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Citations to this article

Prophylactic human papillomavirus vaccines
Douglas R. Lowy, John T. Schiller
Douglas R. Lowy, John T. Schiller
Published May 1, 2006
Citation Information: J Clin Invest. 2006;116(5):1167-1173. https://doi.org/10.1172/JCI28607.
View: Text | PDF
Review Series Article has an altmetric score of 68

Prophylactic human papillomavirus vaccines

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Abstract

Human papillomavirus (HPV) infection causes virtually all cases of cervical cancer, the second most common cause of death from cancer among women worldwide. This Review examines prophylactic HPV subunit vaccines based on the ability of the viral L1 capsid protein to form virus-like particles (VLPs) that induce high levels of neutralizing antibodies. Following preclinical research by laboratories in the nonprofit sector, Merck and GlaxoSmithKline are developing commercial versions of the vaccine. Both vaccines target HPV16 and HPV18, which account for approximately 70% of cervical cancer. The Merck vaccine also targets HPV6 and HPV11, which account for approximately 90% of external genital warts. The vaccines have an excellent safety profile, are highly immunogenic, and have conferred complete type-specific protection against persistent infection and associated lesions in fully vaccinated women. Unresolved issues include the most critical groups to vaccinate and when the vaccine’s cost may be low enough for widespread implementation in the developing world, where 80% of cervical cancer occurs.

Authors

Douglas R. Lowy, John T. Schiller

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 1989 Total
Citations: 5 6 3 3 11 13 4 9 8 15 12 17 11 20 14 15 25 24 35 10 1 261
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2022 (3)

Title and authors Publication Year
Adenovirus-based vaccines—a platform for pandemic preparedness against emerging viral pathogens
L Coughlan, E Kremer, D Shayakhmetov
Molecular Therapy 2022
Development of Peptide-Based Vaccines for Cancer
N Abd-Aziz, C Poh, X Ding
Journal of Oncology 2022
Emerging Trends in Immunotherapy for Cancer
Mishra AK, Ali A, Dutta S, Banday S, Malonia SK
Diseases 2022

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ISSN: 0021-9738 (print), 1558-8238 (online)

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