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Citations to this article

Altered macrophage differentiation and immune dysfunction in tumor development
Antonio Sica, Vincenzo Bronte
Antonio Sica, Vincenzo Bronte
Published May 1, 2007
Citation Information: J Clin Invest. 2007;117(5):1155-1166. https://doi.org/10.1172/JCI31422.
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Review Series Article has an altmetric score of 6

Altered macrophage differentiation and immune dysfunction in tumor development

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Abstract

Tumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which cause sustained myelopoiesis and the accumulation and functional differentiation of myelomonocytic cells, most of which are macrophages, at the tumor site. An important side effect of the accumulation and functional differentiation of these cells is that they can induce lymphocyte dysfunction. A complete understanding of the complex interplay between neoplastic and myelomonocytic cells might offer novel targets for therapeutic intervention aimed at depriving tumor cells of important growth support and enhancing the antitumor immune response.

Authors

Antonio Sica, Vincenzo Bronte

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 11 25 21 41 35 41 32 32 35 29 33 44 36 47 33 48 27 22 3 595
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2007 (3)

Title and authors Publication Year
Microbial translocation augments the function of adoptively transferred self/tumor-specific CD8+ T cells via toll-like receptor 4 signaling
Chrystal M. Paulos, Claudia Wrzesinski, Andrew Kaiser, Christian S. Hinrichs, Marcello Chieppa, Lydie Cassard, Douglas C. Palmer, Andrea Boni, Pawel Muranski, Zhiya Yu, Luca Gattinoni, Paul A. Antony, Steven A. Rosenberg, and Nicholas P. Restifo
Journal of Clinical Investigation 2007
Series overview: Harnessing the immune system to treat cancer
Nina Bhardwaj
Journal of Clinical Investigation 2007
Toll-like receptors in tumor immunotherapy
CM Paulos, A Kaiser, C Wrzesinski, CS Hinrichs, L Cassard, A Boni, P Muranski, L Sanchez-Perez, DC Palmer, Z Yu, PA Antony, L Gattinoni, SA Rosenberg, NP Restifo
Clinical cancer research 2007

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ISSN: 0021-9738 (print), 1558-8238 (online)

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Referenced in 8 patents
670 readers on Mendeley
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