Go to
JCI Insight
Citations to this article
Joerg Heineke, … , Timothy M. Crombleholm, Jeffery D. Molkentin
Published November 1, 2007
Citation Information: J Clin Invest. 2007;117(11):3198-3210. https://doi.org/10.1172/JCI32573.
Citation Information: J Clin Invest. 2007;117(11):3198-3210. https://doi.org/10.1172/JCI32573.
Abstract
The transcription factor GATA4 is a critical regulator of cardiac gene expression, modulating cardiomyocyte differentiation and adaptive responses of the adult heart. We report what we believe to be a novel function for GATA4 in murine cardiomyocytes as a nodal regulator of cardiac angiogenesis. Conditional overexpression of GATA4 within adult cardiomyocytes increased myocardial capillary and small conducting vessel densities and increased coronary flow reserve and perfusion-dependent cardiac contractility. Coculture of HUVECs with either GATA4-expressing cardiomyocytes or with myocytes expressing a dominant-negative form of GATA4 enhanced or reduced HUVEC tube formation, respectively. Expression of GATA4 in skeletal muscle by adenoviral gene transfer enhanced capillary densities and hindlimb perfusion following femoral artery ablation. Deletion of Gata4 specifically from cardiomyocytes reduced myocardial capillary density and prevented pressure overload–augmented angiogenesis in vivo. GATA4 induced the angiogenic factor VEGF-A, directly binding the Vegf-A promoter and enhancing transcription. GATA4-overexpressing mice showed increased levels of cardiac VEGF-A, while Gata4-deleted mice demonstrated decreased VEGF-A levels. The induction of HUVEC tube formation in GATA4-overexpressing cocultured myocytes was blocked with a VEGF receptor antagonist. Pressure overload–induced dysfunction in Gata4-deleted hearts was partially rescued by adenoviral gene delivery of VEGF and angiopoietin-1. To our knowledge, these results demonstrate what is to our knowledge a previously unrecognized function for GATA4 as a regulator of cardiac angiogenesis through a nonhypoxic, load, and/or disease-responsive mechanism.
Authors
Joerg Heineke, Mannix Auger-Messier, Jian Xu, Toru Oka, Michelle A. Sargent, Allen York, Raisa Klevitsky, Sachin Vaikunth, Stephen A. Duncan, Bruce J. Aronow, Jeffrey Robbins, Timothy M. Crombleholm, Jeffery D. Molkentin
Total citations by year
Citation information
Citations to this article (124)
| Title and authors | Publication | Year |
|---|---|---|
|
A biodegradable, microstructured, electroconductive and nano-integrated drug eluting patch (MENDEP) for myocardial tissue engineering
Cristallini C, Rossin D, Vanni R, Barbani N, Bulgheresi C, Labardi M, Perveen S, Burchielli S, Terlizzi D, Kusmic C, Del Ry S, Cabiati M, Trouki C, Rossino D, Sergi F, Villano A, Aquaro GD, Scarpellino G, Ruffinatti FA, Amorim S, Pires RA, Reis RL, Rastaldo R, Giachino C |
Bioactive Materials | 2025 |
|
Upstream open reading frame inactivation augments GATA4 translation and cardiomyocyte hypertrophy in mice
Hedaya OM, Jiang F, Baliga U, Ivanov A, Chen S, Schwartz JL, Kawakami Y, Yan C, Yao P |
bioRxiv | 2025 |
|
Mechanisms and functions of SUMOylation in health and disease: a review focusing on immune cells.
Huang CH, Yang TT, Lin KI |
Journal of biomedical science | 2024 |
|
Somatic GATA4 mutation contributes to tetralogy of Fallot.
Abhinav P, Li YJ, Huang RT, Liu XY, Gu JN, Yang CX, Xu YJ, Wang J, Yang YQ |
Experimental and therapeutic medicine | 2024 |
|
P53 Acetylation Exerts Critical Roles in Pressure Overload-Induced Coronary Microvascular Dysfunction and Heart Failure in Mice
He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H |
Arteriosclerosis, thrombosis, and vascular biology | 2024 |
|
A reduced proteomic signature in critically ill Covid-19 patients determined with plasma antibody micro-array and machine learning.
Patel MA, Daley M, Van Nynatten LR, Slessarev M, Cepinskas G, Fraser DD |
Clinical Proteomics | 2024 |
|
A genomic link from heart failure to atrial fibrillation risk: FOG2 modulates a TBX5/GATA4-dependent atrial gene regulatory network
Broman MT, Nadadur RD, Perez-Cervantes C, Burnicka-Turek O, Lazarevic S, Gams A, Laforest B, Steimle JD, Iddir S, Wang Z, Smith L, Mazurek SR, Olivey HE, Zhou P, Gadek M, Shen KM, Khan Z, Theisen JW, Yang XH, Ikegami K, Efimov IR, Pu WT, Weber CR, McNally EM, Svensson EC, Moskowitz IP |
Circulation | 2024 |
|
Endothelial derived, secreted long non-coding RNAs Gadlor1 and Gadlor2 aggravate cardiac remodeling
Keles M, Grein S, Froese N, Wirth D, Trogisch FA, Wardman R, Hemanna S, Weinzierl N, Koch PS, Uhlig S, Lomada S, Dittrich GM, Szaroszyk M, Haustein R, Hegermann J, Martin-Garrido A, Bauersachs J, Frank D, Frey N, Bieback K, Cordero J, Dobreva G, Wieland T, Heineke J |
Molecular Therapy. Nucleic Acids | 2024 |
|
Inter- and Intracellular Signaling Pathways.
Dobreva G, Heineke J |
Advances in experimental medicine and biology | 2024 |
|
Unraveling the Molecular Mechanisms of SIRT7 in Angiogenesis: Insights from Substrate Clues
Ma J, Yang L, Wu J, Huang Z, Zhang J, Liu M, Li M, Luo J, Wang H |
International Journal of Molecular Sciences | 2024 |
|
Activation of a GPCR, ORL1 Receptor: A Novel Therapy to Prevent Heart Failure Progression
Pathan SS, Pugazenthi A, Dixon BR, Wensel TG, Rosengart TK, Mathison M |
Journal of Cardiovascular Development and Disease | 2024 |
|
IL33 mediates cardiomyopathy after acute kidney injury by directly signaling to cardiomyocytes
Nans Florens, Valeria Rudman-Melnick, Suh-Chin Lin, Rajesh Kasam, Vikram Prasad, Jeffery Molkentin |
Circulation | 2023 |
|
P53 Acetylation Exerts Critical Roles In Pressure Overload Induced Coronary Microvascular Dysfunction and Heart Failure
He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H |
2023 | |
|
Associations of Modified Healthy Aging Index With Major Adverse Cardiac Events, Major Coronary Events, and Ischemic Heart Disease
Huang N, Zhuang Z, Song Z, Wang W MD, Li Y, Zhao Y, Xiao W, Dong X, Jia J, Liu Z, Smith CE, Huang T |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2023 |
|
Locational memory of macrovessel vascular cells is transcriptionally imprinted
Spanjersberg TC, Oosterhoff LA, Kruitwagen HS, van den Dungen NA, Vernooij JC, Asselbergs FW, Mokry M, Spee B, Harakalova M, van Steenbeek FG |
Scientific Reports | 2023 |
|
Associations between eGFR and albuminuria with right ventricular measures: the MESA-Right Ventricle study
Husain-Syed F, DiFrancesco MF, Deo R, Barr RG, Scialla JJ, Bluemke DA, Kronmal RA, Lima JA, Praestgaard A, Tracy RP, Shlipak M, Kawut SM, Kim JS |
Clinical Kidney Journal | 2023 |
|
MDM2 Regulation of HIF Signaling Causes Microvascular Dysfunction in Hypertrophic Cardiomyopathy
Shridhar P, Glennon MS, Pal S, Waldron CJ, Chetkof EJ, Basak P, Clavere NG, Banerjee D, Gingras S, Becker JR |
Circulation | 2023 |
|
scGRN: a comprehensive single-cell gene regulatory network platform of human and mouse
Huang X, Song C, Zhang G, Li Y, Zhao Y, Zhang Q, Zhang Y, Fan S, Zhao J, Xie L, Li C |
Nucleic Acids Research | 2023 |
|
Analysis of myocardial cellular gene expression during pressure overload reveals matrix based functional intercellular communication
N Froese, J Cordero, A Abouissa, F Trogisch, S Grein, M Szaroszyk, Y Wang, A Gigina, M Korf-Klingebiel, B Bosnjak, C Davenport, L Wiehlmann, R Geffers, E Riechert, L Jürgensen, E Boileau, Y Lin, C Dieterich, R Förster, J Bauersachs, R Ola, G Dobreva, M Völkers, J Heineke |
iScience | 2022 |
|
Therapeutic Targets for DOX-Induced Cardiomyopathy: Role of Apoptosis vs. Ferroptosis
H Kitakata, J Endo, H Ikura, H Moriyama, K Shirakawa, Y Katsumata, M Sano |
International journal of molecular sciences | 2022 |
|
Comprehensive Expression Analysis of Cardiac Fibroblast Growth Factor 23 in Health and Pressure-induced Cardiac Hypertrophy.
Eitner F, Richter B, Schwänen S, Szaroszyk M, Vogt I, Grund A, Thum T, Heineke J, Haffner D, Leifheit-Nestler M |
Frontiers in Cell and Developmental Biology | 2022 |
|
GATA4 Regulates Developing Endocardium Through Interaction with ETS1
Zhou P, Zhang Y, Sethi I, Ye L, Trembley MA, Cao Y, Akerberg BN, Xiao F, Zhang X, Li K, Jardin BD, Mazumdar N, Ma Q, He A, Zhou B, Pu WT |
Circulation research | 2022 |
|
Endothelial Cell GATA2 Modulates the Cardiomyocyte Stress Response through the Regulation of Two Long Non-Coding RNAs
Froese N, Szaroszyk M, Korf-Klingebiel M, Koch K, Schmitto JD, Geffers R, Hilfiker-Kleiner D, Riehle C, Wollert KC, Bauersachs J, Heineke J |
Biology | 2022 |
|
A human cell atlas of the pressure-induced hypertrophic heart
Nicin L, Schroeter SM, Glaser SF, Schulze-Brüning R, Pham MD, Hille SS, Yekelchyk M, Kattih B, Abplanalp WT, Tombor L, Müller OJ, Braun T, Meder B, Reich C, Arsalan M, Holubec T, Walther T, Emrich F, Krishnan J, Zeiher AM, John D, Dimmeler S |
Nature Cardiovascular Research | 2022 |
|
Transcriptional Regulation of Postnatal Cardiomyocyte Maturation and Regeneration
SL Padula, N Velayutham, KE Yutzey |
International journal of molecular sciences | 2021 |
|
Identification and functional study of GATA4 gene regulatory variants in atrial septal defects
D Fan, S Pang, J Chen, J Shan, Q Cheng, B Yan |
BMC Cardiovascular Disorders | 2021 |
|
Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis
GM Dittrich, N Froese, X Wang, H Kroeger, H Wang, M Szaroszyk, M Malek-Mohammadi, J Cordero, M Keles, M Korf-Klingebiel, KC Wollert, R Geffers, M Mayr, SJ Conway, G Dobreva, J Bauersachs, J Heineke |
Basic Research in Cardiology | 2021 |
|
Loss of GATA4 C-Terminus by p.S335X Mutation Modulates Coronary Artery Vascular Smooth Muscle Cell Phenotype
TY Yu, XX Chen, QW Liu, FF Ma, HL Huang, L Zhou, W Zhang, A Ugusman |
Mediators of Inflammation | 2021 |
|
Exercise Training Preserves Myocardial Strain and Improves Exercise Tolerance in Doxorubicin-Induced Cardiotoxicity
IL Gomes-Santos, CP Jordão, CS Passos, PC Brum, EM Oliveira, R Chammas, AA Camargo, CE Negrão |
Frontiers in Cardiovascular Medicine | 2021 |
|
GATA-targeted compounds modulate cardiac subtype cell differentiation in dual reporter stem cell line
Välimäki MJ, Leigh RS, Kinnunen SM, March AR, de Sande AH, Kinnunen M, Varjosalo M, Heinäniemi M, Kaynak BL, Ruskoaho H |
Stem Cell Research & Therapy | 2021 |
|
Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration
MT Zhao, S Ye, J Su, V Garg |
Frontiers in Cell and Developmental Biology | 2020 |
|
VEGF-A in Cardiomyocytes and Heart Diseases
M Braile, S Marcella, L Cristinziano, MR Galdiero, L Modestino, AL Ferrara, G Varricchi, G Marone, S Loffredo |
International journal of molecular sciences | 2020 |
|
Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association ( HFA ) of the European Society of Cardiology ( ESC )
RA Boer, JS Hulot, CG Tocchetti, JP Aboumsallem, P Ameri, SD Anker, J Bauersachs, E Bertero, AJ Coats, J Čelutkienė, O Chioncel, P Dodion, T Eschenhagen, D Farmakis, A BayesGenis, D Jäger, EA Jankowska, RN Kitsis, SH Konety, J Larkin, L Lehmann, DJ Lenihan, C Maack, JJ Moslehi, OJ Müller, P NowakSliwinska, MF Piepoli, P Ponikowski, R Pudil, PP Rainer, F Ruschitzka, D Sawyer, PM Seferovic, T Suter, T Thum, P Meer, LW Laake, S Haehling, S Heymans, AR Lyon, J Backs |
European Journal of Heart Failure | 2020 |
|
BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes
A Padmanabhan, M Alexanian, R Linares-Saldana, B González-Terán, G Andreoletti, Y Huang, AJ Connolly, W Kim, A Hsu, Q Duan, SA Winchester, F Felix, JA Perez-Bermejo, Q Wang, L Li, PP Shah, SM Haldar, R Jain, D Srivastava |
Circulation | 2020 |
|
Vezf1 regulates cardiac structure and contractile function
J Paavola, T Alakoski, J Ulvila, T Kilpiö, J Sirén, S Perttunen, S Narumanchi, H Wang, R Lin, K Porvari, J Junttila, H Huikuri, K Immonen, P Lakkisto, J Magga, I Tikkanen, R Kerkelä |
EBioMedicine | 2020 |
|
Implications of venous thromboembolism GWAS reported genetic makeup in the clinical outcome of ovarian cancer patients.
Tavares V, Pinto R, Assis J, Coelho S, Brandão M, Alves S, Pereira D, Medeiros R |
The Pharmacogenomics Journal | 2020 |
|
Induction of cardiomyocyte proliferation and angiogenesis protects neonatal mice from pressure overload-associated maladaptation
Mona Malek Mohammadi, Aya Abouissa, Azizah Isyatul, Yinou Xie, Julio Cordero, Amir Shirvani, Anna Gigina, Maren Engelhardt, Felix A Trogisch, Robert Geffers, Gergana Dobreva, Johann Bauersachs, Joerg Heineke |
JCI Insight | 2019 |
|
Atrial fibrillation risk loci interact to modulate Ca2+-dependent atrial rhythm homeostasis
Brigitte Laforest, Wenli Dai, Leonid Tyan, Sonja Lazarevic, Kaitlyn M. Shen, Margaret Gadek, Michael Broman, Christopher R. Weber, Ivan Moskowitz |
Journal of Clinical Investigation | 2019 |
|
Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure
R Gogiraju, ML Bochenek, K Schäfer |
Frontiers in Cardiovascular Medicine | 2019 |
|
Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation
S LaHaye, U Majumdar, J Yasuhara, SN Koenig, A Matos-Nieves, R Kumar, V Garg |
Disease models & mechanisms | 2019 |
|
Transcription Factors That Govern Development and Disease: An Achilles Heel in Cancer
D Huilgol, P Venkataramani, S Nandi, S Bhattacharjee |
Genes & development | 2019 |
|
TIP 30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
A Grund, M Szaroszyk, M KorfKlingebiel, MM Mohammadi, FA Trogisch, U Schrameck, A Gigina, C Tiedje, M Gaestel, T Kraft, J Hegermann, S Batkai, T Thum, A Perrot, C dos Remedios, E Riechert, M Völkers, S Doroudgar, A Jungmann, R Bauer, X Yin, M Mayr, KC Wollert, A Pich, H Xiao, HA Katus, J Bauersachs, OJ Müller, J Heineke |
EMBO Molecular Medicine | 2019 |
|
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy
AP Nath, SC Ritchie, NF Grinberg, HH Tang, QQ Huang, SM Teo, AV Ahola-Olli, P Würtz, AS Havulinna, K Santalahti, N Pitkänen, T Lehtimäki, M Kähönen, LP Lyytikäinen, E Raitoharju, I Seppälä, AP Sarin, S Ripatti, A Palotie, M Perola, JS Viikari, S Jalkanen, M Maksimow, M Salmi, C Wallace, OT Raitakari, V Salomaa, G Abraham, J Kettunen, M Inouye |
The American Journal of Human Genetics | 2019 |
|
Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy J Yee, W Kim, BC Chang, JE Chung, KE Lee, HS Gwak |
Drug design, development and therapy | 2019 |
|
Functional analysis of the congenital heart disease‑associated GATA4 H436Y mutation in�vitro
T Fang, Y Zhu, A Xu, Y Zhang, Q Wu, G Huang, W Sheng, M Chen |
Molecular medicine reports | 2019 |
|
Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators.
Jumppanen M, Kinnunen SM, Välimäki MJ, Talman V, Auno S, Bruun T, Boije Af Gennäs G, Xhaard H, Aumüller IB, Ruskoaho H, Yli-Kauhaluoma J |
Journal of Medicinal Chemistry | 2019 |
|
Assessment of Right Ventricular Function in the Research Setting: Knowledge Gaps and Pathways Forward. An Official American Thoracic Society Research Statement
T Lahm, IS Douglas, SL Archer, HJ Bogaard, NC Chesler, F Haddad, AR Hemnes, SM Kawut, JA Kline, TM Kolb, SC Mathai, O Mercier, ED Michelakis, R Naeije, RM Tuder, CE Ventetuolo, A Vieillard-Baron, NF Voelkel, A Vonk-Noordegraaf, PM Hassoun |
American journal of respiratory and critical care medicine | 2018 |
|
GATA4 regulates angiogenesis and persistence of inflammation in rheumatoid arthritis
W Jia, W Wu, D Yang, C Xiao, M Huang, F Long, Z Su, M Qin, X Liu, YZ Zhu |
Cell Death and Disease | 2018 |
|
Cardiac Actions of a Small Molecule Inhibitor Targeting GATA4–NKX2-5 Interaction
SM Kinnunen, M Tölli, MJ Välimäki, E Gao, Z Szabo, J Rysä, MP Ferreira, P Ohukainen, R Serpi, A Correia, E Mäkilä, J Salonen, J Hirvonen, HA Santos, H Ruskoaho |
Scientific Reports | 2018 |
|
Effect of equiaxial cyclic strain on cardiomyogenic induction in mesenchymal stem cells
N Rezaee, M Tafazzoli-Shadpour, N Haghighipour |
Progress in Biomaterials | 2018 |
|
Redirecting cardiac growth mechanisms for therapeutic regeneration
Ravi Karra, Kenneth Poss |
Journal of Clinical Investigation | 2017 |
|
The transcription factor GATA4 promotes myocardial regeneration in neonatal mice
MM Mohammadi, B Kattih, A Grund, N Froese, M KorfKlingebiel, A Gigina, U Schrameck, C Rudat, Q Liang, A Kispert, KC Wollert, J Bauersachs, J Heineke |
EMBO Molecular Medicine | 2017 |
|
Human Pericardial Fluid Contains Exosomes Enriched with Cardiovascular-Expressed MicroRNAs and Promotes Therapeutic Angiogenesis
C Beltrami, M Besnier, S Shantikumar, AI Shearn, C Rajakaruna, A Laftah, F Sessa, G Spinetti, E Petretto, GD Angelini, C Emanueli |
Molecular Therapy | 2017 |
|
Cardiac myocyte p38α kinase regulates angiogenesis via myocyte-endothelial cell cross-talk during stress-induced remodeling in the heart
BA Rose, T Yokota, V Chintalgattu, S Ren, L Iruela-Arispe, AY Khakoo, S Minamisawa, Y Wang |
The Journal of biological chemistry | 2017 |
|
G protein, phosphorylated-GATA4 and VEGF expression in the hearts of transgenic mice overexpressing β1- and β2-adrenergic receptors
HJ Tae, N Petrashevskaya, IH Kim, JH Park, JC Lee, MH Won, YH Kim, JH Ahn, J Park, SY Choi, YH Jeon |
Molecular medicine reports | 2017 |
|
Regulation of microvascularization in heart failure - an endothelial cell, non-coding RNAs and exosome liaison
RP Juni, RC Abreu, PA da Costa Martins |
Non-coding RNA Research | 2017 |
|
Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload–induced angiogenesis
JH Suh, L Lai, D Nam, J Kim, J Jo, GE Taffet, E Kim, JT Kaelber, HK Lee, ML Entman, JP Cooke, EL Reineke |
The Journal of biological chemistry | 2017 |
|
Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells
T Al-Maqtari, KU Hong, BN Vajravelu, A Moktar, P Cao, JB Moore, R Bolli, M Pesce |
PloS one | 2017 |
|
Role of GATA binding protein 4 (GATA4) in the regulation of tooth development via GNAI3
S Guo, Y Zhang, T Zhou, D Wang, Y Weng, L Wang, J Ma |
Scientific Reports | 2017 |
|
Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail
M Mathison, VP Singh, D Sanagasetti, L Yang, JP Pinnamaneni, J Yang, TK Rosengart |
The Journal of Thoracic and Cardiovascular Surgery | 2017 |
|
Comprehensive transcriptome mining of the direct conversion of mesodermal cells
B Akbari, P Wee, M Yaqubi, A Mohammadnia |
Scientific Reports | 2017 |
|
Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion
N Pavo, D Lukovic, K Zlabinger, D Lorant, G Goliasch, J Winkler, D Pils, K Auer, HJ Ankersmit, Z Giricz, M Sárközy, A Jakab, R Garamvölgyi, MY Emmert, SP Hoerstrup, DJ Hausenloy, P Ferdinandy, G Maurer, M Gyöngyösi |
Oncotarget | 2017 |
|
Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis
X Yue, X Lin, T Yang, X Yang, X Yi, X Jiang, X Li, T Li, J Guo, Y Dai, J Shi, L Wei, KA Youker, G Torre-Amione, Y Yu, KC Andrade, J Chang |
Hypertension | 2016 |
|
Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Remodeling
S Yuan, CG Kevil |
Microcirculation | 2016 |
|
miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart
N Li, C Hwangbo, IM Jaba, J Zhang, I Papangeli, J Han, N Mikush, B Larrivée, A Eichmann, HJ Chun, LH Young, D Tirziu |
Scientific Reports | 2016 |
|
The emerging role of GATA transcription factors in development and disease
MH Lentjes, HE Niessen, Y Akiyama, AP de Bruïne, V Melotte, M Engeland |
Expert Reviews in Molecular Medicine | 2016 |
|
Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality
X Lin, W Zhao, J Jia, T Lin, G Xiao, S Wang, X Lin, Y Liu, L Chen, Y Qin, J Li, T Zhang, W Hao, B Chen, R Xie, Y Cheng, K Xu, K Yao, W Huang, D Xiao, Y Sun |
Scientific Reports | 2016 |
|
A Novel Missense Mutation of GATA4 in a Chinese Family with Congenital Heart Disease
X Zhang, J Wang, B Wang, S Chen, Q Fu, K Sun, YB Yan |
PloS one | 2016 |
|
Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice
R Gogiraju, X Xu, ML Bochenek, JH Steinbrecher, SE Lehnart, P Wenzel, M Kessel, EM Zeisberg, M Dobbelstein, K Schafer |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2015 |
|
Overexpression of Cardiomyocyte α 1A -Adrenergic Receptors Attenuates Postinfarct Remodeling by Inducing Angiogenesis Through Heterocellular SignalingSignificance
X Zhao, P Balaji, R Pachon, DM Beniamen, DE Vatner, RM Graham, SF Vatner |
Arteriosclerosis, thrombosis, and vascular biology | 2015 |
|
Cellular Origin and Developmental Program of Coronary Angiogenesis
X Tian, WT Pu, B Zhou |
Circulation research | 2015 |
|
Pathological hypertrophy reverses 2-adrenergic receptor-induced angiogenesis in mouse heart
Q Xu, NL Jennings, K Sim, L Chang, XM Gao, H Kiriazis, YY Lee, MN Nguyen, EA Woodcock, YY Zhang, A El-Osta, AM Dart, XJ Du |
Physiological Reports | 2015 |
|
Mechanical stretch-induced vascular hypertrophy occurs through modulation of leptin synthesis-mediated ROS formation and GATA-4 nuclear translocation
CM Ghantous, FH Kobeissy, N Soudani, FA Rahman, M Al-Hariri, HA Itani, R Sabra, A Zeidan |
Frontiers in pharmacology | 2015 |
|
Nuclear Receptor-Like Structure and Interaction of Congenital Heart Disease-Associated Factors GATA4 and NKX2-5
S Kinnunen, M Välimäki, M Tölli, G Wohlfahrt, R Darwich, H Komati, M Nemer, H Ruskoaho, E Porrello |
PloS one | 2015 |
|
VEGF-C and aortic cardiomyocytes guide coronary artery stem development
Heidi I. Chen, Aruna Poduri, Harri Nurmi, Riikka Kivelä, Pipsa Saharinen, Andrew S. McKay, Brian Raftrey, Jared Churko, Xueying Tian, Bin Zhou, Joseph C. Wu, Kari Alitalo, Kristy Red-Horse |
Journal of Clinical Investigation | 2014 |
|
Dynamic GATA4 enhancers shape the chromatin landscape central to heart development and disease
A He, F Gu, Y Hu, Q Ma, LY Ye, JA Akiyama, A Visel, LA Pennacchio, WT Pu |
Nature Communications | 2014 |
|
Desregulated microRNAs in aging-related heart failure
R Zhuo, S Fu, S Li, M Yao, D Lv, T Xu, Y Bei |
Frontiers in Genetics | 2014 |
|
Integrated mechanisms of CaMKII-dependent ventricular remodeling
MM Kreusser, J Backs |
Frontiers in pharmacology | 2014 |
|
Caspase-1 cleavage of transcription factor GATA4 and regulation of cardiac cell fate
A Aries, J Whitcomb, W Shao, H Komati, M Saleh, M Nemer |
Cell Death and Disease | 2014 |
|
A study of the role of GATA4 polymorphism in cardiovascular metabolic disorders
NP Muiya, SM Wakil, AI Tahir, S Hagos, M Najai, D Gueco, N Al-Tassan, E Andres, N Mazher, BF Meyer, N Dzimiri |
Human genomics | 2013 |
|
Inducible re-expression of HEXIM1 causes physiological cardiac hypertrophy in the adult mouse
MM Montano, CL Desjardins, YQ Doughman, YH Hsieh, Y Hu, HM Bensinger, C Wang, JE Stelzer, TE Dick, BD Hoit, MP Chandler, X Yu, M Watanabe |
Cardiovascular Research | 2013 |
|
BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
P Anand, JD Brown, CY Lin, J Qi, R Zhang, PC Artero, MA Alaiti, J Bullard, K Alazem, KB Margulies, TP Cappola, M Lemieux, J Plutzky, JE Bradner, SM Haldar |
Cell | 2013 |
|
Parsing the roles of the transcription factors GATA-4 and GATA-6 in the adult cardiac hypertrophic response
JH van Berlo, BJ Aronow, JD Molkentin |
PloS one | 2013 |
|
Isolated hypoplastic circumflex coronary artery: a rare cause of haemorrhagic myocardial infarction in a young athlete
FN Riede, S Bulla, S Grundmann, M Werner, UN Riede, C Otto |
Diagnostic Pathology | 2013 |
|
Cardiac Aging: From Molecular Mechanisms to Significance in Human Health and Disease
DF Dai, T Chen, SC Johnson, H Szeto, PS Rabinovitch |
Antioxidants & Redox Signaling | 2012 |
|
Endocardial and Epicardial Epithelial to Mesenchymal Transitions in Heart Development and Disease
A von Gise, WT Pu |
Circulation research | 2012 |
|
Cyclin D2 rescues size and function of GATA4 haplo-insufficient hearts
A Yamak, R Temsah, W Maharsy, S Caron, P Paradis, A Aries, M Nemer |
American journal of physiology. Heart and circulatory physiology | 2012 |
|
Von Willebrand Factor and the Right Ventricle (the MESA-Right Ventricle Study)
PJ Leary, RG Barr, DA Bluemke, MR Bristow, CL Hough, RA Kronmal, JA Lima, RL McClelland, RP Tracy, SM Kawut |
The American Journal of Cardiology | 2012 |
|
Calcineurin Controls Voltage-Dependent-Inactivation (VDI) of the Normal and Timothy Cardiac Channels
M Cohen-Kutner, Y Yahalom, M Trus, D Atlas |
Scientific Reports | 2012 |
|
Molecular signature of a right heart failure program in chronic severe pulmonary hypertension
JI Drake, HJ Bogaard, S Mizuno, B Clifton, B Xie, Y Gao, CI Dumur, P Fawcett, NF Voelkel, R Natarajan |
American journal of respiratory cell and molecular biology | 2011 |
|
Redox signaling in cardiac myocytes
CX Santos, N Anilkumar, M Zhang, AC Brewer, AM Shah |
Free radical biology & medicine | 2011 |
|
Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failure
AL Moens, EA Ketner, E Takimoto, TS Schmidt, CA O'Neill, MS Wolin, NJ Alp, KM Channon, DA Kass |
Journal of Molecular and Cellular Cardiology | 2011 |
|
In search of new therapeutic targets and strategies for heart failure: recent advances in basic science
AM Shah, DL Mann |
The Lancet | 2011 |
|
Placental growth factor regulates cardiac adaptation and hypertrophy through a paracrine mechanism
F Accornero, JH van Berlo, MJ Benard, JN Lorenz, P Carmeliet, JD Molkentin |
Circulation research | 2011 |
|
Serine 105 phosphorylation of transcription factor GATA4 is necessary for stress-induced cardiac hypertrophy in vivo
JH van Berlo, JW Elrod, BJ Aronow, WT Pu, JD Molkentin |
Proceedings of the National Academy of Sciences | 2011 |
|
Activation of growth hormone releasing hormone (GHRH) receptor stimulates cardiac reverse remodeling after myocardial infarction (MI)
RM Kanashiro-Takeuchi, LM Takeuchi, FG Rick, R Dulce, AV Treuer, V Florea, CO Rodrigues, EC Paulino, KE Hatzistergos, SM Selem, DR Gonzalez, NL Block, AV Schally, JM Hare |
Proceedings of the National Academy of Sciences | 2011 |
|
Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure.
Aoyagi T, Matsui T |
Current pharmaceutical design | 2011 |
|
Cardiomyocyte PDGFR-beta signaling is an essential component of the cardiac response to load induced stress
Vishnu Chintalgattu, Di Ai, Robert Langley, Jianhu Zhang, James Bankson, Tiffany Shih, Anilkumar Reddy, Kevin Coombes, Iyad Daher, Shibani Pati, Shalin Patel, Jennifer Pocius, George Taffet, L. Maximilian Buja, Mark L. Entman, Aarif Khakoo |
Journal of Clinical Investigation | 2010 |
|
Sonic hedgehog is a critical mediator of erythropoietin-induced cardiac protection
Kazutaka Ueda, Hiroyuki Takano, Yuriko Niitsuma, Hiroshi Hasegawa, Raita Uchiyama, Toru Oka, Masaru Miyazaki, Haruaki Nakaya, Issei Komuro |
Journal of Clinical Investigation | 2010 |
|
NADPH oxidase-4 mediates protection against chronic load-induced stress in mouse hearts by enhancing angiogenesis
M Zhang, AC Brewer, K Schröder, CX Santos, DJ Grieve, M Wang, N Anilkumar, B Yu, X Dong, SJ Walker, RP Brandes, AM Shah |
Proceedings of the National Academy of Sciences | 2010 |
|
PGC-1 Coactivators in Cardiac Development and Disease
GC Rowe, A Jiang, Z Arany, DP Kelly |
Circulation research | 2010 |
|
Bone marrow support of the heart in pressure overload is lost with aging
NA Sopko, BA Turturice, ME Becker, CR Brown, F Dong, ZB Popović, MS Penn |
PloS one | 2010 |
|
c-kitpos GATA-4 High Rat Cardiac Stem Cells Foster Adult Cardiomyocyte Survival through IGF-1 Paracrine Signalling
N Kawaguchi, AJ Smith, CD Waring, MK Hasan, S Miyamoto, R Matsuoka, GM Ellison, NA Hotchin |
PloS one | 2010 |
|
Gata4 directs development of cardiac-inducing endoderm from ES cells
A Holtzinger, GE Rosenfeld, T Evans |
Developmental Biology | 2010 |
|
The Transcription Factor GATA-6 Regulates Pathological Cardiac Hypertrophy
JH van Berlo, JW Elrod, MM van den Hoogenhof, AJ York, BJ Aronow, SA Duncan, JD Molkentin |
Circulation research | 2010 |
|
Erythropoietin and ventricular remodelling: a VEGF-dependent neovascularity
T Hamid, SD Prabhu |
Cardiovascular Research | 2010 |
|
Cell communications in the heart
D Tirziu, FJ Giordano, M Simons |
Circulation | 2010 |
|
Signaling mechanisms in thyroid hormone-induced cardiac hypertrophy
K Ojamaa |
Vascular Pharmacology | 2010 |
|
An Association Between Gene Expression and Better Survival in Female Mice Following Myocardial Infarction
Q Chen, R Williams, CL Healy, CD Wright, SC Wu, TD O'Connell |
Journal of Molecular and Cellular Cardiology | 2010 |
|
Klf15 Deficiency Is a Molecular Link Between Heart Failure and Aortic Aneurysm Formation
SM Haldar, Y Lu, D Jeyaraj, D Kawanami, Y Cui, SJ Eapen, C Hao, Y Li, YQ Doughman, M Watanabe, K Shimizu, H Kuivaniemi, J Sadoshima, KB Margulies, TP Cappola, MK Jain |
Science Translational Medicine | 2010 |
|
GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor β/Activin Receptor-like Kinase 5 Signaling*
N Froese, B Kattih, A Breitbart, A Grund, R Geffers, JD Molkentin, A Kispert, KC Wollert, H Drexler, J Heineke |
The Journal of biological chemistry | 2010 |
|
ZFP260 Is an Inducer of Cardiac Hypertrophy and a Nuclear Mediator of Endothelin-1 Signaling*
H Komati, W Maharsy, J Beauregard, S Hayek, M Nemer |
The Journal of biological chemistry | 2010 |
|
Adenylyl Cyclase 6 Deletion Reduces Left Ventricular Hypertrophy, Dilation, Dysfunction, and Fibrosis in Pressure-Overloaded Female Mice
T Tang, NC Lai, HK Hammond, DM Roth, Y Yang, T Guo, MH Gao |
Journal of the American College of Cardiology | 2010 |
|
Epicardial–Myocardial Signaling Directing Coronary Vasculogenesis
HE Olivey, EC Svensson |
Circulation research | 2010 |
|
Cardiomyogenesis in the Adult Human Heart
J Kajstura, K Urbanek, S Perl, T Hosoda, H Zheng, B Ogórek, J Ferreira-Martins, P Goichberg, C Rondon-Clavo, F Sanada, D D'Amario, M Rota, F del Monte, D Orlic, J Tisdale, A Leri, P Anversa |
Circulation research | 2010 |
|
Fog2 is critical for maintenance of heart function and coronary vasculature in the adult heart
Bin Zhou, Qing Ma, Sek Won Kong, Yongwu Hu, Patrick. H. Campbell, Francis X. McGowan, Bingruo Wu, Bin Zhou, Sergei G. Tevosian, William T. Pu |
Journal of Clinical Investigation | 2009 |
|
The natriuretic peptide / guanylyl cyclase-A system functions as a stress-responsive regulator of angiogenesis in mice
Michaela Kuhn, Katharina Völker, Kristine Schwarz, Javier Carbajo-Lozoya, Ulrich Flögel, Christoph Jacoby, Jörg Stypmann, Martin van Eickels, Stepan Gambaryan, Michael Hartmann, Matthias Werner, Thomas Wieland, Jürgen Schrader, and Hideo A. Baba |
Journal of Clinical Investigation | 2009 |
|
Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature
KJ Lavine, DM Ornitz |
Circulation research | 2009 |
|
Oxytocin: Old Hormone, New Drug
J Gutkowska, M Jankowski |
Pharmaceuticals (Basel, Switzerland) | 2009 |
|
Heart-specific deletion of CnB1 reveals multiple mechanisms whereby calcineurin regulates cardiac growth and function
M Maillet, J Davis, M Auger-Messier, A York, H Osinska, J Piquereau, JN Lorenz, J Robbins, R Ventura-Clapier, JD Molkentin |
The Journal of biological chemistry | 2009 |
|
VEGF and IHH rescue definitive hematopoiesis in Gata-4 and Gata-6-deficient murine embryoid bodies
M Pierre, M Yoshimoto, L Huang, M Richardson, MC Yoder |
Experimental Hematology | 2009 |
|
Endothelium-Driven Myocardial Growth or Nitric Oxide at the Crossroads
D Tirziu, M Simons |
Trends in Cardiovascular Medicine | 2008 |
|
Cardiac overexpression of alcohol dehydrogenase exacerbates chronic ethanol ingestion-induced myocardial dysfunction and hypertrophy: role of insulin signaling and ER stress
SY Li, J Ren |
Journal of Molecular and Cellular Cardiology | 2008 |
|
Cardiac growth and angiogenesis coordinated by intertissue interactions
Kenneth Walsh, Ichiro Shiojima |
Journal of Clinical Investigation | 2007 |
Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)