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Citations to this article

Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice
Tianju Liu, … , Fuyuki Ishikawa, Sem H. Phan
Tianju Liu, … , Fuyuki Ishikawa, Sem H. Phan
Published November 15, 2007
Citation Information: J Clin Invest. 2007;117(12):3800-3809. https://doi.org/10.1172/JCI32369.
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Research Article Pulmonology Article has an altmetric score of 8

Telomerase activity is required for bleomycin-induced pulmonary fibrosis in mice

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Abstract

In addition to its well-known expression in the germline and in cells of certain cancers, telomerase activity is induced in lung fibrosis, although its role in this process is unknown. To identify the pathogenetic importance of telomerase in lung fibrosis, we examined the effects of telomerase reverse transcriptase (TERT) deficiency in a murine model of pulmonary injury. TERT-deficient mice showed significantly reduced lung fibrosis following bleomycin (BLM) insult. This was accompanied by a significant reduction in expression of lung α-SMA, a marker of myofibroblast differentiation. Furthermore, lung fibroblasts isolated from BLM-treated TERT-deficient mice showed significantly decreased proliferation and increased apoptosis rates compared with cells isolated from control mice. Transplantation of WT BM into TERT-deficient mice restored BLM-induced lung telomerase activity and fibrosis to WT levels. Conversely, transplantation of BM from TERT-deficient mice into WT recipients resulted in reduced telomerase activity and fibrosis. These findings suggest that induction of telomerase in injured lungs may be caused by BM-derived cells, which appear to play an important role in pulmonary fibrosis. Moreover, TERT induction is associated with increased survival of lung fibroblasts, which favors the development of fibrosis instead of injury resolution.

Authors

Tianju Liu, Myoung Ja Chung, Matthew Ullenbruch, Hongfeng Yu, Hong Jin, Biao Hu, Yoon Young Choi, Fuyuki Ishikawa, Sem H. Phan

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Total citations by year

Year: 2025 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 2 2 2 1 5 5 3 2 2 6 6 10 2 3 3 5 3 62
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2013 (10)

Title and authors Publication Year
Telomerase and telomere length in pulmonary fibrosis
T Liu, M Ullenbruch, YY Choi, H Yu, L Ding, A Xaubet, J Pereda, CA Feghali-Bostwick, PB Bitterman, CA Henke, A Pardo, M Selman, SH Phan
American journal of respiratory cell and molecular biology 2013
A novel telomerase activator suppresses lung damage in a murine model of idiopathic pulmonary fibrosis
CJ le Saux, P Davy, C Brampton, SS Ahuja, S Fauce, P Shivshankar, H Nguyen, M Ramaseshan, R Tressler, Z Pirot, CB Harley, R Allsopp
PloS one 2013
Essential role of stem cell factor-c-Kit signalling pathway in bleomycin-induced pulmonary fibrosis
L Ding, V Dolgachev, Z Wu, T Liu, T Nakashima, Z Wu, M Ullenbruch, NW Lukacs, Z Chen, SH Phan
The Journal of Pathology 2013
Animal Models of Fibrotic Lung Disease
BB Moore, WE Lawson, TD Oury, TH Sisson, K Raghavendran, CM Hogaboam
American journal of respiratory cell and molecular biology 2013
Mechanistic links between aging and lung fibrosis
VJ Thannickal
Biogerontology 2013
Genetic studies provide clues on the pathogenesis of idiopathic pulmonary fibrosis
JA Kropski, WE Lawson, LR Young, TS Blackwell
Disease models & mechanisms 2013
Genetic architecture of human fibrotic diseases: disease risk and disease progression
A Gardet, TS Zheng, JL Viney
Frontiers in pharmacology 2013
Telomere dynamics in mice and humans
RT Calado, B Dumitriu
Seminars in Hematology 2013
Cellular senescence in normal and premature lung aging
B Bartling
Zeitschrift für Gerontologie und Geriatrie 2013
Common pathways in idiopathic pulmonary fibrosis and cancer.
Vancheri C
2013

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