The CXC chemokine family is a pleiotropic family of cytokines that are involved in promoting the trafficking of various leukocytes, in regulating angiogenesis and vascular remodeling, and in promoting the mobilization and trafficking of mesenchymal progenitor cells such as fibrocytes. These functions of CXC chemokines are important in the pathogenesis of pulmonary fibrosis and other fibroproliferative disorders. In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates to their role in regulating vascular remodeling and trafficking of circulating mesenchymal progenitor cells (also known as fibrocytes) in pulmonary fibrosis.
Robert M. Strieter, Brigitte N. Gomperts, Michael P. Keane
Title and authors | Publication | Year |
---|---|---|
Primary myelofibrosis progression: a game of cellular telephone
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Haematologica | 2025 |
Single cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa
Kelsey. Straalen, Feiyang Ma, Eliza Tsou, Olesya Plazyo, Mehrnaz Gharaee-Kermani, Marta Calbet, Xianying Xing, Mrinal Sarkar, Ranjitha Uppala, Paul Harms, Rachael Wasikowski, Lina Nahlawi, Mio Nakamura, Milad Eshaq, Cong Wang, Craig Dobry, Jeffrey Kozlow, Jill Cherry-Bukowiec, William Brodie, Kerstin Wolk, Özge Uluçkan, Megan Mattichak, Matteo Pellegrini, Robert Modlin, Emanual Maverakis, Robert Sabat, J. Kahlenberg, Allison Billi, Lam Tsoi, Johann Gudjonsson |
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ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly
Reddy KD, Bizymi N, Schweikert A, Ananth S, Lim CX, Lodge KM, Joannes A, Ubags N, van der Does AM, Cloonan SM, Mailleux A, Mansouri N, Reynaert NL, Heijink IH, Cuevas-Ocaña S |
ERJ Open Research | 2024 |
Bortezomib restrains M2 polarization and reduces CXCL16-associated CXCR6+CD4 T cell chemotaxis in bleomycin-induced pulmonary fibrosis
Zhou T, lin L, Zhan Y, Zhang Z, Jiang Y, Wu M, Xue D, Chen L, Weng X, Huang Z |
Molecular Medicine | 2024 |
Radiation Induced Skin Fibrosis (RISF): Opportunity for Angiotensin II-Dependent Intervention
Boothe PF, Kumar VP, Kong Y, Wang K, Levinson H, Mu D, Brown ML |
International journal of molecular sciences | 2024 |
Spatial transcriptomic validation of a biomimetic model of fibrosis enables re-evaluation of a therapeutic antibody targeting LOXL2.
Bell JA, Davies ER, Brereton CJ, Vukmirovic M, Roberts JJW, Lunn K, Wickens L, Conforti F, Ridley RA, Ceccato J, Sayer LN, Johnston DA, Vallejo AF, Alzetani A, Jogai S, Marshall BG, Fabre A, Richeldi L, Monk PD, Skipp P, Kaminski N, Offer E, Wang Y, Davies DE, Jones MG |
Cell reports. Medicine | 2024 |
Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice
McDonald OF, Wagner JG, Lewandowski RP, Heine LK, Estrada V, Pourmand E, Singhal M, Harkema JR, Lee KS, Pestka JJ |
Inhalation toxicology | 2024 |
The Chemokine System as a Key Regulator of Pulmonary Fibrosis: Converging Pathways in Human Idiopathic Pulmonary Fibrosis (IPF) and the Bleomycin-Induced Lung Fibrosis Model in Mice
Russo RC, Ryffel B |
Cells | 2024 |
Different inflammatory, fibrotic, and immunological signatures between pre-fibrotic and overt primary myelofibrosis
Jung SH, Lee SE, Yun S, Min DE, Shin Y, Chung YJ, Lee SH |
Haematologica | 2024 |
Immune Mechanisms of Pulmonary Fibrosis with Bleomycin
Ishida Y, Kuninaka Y, Mukaida N, Kondo T |
International journal of molecular sciences | 2023 |
Identification and validation of chemokine system-related genes in idiopathic pulmonary fibrosis
Zhao T, Wu X, Zhao X, Yao K, Li X, Ni J |
Frontiers in immunology | 2023 |
Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures
Kastlmeier MT, Gonzalez-Rodriguez E, Cabanis P, Guenther EM, König AC, Han L, Hauck SM, See F, Asgharpour S, Bukas C, Burgstaller G, Piraud M, Lehmann M, Hatz RA, Behr J, Stoeger T, Hilgendorff A, Voss C |
Frontiers in immunology | 2023 |
Identification of potential biomarkers for idiopathic pulmonary fibrosis and validation of TDO2 as a potential therapeutic target.
Wang R, Yang YM |
World journal of cardiology | 2023 |
TLR7 activation in M-CSF-dependent monocyte-derived human macrophages potentiates inflammatory responses and prompts neutrophil recruitment.
Simón-Fuentes M, Herrero C, Acero-Riaguas L, Nieto C, Lasala F, Labiod N, Luczkowiak J, Alonso B, Delgado R, Colmenares M, Corbí ÁL, Domínguez-Soto Á |
Journal of Innate Immunity | 2023 |
Prolyl oligopeptidase inhibition ameliorates experimental pulmonary fibrosis both in vivo and in vitro.
Cucinotta L, Mannino D, Casili G, Repici A, Crupi L, Paterniti I, Esposito E, Campolo M |
Respiratory Research | 2023 |
Perfluorocarbon Nanoemulsions Enhance Therapeutic siRNA Delivery in the Treatment of Pulmonary Fibrosis
L Ding, S Tang, W Tang, D Mosley, A Yu, D Sil, S Romanova, K Bailey, D Knoell, T Wyatt, D Oupický |
Advanced Science | 2022 |
Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 During Unfavorable Peritoneal Tissue Remodeling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy
Catar RA, Bartosova M, Kawka E, Chen L, Marinovic I, Zhang C, Zhao H, Wu D, Zickler D, Stadnik H, Karczewski M, Kamhieh-Milz J, Jörres A, Moll G, Schmitt CP, Witowski J |
Frontiers in immunology | 2022 |
CXC Chemokines in the Pathogenesis of Pulmonary Disease and Pharmacological Relevance
Komolafe K, Pacurari M |
International Journal of Inflammation | 2022 |
Pulmonary exposure of mice to ammonium perfluoro(2-methyl-3-oxahexanoate) (GenX) suppresses the innate immune response to carbon black nanoparticles and stimulates lung cell proliferation.
Lee HY, You DJ, Taylor-Just AJ, Linder KE, Atkins HM, Ralph LM, De la Cruz G, Bonner JC |
Inhalation Toxicology | 2022 |
Deciphering the Antifibrotic Property of Metformin
Septembre-Malaterre A, Boina C, Douanier A, Gasque P |
Cells | 2022 |
Identification of Impacted Pathways and Transcriptomic Markers as Potential Mediators of Pulmonary Fibrosis in Transgenic Mice Expressing Human IGFBP5
XX Nguyen, L Renaud, C Feghali-Bostwick |
International journal of molecular sciences | 2021 |
Human umbilical cord mesenchymal stromal cells attenuate pulmonary fibrosis via regulatory T cell through interaction with macrophage
Z Tang, J Gao, J Wu, G Zeng, Y Liao, Z Song, X Liang, J Hu, Y Hu, M Liu, N Li |
Stem Cell Research & Therapy | 2021 |
Tetrathiomolybdate Treatment Attenuates Bleomycin-Induced Angiogenesis and Lung Pathology in a Sheep Model of Pulmonary Fibrosis
HB Derseh, KU Perera, SN Dewage, A Stent, E Koumoundouros, L Organ, CN Pagel, KJ Snibson |
Frontiers in pharmacology | 2021 |
Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms
R Malaviya, HM Kipen, R Businaro, JD Laskin, DL Laskin |
Toxicology and Applied Pharmacology | 2020 |
Molecular and cellular mechanisms of liver fibrosis and its regression
T Kisseleva, D Brenner |
Nature Reviews Gastroenterology & Hepatology | 2020 |
Dexamethasone Attenuates X-Ray-Induced Activation of the Autotaxin-Lysophosphatidate-Inflammatory Cycle in Breast Tissue and Subsequent Breast Fibrosis
G Meng, M Wuest, X Tang, J Dufour, TP McMullen, F Wuest, D Murray, DN Brindley |
Cancers | 2020 |
CXCL9, CXCL10, and CXCL11; biomarkers of pulmonary inflammation associated with autoimmunity in patients with collagen vascular diseases–associated interstitial lung disease and interstitial pneumonia with autoimmune features
M Kameda, M Otsuka, H Chiba, K Kuronuma, T Hasegawa, H Takahashi, H Takahashi, M Kuwana |
PloS one | 2020 |
Monocyte-derived multipotent cell delivered programmed therapeutics to reverse idiopathic pulmonary fibrosis
X Chang, L Xing, Y Wang, CX Yang, YJ He, TJ Zhou, XD Gao, L Li, HP Hao, HL Jiang |
Science Advances | 2020 |
Fibroblast Heterogeneity in and Its Implications for Plastic and Reconstructive Surgery: A Basic Science Review
HE desJardins-Park, MS Chinta, DS Foster, MR Borrelli, AH Shen, DC Wan, MT Longaker |
Plastic and Reconstructive Surgery Global Open | 2020 |
Modulation of the immune microenvironment by tumor-intrinsic oncogenic signaling
KB Nguyen, S Spranger |
The Journal of Cell Biology | 2019 |
CXCR4 Antagonism Reduces Cardiac Fibrosis and Improves Cardiac Performance in Dilated Cardiomyopathy
PY Chu, MS Joshi, D Horlock, H Kiriazis, DM Kaye |
Frontiers in pharmacology | 2019 |
Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4
K Griffiths, U Binder, W McDowell, R Tommasi, M Frigerio, WG Darby, CG Hosking, L Renaud, M Machacek, P Lloyd, A Skerra, M Foley |
mAbs | 2019 |
Morphological and molecular motifs of fibrosing pulmonary injury patterns
D Jonigk, H Stark, P Braubach, L Neubert, H Shin, N Izykowski, T Welte, S Janciauskiene, G Warnecke, A Haverich, M Kuehnel, F Laenger |
The Journal of Pathology: Clinical Research | 2019 |
Anti-fibrotic Effects of CXCR4-Targeting i-body AD-114 in Preclinical Models of Pulmonary Fibrosis
K Griffiths, DM Habiel, J Jaffar, U Binder, WG Darby, CG Hosking, A Skerra, GP Westall, CM Hogaboam, M Foley |
Scientific Reports | 2018 |
Transient Blockade of Endothelin-1 Mitigates Amiodarone-Induced Pulmonary Fibrosis
X Liu, N Khadtare, H Patel, R Stephani, Jerome |
Lung | 2018 |
Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro-inflammatory, pro-repair, angiogenic activation pattern, likely associated with macrophage iron accumulation
J Lee, I Arisi, E Puxeddu, LK Mramba, M Amicosante, CM Swaisgood, M Pallante, ML Brantly, CM Sköld, C Saltini, G Zissel |
PloS one | 2018 |
Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4
LR Rodriguez, M Emblom-Callahan, M Chhina, S Bui, B Aljeburry, LH Tran, R Novak, M Lemma, SD Nathan, GM Grant |
Scientific Reports | 2018 |
IL-17 in Peritoneal Dialysis-Associated Inflammation and Angiogenesis: Conclusions and Perspectives
J Witowski, J Kamhieh-Milz, E Kawka, R Catar, A Jörres |
Frontiers in physiology | 2018 |
Circulating fibrocyte mobilization in negative pressure wound therapy
D Chen, Y Zhao, Z Li, K Shou, X Zheng, P Li, B Qi, A Yu |
Journal of Cellular and Molecular Medicine | 2017 |
Meta-analytic support vector machine for integrating multiple omics data
SH Kim, JH Jhong, JJ Lee, JY Koo |
BioData mining | 2017 |
Photobiomodulation therapy improves both inflammatory and fibrotic parameters in experimental model of lung fibrosis in mice
RA Brochetti, MP Leal, R Rodrigues, RK da Palma, LV de Oliveira, AC Horliana, AS Damazo, AP de Oliveira, RP Vieira, A Lino-dos-Santos-Franco |
Lasers in Medical Science | 2017 |
Swyer-James-MacLeod syndrome with unilateral pulmonary fibrosis: a case report
O Abdulla, J Cain, J Howells |
BJR|case reports | 2017 |
Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy
X Wang, W Zhao, RM Ransohoff, L Zhou |
Journal of immunology (Baltimore, Md. : 1950) | 2016 |
Immunomodulation by mesenchymal stem cells in treating human autoimmune disease-associated lung fibrosis
M Liu, X Zeng, J Wang, Z Fu, J Wang, M Liu, D Ren, B Yu, L Zheng, X Hu, W Shi, J Xu |
Stem Cell Research & Therapy | 2016 |
Intersection of Chemokine and TSH Receptor Pathways in Human Fibrocytes: Emergence of CXCL-12/CXCR4 Cross Talk Potentially Relevant to Thyroid-Associated Ophthalmopathy
R Fernando, SJ Atkins, TJ Smith |
Endocrinology | 2016 |
Suppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis
Q Zhou, T Chen, W Zhang, M Bozkanat, Y Li, L Xiao, RB van Breemen, JW Christman, JI Sznajder, G Zhou |
American journal of respiratory cell and molecular biology | 2016 |
Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis
Q Liang, N Cheng, G Zhang, Y Liang, F Qian, D Wu, RD Ye |
Scientific Reports | 2016 |
Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis
TY Besschetnova, T Ichimura, N Katebi, BS Croix, JV Bonventre, BR Olsen |
Matrix Biology | 2015 |
CXCR3 Requirement for the Interleukin-13–Mediated Up-Regulation of Interleukin-13Rα2 in Pulmonary Fibroblasts
JC Barnes, RV Lumsden, J Worrell, IP Counihan, SL O’Beirne, JA Belperio, A Fabre, SC Donnelly, D Boylan, R Kane, MP Keane |
American journal of respiratory cell and molecular biology | 2015 |
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva |
Experimental biology and medicine (Maywood, N.J.) | 2015 |
Bone marrow-derived fibrocytes contribute to liver fibrosis
J Xu, T Kisseleva |
Experimental biology and medicine (Maywood, N.J.) | 2015 |
TSH-Mediated TNFα Production in Human Fibrocytes Is Inhibited by Teprotumumab, an IGF-1R Antagonist
H Chen, SJ Shan, T Mester, YH Wei, RS Douglas, N Vij |
PloS one | 2015 |
Current concepts in the molecular pathogenesis of thyroid-associated ophthalmopathy
Y Wang, TJ Smith |
Investigative ophthalmology & visual science | 2014 |
The types of hepatic myofibroblasts contributing to liver fibrosis of different etiologies
J Xu, X Liu, Y Koyama, P Wang, T Lan, IG Kim, IH Kim, HY Ma, T Kisseleva |
Frontiers in pharmacology | 2014 |
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice
D Li, R Guabiraba, AG Besnard, M Komai-Koma, MS Jabir, L Zhang, GJ Graham, M Kurowska-Stolarska, FY Liew, C McSharry, D Xu |
Journal of Allergy and Clinical Immunology | 2014 |
Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway:
DM Smadja, P Dorfmüller, C Guerin, I Bieche, C Badoual, E Boscolo, M Kambouchner, A Cazes, O Mercier, M Humbert, P Gaussem, J Bischoff, D Israël-Biet |
Thrombosis and Haemostasis | 2014 |
Graft microvascular disease in solid organ transplantation
X Jiang, YK Sung, W Tian, J Qian, GL Semenza, MR Nicolls |
Journal of Molecular Medicine | 2014 |
Pulmonary Hypertension and Right Heart Dysfunction in Chronic Lung Disease
A Zangiabadi, CG de Pasquale, D Sajkov |
BioMed Research International | 2014 |
Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition
D Balli, V Ustiyan, Y Zhang, IC Wang, AJ Masino, X Ren, JA Whitsett, VV Kalinichenko, TV Kalin |
The EMBO Journal | 2013 |
Dynamic Regulation of Integrin α6β4 During Angiogenesis: Potential Implications for Pathogenic Wound Healing
D Desai, P Singh, LV de Water, SE Laflamme |
Advances in Skin & Wound Care | 2013 |
Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-β and Associated Transcripts in Pulmonary Fibrosis
R Vittal, EA Mickler, AJ Fisher, C Zhang, K Rothhaar, H Gu, KM Brown, A Emtiazdjoo, JM Lott, SB Frye, GN Smith, GE Sandusky, OW Cummings, DS Wilkes |
PloS one | 2013 |
Adoptive Transfer of Fibrocytes Enhances Splenic T-Cell Numbers and Survival in Septic Peritonitis:
JA Nemzek, C Fry, BB Moore |
Shock | 2013 |
Defensin Production by Human Limbo-Corneal Fibroblasts Infected with Mycobacteria
J Castañeda-Sánchez, B García-Pérez, A Muñoz-Duarte, S Baltierra-Uribe, H Mejia-López, C López-López, VB Lucio, A Robles-Contreras, J Luna-Herrera |
Pathogens | 2013 |
Chemokine localization in bronchial angiogenesis
MG Perino, A Moldobaeva, J Jenkins, EM Wagner |
PloS one | 2013 |
Glucose Transporter-1 Distribution in Fibrotic Lung Disease
S El-Chemaly, D Malide, J Yao, SD Nathan, IO Rosas, WA Gahl, J Moss, BR Gochuico |
Chest | 2013 |
The Role of Fibrocytes in Sickle Cell Lung Disease
JJ Field, MD Burdick, MR DeBaun, BA Strieter, L Liu, B Mehrad, CE Rose, J Linden, RM Strieter |
PloS one | 2012 |
Inhibiting CXCL12 blocks fibrocyte migration and differentiation and attenuates bronchiolitis obliterans in a murine heterotopic tracheal transplant model
DA Harris, Y Zhao, DJ LaPar, A Emaminia, JF Steidle, M Stoler, J Linden, IL Kron, CL Lau |
The Journal of Thoracic and Cardiovascular Surgery | 2012 |
Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis
MJ Xu, XJ Liu, YL Zhao, D Liu, ZH Xu, XM Lang, P Ao, WH Lin, SL Yang, ZG Zhang, J Xu |
Marine drugs | 2012 |
Origin of myofibroblasts in liver fibrosis
DA Brenner, T Kisseleva, D Scholten, YH Paik, K Iwaisako, S Inokuchi, B Schnabl, E Seki, SD Minicis, C Oesterreicher, K Taura |
Fibrogenesis & Tissue Repair | 2012 |
The 3 R's of Lung Health and Disease: Repair, Remodeling, and Regeneration
Michael F. Beers and Edward E. Morrisey |
Journal of Clinical Investigation | 2011 |
Migration of Fibrocytes in Fibrogenic Liver Injury
D Scholten, D Reichart, YH Paik, J Lindert, J Bhattacharya, CK Glass, DA Brenner, T Kisseleva |
The American Journal of Pathology | 2011 |
Negative Regulation of Lung Inflammation and Immunopathology by TNF-α during Acute Influenza Infection
D Damjanovic, M Divangahi, K Kugathasan, CL Small, A Zganiacz, EG Brown, CM Hogaboam, J Gauldie, Z Xing |
The American Journal of Pathology | 2011 |
Integrating mechanisms of pulmonary fibrosis
TA Wynn |
Journal of Experimental Medicine | 2011 |
The Pivotal Role of Airway Smooth Muscle in Asthma Pathophysiology
A Ozier, B Allard, I Bara, PO Girodet, T Trian, R Marthan, P Berger |
Journal of allergy | 2011 |
Anti-fibrogenic Strategies and the regression of fibrosis
T Kisseleva, DA Brenner |
Best practice & research. Clinical gastroenterology | 2011 |
Recruited exudative macrophages selectively produce CXCL10 after noninfectious lung injury
RM Tighe, J Liang, N Liu, Y Jung, D Jiang, MD Gunn, PW Noble |
American journal of respiratory cell and molecular biology | 2011 |
Epithelial-mesenchymal interactions in biliary diseases
L Fabris, M Strazzabosco |
Seminars in liver disease | 2011 |
The role of fibrocytes in fibrotic diseases of the lungs and heart
EC Keeley, B Mehrad, RM Strieter |
Fibrogenesis & Tissue Repair | 2011 |
The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis
T Kisseleva, DA Brenner |
Journal of Hepatology | 2011 |
Characterization of Quin-C1 for its anti-inflammatory property in a mouse model of bleomycin-induced lung injury
M He, N Cheng, W Gao, M Zhang, Y Zhang, RD Ye, M Wang |
Acta Pharmacologica Sinica | 2011 |
Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
TR Cox, JT Erler |
Disease models & mechanisms | 2011 |
Fibrocytes and the tissue niche in lung repair
A Andersson-Sjöland, K Nihlberg, L Eriksson, L Bjermer, G Westergren-Thorsson |
Respiratory Research | 2011 |
Evolving Genomic Approaches to Idiopathic Pulmonary Fibrosis: Moving Beyond Genes
DJ Kass, N Kaminski |
Clinical and Translational Science | 2011 |
Switch from stress response to homeobox transcription factors in adipose tissue after profound fat loss
SN Dankel, DJ Fadnes, AK Stavrum, C Stansberg, R Holdhus, T Hoang, VL Veum, BJ Christensen, V Våge, JV Sagen, VM Steen, G Mellgren |
PloS one | 2010 |
A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice
Y Zhu, Y Liu, W Zhou, R Xiang, L Jiang, K Huang, Y Xiao, Z Guo, J Gao |
Respiratory Research | 2010 |
Kinetics of Chemokine–Glycosaminoglycan Interactions Control Neutrophil Migration into the Airspaces of the Lungs
Y Tanino, DR Coombe, SE Gill, WC Kett, O Kajikawa, AE Proudfoot, TN Wells, WC Parks, TN Wight, TR Martin, CW Frevert |
Journal of immunology (Baltimore, Md. : 1950) | 2010 |
Can scarring be turned off?
JM Davidson |
The American Journal of Pathology | 2010 |
Bone marrow-derived cells contribute to fibrosis in the chronically failing heart
PY Chu, J Mariani, S Finch, JR McMullen, J Sadoshima, T Marshall, DM Kaye |
The American Journal of Pathology | 2010 |
Cell-matrix interactions in dermal repair and scarring
B Eckes, R Nischt, T Krieg |
Fibrogenesis & Tissue Repair | 2010 |
T regulatory cells and attenuated bleomycin-induced fibrosis in lungs of CCR7-/- mice
G Trujillo, AJ Hartigan, CM Hogaboam |
Fibrogenesis & Tissue Repair | 2010 |
Reactive response of fibrocytes to vocal fold mucosal injury in rat
C Ling, M Yamashita, J Zhang, DM Bless, NV Welham |
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society | 2010 |
Iron deposition and increased alveolar septal capillary density in nonfibrotic lung tissue are associated with pulmonary hypertension in idiopathic pulmonary fibrosis
KH Kim, F Maldonado, JH Ryu, PW Eiken, TE Hartman, BJ Bartholmai, PA Decker, ES Yi |
Respiratory Research | 2010 |
WISP1, a matricellular protein of the CCN family, is a novel mediator of pulmonary fibrosis
Melanie Königshoff, Monika Kramer, Nisha Balsara, Jochen Wilhelm, Oana Veronica Amarie, Andreas Jahn, Frank Rose, Ludger Fink, Werner Seeger, Liliana Schaefer, Andreas Günther, Oliver Eickelberg |
Journal of Clinical Investigation | 2009 |
VEGF ameliorates pulmonary hypertension through inhibition of endothelial apoptosis in experimental lung fibrosis
Laszlo Farkas, Kjetil Ask, Daniela Farkas, Antje Moeller, Jack Gauldie, Peter J. Margetts, Mark D. Inman, Martin R.J. Kolb |
Journal of Clinical Investigation | 2009 |
Antifibrotic effects of CXCL9 and its receptor CXCR3 in livers of mice and humans
HE Wasmuth, F Lammert, MM Zaldivar, R Weiskirchen, C Hellerbrand, D Scholten, ML Berres, H Zimmermann, KL Streetz, F Tacke, S Hillebrandt, P Schmitz, H Keppeler, T Berg, E Dahl, N Gassler, SL Friedman, C Trautwein |
Gastroenterology | 2009 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Cellular and molecular basis of pulmonary arterial hypertension
NW Morrell, S Adnot, SL Archer, J Dupuis, PL Jones, MR MacLean, IF McMurtry, KR Stenmark, PA Thistlethwaite, N Weissmann, JX Yuan, EK Weir |
Journal of the American College of Cardiology | 2009 |
New mechanisms of pulmonary fibrosis
RM Strieter, B Mehrad |
Chest | 2009 |
Engraftment of bone marrow-derived stem cells to the lung in a model of acute respiratory infection by Pseudomonas aeruginosa
J Rejman, C Colombo, M Conese |
Molecular Therapy | 2009 |
Pulmonary fibrosis: pathogenesis, etiology and regulation
MS Wilson, TA Wynn |
Mucosal Immunology | 2009 |
The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
RM Strieter, EC Keeley, MA Hughes, MD Burdick, B Mehrad |
Journal of leukocyte biology | 2009 |
Fibrocytes are associated with vascular and parenchymal remodelling in patients with obliterative bronchiolitis
A Andersson-Sjöland, JS Erjefält, L Bjermer, L Eriksson, G Westergren-Thorsson |
Respiratory Research | 2009 |
Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis
V Pozharskaya, E Torres-González, M Rojas, A Gal, M Amin, S Dollard, J Roman, AA Stecenko, AL Mora |
PloS one | 2009 |
Induction of the CXC Chemokine Interferon-γ-Inducible Protein 10 Regulates the Reparative Response Following Myocardial Infarction
M Bujak, M Dobaczewski, C Gonzalez-Quesada, Y Xia, T Leucker, P Zymek, V Veeranna, AM Tager, AD Luster, NG Frangogiannis |
Circulation research | 2009 |
Increased generation of fibrocytes in thyroid-associated ophthalmopathy
RS Douglas, NF Afifiyan, CJ Hwang, K Chong, U Haider, P Richards, AG Gianoukakis, TJ Smith |
The Journal of clinical endocrinology and metabolism | 2009 |
Comprehensive analysis of inflammatory immune mediators in vitreoretinal diseases
T Yoshimura, K Sonoda, M Sugahara, Y Mochizuki, H Enaida, Y Oshima, A Ueno, Y Hata, H Yoshida, T Ishibashi |
PloS one | 2009 |
Serum Albumin Concentration and Waiting List Mortality in Idiopathic Interstitial Pneumonia
DA Zisman, SM Kawut, DJ Lederer, JA Belperio, JP Lynch, MI Schwarz, JA Tayek, DB Reuben, AS Karlamangla |
Chest | 2009 |
Chemokines and cardiac fibrosis.
Dobaczewski M, Frangogiannis NG |
Frontiers in bioscience (Scholar edition) | 2009 |
Biomarker profiles in serum and saliva of experimental Sjögren's syndrome: associations with specific autoimmune manifestations
N Delaleu, H Immervoll, J Cornelius, R Jonsson |
Arthritis Research & Therapy | 2008 |
Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1
R Eferl, P Hasselblatt, M Rath, H Popper, R Zenz, V Komnenovic, MH Idarraga, L Kenner, EF Wagner |
Proceedings of the National Academy of Sciences | 2008 |
NOX enzymes as novel targets for drug development
JD Lambeth, KH Krause, RA Clark |
Seminars in Immunopathology | 2008 |
Cellular and molecular mechanisms of fibrosis
TA Wynn |
The Journal of Pathology | 2008 |
What differentiates normal lung repair and fibrosis? Inflammation, resolution of repair, and fibrosis
RM Strieter |
Proceedings of the American Thoracic Society | 2008 |
Idiopathic pulmonary fibrosis
EB Meltzer, PW Noble |
Orphanet Journal of Rare Diseases | 2008 |
Fibrogenesis of parenchymal organs
T Kisseleva, DA Brenner |
Proceedings of the American Thoracic Society | 2008 |
Viruses as co-factors for the initiation or exacerbation of lung fibrosis
KM Vannella, BB Moore |
Fibrogenesis & Tissue Repair | 2008 |
Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
K Asosingh, MA Aldred, A Vasanji, J Drazba, J Sharp, C Farver, SA Comhair, W Xu, L Licina, L Huang, B Anand-Apte, MC Yoder, RM Tuder, SC Erzurum |
The American Journal of Pathology | 2008 |
Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload
Y Xia, K Lee, N Li, D Corbett, L Mendoza, NG Frangogiannis |
Histochemistry and Cell Biology | 2008 |
Thy-1 promoter hypermethylation: a novel epigenetic pathogenic mechanism in pulmonary fibrosis
YY Sanders, A Pardo, M Selman, GJ Nuovo, TO Tollefsbol, GP Siegal, JS Hagood |
American journal of respiratory cell and molecular biology | 2008 |
Pten Inactivation Accelerates Oncogenic K-ras –Initiated Tumorigenesis in a Mouse Model of Lung Cancer
K Iwanaga, Y Yang, MG Raso, L Ma, AE Hanna, N Thilaganathan, S Moghaddam, CM Evans, H Li, WW Cai, M Sato, JD Minna, H Wu, CJ Creighton, FJ Demayo, II Wistuba, JM Kurie |
Cancer research | 2008 |
Common and Unique Mechanisms Regulate Fibrosis in Various Fibroproliferative Diseases
Thomas A. Wynn |
Journal of Clinical Investigation | 2007 |
Circulating progenitor cells in chronic lung disease
B Mehrad, MP Keane, BN Gomperts, RM Strieter |
Expert Review of Respiratory Medicine | 2007 |