JCI - Citations to Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

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Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Varman T. Samuel, … , Sanjay Bhanot, Gerald I. Shulman

Varman T. Samuel, … , Sanjay Bhanot, Gerald I. Shulman

Published March 1, 2007
Citation Information: J Clin Invest. 2007;117(3):739-745. https://doi.org/10.1172/JCI30400.

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Hepatic Steatosis as a Marker of Metabolic Dysfunction E Fabbrini, F Magkos	Nutrients	2015
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Intravenous Mycobacterium Bovis Bacillus Calmette-Guérin Ameliorates Nonalcoholic Fatty Liver Disease in Obese, Diabetic ob/ob Mice M Inafuku, G Matsuzaki, H Oku, M Makishima	PloS one	2015
3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats DF Vatner, J Snikeris, V Popov, RJ Perry, Y Rahimi, VT Samuel, C Moro	PloS one	2015
FFA-induced hepatic insulin resistance in vivo is mediated by PKC , NADPH oxidase, and oxidative stress S Pereira, E Park, Y Mori, CA Haber, P Han, T Uchida, L Stavar, AI Oprescu, K Koulajian, A Ivovic, Z Yu, D Li, TA Bowman, J Dewald, J El-Benna, DN Brindley, R Gutierrez-Juarez, TK Lam, SM Najjar, RA McKay, S Bhanot, IG Fantus, A Giacca	American journal of physiology. Endocrinology and metabolism	2014
A Role for Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) in the Regulation of Hepatic Gluconeogenesis R Stark, F Guebre-Egziabher, X Zhao, C Feriod, J Dong, TC Alves, S Ioja, RL Pongratz, S Bhanot, M Roden, GW Cline, GI Shulman, RG Kibbey	The Journal of biological chemistry	2014
Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 Diabetes AL Birkenfeld, GI Shulman	Hepatology	2014
The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes RJ Perry, VT Samuel, KF Petersen, GI Shulman	Nature	2014
Insulin Receptor Signaling in Normal and Insulin-Resistant States J Boucher, A Kleinridders, CR Kahn	Cold Spring Harbor perspectives in biology	2014
Effect of diacylglycerol acyltransferase 2 overexpression in 3T3-L1 is associated to an increase in mono-unsaturated fatty acid accumulation Z Zhang, G Shu, X Zhu, J Guo, H Cai, S Wang, L Wang, P Gao, Q Xi, Y Zhang, L Yuan, Q Jiang	Journal of Animal Science and Biotechnology	2014
Defect of insulin signal in peripheral tissues: Important role of ceramide RH Hassan, O Bourron, E Hajduch	World journal of diabetes	2014
Apolipoprotein C3 (-455T>C) polymorphism confers susceptibility to nonalcoholic fatty liver disease in the Southern Han Chinese population MR Li	World journal of gastroenterology : WJG	2014
Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance Y Rahimi, JP Camporez, MC Petersen, D Pesta, RJ Perry, MJ Jurczak, GW Cline, GI Shulman	Proceedings of the National Academy of Sciences	2014
(−)-Epicatechin mitigates high-fructose-associated insulin resistance by modulating redox signaling and endoplasmic reticulum stress A Bettaieb, MA Prieto, CR Lanzi, RM Miatello, FG Haj, CG Fraga, PI Oteiza	Free radical biology & medicine	2014
Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice AM Hall, N Soufi, KT Chambers, Z Chen, GG Schweitzer, KS McCommis, DM Erion, MJ Graham, X Su, BN Finck	Diabetes	2014
Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population TH Niu, M Jiang, YN Xin, XJ Jiang, ZH Lin, SY Xuan	World journal of gastroenterology : WJG	2014
Inputs and outputs of insulin receptor Y Du, T Wei	Protein & Cell	2014
Alimentary regimen in non-alcoholic fatty liver disease: Mediterranean diet L Abenavoli	World journal of gastroenterology : WJG	2014
Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats JL Cantley, DF Vatner, T Galbo, A Madiraju, M Petersen, RJ Perry, N Kumashiro, F Guebre-Egziabher, AK Gattu, MR Stacy, DP Dione, AJ Sinusas, L Ragolia, CE Hall, VP Manchem, S Bhanot, JS Bogan, VT Samuel	American journal of physiology. Endocrinology and metabolism	2014
Molecular Mechanisms Underlying Fasting Modulated Liver Insulin Sensitivity and Metabolism in Male Lipodystrophic Bscl2 /Seipin-Deficient Mice W Chen, H Zhou, P Saha, L Li, L Chan	Endocrinology	2014
Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance N Kumashiro, SA Beddow, DF Vatner, SK Majumdar, JL Cantley, F Guebre-Egziabher, I Fat, B Guigni, MJ Jurczak, AL Birkenfeld, M Kahn, BK Perler, MA Puchowicz, VP Manchem, S Bhanot, CD Still, GS Gerhard, KF Petersen, GW Cline, GI Shulman, VT Samuel	Diabetes	2013
Duration of rise in free fatty acids determines salicylate's effect on hepatic insulin sensitivity S Pereira, WQ Yu, ME Frigolet, JL Beaudry, Y Shpilberg, E Park, C Dirlea, BL Nyomba, MC Riddell, IG Fantus, A Giacca	Journal of Endocrinology	2013
Selective hepatic insulin resistance in a murine model heterozygous for a mitochondrial trifunctional protein defect RS Rector, EM Morris, S Ridenhour, GM Meers, FF Hsu, J Turk, JA Ibdah	Hepatology	2013
Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin MD Fullerton, S Galic, K Marcinko, S Sikkema, T Pulinilkunnil, ZP Chen, HM O'Neill, RJ Ford, R Palanivel, M O'Brien, DG Hardie, SL Macaulay, JD Schertzer, JR Dyck, BJ van Denderen, BE Kemp, GR Steinberg	Nature Medicine	2013
Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways DF Vatner, D Weismann, SA Beddow, N Kumashiro, DM Erion, XH Liao, GJ Grover, P Webb, KJ Phillips, RE Weiss, JS Bogan, J Baxter, GI Shulman, VT Samuel	American journal of physiology. Endocrinology and metabolism	2013
Nonalcoholic Fatty liver: a possible new target for type 2 diabetes prevention and treatment B Fruci, S Giuliano, A Mazza, R Malaguarnera, A Belfiore	International journal of molecular sciences	2013
Liver and diabetes. A vicious circle P Loria, A Lonardo, F Anania	Hepatology Research	2013
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo T Galbo, RJ Perry, MJ Jurczak, JP Camporez, TC Alves, M Kahn, BA Guigni, J Serr, D Zhang, S Bhanot, VT Samuel, GI Shulman	Proceedings of the National Academy of Sciences	2013
Impaired PI3 K Akt expression in liver and skeletal muscle of ovariectomized rats Y Wang, B Li, W Zhang, Y Liu, P Xue, J Ma, Y Li	Endocrine	2013
The Role of the Carbohydrate Response Element-Binding Protein in Male Fructose-Fed Rats DM Erion, V Popov, JJ Hsiao, D Vatner, K Mitchell, S Yonemitsu, Y Nagai, M Kahn, MP Gillum, J Dong, SF Murray, VP Manchem, S Bhanot, GW Cline, GI Shulman, VT Samuel	Endocrinology	2013
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance JL Cantley, T Yoshimura, JP Camporez, D Zhang, FR Jornayvaz, N Kumashiro, F Guebre-Egziabher, MJ Jurczak, M Kahn, BA Guigni, J Serr, J Hankin, RC Murphy, GW Cline, S Bhanot, VP Manchem, JM Brown, VT Samuel, GI Shulman	Proceedings of the National Academy of Sciences	2013
Lipid signals and insulin resistance C Zhang, EL Klett, RA Coleman	Clinical Lipidology	2013
The Role of INDY in Metabolic Regulation DM Willmes, AL Birkenfeld	Computational and Structural Biotechnology Journal	2013
Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype S Fayyaz, J Henkel, L Japtok, S Krämer, G Damm, D Seehofer, GP Püschel, B Kleuser	Diabetologia	2013
Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats N Kumashiro, T Yoshimura, JL Cantley, SK Majumdar, F Guebre-Egziabher, R Kursawe, DF Vatner, I Fat, M Kahn, DM Erion, XM Zhang, D Zhang, VP Manchem, S Bhanot, GS Gerhard, KF Petersen, GW Cline, VT Samuel, GI Shulman	Hepatology	2013
Reversal of Hypertriglyceridemia, Fatty Liver Disease, and Insulin Resistance by a Liver-Targeted Mitochondrial Uncoupler RJ Perry, T Kim, XM Zhang, HY Lee, D Pesta, VB Popov, D Zhang, Y Rahimi, MJ Jurczak, GW Cline, DA Spiegel, GI Shulman	Cell Metabolism	2013
Protein kinase Cε modulates insulin receptor localization and trafficking in mouse embryonic fibroblasts DJ Pedersen, B Diakanastasis, J Stöckli, C Schmitz-Peiffer	PloS one	2013
The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans Fadila Rayah, Pierre-Damien Denechaud, Maud Lemoine, Céline Robichon, Marthe Moldes, Justine Bertrand -Michel, Vlad Ratziu, Lawrence Serfaty, Chantal Housset, Jacqueline Capeau, Jean Girard, Hervé Guillou, Catherine Postic	Journal of Clinical Investigation	2012
Diacylglycerol Activation of Protein Kinase Cε and Hepatic Insulin Resistance FR Jornayvaz, GI Shulman	Cell Metabolism	2012
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 KD Copps, MF White	Diabetologia	2012
Targeted overexpression of inducible 6-phosphofructo-2-kinase in adipose tissue increases fat deposition but protects against diet-induced insulin resistance and inflammatory responses Y Huo, X Guo, H Li, H Xu, V Halim, W Zhang, H Wang, YY Fan, KT Ong, SL Woo, RS Chapkin, DG Mashek, Y Chen, H Dong, F Lu, L Wei, C Wu	The Journal of biological chemistry	2012
The inflammation highway: metabolism accelerates inflammatory traffic in obesity AR Johnson, JJ Milner, L Makowski	Immunological Reviews	2012
Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes KF Petersen, S Dufour, K Morino, PS Yoo, GW Cline, GI Shulman	Proceedings of the National Academy of Sciences	2012
Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages Z Papackova, E Palenickova, H Dankova, J Zdychova, V Skop, L Kazdova, M Cahova	Nutrition & Metabolism	2012
Localisation and composition of skeletal muscle diacylglycerol predicts insulin resistance in humans BC Bergman, DM Hunerdosse, A Kerege, MC Playdon, L Perreault	Diabetologia	2012
Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration Z Sun, RA Miller, RT Patel, J Chen, R Dhir, H Wang, D Zhang, MJ Graham, TG Unterman, GI Shulman, C Sztalryd, MJ Bennett, RS Ahima, MJ Birnbaum, MA Lazar	Nature Medicine	2012
The Increased Activity of Liver Lysosomal Lipase in Nonalcoholic Fatty Liver Disease Contributes to the Development of Hepatic Insulin Resistance M Cahova, H Dankova, E Palenickova, Z Papackova, R Komers, J Zdychova, E Sticova, L Kazdova	Biochemistry Research International	2012
Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice RM Carr, RT Patel, V Rao, R Dhir, MJ Graham, RM Crooke, RS Ahima	American Journal of Physiology - Regulatory, Integrative and Comparative Physiology	2012
Decreased Transcription of ChREBP- / Isoforms in Abdominal Subcutaneous Adipose Tissue of Obese Adolescents With Prediabetes or Early Type 2 Diabetes: Associations With Insulin Resistance and Hyperglycemia R Kursawe, S Caprio, C Giannini, D Narayan, A Lin, E D'Adamo, M Shaw, B Pierpont, SW Cushman, GI Shulman	Diabetes	2012
Foxa1 Reduces Lipid Accumulation in Human Hepatocytes and Is Down-Regulated in Nonalcoholic Fatty Liver M Moya, M Benet, C Guzmán, L Tolosa, C García-Monzón, E Pareja, JV Castell, R Jover	PloS one	2012
Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism WH Brown, MP Gillum, HY Lee, JP Camporez, X Zhang, JK Jeong, TC Alves, DM Erion, BA Guigni, M Kahn, VT Samuel, BF Cravatt, S Diano, GI Shulman	Proceedings of the National Academy of Sciences	2012
Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL/6 J mice fed a high-fat diet via fatty acid oxidation HH Jang, MY Park, HW Kim, YM Lee, KA Hwang, JH Park, DS Park, O Kwon	Nutrition & Metabolism	2012
Novel nongenomic signaling by glucocorticoid may involve changes to liver membrane order in rainbow trout L Dindia, J Murray, E Faught, TL Davis, Z Leonenko, MM Vijayan	PloS one	2012
E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia EJ Dhurandhar, R Krishnapuram, V Hegde, O Dubuisson, R Tao, XC Dong, J Ye, NV Dhurandhar	PloS one	2012
PKCd Serves as a Regulator of Hepatic Insulin Sensitivity and Risk of Hepatosteatosis in Humans and Mice Olivier Bezy, Thien T. Tran, Jussi Pihlajamäki, Ryo Suzuki, Brice Emanuelli, Jonathan Winnay, Marcelo Mori, Joel Haas, Sudha B. Biddinger, Michael Leitges, Allison Goldfine, Patti Mary Elizabeth, George King, C. Ronald Kahn	Journal of Clinical Investigation	2011
Influence of the Hepatic Eukaryotic Initiation Factor 2α (eIF2α) Endoplasmic Reticulum (ER) Stress Response Pathway on Insulin-mediated ER Stress and Hepatic and Peripheral Glucose Metabolism* AL Birkenfeld, HY Lee, S Majumdar, MJ Jurczak, JP Camporez, FR Jornayvaz, DW Frederick, B Guigni, M Kahn, D Zhang, D Weismann, AM Arafat, AF Pfeiffer, S Lieske, S Oyadomari, D Ron, VT Samuel, GI Shulman	The Journal of biological chemistry	2011
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance HY Lee, AL Birkenfeld, FR Jornayvaz, MJ Jurczak, S Kanda, V Popov, DW Frederick, D Zhang, B Guigni, KG Bharadwaj, CS Choi, IJ Goldberg, JH Park, KF Petersen, VT Samuel, GI Shulman	Hepatology	2011
Dissociation of Inositol-requiring Enzyme (IRE1α)-mediated c-Jun N-terminal Kinase Activation from Hepatic Insulin Resistance in Conditional X-box-binding Protein-1 (XBP1) Knock-out Mice* MJ Jurczak, AH Lee, FR Jornayvaz, HY Lee, AL Birkenfeld, BA Guigni, M Kahn, VT Samuel, LH Glimcher, GI Shulman	The Journal of biological chemistry	2011
Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice K Raddatz, N Turner, G Frangioudakis, BM Liao, DJ Pedersen, J Cantley, D Wilks, E Preston, BD Hegarty, M Leitges, MJ Raftery, TJ Biden, C Schmitz-Peiffer	Diabetologia	2011
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease N Kumashiro, DM Erion, D Zhang, M Kahn, SA Beddow, X Chu, CD Still, GS Gerhard, X Han, J Dziura, KF Petersen, VT Samuel, GI Shulman	Proceedings of the National Academy of Sciences	2011
The macrophage at the intersection of immunity and metabolism in obesity MC Samaan	Diabetology & metabolic syndrome	2011
Tumor Progression Locus 2 (TPL2) Regulates Obesity-Associated Inflammation and Insulin Resistance JW Perfield, Y Lee, GI Shulman, VT Samuel, MJ Jurczak, E Chang, C Xie, PN Tsichlis, MS Obin, AS Greenberg	Diabetes	2011
Hepatic steatosis does not cause insulin resistance in people with familial hypobetalipoproteinaemia ME Visser, NM Lammers, AJ Nederveen, M der Graaf, A Heerschap, MT Ackermans, HP Sauerwein, ES Stroes, MJ Serlie	Diabetologia	2011
Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2 FR Jornayvaz, AL Birkenfeld, MJ Jurczak, S Kanda, BA Guigni, DC Jiang, D Zhang, HY Lee, VT Samuel, GI Shulman	Proceedings of the National Academy of Sciences	2011
Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction DA Ghareeb, HS Hafez, HM Hussien, NF Kabapy	Metabolic Brain Disease	2011
Mammalian TOR signaling to the AGC kinases B Su, E Jacinto	Critical Reviews in Biochemistry and Molecular Biology	2011
Deletion of the Mammalian INDY Homologue Mimics Aspects of Dietary Restriction and Protects Against Adiposity and Insulin Resistance in Mice AL Birkenfeld, HY Lee, F Guebre-Egziabher, TC Alves, MJ Jurczak, FR Jornayvaz, D Zhang, JJ Hsiao, A Martin-Montalvo, A Fischer-Rosinsky, J Spranger, AF Pfeiffer, J Jordan, MF Fromm, J König, S Lieske, CM Carmean, DW Frederick, D Weismann, F Knauf, PM Irusta, RD Cabo, SL Helfand, VT Samuel, GI Shulman	Cell Metabolism	2011
Missense Mutation in APOC3 within the C-terminal Lipid Binding Domain of Human ApoC-III Results in Impaired Assembly and Secretion of Triacylglycerol-rich Very Low Density Lipoproteins W Qin, M Sundaram, Y Wang, H Zhou, S Zhong, CC Chang, S Manhas, EF Yao, RJ Parks, PJ McFie, SJ Stone, ZG Jiang, C Wang, D Figeys, W Jia, Z Yao	The Journal of biological chemistry	2011
Coordinated Defects in Hepatic Long Chain Fatty Acid Metabolism and Triglyceride Accumulation Contribute to Insulin Resistance in Non-Human Primates S Kamath, AO Chavez, A Gastaldelli, F Casiraghi, GA Halff, GA Abrahamian, AM Davalli, RA Bastarrachea, AG Comuzzie, R Guardado-Mendoza, LM Jimenez-Ceja, V Mattern, AM Paez, A Ricotti, ME Tejero, PB Higgins, IP Rodriguez-Sanchez, D Tripathy, RA DeFronzo, EJ Dick, GW Cline, F Folli	PloS one	2011
Regulation of Hepatic Fat and Glucose Oxidation in Rats with Lipid-Induced Hepatic Insulin Resistance TC Alves, DE Befroy, RG Kibbey, M Kahn, R Codella, RA Carvalho, KF Petersen, GI Shulman	Hepatology	2011
Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet JE Mells, PP Fu, S Sharma, D Olson, L Cheng, JA Handy, NK Saxena, D Sorescu, FA Anania	American journal of physiology. Gastrointestinal and liver physiology	2011
Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance FR Jornayvaz, HY Lee, MJ Jurczak, TC Alves, F Guebre-Egziabher, BA Guigni, D Zhang, VT Samuel, JE Silva, GI Shulman	Endocrinology	2011
Estrogen-related receptor γ (ERRγ) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling DK Kim, JR Kim, M Koh, YD Kim, JM Lee, D Chanda, SB Park, JJ Min, CH Lee, TS Park, HS Choi	The Journal of biological chemistry	2011
High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB E Shankar, EV Vykhovanets, OV Vykhovanets, GT Maclennan, R Singh, N Bhaskaran, S Shukla, S Gupta	The Prostate	2011
Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance D Ryu, WY Seo, YS Yoon, YN Kim, SS Kim, HJ Kim, TS Park, CS Choi, SH Koo	Diabetes	2011
Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) transgenic mice Jornayvaz FR, Jurczak MJ, Samuel VT, Shulman GI	Proceedings of the National Academy of Sciences	2011
A Common Variant in the Patatin-Like Phospholipase 3 Gene (PNPLA3) Is Associated with Fatty Liver Disease in Obese Children and Adolescents N Santoro, R Kursawe, E D'Adamo, DJ Dykas, CK Zhang, AE Bale, AM Calí, D Narayan, MM Shaw, B Pierpont, M Savoye, D Lartaud, S Eldrich, SW Cushman, H Zhao, GI Shulman, S Caprio	Hepatology	2010
Protein kinase Cbeta mediates hepatic induction of sterol-regulatory element binding protein-1c by insulin T Yamamoto, K Watanabe, N Inoue, Y Nakagawa, N Ishigaki, T Matsuzaka, Y Takeuchi, K Kobayashi, S Yatoh, A Takahashi, H Suzuki, N Yahagi, T Gotoda, N Yamada, H Shimano	Journal of lipid research	2010
The Role of Muscle Insulin Resistance in the Pathogenesis of Atherogenic Dyslipidemia and Nonalcoholic Fatty Liver Disease Associated with the Metabolic Syndrome FR Jornayvaz, VT Samuel, GI Shulman	Annual Review of Nutrition	2010
PKCδ Is Activated in a Dietary Model of Steatohepatitis and Regulates Endoplasmic Reticulum Stress and Cell Death* MW Greene, CM Burrington, MS Ruhoff, AK Johnson, T Chongkrairatanakul, A Kangwanpornsiri	The Journal of biological chemistry	2010
The role of hepatic fat accumulation in pathogenesis of non-alcoholic fatty liver disease (NAFLD) Q Liu, S Bengmark, S Qu	Lipids in Health and Disease	2010
CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance[S] JM Brown, JL Betters, C Lord, Y Ma, X Han, K Yang, HM Alger, J Melchior, J Sawyer, R Shah, MD Wilson, X Liu, MJ Graham, R Lee, R Crooke, GI Shulman, B Xue, H Shi, L Yu	Journal of lipid research	2010
Diacylglycerol-mediated insulin resistance DM Erion, GI Shulman	Nature Medicine	2010
Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms JA Chavez, SA Summers	Biochimica et Biophysica Acta	2010
Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance D Weismann, DM Erion, I Ignatova-Todorava, Y Nagai, R Stark, JJ Hsiao, C Flannery, AL Birkenfeld, T May, M Kahn, D Zhang, XX Yu, SF Murray, S Bhanot, BP Monia, GW Cline, GI Shulman, VT Samuel	Diabetologia	2010
Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease KF Petersen, S Dufour, A Hariri, C Nelson-Williams, JN Foo, XM Zhang, J Dziura, RP Lifton, GI Shulman	The New England journal of medicine	2010
Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice SM Turpin, AJ Hoy, RD Brown, CG Rudaz, J Honeyman, M Matzaris, MJ Watt	Diabetologia	2010
Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity AA Wendel, LO Li, Y Li, GW Cline, GI Shulman, RA Coleman	Diabetes	2010
A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain FR Jornayvaz, MJ Jurczak, HY Lee, AL Birkenfeld, DW Frederick, D Zhang, XM Zhang, VT Samuel, GI Shulman	American journal of physiology. Endocrinology and metabolism	2010
Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats JW Han, XR Zhan, XY Li, B Xia, YY Wang, J Zhang, BX Li	World journal of gastroenterology : WJG	2010
Resistance to High-Fat Diet-Induced Obesity and Insulin Resistance in Mice with Very Long-Chain Acyl-CoA Dehydrogenase Deficiency D Zhang, J Christianson, ZX Liu, L Tian, CS Choi, S Neschen, J Dong, PA Wood, GI Shulman	Cell Metabolism	2010
Fructose consumption: recent results and their potential implications KL Stanhope, PJ Havel	Annals of the New York Academy of Sciences	2010
Lack of association between peroxisome proliferator-activated receptors alpha and gamma2 polymorphisms and progressive liver damage in patients with non-alcoholic fatty liver disease: a case control study P Dongiovanni, R Rametta, AL Fracanzani, L Benedan, V Borroni, P Maggioni, M Maggioni, S Fargion, L Valenti	BMC Gastroenterology	2010
Early Hepatic Insulin Resistance in Mice: A Metabolomics Analysis LO Li, YF Hu, L Wang, M Mitchell, A Berger, RA Coleman	Molecular Endocrinology	2010
GRP78 inhibits SREBP-1c cleavage induced by insulin and endoplasmic reticulum stress: consequences for hepatic steatosis Hélène L. Kammoun, Hervé Chabanon, Isabelle Hainault, Serge Luquet, Christophe Magnan, Tatsuro Koike, Pascal Ferré, Fabienne Foufelle	Journal of Clinical Investigation	2009
Effects of consuming fructose- or glucose-sweetened beverages for 10 weeks on lipids, insulin sensitivity and adiposity Kimber L. Stanhope, Jean Marc Schwarz, Nancy L. Keim, Steven C. Griffen, Andrew A. Bremer, James L. Graham, Bonnie Hatcher, Artem Dyachenko, Wei Zhang, Chad L. Cox, John P. McGahan, Anthony Seibert, Ronald M. Krauss, Sally Chiu, Ernst J. Schaefer, Masumi Ai, Seiko Otokozawa, Katsuyuki Nakajima, Takamitsu Nakano, Carine Beysen, Marc K. Hellerstein, Lars Berglund, Peter J. Havel	Journal of Clinical Investigation	2009
Palmitic Acid mediates hypothalamic insulin resistance via Protein kinase-C (PKC) theta Christopher J. Kemp, Stephen C. Benoit, Carol F. Elias, William Abplanalp, , James P. Herman, Stephanie Migrenne, Anne-Laure Lefevre, Céline Cruciani-Guglielmacci, Christophe Magnan, Fang Yu, Kevin Niswender, Boman G. Irani, William L. Holland, and Deborah J. Clegg	Journal of Clinical Investigation	2009
Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein DM Erion, ID Ignatova, S Yonemitsu, Y Nagai, P Chatterjee, D Weismann, JJ Hsiao, D Zhang, T Iwasaki, R Stark, C Flannery, M Kahn, CM Carmean, XX Yu, SF Murray, S Bhanot, BP Monia, GW Cline, VT Samuel, GI Shulman	Cell Metabolism	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Molecular mechanisms involved in NAFLD progression M Malaguarnera, MD Rosa, F Nicoletti, L Malaguarnera	Journal of Molecular Medicine	2009
The immunopathogenesis of alcoholic and nonalcoholic steatohepatitis: two triggers for one disease? L Valenti, AL Fracanzani, S Fargion	Seminars in Immunopathology	2009
Diverse roles for protein kinase C δ and protein kinase C ε in the generation of high-fat-diet-induced glucose intolerance in mice: regulation of lipogenesis by protein kinase C δ G Frangioudakis, JG Burchfield, S Narasimhan, GJ Cooney, M Leitges, TJ Biden, C Schmitz-Peiffer	Diabetologia	2009
The role of mitochondria in the pathophysiology of skeletal muscle insulin resistance I Pagel-Langenickel, J Bao, L Pang, MN Sack	Endocrine reviews	2009
SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats DM Erion, S Yonemitsu, Y Nie, Y Nagai, MP Gillum, JJ Hsiao, T Iwasaki, R Stark, D Weismann, XX Yu, SF Murray, S Bhanot, BP Monia, TL Horvath, Q Gao, VT Samuel, GI Shulman	Proceedings of the National Academy of Sciences	2009
The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator-1 β in the Pathogenesis of Fructose-Induced Insulin Resistance Y Nagai, S Yonemitsu, DM Erion, T Iwasaki, R Stark, D Weismann, J Dong, D Zhang, MJ Jurczak, MG Löffler, J Cresswell, XX Yu, SF Murray, S Bhanot, BP Monia, JS Bogan, V Samuel, GI Shulman	Cell Metabolism	2009
Exercise therapy in type 2 diabetes SF Praet, LJ van Loon	Acta Diabetologica	2009
Hepatic triacylglycerol accumulation and insulin resistance CA Nagle, EL Klett, RA Coleman	Journal of lipid research	2009
A negative regulatory pathway of GLUT4 trafficking in adipocyte: new function of RIP140 in the cytoplasm via AS160 PC Ho, YW Lin, YC Tsui, P Gupta, LN Wei	Cell Metabolism	2009
Deletion of PKC Selectively Enhances the Amplifying Pathways of Glucose-Stimulated Insulin Secretion via Increased Lipolysis in Mouse -Cells J Cantley, JG Burchfield, GL Pearson, C Schmitz-Peiffer, M Leitges, TJ Biden	Diabetes	2009
Olive oil consumption and non-alcoholic fatty liver disease N Assy, F Nassar, G Nasser, M Grosovski	World journal of gastroenterology : WJG	2009
Insulin resistance due to lipid-induced signaling defects could be prevented by mahanine A Biswas, S Bhattacharya, S Dasgupta, R Kundu, SS Roy, BC Pal, S Bhattacharya	Molecular and Cellular Biochemistry	2009
Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene K Kantartzis, A Peter, F Machicao, J Machann, S Wagner, I Königsrainer, A Königsrainer, F Schick, A Fritsche, HU Häring, N Stefan	Diabetes	2009
Elovl6: a new player in fatty acid metabolism and insulin sensitivity T Matsuzaka, H Shimano	Journal of Molecular Medicine	2009
D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression C Zeng, Y Han, H Huang, C Yu, H Ren, W Shi, D He, L Huang, C Yang, X Wang, L Zhou, PA Jose	Journal of Hypertension	2009
Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: Lessons from genetically engineered mice Catherine Postic*1,2 and Jean Girard1,2	Journal of Clinical Investigation	2008
Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia H Doege, D Grimm, A Falcon, B Tsang, TA Storm, H Xu, AM Ortegon, M Kazantzis, MA Kay, A Stahl	The Journal of biological chemistry	2008
PKCepsilon plays a causal role in acute ethanol-induced steatosis JP Kaiser, JI Beier, J Zhang, JD Hoetker, C Montfort, L Guo, Y Zheng, BP Monia, A Bhatnagar, GE Arteel	Archives of Biochemistry and Biophysics	2008
Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis JJ Maher, P Leon, JC Ryan	Hepatology	2008
Inflammatory Mechanisms in the Regulation of Insulin Resistance H Tilg, AR Moschen	Molecular Medicine	2008
Protein Kinase C Function in Muscle, Liver, and -Cells and Its Therapeutic Implications for Type 2 Diabetes C Schmitz-Peiffer, TJ Biden	Diabetes	2008
Pck1 Gene Silencing in the Liver Improves Glycemia Control, Insulin Sensitivity, and Dyslipidemia in db/db Mice AG Gomez-Valades, A Mendez-Lucas, A Vidal-Alabro, FX Blasco, M Chillon, R Bartrons, J Bermudez, JC Perales	Diabetes	2008
Inhibition of ADRP prevents diet-induced insulin resistance GM Varela, DA Antwi, R Dhir, X Yin, NS Singhal, MJ Graham, RM Crooke, RS Ahima	American journal of physiology. Gastrointestinal and liver physiology	2008
Ectopic fat and insulin resistance A Lettner, M Roden	Current Diabetes Reports	2008
Mechanism by Which Overexpression of Uncoupling Protein 3 in Skeletal Muscle Protects Against Fat-Induced Insulin Resistance Cheol Soo Choi, Jonathan J. Fillmore, Jason K. Kim, Zhen-Xiang Liu, Sheene Kim, Emily F. Collier, Ameya Kulkarni, Alberto Distefano, Yu-Jin Hwang, Mario Kahn, Yan Chen, Chunli Yu, Irene K. Moore, Richard M. Reznick, Takamasa Higashimori, Gerald I. Shulman	Journal of Clinical Investigation	2007
Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance D Zhang, ZX Liu, CS Choi, L Tian, R Kibbey, J Dong, GW Cline, PA Wood, GI Shulman	Proceedings of the National Academy of Sciences	2007
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance CA Nagle, J An, M Shiota, TP Torres, GW Cline, ZX Liu, S Wang, RL Catlin, GI Shulman, CB Newgard, RA Coleman	The Journal of biological chemistry	2007
The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome KF Petersen, S Dufour, DB Savage, S Bilz, G Solomon, S Yonemitsu, GW Cline, D Befroy, L Zemany, BB Kahn, X Papademetris, DL Rothman, GI Shulman	Proceedings of the National Academy of Sciences	2007
Benefits of lifestyle modification in NAFLD SA Harrison, CP Day	Gut	2007
Continuous fat oxidation in acetyl CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity CS Choi, DB Savage, L Abu-Elheiga, ZX Liu, S Kim, A Kulkarni, A Distefano, YJ Hwang, RM Reznick, R Codella, D Zhang, GW Cline, SJ Wakil, GI Shulman	Proceedings of the National Academy of Sciences	2007
Metabolic stress signaling mediated by mixed-lineage kinases A Jaeschke, RJ Davis	Molecular Cell	2007
Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance M Adiels, J Westerbacka, A Soro-Paavonen, AM Häkkinen, S Vehkavaara, MJ Caslake, C Packard, SO Olofsson, H Yki-Järvinen, MR Taskinen, J Borén	Diabetologia	2007

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