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Citations to this article

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.
A Leri, … , J Kajstura, P Anversa
A Leri, … , J Kajstura, P Anversa
Published April 1, 1998
Citation Information: J Clin Invest. 1998;101(7):1326-1342. https://doi.org/10.1172/JCI316.
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Research Article Article has an altmetric score of 3

Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.

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Abstract

Physical forces activate apoptosis and gene expression, but the mechanism is unknown. For this purpose, adult myocytes were stretched in an equibiaxial stretch apparatus and the magnitude of cell death was examined 4 and 24 h later. The possibility of stretch-mediated activation of p53 and p53-dependent genes was evaluated at 30 min, 2, 4, 8, and 24 h. Myocyte apoptosis increased by 4.4- and 7.6-fold at 4 and 24 h after stretch. p53 binding to the promoter of angiotensinogen, AT1 receptor, and Bax also increased. Expression of angiotensinogen, AT1 receptor, p53, and Bax increased and Bcl-2 decreased in stretched myocytes. The changes in AT1 receptor, p53, Bax, and Bcl-2 became more apparent with the duration of stretch. Angiotensin II concentration in the medium increased at 10 min, reaching maximal levels at 1 and 20 h. The AT1 blocker, losartan, abolished apoptosis in stretched myocytes. Myocyte volume was not influenced by stretch. In conclusion, stretch-mediated release of angiotensin II is coupled with apoptosis and the activation of p53 which may be responsible for the prolonged upregulation of the local renin-angiotensin system and the increased susceptibility of myocytes to undergo apoptosis.

Authors

A Leri, P P Claudio, Q Li, X Wang, K Reiss, S Wang, A Malhotra, J Kajstura, P Anversa

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Citations to this article in year 2017 (12)

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E Papadakis, M Kanakis, A Kataki, D Spandidos
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R Kannappan, A Matsuda, J Ferreira-Martins, E Zhang, G Palano, A Czarna, MC Cabral-Da-Silva, A Bastos-Carvalho, F Sanada, N Ide, M Rota, MA Blasco, M Serrano, P Anversa, A Leri
EBioMedicine 2017
Bendopnea and risk of adverse clinical outcomes in ambulatory patients with systolic heart failure
JT Thibodeau, BE Jenny, JO Maduka, PH Divanji, CR Ayers, F Araj, AA Amin, RM Morlend, PP Mammen, MH Drazner
American Heart Journal 2017
A Reassessment of the Pathophysiology of Progressive Cardiorenal Disorders
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Quercetin from Polygonum capitatum Protects against Gastric Inflammation and Apoptosis Associated with Helicobacter pylori Infection by Affecting the Levels of p38MAPK, BCL-2 and BAX
S Zhang, J Huang, X Xie, Y He, F Mo, Z Luo
Molecules (Basel, Switzerland) 2017
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Fast Detection of DNA Damage 2017
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I Müller, K Pappritz, K Savvatis, K Puhl, F Dong, M El-Shafeey, N Hamdani, I Hamann, M Noutsias, C Infante-Duarte, WA Linke, SV Linthout, C Tschöpe, N Frangogiannis
PloS one 2017
Platycodon grandiflorum (PG) reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression
YC Lin, CH Lin, HT Yao, WW Kuo, CY Shen, YL Yeh, TJ Ho, VV Padma, YC Lin, CY Huang, CY Huang
Journal of Ethnopharmacology 2017
Exogenous Cathepsin V Protein Protects Human Cardiomyocytes HCM from Angiotensin Ⅱ-Induced Hypertrophy
K Huang, L Gao, M Yang, J Wang, Z Wang, L Wang, G Wang, H Li
The International Journal of Biochemistry & Cell Biology 2017
Celecoxib aggravates cardiac apoptosis in L-NAME-induced pressure overload model in rats: Immunohistochemical determination of cardiac caspase-3, Mcl-1, Bax and Bcl-2
SM Mosaad, SA Zaitone, A Ibrahim, AA El-Baz, DM Abo-Elmatty, YM Moustafa
Chemico-Biological Interactions 2017
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AN Tolekova
Renin-Angiotensin System - Past, Present and Future 2017
Stretch-activated channel Piezo1 is up-regulated in failure heart and cardiomyocyte stimulated by AngII
Jianlin Liang, Boshui Huang, Guiyi Yuan, Ying Chen, Fasheng Liang, Huayuan Zeng, Shaoxin Zheng, Liang Cao, Dengfeng Geng, Shuxian Zhou
American journal of translational research 2017

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