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Citations to this article

T cell control in autoimmune bullous skin disorders
Michael Hertl, … , Rüdiger Eming, Christian Veldman
Michael Hertl, … , Rüdiger Eming, Christian Veldman
Published May 1, 2006
Citation Information: J Clin Invest. 2006;116(5):1159-1166. https://doi.org/10.1172/JCI28547.
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T cell control in autoimmune bullous skin disorders

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Abstract

Autoimmune bullous disorders are a group of severe skin diseases characterized clinically by blisters and erosions of skin and/or mucous membranes. A hallmark of these disorders is the presence of IgG and occasionally IgA autoantibodies that target distinct adhesion structures of the epidermis, dermoepidermal basement membrane, and anchoring fibrils of the dermis. This Review focuses on the potential role of autoreactive T cells in the pathogenesis of these disorders. Pemphigus vulgaris (PV) and bullous pemphigoid (BP) are the best-characterized bullous disorders with regard to pathogenesis and T cell involvement. Activation of autoreactive T cells in PV and BP is restricted by distinct HLA class II alleles that are prevalent in individuals with these disorders. Autoreactive T cells are not only present in patients but can also be detected in healthy individuals. Recently, a subset of autoreactive T cells with remarkable regulatory function was identified in healthy individuals and to a much lesser extent in patients with PV, suggesting that the occurrence of autoimmune bullous disorders may be linked to a dysfunction of Tregs.

Authors

Michael Hertl, Rüdiger Eming, Christian Veldman

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A Perspective of Pemphigus from Bedside and Laboratory-Bench
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Clinical Reviews in Allergy & Immunology 2007
Pemphigus: A Complex T Cell-dependent Autoimmune Disorder Leading to Acantholysis
C Veldman, C Feliciani
Clinical Reviews in Allergy & Immunology 2007
A new passive transfer animal model of bullous pemphigoid
AM Powell
Expert Review of Dermatology 2007
Experimental models of epidermolysis bullosa acquisita
C Sitaru
Experimental Dermatology 2007
The CD40/CD40 ligand system is involved in the pathogenesis of pemphigus
M Caproni, E Antiga, D Torchia, W Volpi, E Bianco, A Cappetti, C Feliciani, P Fabbri
Clinical Immunology 2007
Detection of low avidity desmoglein 3-reactive T cells in pemphigus vulgaris using HLA-DRβ1⁎0402 tetramers
C Veldman, R Eming, S Wolff-Franke, G Sonderstrup, WW Kwok, M Hertl
Clinical Immunology 2007
Genotyping of HLA-I and HLA-II alleles in Chinese patients with paraneoplastic pemphigus
Q Liu, DF Bu, D Li, XJ Zhu
British Journal of Dermatology 2007
Variations in Serum Hemoglobin, Albumin, and Electrolytes in Patients Receiving Intravenous Immunoglobulin Therapy
MD Mignogna, G Fortuna, E Ruoppo, D Adamo, S Leuci, S Fedele
American Journal of Clinical Dermatology 2007
Pemphigus vulgaire évolutif sous corticoïdes et immunosuppresseurs: rémission sous rituximab. Deux observations
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La Revue de Médecine Interne 2007
Increased Serum Levels of Circulating CD40 Ligand in Patients with Bullous Pemphigoid: Preliminary Results
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Dermatology 2007
Epidermolysis Bullosa Acquisita following Bullous Pemphigoid, Successfully Treated with the Anti-CD20 Monoclonal Antibody Rituximab
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Dermatology 2007
Biologics in General Medicine
WH Boehncke, HH Radeke
2007
Nothing but skin and bone
FP Ross, AM Christiano
Journal of Clinical Investigation 2006
Are desmoglein autoantibodies essential for the immunopathogenesis of pemphigus vulgaris, or just ‘witnesses of disease'?
R Paus, M Amagai, AR Ahmed, Y Kitajima, JC Bystryn, Y Milner, R Gniadecki, M Hertl, C Pincelli, M Fridkis-Hareli, Y Aoyama, M Frušić-Zlotkin, E Müller, M David, D Mimouni, D Vind-Kezunovic, B Michel, M Mahoney, S Grando
Experimental Dermatology 2006
Commentary 3
M Hertl
Experimental Dermatology 2006
Who is really in control of skin immunity underphysiologicalcircumstances - lymphocytes, dendritic cells or keratinocytes?
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Experimental Dermatology 2006
Autoimmune Diseases of the Skin
M Hertl
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Bullous pemphigoid
D Mimouni, HC Nousari
Dermatologic Therapy 2002
Pruritus
J Martin
International Journal of Dermatology 1985

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