandig, M Papaioannou, K Evangelou, PG Foukas, VG Gorgoulis, S Bulfone-Paus
OncoImmunology 2015
Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
SC Nalle, JR Turner
Mucosal Immunology 2015
Immunopathogenesis of IBD: current state of the art
HS de Souza, C Fiocchi
Nature Reviews Gastroenterology & Hepatology 2015
The role of Th17-associated cytokines in the pathogenesis of experimental autoimmune uveitis (EAU)
D Sun, D Liang, HJ Kaplan, H Shao
Cytokine 2015
Cytokines, IBD, and Colitis-associated Cancer:
R Francescone, V Hou, SI Grivennikov
Inflammatory Bowel Diseases 2015
Targeting JAK kinase in solid tumors: emerging opportunities and challenges
M Buchert, CJ Burns, M Ernst
Oncogene 2015
Roles and regulation of the mucus barrier in the gut
S Cornick, A Tawiah, K Chadee
Tissue Barriers 2015
STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?
PM Nguyen, TL Putoczki, M Ernst
Journal of Interferon & Cytokine Research 2015
The role of Gr-1 + cells and tumour necrosis factor- α signalling during Clostridium difficile colitis in mice
AJ McDermott, KE Higdon, R Muraglia, JR Erb-Downward, NR Falkowski, RA McDonald, VB Young, GB Huffnagle
Immunology 2015
Interleukin-22: Immunobiology and Pathology
JA Dudakov, AM Hanash, MR van Brink
Annual Review of Immunology 2015
Role of group 3 innate lymphoid cells in antibody production
G Magri, A Cerutti
Current Opinion in Immunology 2015
Innate lymphoid cells in the initiation, regulation and resolution of inflammation
GF Sonnenberg, D Artis
Nature Medicine 2015
Inhibition on JAK-STAT3 Signaling Transduction Cascade Is Taken by Bioactive Peptide Alpha-S2 Casein Protein from Goat Ethawah Breed Milk
R Rohmah, F Hardiyanti, F Fatchiyah
Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : časopis Društva za medicinsku informatiku BiH 2015
Group 3 innate lymphoid cells: regulating host–commensal bacteria interactions in inflammation and cancer
J Goc, MR Hepworth, GF Sonnenberg
International Immunology 2015
Th17 plasticity and its changes associated with inflammatory bowel disease
A Ueno
World journal of gastroenterology : WJG 2015
Tristetraprolin regulation of interleukin-22 production
L Härdle, M Bachmann, F Bollmann, A Pautz, T Schmid, W Eberhardt, H Kleinert, J Pfeilschifter, H Mühl
Scientific Reports 2015
Differential Requirements for IL-17A and IL-22 in Cecal versus Colonic Inflammation Induced by Helicobacter hepaticus
PJ Morrison, SJ Ballantyne, SJ Macdonald, JW Moore, D Jenkins, JF Wright, LA Fouser, MC Kullberg
The American Journal of Pathology 2015
Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis
E Hainzl, S Stockinger, I Rauch, S Heider, D Berry, C Lassnig, C Schwab, F Rosebrock, G Milinovich, M Schlederer, M Wagner, C Schleper, A Loy, T Urich, L Kenner, X Han, T Decker, B Strobl, M Muller
Journal of immunology (Baltimore, Md. : 1950) 2015
Attenuated Airway Epithelial Cell Interleukin-22R1 Expression in the Infant Nonhuman Primate Lung
DT Dugger, JE Gerriets, LA Miller
American journal of respiratory cell and molecular biology 2015
Relationship between female genital tract infections, mucosal interleukin-17 production and local T helper type 17 cells
L Masson, AL Salkinder, AJ Olivier, LR McKinnon, H Gamieldien, K Mlisana, TJ Scriba, DA Lewis, F Little, HB Jaspan, K Ronacher, L Denny, SS Karim, JA Passmore
Immunology 2015
IL-22BP is produced by eosinophils in human gut and blocks IL-22 protective actions during colitis
JC Martin, G Bériou, M Heslan, C Bossard, A Jarry, A Abidi, P Hulin, S Ménoret, R Thinard, I Anegon, C Jacqueline, B Lardeux, F Halary, JC Renauld, A Bourreille, R Josien
Mucosal Immunology 2015
Role of epithelial cells in the pathogenesis and treatment of inflammatory bowel disease
R Okamoto, M Watanabe
Journal of Gastroenterology 2015
CD4 T cells are required for both development and maintenance of disease in a new mouse model of reversible colitis
J Brasseit, E Althaus-Steiner, M Faderl, N Dickgreber, L Saurer, V Genitsch, T Dolowschiak, H Li, D Finke, WD Hardt, KD McCoy, AJ Macpherson, N Corazza, M Noti, C Mueller
Mucosal Immunology 2015
IL-22 Up-Regulates β-Defensin-2 Expression in Human Alveolar Epithelium via STAT3 but Not NF-κB Signaling Pathway.
Li A, Gan Y, Wang R, Liu Y, Ma T, Huang M, Cui X
Inflammation 2015
Distinct immune signatures in the colon of Crohn's disease and ankylosing spondylitis patients in the absence of inflammation.
Dunn ET, Taylor ES, Stebbings S, Schultz M, Butt AG, Kemp RA
Immunology and Cell Biology 2015
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IL-21 induces IL-22 production in CD4+ T cells
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Nature Communications 2014
PTPN2 controls differentiation of CD4+ T cells and limits intestinal inflammation and intestinal dysbiosis
MR Spalinger, S Kasper, C Chassard, T Raselli, I Frey-Wagner, C Gottier, S Lang, K Atrott, SR Vavricka, F Mair, B Becher, C Lacroix, M Fried, G Rogler, M Scharl
Mucosal Immunology 2014
Cytokines in inflammatory bowel disease
MF Neurath
Nature Reviews Immunology 2014
Stat3: Friend or Foe in Colitis and Colitis-associated Cancer?
J Han, AL Theiss
Inflammatory Bowel Diseases 2014
Interleukin 23 in Crohnʼs Disease:
A Eken, AK Singh, M Oukka
Inflammatory Bowel Diseases 2014
Interactions between the intestinal microbiota and innate lymphoid cells
VL Chen, DL Kasper
Gut microbes 2014
Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production
MM Lowe, JE Mold, B Kanwar, Y Huang, A Louie, MP Pollastri, C Wang, G Patel, DG Franks, J Schlezinger, DH Sherr, AE Silverstone, ME Hahn, JM McCune
PloS one 2014
Targeting Interleukins for the Treatment of Inflammatory Bowel Disease—What Lies Beyond Anti-TNF Therapy?:
MH McLean, MF Neurath, SK Durum
Inflammatory Bowel Diseases 2014
Unexpected Targets and Triggers of Autoimmunity
Y Lee, M Collins, VK Kuchroo
Journal of Clinical Immunology 2014
Role of Th17 Cells in the Pathogenesis of Human IBD
J Gálvez
ISRN Inflammation 2014
Toll-Like Receptor 4-Induced IL-22 Accelerates Kidney Regeneration
OP Kulkarni, I Hartter, SR Mulay, J Hagemann, MN Darisipudi, SK Vr, S Romoli, D Thomasova, M Ryu, S Kobold, HJ Anders
Journal of the American Society of Nephrology : JASN 2014
Update on Ankylosing Spondylitis: Current Concepts in Pathogenesis
JA Smith
Current Allergy and Asthma Reports 2014
Nod/Ripk2 signaling in dendritic cells activates IL-17A-secreting innate lymphoid cells and drives colitis in T-bet-/-.Rag2-/- (TRUC) mice
J Ermann, T Staton, JN Glickman, RW Malefyt, LH Glimcher
Proceedings of the National Academy of Sciences 2014
Review: The Interleukin-23/Interleukin-17 Axis in Spondyloarthritis Pathogenesis: Th17 and Beyond: IL-23/IL-17 Axis in SpA
JA Smith, RA Colbert
Arthritis & Rheumatology 2014
Recognition Strategies of Group 3 Innate Lymphoid Cells
M Killig, T Glatzer, C Romagnani
Frontiers in immunology 2014
Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-γ responses
S Justa, X Zhou, S Sarkar
PloS one 2014
Interleukin-22 promotes T helper 1 (Th1)/Th17 immunity in chlamydial lung infection
Y Peng, X Gao, J Yang, S Shekhar, S Wang, Y Fan, W Zhao, X Yang
Molecular Medicine 2014
The role of commensal bacteria in the regulation of sensitization to food allergens
S Cao, TJ Feehley, CR Nagler
FEBS Letters 2014
Effects of Mycobacteria Major Secretion Protein, Ag85B, on Allergic Inflammation in the Lung
Y Tsujimura, H Inada, M Yoneda, T Fujita, K Matsuo, Y Yasutomi
PloS one 2014
Role of interleukin-22 in inflammatory bowel disease
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World journal of gastroenterology : WJG 2014
Initiation of ART during Early Acute HIV Infection Preserves Mucosal Th17 Function and Reverses HIV-Related Immune Activation
A Schuetz, C Deleage, I Sereti, R Rerknimitr, N Phanuphak, Y Phuang-Ngern, JD Estes, NG Sandler, S Sukhumvittaya, M Marovich, S Jongrakthaitae, S Akapirat, JL Fletscher, E Kroon, R Dewar, R Trichavaroj, N Chomchey, DC Douek, RJ O′Connell, V Ngauy, ML Robb, P Phanuphak, NL Michael, JL Excler, JH Kim, MS de Souza, J Ananworanich, RC Desrosiers
PLoS pathogens 2014
Myelin-specific T helper 17 cells promote adult hippocampal neurogenesis through indirect mechanisms
J Niebling, AE Rünker, S Schallenberg, K Kretschmer, G Kempermann
F1000Research 2014
Immune Modulatory Effects of IL-22 on Allergen-Induced Pulmonary Inflammation
P Fang, L Zhou, Y Zhou, JK Kolls, T Zheng, Z Zhu, B Ryffel
PloS one 2014
T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis: Th17 pathway, appendectomy and colitis
R Cheluvappa, AS Luo, MC Grimm
Clinical & Experimental Immunology 2014
Chitinase 3-like 1 Synergistically Activates IL6-mediated STAT3 Phosphorylation in Intestinal Epithelial Cells in Murine Models of Infectious Colitis:
HT Tran, IA Lee, D Low, A Kamba, A Mizoguchi, HN Shi, CG Lee, JA Elias, E Mizoguchi
Inflammatory Bowel Diseases 2014
The Necroptosis Adaptor RIPK3 Promotes Injury-Induced Cytokine Expression and Tissue Repair
K Moriwaki, S Balaji, T McQuade, N Malhotra, J Kang, FK Chan
Immunity 2014
Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells
E Macho-Fernandez, EP Koroleva, CM Spencer, M Tighe, E Torrado, AM Cooper, YX Fu, AV Tumanov
Mucosal Immunology 2014
Interleukin-22: A likely target for treatment of autoimmune diseases
X Yang, SG Zheng
Autoimmunity Reviews 2014
Cytokine crowdsourcing: multicellular production of TH17-associated cytokines
KO Busman-Sahay, T Walrath, S Huber, W O'Connor
Journal of leukocyte biology 2014
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
S Rutz, X Wang, W Ouyang
Nature Reviews Immunology 2014
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
X Wang, N Ota, P Manzanillo, L Kates, J Zavala-Solorio, C Eidenschenk, J Zhang, J Lesch, WP Lee, J Ross, L Diehl, N Bruggen, G Kolumam, W Ouyang
Nature 2014
Therapeutic opportunities of the IL-22-IL-22R1 system.
Sabat R, Ouyang W, Wolk K
Nature reviews. Drug discovery 2014
STAT3 and importins are novel mediators of early molecular and cellular responses in experimental duodenal ulceration.
Khomenko T, Deng X, Ahluwalia A, Tarnawski A, Patel KN, Sandor Z, Szabo S
Digestive Diseases and Sciences 2014
Experimental appendicitis and appendectomy modulate the CCL20-CCR6 axis to limit inflammatory colitis pathology.
Cheluvappa R
International Journal of Colorectal Disease 2014
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress.
Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen AC, Loudovaris T, Kay TW, Thomas HE, Whitehead JP, Forbes JM, Prins JB, McGuckin MA
Nature Medicine 2014
Essentials of Th17 cell commitment and plasticity
P Muranski, NP Restifo
Blood 2013
Over-expression of CXCR4 on mesenchymal stem cells protect against experimental colitis via immunomodulatory functions in impaired tissue
X Liu, D Zuo, H Fan, Q Tang, Z Shou, D Cao, Z Zou
Journal Of Molecular Histology 2013
Microbial translocation in the pathogenesis of HIV infection and AIDS
G Marchetti, C Tincati, G Silvestri
Clinical microbiology reviews 2013
CD4(+) T-cell subsets in intestinal inflammation
M Shale, C Schiering, F Powrie
Immunological Reviews 2013
HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes
JW Shui, M Kronenberg
Gut microbes 2013
Identification of Potential Cytokine Pathways for Therapeutic Intervention in Murine Primary Biliary Cirrhosis
K Kawata, M Tsuda, GX Yang, W Zhang, H Tanaka, K Tsuneyama, P Leung, XS He, S Knechtle, AA Ansari, RL Coppel, ME Gershwin, AS Basso
PloS one 2013
β-Arrestin-1 Deficiency Protects Mice from Experimental Colitis
T Lee, E Lee, R Irwin, PC Lucas, LR McCabe, N Parameswaran
The American Journal of Pathology 2013
Immune activation and HIV persistence: implications for curative approaches to HIV infection
NR Klatt, N Chomont, DC Douek, SG Deeks
Immunological Reviews 2013
IL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism
A Eken, AK Singh, PM Treuting, M Oukka
Mucosal Immunology 2013
High intestinal and systemic levels of interleukin-23/T-helper 17 pathway in Chinese patients with inflammatory bowel disease
L Song, R Zhou, S Huang, F Zhou, S Xu, W Wang, F Yi, X Wang, B Xia
Mediators of Inflammation 2013
Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections
J Kim, W Khan
Pathogens 2013
Lyn activity protects mice from DSS colitis and regulates the production of IL-22 from innate lymphoid cells
JL Bishop, ME Roberts, JL Beer, M Huang, MK Chehal, X Fan, LA Fouser, HL Ma, JT Bacani, KW Harder
Mucosal Immunology 2013
IL-22 Is Essential for Lung Epithelial Repair following Influenza Infection
DA Pociask, EV Scheller, S Mandalapu, KJ McHugh, RI Enelow, CL Fattman, JK Kolls, JF Alcorn
The American Journal of Pathology 2013
Mucosal immunity in human and simian immunodeficiency lentivirus infections
JM Brenchley
Mucosal Immunology 2013
Card9 mediates intestinal epithelial cell restitution, T-helper 17 responses, and control of bacterial infection in mice
H Sokol, KL Conway, M Zhang, M Choi, B Morin, Z Cao, EJ Villablanca, C Li, C Wijmenga, SH Yun, HN Shi, RJ Xavier
Gastroenterology 2013
Carbon monoxide attenuates dextran sulfate sodium-induced colitis via inhibition of GSK-3β signaling
MJ Uddin, S Jeong, M Zheng, Y Chen, GJ Cho, HT Chung, Y Joe
Oxidative Medicine & Cellular Longevity 2013
Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?
H Mühl
Frontiers in immunology 2013
IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection
JE Turner, B Stockinger, H Helmby
PLoS pathogens 2013
Why interleukin-10 supplementation does not work in Crohn's disease patients
GJ Marlow, D Gent, LR Ferguson
World journal of gastroenterology : WJG 2013
IL-22-producing neutrophils contribute to antimicrobial defense and restitution of colonic epithelial integrity during colitis
CL Zindl, JF Lai, YK Lee, CL Maynard, SN Harbour, W Ouyang, DD Chaplin, CT Weaver
Proceedings of the National Academy of Sciences 2013
Expression of interleukin-22/STAT3 signaling pathway in ulcerative colitis and related carcinogenesis
LZ Yu, HY Wang, SP Yang, ZP Yuan, FY Xu, C Sun, RH Shi
World journal of gastroenterology : WJG 2013
Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection
S Ivanov, J Renneson, J Fontaine, A Barthelemy, C Paget, EM Fernandez, F Blanc, CD Trez, LV Maele, L Dumoutier, MR Huerre, G Eberl, M Si-Tahar, P Gosset, JC Renauld, JC Sirard, C Faveeuw, F Trottein
Journal of virology 2013
Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model
S Kirchberger, DJ Royston, O Boulard, E Thornton, F Franchini, RL Szabady, O Harrison, F Powrie
Journal of Experimental Medicine 2013
IL-22 deficiency alters colonic microbiota to be transmissible and colitogenic
LA Zenewicz, X Yin, G Wang, E Elinav, L Hao, L Zhao, RA Flavell
Journal of immunology (Baltimore, Md. : 1950) 2013
An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides
C Kozlowski, S Jeet, J Beyer, S Guerrero, J Lesch, X Wang, J Devoss, L Diehl
Disease models & mechanisms 2013
IL-22 in tissue-protective therapy
H Mühl, P Scheiermann, M Bachmann, L Härdle, A Heinrichs, J Pfeilschifter
British Journal of Pharmacology 2013
IL-22 is related to development of human colon cancer by activation of STAT3
R Jiang, H Wang, L Deng, J Hou, R Shi, M Yao, Y Gao, A Yao, X Wang, L Yu, B Sun
BMC Cancer 2013
Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10
S Sarkar, X Zhou, S Justa, SR Bommireddy
Arthritis & Rheumatism 2013
Interleukin-22 modulates gut epithelial and immune barrier functions following acute alcohol exposure and burn injury
JL Rendon, X Li, S Akhtar, MA Choudhry
Shock (Augusta, Ga.) 2013
Microbial-immune cross-talk and regulation of the immune system
J Cahenzli, ML Balmer, KD McCoy
Immunology 2013
IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue
JM Leung, M Davenport, MJ Wolff, KE Wiens, WM Abidi, MA Poles, I Cho, T Ullman, L Mayer, P Loke
Mucosal Immunology 2013
IL-23 Induces IL-22 and IL-17 Production in Response to Chlamydia muridarum Genital Tract Infection, but the Absence of these Cytokines does not Influence Disease Pathogenesis
LC Frazer, AM Scurlock, MA Zurenski, MM Riley, M Mintus, DA Pociask, JE Sullivan, CW Andrews, T Darville
American Journal of Reproductive Immunology 2013
Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid
JC Martin, G Bériou, M Heslan, C Chauvin, L Utriainen, A Aumeunier, CL Scott, A Mowat, V Cerovic, SA Houston, M Leboeuf, FX Hubert, C Hémont, M Merad, S Milling, R Josien
Mucosal Immunology 2013
Deletion of Intestinal Epithelial Cell STAT3 Promotes T-Lymphocyte STAT3 Activation and Chronic Colitis Following Acute Dextran Sodium Sulfate Injury in Mice:
TA Willson, I Jurickova, M Collins, LA Denson
Inflammatory Bowel Diseases 2013
Gene–gene and gene–environment interactions in ulcerative colitis
MH Wang, C Fiocchi, X Zhu, S Ripke, MI Kamboh, N Rebert, RH Duerr, JP Achkar
Human Genetics 2013
Role of IL-22– and TNF-α–Producing Th22 Cells in Uveitis Patients with Behçet’s Disease
S Sugita, Y Kawazoe, A Imai, T Kawaguchi, S Horie, H Keino, M Takahashi, M Mochizuki
Journal of immunology (Baltimore, Md. : 1950) 2013
How Cytokine networks fuel inflammation: Interleukin-17 and a tale of two autoimmune diseases.
Baeten DL, Kuchroo VK
Nature Medicine 2013
Aryl hydrocarbon receptor and colitis.
Monteleone I, Pallone F, Monteleone G
Seminars in Immunopathology 2013
Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells
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Interleukin-22 Ameliorates Cerulein-Induced Pancreatitis in Mice by Inhibiting the Autophagic Pathway
D Feng, O Park, S Radaeva, H Wang, S Yin, X Kong, M Zheng, S Zakhari, JK Kolls, B Gao
International journal of biological sciences 2012
The transition of acute to chronic bowel inflammation in spondyloarthritis
LV Praet, P Jacques, FV Bosch, D Elewaut
Nature Reviews Rheumatology 2012
TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?
AK Marwaha, NJ Leung, AN McMurchy, MK Levings
Frontiers in immunology 2012
Microbial translocation across the GI tract
JM Brenchley, DC Douek
Annual Review of Immunology 2012
Helminth infection in populations undergoing epidemiological transition: a friend or foe?
AE Wiria, Y Djuardi, T Supali, E Sartono, M Yazdanbakhsh
Seminars in Immunopathology 2012
Th17 cells: critical mediators of host responses to burn injury and sepsis
JL Rendon, MA Choudhry
Journal of leukocyte biology 2012
Association of single nucleotide polymorphisms of IL23R and IL17 with ulcerative colitis risk in a Chinese Han population
P Yu, F Shen, X Zhang, R Cao, X Zhao, P Liu, H Tu, X Yang, R Shi, H Zhang
PloS one 2012
Cellular and molecular mechanisms of intestinal fibrosis
S Speca, I Giusti, F Rieder, G Latella
World journal of gastroenterology : WJG 2012
A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing
X Sun, L Chalmers, X Fu, M Zhao
Advances in Skin & Wound Care 2012
Comparison of interferon-γ-, interleukin (IL)-17- and IL-22-expressing CD4 T cells, IL-22-expressing granulocytes and proinflammatory cytokines during latent and active tuberculosis infection
J Cowan, S Pandey, LG Filion, JB Angel, A Kumar, DW Cameron
Clinical & Experimental Immunology 2012
Healing of intestinal inflammation by IL-22
A Mizoguchi
Inflammatory Bowel Diseases 2012
Role of the Aryl Hydrocarbon Receptor in Controlling Maintenance and Functional Programs of RORγt+ Innate Lymphoid Cells and Intraepithelial Lymphocytes
EA Kiss, A Diefenbach
Frontiers in immunology 2012
Analysis of IL12B Gene Variants in Inflammatory Bowel Disease
J Glas, J Seiderer, J Wagner, T Olszak, C Fries, C Tillack, M Friedrich, F Beigel, J Stallhofer, C Steib, M Wetzke, B Göke, T Ochsenkühn, J Diegelmann, D Czamara, S Brand
PloS one 2012
A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity
JM Leung, P Loke
International Journal for Parasitology 2012
Helminthic therapy: improving mucosal barrier function
MJ Wolff, MJ Broadhurst, P Loke
Trends in Parasitology 2012
Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection
C Cosgrove, JE Ussher, A Rauch, K Gärtner, A Kurioka, MH Hühn, K Adelmann, YH Kang, JR Fergusson, P Simmonds, P Goulder, TH Hansen, J Fox, HF Günthard, N Khanna, F Powrie, A Steel, B Gazzard, RE Phillips, J Frater, H Uhlig, P Klenerman
Blood 2012
IL-22: An Evolutionary Missing-Link Authenticating the Role of the Immune System in Tissue Regeneration
P Kumar, K Rajasekaran, JM Palmer, MS Thakar, S Malarkannan
Journal of Cancer 2012
Th22 cells as well as Th17 cells expand differentially in patients with early-stage and late-stage myelodysplastic syndrome
L Shao, L Zhang, Y Hou, S Yu, X Liu, X Huang, Y Sun, T Tian, N He, D Ma, J Peng, M Hou
PloS one 2012
Mitigating colon cancer with a novel strain of Lactobacillus acidophilus: a (re-)balancing act
YL Lightfoot, HU Rehman, AD Myers, M Mohamadzadeh
Immunotherapy 2012
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
S Huber, N Gagliani, LA Zenewicz, FJ Huber, L Bosurgi, B Hu, M Hedl, W Zhang, W O'Connor, AJ Murphy, DM Valenzuela, GD Yancopoulos, CJ Booth, JH Cho, W Ouyang, C Abraham, RA Flavell
Nature 2012
Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22
JP Huai, XC Sun, MJ Chen, Y Jin, XH Ye, JS Wu, ZM Huang
World journal of gastroenterology : WJG 2012
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
B Kronenberger, I Rudloff, M Bachmann, F Brunner, L Kapper, N Filmann, O Waidmann, E Herrmann, J Pfeilschifter, S Zeuzem, A Piiper, H Mühl
BMC Medicine 2012
The β-glucan receptor dectin-1 promotes lung immunopathology during fungal allergy via IL-22
LM Lilly, MA Gessner, CW Dunaway, AE Metz, L Schwiebert, CT Weaver, GD Brown, C Steele
Journal of immunology (Baltimore, Md. : 1950) 2012
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium
C Manta, E Heupel, K Radulovic, V Rossini, N Garbi, CU Riedel, JH Niess
Mucosal Immunology 2012
HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria
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Nature 2012
Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection
NR Klatt, JD Estes, X Sun, AM Ortiz, JS Barber, LD Harris, B Cervasi, LK Yokomizo, L Pan, CL Vinton, B Tabb, LA Canary, Q Dang, VM Hirsch, G Alter, Y Belkaid, JD Lifson, G Silvestri, JD Milner, M Paiardini, EK Haddad, JM Brenchley
Mucosal Immunology 2012
IL-22 is expressed by the invasive trophoblast of the equine (Equus caballus) chorionic girdle
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Journal of immunology (Baltimore, Md. : 1950) 2012
Interleukin-22: implications for liver ischemia-reperfusion injury
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Transplantation 2012
Interleukin-10 and interleukin-10-receptor defects in inflammatory bowel disease.
Shah N, Kammermeier J, Elawad M, Glocker EO
Current Allergy and Asthma Reports 2012
Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond.
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Cellular and molecular life sciences : CMLS 2012
Dual Role of Th17 Cytokines, IL-17A,F, and IL-22 in Allergic Asthma
Schnyder B, Schnyder-Candrian S
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In vivo consequences of liver-specific interleukin-22 expression: implications for human liver disease progression
O Park, H Wang, H Weng, L Feigenbaum, H Li, S Yin, SH Ki, SH Yoo, S Dooley, FS Wang, HA Young, B Gao
Hepatology 2011
IL-22 Is Produced by Innate Lymphoid Cells and Limits Inflammation in Allergic Airway Disease
C Taube, C Tertilt, G Gyülveszi, N Dehzad, K Kreymborg, K Schneeweiss, E Michel, S Reuter, JC Renauld, D Arnold-Schild, H Schild, R Buhl, B Becher
PloS one 2011
IL-22–Induced Regulatory CD11b + APCs Suppress Experimental Autoimmune Uveitis
Y Ke, D Sun, G Jiang, HJ Kaplan, H Shao
Journal of immunology (Baltimore, Md. : 1950) 2011
Th17-related cytokines: new players in the control of chronic intestinal inflammation
I Monteleone, F Pallone, G Monteleone
BMC Medicine 2011
Interleukin-23 and T helper 17-type responses in intestinal inflammation: from cytokines to T-cell plasticity
PJ Morrison, SJ Ballantyne, MC Kullberg
Immunology 2011
Interactions Between the Host Innate Immune System and Microbes in Inflammatory Bowel Disease
C Abraham, R Medzhitov
Gastroenterology 2011
Pro-Inflammatory Cytokines in the Pathogenesis of IBD
W Strober, IJ Fuss
Gastroenterology 2011
Th17 cell cytokine secretion profile in host defense and autoimmunity
KE Graeber, NJ Olsen
Inflammation Research 2011
Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression
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Journal of leukocyte biology 2011
Membrane-bound IL-22 after de novo production in tuberculosis and anti-Mycobacterium tuberculosis effector function of IL-22+ CD4+ T cells
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Journal of immunology (Baltimore, Md. : 1950) 2011
The Membrane-Bound Mucin Muc1 Regulates T Helper 17-Cell Responses and Colitis in Mice
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Gastroenterology 2011
Mucin dynamics and enteric pathogens
MA McGuckin, SK Lindén, P Sutton, TH Florin
Nature Reviews Microbiology 2011
Neutrophils Produce Interleukin 17A (IL-17A) in a Dectin-1- and IL-23-Dependent Manner during Invasive Fungal Infection
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Infection and immunity 2011
The light and dark sides of intestinal intraepithelial lymphocytes
H Cheroutre, F Lambolez, D Mucida
Nature reviews. Immunology 2011
In vivo dioxin favors interleukin-22 production by human CD4+ T cells in an aryl hydrocarbon receptor (AhR)-dependent manner
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PloS one 2011
Control of epithelial cell function by interleukin-22-producing RORγt+ innate lymphoid cells
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Immunology 2011
High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22
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PloS one 2011
Memory/effector (CD45RBlo) CD4 T cells are controlled directly by IL-10 and cause IL-22–dependent intestinal pathology
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Journal of Experimental Medicine 2011
An Anti-Inflammatory Role for Carbon Monoxide and Heme Oxygenase-1 in Chronic Th2-Mediated Murine Colitis
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Journal of immunology (Baltimore, Md. : 1950) 2011
Lymphotoxin controls the IL-22 protection pathway in gut innate lymphoid cells during mucosal pathogen challenge
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Cell Host & Microbe 2011
The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells
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Immunity 2011
Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a
I Rudloff, M Bachmann, J Pfeilschifter, H Mühl
The Journal of biological chemistry 2011
Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus
MA Gessner, JL Werner, LM Lilly, MP Nelson, AE Metz, CW Dunaway, YR Chan, W Ouyang, GD Brown, CT Weaver, C Steele, GS Deepe
Infection and immunity 2011
The Role of Osteopontin (OPN/SPP1) Haplotypes in the Susceptibility to Crohn's Disease
J Glas, J Seiderer, C Bayrle, M Wetzke, C Fries, C Tillack, T Olszak, F Beigel, C Steib, M Friedrich, J Diegelmann, D Czamara, S Brand, JH Niess
PloS one 2011
The Pathogenicity of an Enteric Citrobacter rodentium Infection Is Enhanced by Deficiencies in the Antioxidants Selenium and Vitamin E
AD Smith, S Botero, T Shea-Donohue, JF Urban, BA McCormick
Infection and immunity 2011
Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22
GF Sonnenberg, LA Fouser, D Artis
Nature Immunology 2011
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium.
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Nature Immunology 2011
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner.
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Nature Immunology 2011
Inflammatory bowel disease: is it a primary immunodeficiency?
Glocker E, Grimbacher B
Cellular and molecular life sciences : CMLS 2011
Averting inflammation by targeting the cytokine environment
M Kopf, MF Bachmann, BJ Marsland
Nature Reviews Drug Discovery 2010
Inflammatory Bowel Disease
A Kaser, S Zeissig, RS Blumberg
Annual Review of Immunology 2010
Infection and apoptosis as a combined inflammatory trigger
MB Torchinsky, J Garaude, JM Blander
Current Opinion in Immunology 2010
New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression
SM Steward-Tharp, Y Song, RM Siegel, JJ O'Shea
Annals of the New York Academy of Sciences 2010
Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?
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Cell division 2010
Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine
C Wang, SG Kang, H HogenEsch, PE Love, CH Kim
Journal of immunology (Baltimore, Md. : 1950) 2010
Toll-like receptors in inflammatory bowel diseases: A decade later
E Cario
Inflammatory Bowel Diseases 2010
Peptidoglycan recognition proteins protect mice from experimental colitis by promoting normal gut flora and preventing induction of interferon-gamma
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Cell Host & Microbe 2010
Animal models of IBD: linkage to human disease
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Current Opinion in Pharmacology 2010
Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation, and IL-17 production in the absence of SIV infection
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Mucosal Immunology 2010
Redundant and Pathogenic Roles for IL-22 in Mycobacterial, Protozoan, and Helminth Infections
MS Wilson, CG Feng, DL Barber, F Yarovinsky, AW Cheever, A Sher, M Grigg, M Collins, L Fouser, TA Wynn
Journal of immunology (Baltimore, Md. : 1950) 2010
Nonprogressive and Progressive Primate Immunodeficiency Lentivirus Infections
JM Brenchley, G Silvestri, DC Douek
Immunity 2010
The role of the immune system in regulating the microbiota
BP Willing, N Gill, BB Finlay
Gut microbes 2010
Genes and Environment: How Will Our Concepts on the Pathophysiology of IBD Develop in the Future?
A Kaser, S Zeissig, RS Blumberg
Digestive diseases (Basel, Switzerland) 2010
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
JG Fox, Z Ge, MT Whary, SE Erdman, BH Horwitz
Mucosal Immunology 2010
Th17 cell dynamics in HIV infection
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Current Opinion in HIV and AIDS 2010
Mucosal T cells in gut homeostasis and inflammation
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Expert Review of Clinical Immunology 2010
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
GF Sonnenberg, MG Nair, TJ Kirn, C Zaph, LA Fouser, D Artis
Journal of Experimental Medicine 2010
Notch signaling drives IL-22 secretion in CD4+ T cells by stimulating the aryl hydrocarbon receptor
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Proceedings of the National Academy of Sciences 2010
Proinflammatory cytokines underlying the inflammation of Crohn's disease
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Current Opinion in Gastroenterology 2010
Unraveling the genetics of autoimmunity
LA Zenewicz, C Abraham, RA Flavell, JH Cho
Cell 2010
Early Production of IL-22 but Not IL-17 by Peripheral Blood Mononuclear Cells Exposed to live Borrelia burgdorferi: The Role of Monocytes and Interleukin-1
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PLoS pathogens 2010
The dual nature of TH17 cells: shifting the focus to function
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Nature Immunology 2010
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Cellular and Molecular Life Sciences 2010
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Cellular and molecular life sciences : CMLS 2010
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Arthritis & Rheumatism 2009
Pulmonary surfactant: an immunological perspective
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Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17
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Journal of Experimental Medicine 2009
Inflammatory Bowel Disease
C Abraham, JH Cho
New England Journal of Medicine 2009
Disturbance of the gut-associated lymphoid tissue is associated with disease progression in chronic HIV infection
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Seminars in Immunopathology 2009
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
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Cancer Cell 2009
Synergy of IL-23 and Th17 Cytokines: New Light on Inflammatory Bowel Disease
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STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
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Journal of Experimental Medicine 2009
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The New England journal of medicine 2009
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Clinical & Experimental Immunology 2009
STAT3 in CD4+ T helper cell differentiation and inflammatory diseases
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Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity
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Nature Genetics 2009
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The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
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Immunity 2008
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Immunity 2008
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Nature 2008
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