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Citations to this article

Molecular pathogenesis of emphysema
Laimute Taraseviciene-Stewart, Norbert F. Voelkel
Laimute Taraseviciene-Stewart, Norbert F. Voelkel
Published February 1, 2008
Citation Information: J Clin Invest. 2008;118(2):394-402. https://doi.org/10.1172/JCI31811.
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Molecular pathogenesis of emphysema

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Abstract

Emphysema is one manifestation of a group of chronic, obstructive, and frequently progressive destructive lung diseases. Cigarette smoking and air pollution are the main causes of emphysema in humans, and cigarette smoking causes emphysema in rodents. This review examines the concept of a homeostatically active lung structure maintenance program that, when attacked by proteases and oxidants, leads to the loss of alveolar septal cells and airspace enlargement. Inflammatory and noninflammatory mechanisms of disease pathogenesis, as well as the role of the innate and adaptive immune systems, are being explored in genetically altered animals and in exposure models of this disease. These recent scientific advances support a model whereby alveolar destruction resulting from a coalescence of mechanical forces, such as hyperinflation, and more recently recognized cellular and molecular events, including apoptosis, cellular senescence, and failed lung tissue repair, produces the clinically recognized syndrome of emphysema.

Authors

Laimute Taraseviciene-Stewart, Norbert F. Voelkel

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R Shaykhiev, A Krause, J Salit, Y Strulovici-Barel, BG Harvey, TP O'Connor, RG Crystal
Journal of immunology (Baltimore, Md. : 1950) 2009
Cigarette Smoke Induces Nucleic-Acid Oxidation in Lung Fibroblasts
G Deslee, TL Adair-Kirk, T Betsuyaku, JC Woods, CH Moore, DS Gierada, SH Conradi, JJ Atkinson, HM Toennies, JT Battaile, DK Kobayashi, GA Patterson, MJ Holtzman, RA Pierce
American journal of respiratory cell and molecular biology 2009
Oxidative Damage to Nucleic Acids in Severe Emphysema
G Deslee, JC Woods, C Moore, SH Conradi, DS Gierada, JJ Atkinson, JT Battaile, L Liu, GA Patterson, TL Adair-Kirk, MJ Holtzman, RA Pierce
Chest 2009
Association of TLR4-T399I Polymorphism with Chronic Obstructive Pulmonary Disease in Smokers
M Speletas, V Merentiti, K Kostikas, K Liadaki, M Minas, K Gourgoulianis, AE Germenis
Clinical and Developmental Immunology 2009
Neutrophil Elastase Increases Airway Epithelial Nonheme Iron Levels
BM Fischer, DA Domowicz, S Zheng, JL Carter, NG McElvaney, C Taggart, JR Lehmann, JA Voynow, AJ Ghio
Clinical and Translational Science 2009
Induction of the interleukin 6/ signal transducer and activator of transcription pathway in the lungs of mice sub-chronically exposed to mainstream tobacco smoke
S Halappanavar, M Russell, MR Stampfli, A Williams, CL Yauk
BMC Medical Genomics 2009
PLAGL2 expression-induced lung epithelium damages at bronchiolar alveolar duct junction in emphysema: bNip3- and SP-C-associated cell death/injury activity
YS Yang, MC Yang, Y Guo, OW Williams, JC Weissler
American journal of physiology. Lung cellular and molecular physiology 2009
Markers of early disease and prognosis in COPD
Dahl M, Nordestgaard BG
International journal of chronic obstructive pulmonary disease 2009
Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema.
Horowitz JC, Martinez FJ, Thannickal VJ
COPD 2009
Molecular Basis of Pulmonary Disease
Farver CF, Zander DS
Molecular Pathology 2009
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Journal of Clinical Investigation 2008
Cigarette smoke triggers code red: p21CIP1/WAF1/SDI1 switches on danger responses in the lung
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American journal of respiratory cell and molecular biology 2008
Smoking and lung cancer: the role of inflammation
T Walser, X Cui, J Yanagawa, JM Lee, E Heinrich, G Lee, S Sharma, SM Dubinett
Proceedings of the American Thoracic Society 2008
The Unfolded Protein Response in Chronic Obstructive Pulmonary Disease
Steven G. Kelsen
Annals of the American Thoracic Society

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