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Citations to this article

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.
A Leri, … , J Kajstura, P Anversa
A Leri, … , J Kajstura, P Anversa
Published April 1, 1998
Citation Information: J Clin Invest. 1998;101(7):1326-1342. https://doi.org/10.1172/JCI316.
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Research Article Article has an altmetric score of 3

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

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Abstract

Physical forces activate apoptosis and gene expression, but the mechanism is unknown. For this purpose, adult myocytes were stretched in an equibiaxial stretch apparatus and the magnitude of cell death was examined 4 and 24 h later. The possibility of stretch-mediated activation of p53 and p53-dependent genes was evaluated at 30 min, 2, 4, 8, and 24 h. Myocyte apoptosis increased by 4.4- and 7.6-fold at 4 and 24 h after stretch. p53 binding to the promoter of angiotensinogen, AT1 receptor, and Bax also increased. Expression of angiotensinogen, AT1 receptor, p53, and Bax increased and Bcl-2 decreased in stretched myocytes. The changes in AT1 receptor, p53, Bax, and Bcl-2 became more apparent with the duration of stretch. Angiotensin II concentration in the medium increased at 10 min, reaching maximal levels at 1 and 20 h. The AT1 blocker, losartan, abolished apoptosis in stretched myocytes. Myocyte volume was not influenced by stretch. In conclusion, stretch-mediated release of angiotensin II is coupled with apoptosis and the activation of p53 which may be responsible for the prolonged upregulation of the local renin-angiotensin system and the increased susceptibility of myocytes to undergo apoptosis.

Authors

A Leri, P P Claudio, Q Li, X Wang, K Reiss, S Wang, A Malhotra, J Kajstura, P Anversa

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Citations to this article in year 2018 (6)

Title and authors Publication Year
The Renin-Angiotensin System and Skeletal Muscle:
SK Powers, AB Morton, H Hyatt, MJ Hinkley
Exercise and Sport Sciences Reviews 2018
Troponin Release and Reversible Left Ventricular Dysfunction After Transient Pressure Overload
BR Weil, Suzuki, RF Young, V Iyer, JM Canty
Journal of the American College of Cardiology 2018
Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat
Y Zhang, KR Somers, C Becari, K Polonis, MA Pfeifer, AM Allen, TA Kellogg, N Covassin, P Singh
Frontiers in physiology 2018
A proposed mechanism for the Berecek phenomenon with implications for cardiovascular reprogramming
RN Re
Journal of the American Society of Hypertension : JASH 2018
Differential Gene Expression Profile of Renin-Angiotensin System in the Left Atrium in Mitral Regurgitation Patients
WH Liu, YN Fang, CC Wu, MC Chen, JP Chang, YS Lin, KL Pan, WC Ho, TH Chang, YK Huang, CY Fang, CJ Chen, WC Lee
Disease Markers 2018
Role of Sirolimus in renal tubular apoptosis in response to unilateral ureteral obstruction
M Yang, Y Zhuang, W Wang, H Zhu, Y Zhang, S Zheng, YR Yang, BC Chen, P Xia, Y Zhang
International journal of medical sciences 2018

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