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Citations to this article

Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis.
F J Gomez, … , R Allendoerfer, G S Deepe Jr
F J Gomez, … , R Allendoerfer, G S Deepe Jr
Published September 1, 1998
Citation Information: J Clin Invest. 1998;102(5):984-995. https://doi.org/10.1172/JCI2963.
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Research Article

Vbeta4(+) T cells promote clearance of infection in murine pulmonary histoplasmosis.

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Abstract

T cells are essential for controlling infection with Histoplasma capsulatum. Because the T cell receptor is vital for transducing the biological activities of these cells, we sought to determine if exposure to this fungus induced an alteration in the Vbeta repertoire in lungs of C57BL/6 mice infected intranasally. Vbeta2(+) cells were elevated on day 3 after infection; Vbeta4(+) cells were higher than controls on days 7, 10, and 14 after infection. Vbeta10(+) cells were increased on days 14 and 21, and Vbeta11(+) exceeded controls only on day 14. We investigated the clonality and function of Vbeta4(+) cells because their expansion transpired during the critical time of infection, that is, when cellular immunity is activated. Sequence analysis demonstrated preferential use of a restricted set of sequences in the complementarity-determining region 3. Elimination of Vbeta4(+) cells from mice impaired their ability to resolve infection. In contrast, depletion of Vbeta7(+) cells, the abundance of which was similar to that of Vbeta4(+), did not alter elimination of the fungus. The identification of clonotypes of Vbeta4(+) cells suggests that a few antigenic determinants may drive proliferation of this subset, which is necessary for optimal clearance.

Authors

F J Gomez, J A Cain, R Gibbons, R Allendoerfer, G S Deepe Jr

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Total citations by year

Year: 2017 2013 2011 2008 2007 2006 2005 2004 2003 2002 2001 2000 Total
Citations: 1 1 2 2 2 3 2 1 1 2 4 1 22
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2007 (2)

Title and authors Publication Year
Vβ1 + Jβ1.1 + /Vα2 + Jα49 + CD4 + T Cells Mediate Resistance against Infection with Blastomyces dermatitidis
M Wüthrich, HI Filutowicz, HL Allen, GS Deepe, BS Klein
Infection and immunity 2007
Immunology of Fungal Infections
GD Brown, MG Netea
2007

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