Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Ja-Young Kim, … , Gary J. Schwartz, Philipp E. Scherer
Ja-Young Kim, … , Gary J. Schwartz, Philipp E. Scherer
Published September 4, 2007
Citation Information: J Clin Invest. 2007;117(9):2621-2637. https://doi.org/10.1172/JCI31021.
View: Text | PDF
Research Article Metabolism Article has an altmetric score of 59

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

  • Text
  • PDF
Abstract

Excess caloric intake can lead to insulin resistance. The underlying reasons are complex but likely related to ectopic lipid deposition in nonadipose tissue. We hypothesized that the inability to appropriately expand subcutaneous adipose tissue may be an underlying reason for insulin resistance and β cell failure. Mice lacking leptin while overexpressing adiponectin showed normalized glucose and insulin levels and dramatically improved glucose as well as positively affected serum triglyceride levels. Therefore, modestly increasing the levels of circulating full-length adiponectin completely rescued the diabetic phenotype in ob/ob mice. They displayed increased expression of PPARγ target genes and a reduction in macrophage infiltration in adipose tissue and systemic inflammation. As a result, the transgenic mice were morbidly obese, with significantly higher levels of adipose tissue than their ob/ob littermates, leading to an interesting dichotomy of increased fat mass associated with improvement in insulin sensitivity. Based on these data, we propose that adiponectin acts as a peripheral “starvation” signal promoting the storage of triglycerides preferentially in adipose tissue. As a consequence, reduced triglyceride levels in the liver and muscle convey improved systemic insulin sensitivity. These mice therefore represent what we believe is a novel model of morbid obesity associated with an improved metabolic profile.

Authors

Ja-Young Kim, Esther van de Wall, Mathieu Laplante, Anthony Azzara, Maria E. Trujillo, Susanna M. Hofmann, Todd Schraw, Jorge L. Durand, Hua Li, Guangyu Li, Linda A. Jelicks, Mark F. Mehler, David Y. Hui, Yves Deshaies, Gerald I. Shulman, Gary J. Schwartz, Philipp E. Scherer

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Total
Citations: 8 26 28 48 46 29 40 37 40 37 33 42 61 46 50 34 43 35 683
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2018 (37)

Title and authors Publication Year
The Gα12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-induced obesity
Keisuke Yanagida, Hidemitsu Igarashi, Daisuke Yasuda, Daiki Kobayashi, Takayo Ohto-Nakanishi, Noriyuki Akahoshi, Atsushi Sekiba, Tsudoi Toyoda, Tomoko Ishijima, Yuji Nakai, Nobuhiro Shojima, Naoto Kubota, Keiko Abe, Takashi Kadowaki, Satoshi Ishii, Takao Shimizu
JCI Insight 2018
Fat fibrosis: friend or foe?
Ritwik Datta, Michael Podolsky, Kamran Atabai
JCI Insight 2018
Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity
Yang Zhang, Alexander J Federation, Soomin Kim, John O'Keefe, Mingyue Lun, Dongxi Xiang, Jonathan D. Brown, Matthew L. Steinhauser
Journal of Clinical Investigation 2018
Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat
H Li, G Wu, Q Fang, M Zhang, X Hui, B Sheng, L Wu, Y Bao, P Li, A Xu, W Jia
Nature Communications 2018
miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity
EH Koh, N Chernis, PK Saha, L Xiao, DA Bader, B Zhu, K Rajapakshe, MP Hamilton, X Liu, D Perera, , B York, M Trauner, C Coarfa, M Bajaj, DD Moore, T Deng, SE McGuire, SM Hartig
Diabetes 2018
An Integrated View of Immunometabolism
YS Lee, J Wollam, JM Olefsky
Cell 2018
Genes that make you fat, but keep you healthy
RJ Loos, TO Kilpeläinen
Journal of Internal Medicine 2018
Knockdown of ANT2 reduces adipocyte hypoxia and improves insulin resistance in obesity
JB Seo, M Riopel, P Cabrales, JY Huh, GK Bandyopadhyay, AY Andreyev, AN Murphy, SC Beeman, GI Smith, S Klein, YS Lee, JM Olefsky
2018
Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity
MD Senagolage, MA Sommars, K Ramachandran, CR Futtner, Y Omura, AL Allred, J Wang, C Yang, D Procissi, RM Evans, X Han, IR Bederman, GD Barish
Cell Reports 2018
Mechanisms of Insulin Action and Insulin Resistance
MC Petersen, GI Shulman
Physiological reviews 2018
Emerging Functions of Regulatory T Cells in Tissue Homeostasis
A Sharma, D Rudra
Frontiers in immunology 2018
De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity
M Shao, L Vishvanath, NC Busbuso, C Hepler, B Shan, AX Sharma, S Chen, X Yu, YA An, Y Zhu, WL Holland, RK Gupta
Nature Communications 2018
Short-term thermoneutral housing alters glucose metabolism and markers of adipose tissue browning in response to a high fat diet in lean mice
ZS Clayton, CE McCurdy
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2018
β-cell-specific overexpression of adiponectin receptor 1 does not improve diabetes mellitus in Akita mice
J Choi, H Kobayashi, H Okuda, KH Harada, M Takeda, H Fujimoto, S Yamane, D Tanaka, S Youssefian, N Inagaki, A Koizumi, V Sánchez-Margalet
PloS one 2018
Eosinophils support adipocyte maturation and promote glucose tolerance in obesity
EH Lee, M Itan, J Jang, HJ Gu, P Rozenberg, MK Mingler, T Wen, J Yoon, SY Park, JY Roh, CS Choi, WJ Park, A Munitz, YJ Jung
Scientific Reports 2018
Safety, tolerability, and preliminary efficacy of an IGF-1 mimetic in patients with spinal and bulbar muscular atrophy: a randomised, placebo-controlled trial
C Grunseich, R Miller, T Swan, DJ Glass, ME Mouelhi, M Fornaro, O Petricoul, I Vostiar, R Roubenoff, MN Meriggioli, A Kokkinis, RD Guber, MS Budron, J Vissing, G Soraru, T Mozaffar, A Ludolph, JT Kissel, KH Fischbeck, C Grunseich, R Miller, T Swan, DJ Glass, ME Mouelhi, M Fornaro, O Petricoul, I Vostiar, R Roubenoff, MN Meriggioli, J Dahlqvist, N Witting, J Vissing, I Martinelli, G Querin, G Soraru, NA Goyal, TM Cash, B Minton, T Mozaffar, A Rosenbohm, U Weiland, P Weydt, A Ludolph, S Chelnick, S Iyadurai, W King, JT Kissel, MS Budron, RD Guber, A Kokkinis, KH Fischbeck
Lancet neurology 2018
Leptin and brain–adipose crosstalks
A Caron, S Lee, JK Elmquist, L Gautron
Nature Reviews Neuroscience 2018
Elevated Pentraxin 3 in Obese Adipose Tissue Promotes Adipogenic Differentiation by Activating Neuropeptide Y Signaling
MK Shin, B Choi, EY Kim, JE Park, ES Hwang, HJ Lee, MK Kim, JE Kim, SW Kim, EJ Chang
Frontiers in immunology 2018
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
A Bartelt, SB Widenmaier, C Schlein, K Johann, RL Goncalves, K Eguchi, AW Fischer, G Parlakgül, NA Snyder, TB Nguyen, OT Bruns, D Franke, MG Bawendi, MD Lynes, LO Leiria, YH Tseng, KE Inouye, AP Arruda, GS Hotamisligil
Nature Medicine 2018
Sex Differences in Inflammatory Responses to Adipose Tissue Lipolysis in Diet-Induced Obesity
M Varghese, C Griffin, K McKernan, L Eter, N Lanzetta, D Agarwal, S Abrishami, K Singer
Endocrinology 2018
The obese adipose tissue microenvironment in cancer development and progression
DF Quail, AJ Dannenberg
Nature Reviews Endocrinology 2018
A reduced M1-like/M2-like ratio of macrophages in healthy adipose tissue expansion during SGLT2 inhibition
Y Miyachi, K Tsuchiya, K Shiba, K Mori, C Komiya, N Ogasawara, Y Ogawa
Scientific Reports 2018
Membrane Trafficking Protein CDP138 Regulates Fat Browning and Insulin Sensitivity through Controlling Catecholamine Release
QL Zhou, Y Song, CH Huang, JY Huang, Z Gong, Z Liao, AG Sharma, L Greene, JZ Deng, MC Rigor, X Xie, S Qi, JE Ayala, ZY Jiang
Molecular and cellular biology 2018
The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function
JF Carli, CA LeDuc, Y Zhang, G Stratigopoulos, RL Leibel
The FASEB Journal 2018
Mesenteric visceral lipectomy using tissue liquefaction technology reverses insulin resistance and causes weight loss in baboons
MS Andrew, DM Huffman, E Rodriguez-Ayala, NN Williams, RM Peterson, RA Bastarrachea
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2018
Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility
S Virtue, K Petkevicius, JM Moreno-Navarrete, B Jenkins, D Hart, M Dale, A Koulman, JM Fernández-Real, A Vidal-Puig
Cell Reports 2018
Myocardin-Related Transcription Factor A Promotes Recruitment of ITGA5+ Profibrotic Progenitors during Obesity-Induced Adipose Tissue Fibrosis
JZ Lin, N Rabhi, SR Farmer
Cell Reports 2018
GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation
K Drareni, R Ballaire, S Barilla, MJ Mathew, A Toubal, R Fan, N Liang, C Chollet, Z Huang, M Kondili, F Foufelle, A Soprani, R Roussel, JF Gautier, F Alzaid, E Treuter, N Venteclef
Cell Reports 2018
Discovery of a novel potent peptide agonist to adiponectin receptor 1
S Kim, Y Lee, JW Kim, YJ Son, MJ Ma, JH Um, ND Kim, SH Min, DI Kim, BB Kim, DG Jo
PloS one 2018
Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease
C Boutari, N Perakakis, CS Mantzoros
Endocrinology and Metabolism 2018
Immunometabolic Activation of Invariant Natural Killer T Cells
FA Ververs, E Kalkhoven, B vant Land, M Boes, HS Schipper
Frontiers in immunology 2018
A20 deubiquitinase controls PGC-1α expression in the adipose tissue
B Bombassaro, LM Ignacio-Souza, CE Nunez, DS Razolli, RM Pedro, A Coope, EP Araujo, EA Chaim, LA Velloso
Lipids in Health and Disease 2018
Whole-genome transcriptomic insights into protective molecular mechanisms in metabolically healthy obese African Americans
A Gaye, AP Doumatey, SK Davis, CN Rotimi, GH Gibbons
npj Genomic Medicine 2018
Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight
LO Huang, RJ Loos, TO Kilpeläinen
Physiological genomics 2018
The many secret lives of adipocytes: implications for diabetes
PE Scherer
Diabetologia 2018
Women with COPD by biomass show different serum profile of adipokines, incretins, and peptide hormones than smokers
O Pérez-Bautista, M Montaño, R Pérez-Padilla, J Zúñiga-Ramos, M Camacho-Priego, T Barrientos-Gutiérrez, I Buendía-Roldan, Y Velasco-Torres, C Ramos
Respiratory Research 2018
Discrepancies Between BMI and Classic Cardiovascular Risk Factors.
van Mil SR, Vijgen GHEJ, van Huisstede A, Klop B, van de Geijn GM, Birnie E, Braunstahl GJ, Mannaerts GHH, Biter LU, Castro Cabezas M
Obesity surgery 2018

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 4 news outlets
Blogged by 1
Posted by 15 X users
Referenced in 3 patents
Mentioned by 1 peer review sites
636 readers on Mendeley
2 readers on CiteULike
See more details