Citations to this article
Citation Information: J Clin Invest. 2007;117(8):2075-2077. https://doi.org/10.1172/JCI32559.
Abstract
The forkhead box O (Foxo) subfamily of transcription factors regulates expression of genes important for many cellular processes, ranging from initiation of cell cycle arrest and apoptosis to induction of DNA damage repair. Invertebrate Foxo orthologs such as DAF-16 also regulate longevity. Cellular responses inducing resistance to ROS are important for cellular survival and organism lifespan, but until recently, mammalian factors regulating resistance to oxidative stress have not been well characterized. Marinkovic and colleagues demonstrate in this issue of the JCI that Foxo3 is specifically required for induction of proteins that regulate the in vivo oxidative stress response in murine erythrocytes (see the related article beginning on page 2133). Their work offers the interesting hypothesis that in so doing, Foxo3 may regulate the lifespan of red blood cells, and underlies the importance of understanding the direct targets of this transcription factor and its regulation.
Authors
Shilpa M. Hattangadi, Harvey F. Lodish
Total citations by year
Citations to this article in year 2009 (2)
| Title and authors | Publication | Year |
|---|---|---|
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Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin
XN Li, J Song, L Zhang, SA LeMaire, X Hou, C Zhang, JS Coselli, L Chen, XL Wang, Y Zhang, YH Shen |
Diabetes | 2009 |
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Up-regulation of thioredoxin interacting protein (Txnip) by p38 MAPK and FOXO1 contributes to the impaired thioredoxin activity and increased ROS in glucose-treated endothelial cells
X Li, Y Rong, M Zhang, XL Wang, SA LeMaire, JS Coselli, Y Zhang, YH Shen |
Biochemical and Biophysical Research Communications | 2009 |
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