Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications
George A. Calin, Carlo M. Croce
George A. Calin, Carlo M. Croce
Published August 1, 2007
Citation Information: J Clin Invest. 2007;117(8):2059-2066. https://doi.org/10.1172/JCI32577.
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Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications

Abstract

There is widespread aberrant expression of mature and/or precursor microRNAs in cancer cells, as microRNAs are deregulated consequent to chromosomal alterations and other genomic abnormalities. The identification of such abnormalities has a clear diagnostic and prognostic significance, and there are ever increasing examples of links between certain human cancers and modifications at microRNA loci.

Authors

George A. Calin, Carlo M. Croce

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Figure 4

Principles of miRNA-based gene therapy and in vivo inhibition of miRNA in cancer cells.

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Principles of miRNA-based gene therapy and in vivo inhibition of miRNA i...
The major types of new miRNA drugs or manipulations toward the therapeutic goal of reverting the malignant phenotype are presented in conjunction with the main miRNA abnormalities found in human cancers. AMOs, anti-mRNA oligonucleotides; LNAs, locked nucleic acids.