Emphysema is one manifestation of a group of chronic, obstructive, and frequently progressive destructive lung diseases. Cigarette smoking and air pollution are the main causes of emphysema in humans, and cigarette smoking causes emphysema in rodents. This review examines the concept of a homeostatically active lung structure maintenance program that, when attacked by proteases and oxidants, leads to the loss of alveolar septal cells and airspace enlargement. Inflammatory and noninflammatory mechanisms of disease pathogenesis, as well as the role of the innate and adaptive immune systems, are being explored in genetically altered animals and in exposure models of this disease. These recent scientific advances support a model whereby alveolar destruction resulting from a coalescence of mechanical forces, such as hyperinflation, and more recently recognized cellular and molecular events, including apoptosis, cellular senescence, and failed lung tissue repair, produces the clinically recognized syndrome of emphysema.
Laimute Taraseviciene-Stewart, Norbert F. Voelkel
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International journal of chronic obstructive pulmonary disease | 2009 |
Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema.
Horowitz JC, Martinez FJ, Thannickal VJ |
COPD | 2009 |
Molecular Basis of Pulmonary Disease
Farver CF, Zander DS |
Molecular Pathology | 2009 |
It takes two to tango: Cigarette smoke partners with viruses to promote emphysema
Rubin M. Tuder and Jeong H. Yun |
Journal of Clinical Investigation | 2008 |
Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung
RM Tuder, JH Yun, BB Graham |
American journal of respiratory cell and molecular biology | 2008 |
Smoking and lung cancer: the role of inflammation
T Walser, X Cui, J Yanagawa, JM Lee, E Heinrich, G Lee, S Sharma, SM Dubinett |
Proceedings of the American Thoracic Society | 2008 |
The Unfolded Protein Response in Chronic Obstructive Pulmonary Disease
Steven G. Kelsen |
Annals of the American Thoracic Society |