Excess caloric intake can lead to insulin resistance. The underlying reasons are
complex but likely related to ectopic lipid deposition in nonadipose tissue. We
hypothesized that the inability to appropriately expand subcutaneous adipose tissue
may be an underlying reason for insulin resistance and β cell failure.
Mice lacking leptin while overexpressing adiponectin showed normalized glucose and
insulin levels and dramatically improved glucose as well as positively affected
serum triglyceride levels. Therefore, modestly increasing the levels of circulating
full-length adiponectin completely rescued the diabetic phenotype in
Ja-Young Kim, Esther van de Wall, Mathieu Laplante, Anthony Azzara, Maria E. Trujillo, Susanna M. Hofmann, Todd Schraw, Jorge L. Durand, Hua Li, Guangyu Li, Linda A. Jelicks, Mark F. Mehler, David Y. Hui, Yves Deshaies, Gerald I. Shulman, Gary J. Schwartz, Philipp E. Scherer
Title and authors | Publication | Year |
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The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity
Keisuke Yanagida, Hidemitsu Igarashi, Daisuke Yasuda, Daiki Kobayashi, Takayo Ohto-Nakanishi, Noriyuki Akahoshi, Atsushi Sekiba, Tsudoi Toyoda, Tomoko Ishijima, Yuji Nakai, Nobuhiro Shojima, Naoto Kubota, Keiko Abe, Takashi Kadowaki, Satoshi Ishii, Takao Shimizu |
JCI Insight | 2018 |
Fat fibrosis: friend or foe?
Ritwik Datta, Michael Podolsky, Kamran Atabai |
JCI Insight | 2018 |
Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity
Yang Zhang, Alexander J Federation, Soomin Kim, John O'Keefe, Mingyue Lun, Dongxi Xiang, Jonathan D. Brown, Matthew L. Steinhauser |
Journal of Clinical Investigation | 2018 |
Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat
H Li, G Wu, Q Fang, M Zhang, X Hui, B Sheng, L Wu, Y Bao, P Li, A Xu, W Jia |
Nature Communications | 2018 |
miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity
EH Koh, N Chernis, PK Saha, L Xiao, DA Bader, B Zhu, K Rajapakshe, MP Hamilton, X Liu, D Perera, , B York, M Trauner, C Coarfa, M Bajaj, DD Moore, T Deng, SE McGuire, SM Hartig |
Diabetes | 2018 |
An Integrated View of Immunometabolism
YS Lee, J Wollam, JM Olefsky |
Cell | 2018 |
Genes that make you fat, but keep you healthy
RJ Loos, TO Kilpeläinen |
Journal of Internal Medicine | 2018 |
Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity
JB Seo, M Riopel, P Cabrales, JY Huh, GK Bandyopadhyay, AY Andreyev, AN Murphy, SC Beeman, GI Smith, S Klein, YS Lee, JM Olefsky |
2018 | |
Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity
MD Senagolage, MA Sommars, K Ramachandran, CR Futtner, Y Omura, AL Allred, J Wang, C Yang, D Procissi, RM Evans, X Han, IR Bederman, GD Barish |
Cell Reports | 2018 |
Mechanisms of Insulin Action and Insulin Resistance
MC Petersen, GI Shulman |
Physiological reviews | 2018 |
Emerging Functions of Regulatory T Cells in Tissue Homeostasis
A Sharma, D Rudra |
Frontiers in immunology | 2018 |
De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
M Shao, L Vishvanath, NC Busbuso, C Hepler, B Shan, AX Sharma, S Chen, X Yu, YA An, Y Zhu, WL Holland, RK Gupta |
Nature Communications | 2018 |
Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high fat diet in lean mice
ZS Clayton, CE McCurdy |
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology | 2018 |
β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice
J Choi, H Kobayashi, H Okuda, KH Harada, M Takeda, H Fujimoto, S Yamane, D Tanaka, S Youssefian, N Inagaki, A Koizumi, V Sánchez-Margalet |
PloS one | 2018 |
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity
EH Lee, M Itan, J Jang, HJ Gu, P Rozenberg, MK Mingler, T Wen, J Yoon, SY Park, JY Roh, CS Choi, WJ Park, A Munitz, YJ Jung |
Scientific Reports | 2018 |
Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial
C Grunseich, R Miller, T Swan, DJ Glass, ME Mouelhi, M Fornaro, O Petricoul, I Vostiar, R Roubenoff, MN Meriggioli, A Kokkinis, RD Guber, MS Budron, J Vissing, G Soraru, T Mozaffar, A Ludolph, JT Kissel, KH Fischbeck, C Grunseich, R Miller, T Swan, DJ Glass, ME Mouelhi, M Fornaro, O Petricoul, I Vostiar, R Roubenoff, MN Meriggioli, J Dahlqvist, N Witting, J Vissing, I Martinelli, G Querin, G Soraru, NA Goyal, TM Cash, B Minton, T Mozaffar, A Rosenbohm, U Weiland, P Weydt, A Ludolph, S Chelnick, S Iyadurai, W King, JT Kissel, MS Budron, RD Guber, A Kokkinis, KH Fischbeck |
Lancet neurology | 2018 |
Leptin and brain–adipose crosstalks
A Caron, S Lee, JK Elmquist, L Gautron |
Nature Reviews Neuroscience | 2018 |
Elevated Pentraxin 3 in Obese Adipose Tissue Promotes Adipogenic Differentiation by Activating Neuropeptide Y Signaling
MK Shin, B Choi, EY Kim, JE Park, ES Hwang, HJ Lee, MK Kim, JE Kim, SW Kim, EJ Chang |
Frontiers in immunology | 2018 |
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
A Bartelt, SB Widenmaier, C Schlein, K Johann, RL Goncalves, K Eguchi, AW Fischer, G Parlakgül, NA Snyder, TB Nguyen, OT Bruns, D Franke, MG Bawendi, MD Lynes, LO Leiria, YH Tseng, KE Inouye, AP Arruda, GS Hotamisligil |
Nature Medicine | 2018 |
Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity
M Varghese, C Griffin, K McKernan, L Eter, N Lanzetta, D Agarwal, S Abrishami, K Singer |
Endocrinology | 2018 |
The obese adipose tissue microenvironment in cancer development and progression
DF Quail, AJ Dannenberg |
Nature Reviews Endocrinology | 2018 |
A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition
Y Miyachi, K Tsuchiya, K Shiba, K Mori, C Komiya, N Ogasawara, Y Ogawa |
Scientific Reports | 2018 |
Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release
QL Zhou, Y Song, CH Huang, JY Huang, Z Gong, Z Liao, AG Sharma, L Greene, JZ Deng, MC Rigor, X Xie, S Qi, JE Ayala, ZY Jiang |
Molecular and cellular biology | 2018 |
The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function
JF Carli, CA LeDuc, Y Zhang, G Stratigopoulos, RL Leibel |
The FASEB Journal | 2018 |
Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons
MS Andrew, DM Huffman, E Rodriguez-Ayala, NN Williams, RM Peterson, RA Bastarrachea |
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery | 2018 |
Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility
S Virtue, K Petkevicius, JM Moreno-Navarrete, B Jenkins, D Hart, M Dale, A Koulman, JM Fernández-Real, A Vidal-Puig |
Cell Reports | 2018 |
Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis
JZ Lin, N Rabhi, SR Farmer |
Cell Reports | 2018 |
GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation
K Drareni, R Ballaire, S Barilla, MJ Mathew, A Toubal, R Fan, N Liang, C Chollet, Z Huang, M Kondili, F Foufelle, A Soprani, R Roussel, JF Gautier, F Alzaid, E Treuter, N Venteclef |
Cell Reports | 2018 |
Discovery of a novel potent peptide agonist to adiponectin receptor 1
S Kim, Y Lee, JW Kim, YJ Son, MJ Ma, JH Um, ND Kim, SH Min, DI Kim, BB Kim, DG Jo |
PloS one | 2018 |
Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease
C Boutari, N Perakakis, CS Mantzoros |
Endocrinology and Metabolism | 2018 |
Immunometabolic Activation of Invariant Natural Killer T Cells
FA Ververs, E Kalkhoven, B vant Land, M Boes, HS Schipper |
Frontiers in immunology | 2018 |
A20 deubiquitinase controls PGC-1α expression in the adipose tissue
B Bombassaro, LM Ignacio-Souza, CE Nunez, DS Razolli, RM Pedro, A Coope, EP Araujo, EA Chaim, LA Velloso |
Lipids in Health and Disease | 2018 |
Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans
A Gaye, AP Doumatey, SK Davis, CN Rotimi, GH Gibbons |
npj Genomic Medicine | 2018 |
Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight
LO Huang, RJ Loos, TO Kilpeläinen |
Physiological genomics | 2018 |
The many secret lives of adipocytes: implications for diabetes
PE Scherer |
Diabetologia | 2018 |
Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers
O Pérez-Bautista, M Montaño, R Pérez-Padilla, J Zúñiga-Ramos, M Camacho-Priego, T Barrientos-Gutiérrez, I Buendía-Roldan, Y Velasco-Torres, C Ramos |
Respiratory Research | 2018 |
Discrepancies Between BMI and Classic Cardiovascular Risk Factors.
van Mil SR, Vijgen GHEJ, van Huisstede A, Klop B, van de Geijn GM, Birnie E, Braunstahl GJ, Mannaerts GHH, Biter LU, Castro Cabezas M |
Obesity surgery | 2018 |