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Sunita R. Patel, … , John H. Hartwig, Joseph E. Italiano Jr.
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3348-3354. https://doi.org/10.1172/JCI26891.
Citation Information: J Clin Invest. 2005;115(12):3348-3354. https://doi.org/10.1172/JCI26891.
Abstract
Platelets are formed and released into the bloodstream by precursor cells called megakaryocytes that reside within the bone marrow. The production of platelets by megakaryocytes requires an intricate series of remodeling events that result in the release of thousands of platelets from a single megakaryocyte. Abnormalities in this process can result in clinically significant disorders. Thrombocytopenia (platelet counts less than 150,000/μl) can lead to inadequate clot formation and increased risk of bleeding, while thrombocythemia (platelet counts greater than 600,000/μl) can heighten the risk for thrombotic events, including stroke, peripheral ischemia, and myocardial infarction. This Review will describe the process of platelet assembly in detail and discuss several disorders that affect platelet production.
Authors
Sunita R. Patel, John H. Hartwig, Joseph E. Italiano Jr.
Total citations by year
Citation information
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CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1
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Blood Cancer Journal | 2019 |
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Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions
A Korniluk, OM Koper-Lenkiewicz, J Kamińska, H Kemona, V Dymicka-Piekarska |
Mediators of Inflammation | 2019 |
|
The cytoskeletal crosslinking protein MACF1 is dispensable for thrombus formation and hemostasis
Y Schurr, M Spindler, H Kurz, M Bender |
Scientific Reports | 2019 |
|
Platelet-Rich Plasma: Principles and Applications in Plastic Surgery
A Abu-Ghname, AT Perdanasari, MJ Davis, EM Reece |
Seminars in plastic surgery | 2019 |
|
Previews
SP Atkinson |
Stem Cells Translational Medicine | 2019 |
|
Kinetics of mean platelet volume predicts mortality in patients with septic shock
F Vardon-Bounes, MP Gratacap, S Groyer, S Ruiz, B Georges, T Seguin, C Garcia, B Payrastre, JM Conil, V Minville, M Crivellari |
PloS one | 2019 |
|
Induction of differentiation of human stem cells ex vivo : Toward large-scale platelet production
XH Lei, YQ Yang, CY Ma, EK Duan |
World journal of stem cells | 2019 |
|
Inorganic Polyphosphates As Storage for and Generator of Metabolic Energy in the Extracellular Matrix
WE Müller, HC Schröder, X Wang |
Chemical Reviews | 2019 |
|
Dynamics of Platelet Behaviors as Defenders and Guardians: Accumulations in Liver, Lung, and Spleen in Mice
Z Yu, M Shibazaki, H Otsuka, H Takada, M Nakamura, Y Endo |
Biological & Pharmaceutical Bulletin | 2019 |
|
Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression
W Zheng, H Zhang, D Zhao, J Zhang, JW Pollard |
Cell Reports | 2019 |
|
Mimicking megakaryopoiesis in vitro using biomaterials: Recent advances and future opportunities
G Ingavle, N Shabrani, A Vaidya, V Kale |
Acta Biomaterialia | 2019 |
|
Biomarkers of platelet dysfunction in non-clinical safety studies and humans
JD Smith, P Narayanan, N Li |
Current Opinion in Toxicology | 2019 |
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Development and validation of novel LC–MS/MS method for determination of Lusutrombopag in rat plasma and its application to pharmacokinetic studies
N Singh, P Bansal, M Maithani, Y Chauhan |
Arabian Journal of Chemistry | 2019 |
|
Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity
PK Suraneni, SJ Corey, MJ Hession, R Ishaq, A Awomolo, S Hasan, C Shah, H Liu, A Wickrema, N Debili, JD Crispino, EA Eklund, Y Chen |
Blood Advances | 2018 |
|
Inherited Macrothrombocytopenia: Correlating Morphology, Epidemiology, Molecular Pathology and Clinical Features
K Ghosh, M Bhattacharya, R Chowdhury, K Mishra, M Ghosh |
Indian Journal of Hematology and Blood Transfusion | 2018 |
|
On the Way to in vitro Platelet Production
C Strassel, C Gachet, F Lanza |
Frontiers in Medicine | 2018 |
|
Toward the Relevance of Platelet Subpopulations for Transfusion Medicine
S Handtke, L Steil, A Greinacher, T Thiele |
Frontiers in Medicine | 2018 |
|
D-dencichine Regulates Thrombopoiesis by Promoting Megakaryocyte Adhesion, Migration and Proplatelet Formation
S Ding, M Wang, S Fang, H Xu, H Fan, Y Tian, Y Zhai, S Lu, X Qi, F Wei, G Sun, X Sun |
Frontiers in pharmacology | 2018 |
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Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels
E Brown, LM Carlin, C Nerlov, CL Celso, AW Poole |
2018 | |
|
Sub-Cellular Localization of Metalloproteinases in Megakaryocytes
A Malara, D Ligi, CD Buduo, F Mannello, A Balduini |
Cells | 2018 |
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Delayed increase of thrombocyte levels after a single sub-anesthetic dose of ketamine – A randomized trial
L Colic, M Woelfer, M Colic, AL Leutritz, T Liebe, L Fensky, ZD Sen, M Li, J Hoffmann, MA Kretzschmar, B Isermann, M Walter |
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology | 2018 |
|
In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells
P Vijey, B Posorske, KR Machlus |
Platelets | 2018 |
|
From blood coagulation to innate and adaptive immunity: the role of platelets in the physiology and pathology of autoimmune disorders
ZM Łukasik, M Makowski, JS Makowska |
Rheumatology International | 2018 |
|
A β1-tubulin–based megakaryocyte maturation reporter system identifies novel drugs that promote platelet production
H Seo, SJ Chen, K Hashimoto, H Endo, Y Nishi, A Ohta, T Yamamoto, A Hotta, A Sawaguchi, H Hayashi, N Koseki, GJ Murphy, K Fukuda, N Sugimoto, K Eto |
Blood Advances | 2018 |
|
Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment
R Li, Y He, S Zhang, J Qin, J Wang |
Acta pharmaceutica Sinica. B | 2018 |
|
Inherited platelet disorders : Management of the bleeding risk
A Dupuis, C Gachet |
Transfusion Clinique et Biologique | 2018 |
|
Blood Cell Proteomics in Chronic Kidney Disease
M Bonomini, L Pieroni, M Ronci, V Sirolli, A Urbani |
The Open Urology & Nephrology Journal | 2018 |
|
Mutations in Tropomyosin-4 underlie a novel form of human macrothrombocytopenia
Pleines Irina, Joanne Woods, Stephane Chappaz, Verity Kew, Nicola Foad, Jose Ballester-Beltran, Katja Aurbach, Chiara Lincetto, Rachael M. Lane, Galina Schevzov, Warren Alexander, Douglas Hilton, William Astle, Kate Downes, Paquita Nurden, Sarah Westbury, Andrew Mumford, Samya Obaji, Peter Collins, NIHR BioResource, Fabien Delerue, Lars Ittner, Nicole Bryce, Mira Holliday, Christine Lucas, Edna Hardeman, Willem Ouwehand, Peter Gunning, Ernest Turro, Marloes Tijssen, Benjamin T. Kile |
Journal of Clinical Investigation | 2017 |
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CK2β critically regulates thrombopoiesis and Ca 2+ -triggered platelet activation in arterial thrombosis in vivo
P Münzer, B Walker-Allgaier, S Geue, F Langhauser, E Geuss, D Stegner, K Aurbach, D Semeniak, M Chatterjee, IG Menendez, M Märklin, L Quintanilla-Martinez, HR Salih, DW Litchfield, T Buchou, C Kleinschnitz, F Lang, B Nieswandt, I Pleines, H Schulze, M Gawaz, O Borst |
Blood | 2017 |
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A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis
S Dütting, F Gaits-Iacovoni, D Stegner, M Popp, A Antkowiak, JM van Eeuwijk, P Nurden, S Stritt, T Heib, K Aurbach, O Angay, D Cherpokova, N Heinz, AA Baig, MG Gorelashvili, F Gerner, KG Heinze, J Ware, G Krohne, ZM Ruggeri, AT Nurden, H Schulze, U Modlich, I Pleines, C Brakebusch, B Nieswandt |
Nature Communications | 2017 |
|
Platelets as crucial partners for tumor metastasis: from mechanistic aspects to pharmacological targeting
A Contursi, A Sacco, R Grande, M Dovizio, P Patrignani |
Cellular and Molecular Life Sciences | 2017 |
|
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
E Lefrançais, G Ortiz-Muñoz, A Caudrillier, B Mallavia, F Liu, DM Sayah, EE Thornton, MB Headley, T David, SR Coughlin, MF Krummel, AD Leavitt, E Passegué, MR Looney |
Nature | 2017 |
|
Platelet dense granules begin to selectively accumulate mepacrine during proplatelet formation
HA Hanby, J Bao, JY Noh, D Jarocha, M Poncz, MJ Weiss, MS Marks |
Blood Advances | 2017 |
|
Thrombopoiesis is spatially regulated by the bone marrow vasculature
D Stegner, JM vanEeuwijk, O Angay, MG Gorelashvili, D Semeniak, J Pinnecker, P Schmithausen, I Meyer, M Friedrich, S Dütting, C Brede, A Beilhack, H Schulze, B Nieswandt, KG Heinze |
Nature Communications | 2017 |
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Nbeal2 interacts with Dock7, Sec16a, and Vac14
L Mayer, M Jasztal, M Pardo, SA de Haro, J Collins, TK Bariana, PA Smethurst, L Grassi, R Petersen, P Nurden, R Favier, L Yu, S Meacham, WJ Astle, J Choudhary, WW Yue, WH Ouwehand, JA Guerrero |
Blood | 2017 |
|
Role of flavonoids and nitrates in cardiovascular health
JA Lovegrove, A Stainer, DA Hobbs |
Proceedings of the Nutrition Society | 2017 |
|
p38 mitogen-activated protein kinase regulates mitochondrial function and microvesicle release in riboflavin- and ultraviolet light-treated apheresis platelet concentrates: PI IMPACTS MITOCHONDRIAL FUNCTION AND RELEASE
Z Chen, P Schubert, S Bakkour, B Culibrk, MP Busch, DV Devine |
Transfusion | 2017 |
|
LiCl regulates mitochondrial biogenesis during megakaryocyte development
RB Undi, U Gutti, RK Gutti |
Journal of Trace Elements in Medicine and Biology | 2017 |
|
Effect of radiation-induced endothelial cell injury on platelet regeneration by megakaryocytes
F Chen, M Shen, D Zeng, C Wang, S Wang, S Chen, Y Tang, M Hu, M Chen, Y Su, X Ran, Y Xu, J Wang |
Journal of Radiation Research | 2017 |
|
The role of RNA uptake in platelet heterogeneity:
L Clancy, LM Beaulieu, K Tanriverdi, JE Freedman |
Thrombosis and Haemostasis | 2017 |
|
Structure-dependent behaviours of skin layers studied by atomic force microscopy: STRUCTURE-DEPENDENT BEHAVIOURS OF SKIN LAYERS
A Chang, B Liu, P Shao, J Liao |
Journal of Microscopy | 2017 |
|
Intersecting Worlds of Transfusion and Transplantation Medicine: An International Symposium organized by the Canadian Blood Services Centre for Innovation
KM Hodgkinson, J Kiernan, AW Shih, Z Solh, WP Sheffield, N Pineault |
Transfusion Medicine Reviews | 2017 |
|
Pattern formation in a nonlocal mathematical model for the multiple roles of the TGF- β pathway in tumour dynamics
R Eftimie, M Perez, PL Buono |
Mathematical Biosciences | 2017 |
|
The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis
K Ntelis, EE Solomou, L Sakkas, SN Liossis, D Daoussis |
Seminars in Arthritis and Rheumatism | 2017 |
|
Modeling thrombus formation and growth: Modeling Thrombus Formation and Growth
H Hosseinzadegan, DK Tafti |
Biotechnology and Bioengineering | 2017 |
|
Platelets as a surrogate disease model of neurodevelopmental disorders: Insights from Fragile X Syndrome
D Pellerin, A Lortie, F Corbin |
Platelets | 2017 |
|
Quantification of Cardiovascular Disease Biomarkers in Human Platelets by Targeted Mass Spectrometry
S Malchow, C Loosse, A Sickmann, C Lorenz |
Proteomes | 2017 |
|
Endothelial-to-Mesenchymal Transition in Bone Marrow and Spleen of Primary Myelofibrosis
BG Erba, C Gruppi, M Corada, F Pisati, V Rosti, N Bartalucci, JL Villeval, AM Vannucchi, G Barosi, A Balduini, E Dejana |
The American Journal of Pathology | 2017 |
|
Platelet pathophysiology, pharmacology, and function in coronary artery disease:
H Ibrahim, NS Kleiman |
Coronary Artery Disease | 2017 |
|
Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau
T Shimizu, C Uchida, R Shimizu, H Motohashi, T Uchida |
Biochemical and Biophysical Research Communications | 2017 |
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Differential expression of CD42b and CD9 proteins in platelets and extracellular membrane vesicles during platelet-concentrate storage
VV Kishenko, KA Kondratov, MV Belyakova, VY Mikhailovskii, SV Sidorkevich, TV Vavilova, AV Fedorov, OV Sirotkina |
Cell and Tissue Biology | 2017 |
|
MEGAKARYOCYTIC ALTERATION IN CASES OF THROMBOCYTOPENIA- A BONE MARROW ASPIRATION STUDY
P Kutum, RS Laishram, KA Devi, MY Ali, TR Chanamthabam, P Das, S Parveen |
2017 | |
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A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss
S Stritt, P Nurden, E Turro, D Greene, SB Jansen, SK Westbury, R Petersen, WJ Astle, S Marlin, TK Bariana, M Kostadima, C Lentaigne, S Maiwald, S Papadia, AM Kelly, JC Stephens, CJ Penkett, S Ashford, S Tuna, S Austin, T Bakchoul, P Collins, R Favier, MP Lambert, M Mathias, CM Millar, R Mapeta, DJ Perry, S Schulman, I Simeoni, C Thys, K Gomez, WN Erber, K Stirrups, A Rendon, JR Bradley, C Geet, FL Raymond, MA Laffan, AT Nurden, B Nieswandt, S Richardson, K Freson, WH Ouwehand, AD Mumford |
Blood | 2016 |
|
Linkage between the mechanisms of thrombocytopenia and thrombopoiesis
K Eto, S Kunishima |
Blood | 2016 |
|
Bcl-2 proteins in development, health, and disease of the hematopoietic system
M Kollek, A Müller, A Egle, M Erlacher |
FEBS Journal | 2016 |
|
Megakaryocyte- and megakaryocyte precursor-related gene therapies
DA Wilcox |
Blood | 2016 |
|
Increased expression of transient receptor potential canonical 6 (TRPC6) in differentiating human megakaryocytes: TRPC6 in megakaryocytes
G Ramanathan, C Mannhalter |
Cell Biology International | 2016 |
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Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol IsomerasesHighlights
M Crescente, FG Pluthero, L Li, RW Lo, TG Walsh, MP Schenk, LM Holbrook, S Louriero, MS Ali, S Vaiyapuri, H Falet, IM Jones, AW Poole, WH Kahr, JM Gibbins |
Arteriosclerosis, thrombosis, and vascular biology | 2016 |
|
Abnormal proplatelet formation and emperipolesis in cultured human megakaryocytes from gray platelet syndrome patients
CA di Buduo, MA Alberelli, AC Glembostky, G Podda, PR Lev, M Cattaneo, R Landolfi, PG Heller, A Balduini, ED Candia |
Scientific Reports | 2016 |
|
Platelet WDR1 suppresses platelet activity and associates with cardiovascular disease
E Montenont, C Echagarruga, N Allen, E Araldi, Y Suarez, JS Berger |
Blood | 2016 |
|
Vascular Responses to Pathogens
S Babu, TB Nutman |
Vascular Responses to Pathogens | 2016 |
|
Hyaluronan Depolymerization by Megakaryocyte Hyaluronidase-2 Is Required for Thrombopoiesis
AC Petrey, DR Obery, SP Kessler, B Flamion, CA de la Motte |
The American Journal of Pathology | 2016 |
|
Noninvasive low-level laser therapy for thrombocytopenia
Q Zhang, T Dong, P Li, MX Wu |
Science Translational Medicine | 2016 |
|
Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis?
II Oz, M Yucel, M Bilici, İ Şerifoğlu, R Sayın, SU Ilikhan, M Acıkgoz |
Journal of Stroke and Cerebrovascular Diseases | 2016 |
|
Proplatelet formation in megakaryocytes is associated with endoplasmic reticulum stress
N Morishima, K Nakanishi |
Genes to Cells | 2016 |
|
Nuclear morphologies: their diversity and functional relevance
BM Skinner, EE Johnson |
Chromosoma | 2016 |
|
Antipsychotic Drugs Inhibit Platelet Aggregation via P2Y 1 and P2Y 12 Receptors
CC Wu, FM Tsai, ML Chen, S Wu, MC Lee, TC Tsai, LK Wang, CH Wang |
BioMed Research International | 2016 |
|
Platelet proteomics applied to the search for novel antiplatelet therapeutic targets
I Izquierdo, Á García |
Expert Review of Proteomics | 2016 |
|
Molecular and Cellular Biology of Platelet Formation
H Schulze, J Italiano |
Molecular and Cellular Biology of Platelet Formation | 2016 |
|
Direct Conversion of Fibroblasts to Megakaryocyte Progenitors
J Pulecio, O Alejo-Valle, S Capellera-Garcia, M Vitaloni, P Rio, E Mejía-Ramírez, I Caserta, JA Bueren, J Flygare, A Raya |
Cell Reports | 2016 |
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Extension of the clinical and molecular phenotype of DIAPH1 -associated autosomal dominant hearing loss ( DFNA1 ): Clinical and molecular phenotype of DIAPH1 -associated autosomal dominant hearing loss
C Neuhaus, R Lang-Roth, U Zimmermann, R Heller, T Eisenberger, M Weikert, S Markus, M Knipper, HJ Bolz |
Clinical Genetics | 2016 |
|
Dawning of the age of genomics for platelet granule disorders: improving insight, diagnosis and management
TK Bariana, WH Ouwehand, JA Guerrero, K Gomez |
British Journal of Haematology | 2016 |
|
Platelet disorders due to genetic defects in megakaryopoiesis and thrombopoiesis
S KUNISHIMA |
Japanese Journal of Thrombosis and Hemostasis | 2016 |
|
Aged garlic extract suppresses platelet aggregation by changing the functional property of platelets
N Morihara, A Hino |
Journal of Natural Medicines | 2016 |
|
IL-1 induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs
S Nishimura, M Nagasaki, S Kunishima, A Sawaguchi, A Sakata, H Sakaguchi, T Ohmori, I Manabe, JE Italiano, T Ryu, N Takayama, I Komuro, T Kadowaki, K Eto, R Nagai |
The Journal of Cell Biology | 2015 |
|
Manipulating megakaryocytes to manufacture platelets ex vivo
P Karagiannis, K Eto |
Journal of Thrombosis and Haemostasis | 2015 |
|
Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation
Tianyu Guo, Xuejun Wang, Yigong Qu, Yu Yin, Tao Jing, Qing Zhang |
Stem Cell Investigation | 2015 |
|
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1
ML Kim, JJ Chae, YH Park, DD Nardo, RA Stirzaker, HJ Ko, H Tye, L Cengia, L DiRago, D Metcalf, AW Roberts, DL Kastner, AM Lew, D Lyras, BT Kile, BA Croker, SL Masters |
Journal of Experimental Medicine | 2015 |
|
Developing a co-culture system for effective megakaryo/thrombopoiesis from umbilical cord blood hematopoietic stem/progenitor cells
J Hatami, PZ Andrade, AP de Matos, D Djokovic, C Lilaia, FC Ferreira, JM Cabral, CL da Silva |
Cytotherapy | 2015 |
|
Immune thrombocytopenia: antiplatelet autoantibodies inhibit proplatelet formation by megakaryocytes and impair platelet production in vitro
M Iraqi, J Perdomo, F Yan, PY Choi, BH Chong |
Haematologica | 2015 |
|
Regulation of actin polymerization by tropomodulin-3 controls megakaryocyte actin organization and platelet biogenesis
Z Sui, RB Nowak, C Sanada, S Halene, DS Krause, VM Fowler |
Blood | 2015 |
|
Recruitment of CD8+ T cells into bone marrow might explain the suppression of megakaryocyte apoptosis through high expression of CX3CR1+ in prolonged isolated thrombocytopenia after allogeneic hematopoietic stem cell transplantation
XH Zhang, GX Wang, HH Zhu, YR Liu, LP Xu, W Han, H Chen, YH Chen, FR Wang, JZ Wang, Y Wang, T Zhao, Y Chen, R Feng, HX Fu, M Wang, Y Zhou, M Lv, KY Liu, XJ Huang |
Annals of Hematology | 2015 |
|
Apoptosis: role in myeloid cell development
S Sarvothaman, RB Undi, SR Pasupuleti, U Gutti, RK Gutti |
Blood Research | 2015 |
|
Phytochemicals as potential therapeutics for thrombocytopenia
K Manasa, R Soumya, R Vani |
Journal of Thrombosis and Thrombolysis | 2015 |
|
Stem cell autotomy and niche interaction in different systems
DC Dorn |
World journal of stem cells | 2015 |
|
Micro-concentration Lipopolysaccharide as a Novel Stimulator of Megakaryocytopoiesis that Synergizes with IL-6 for Platelet Production
D Wu, J Xie, X Wang, B Zou, Y Yu, T Jing, S Zhang, Q Zhang |
Scientific Reports | 2015 |
|
Microparticle of drug and nanoparticle: a biosynthetic route
S Sarkar, AK Dasgupta |
Pharmacology Research & Perspectives | 2015 |
|
Chlorpromazine-Induced Changes in Membrane Micro-Architecture Inhibit Thrombopoiesis in Rat Megakaryocytes
I Kazama, Y Endo, H Toyama, Y Ejima, M Matsubara, A Baba, M Tachi |
Biochimica et Biophysica Acta (BBA) - Biomembranes | 2015 |
|
A biochemical and mechanical model of injury-induced intimal thickening
PW Fok, R Sanft |
Mathematical Medicine and Biology | 2015 |
|
Expandable Megakaryocyte Cell Lines Enable Clinically Applicable Generation of Platelets from Human Induced Pluripotent Stem Cells
S Nakamura, N Takayama, S Hirata, H Seo, H Endo, K Ochi, K Fujita, T Koike, K Harimoto, T Dohda, A Watanabe, K Okita, N Takahashi, A Sawaguchi, S Yamanaka, H Nakauchi, S Nishimura, K Eto |
Cell Stem Cell | 2014 |
|
Platelet bioreactor-on-a-chip
Jonathan N Thon, Linas Mazutis, Stephen Wu, Joanna L Sylman, Allen Ehrlicher, Kellie R Machlus, Qiang Feng, Shijiang Lu, Robert Lanza, Keith B Neeves, David A Weitz, Joseph E Italiano Jr |
Blood | 2014 |
|
Platelets and Infection – An Emerging Role of Platelets in Viral Infection
A Assinger |
Frontiers in immunology | 2014 |
|
Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation
KR Machlus, JN Thon, JE Italiano |
British Journal of Haematology | 2014 |
|
Serum Thrombopoietin and cMpl Expression in Thrombocytopenia of Different Etiologies
F Vianello, S Vettore, F Tezza, LD Toni, R Scandellari, L Sambado, M Treleani, F Fabris |
Hematology Reports | 2014 |
|
Proliferation extent of CD34+ cells as a key parameter to maximize megakaryocytic differentiation of umbilical cord blood-derived hematopoietic stem/progenitor cells in a two-stage culture protocol
J Hatami, PZ Andrade, D Bacalhau, F Cirurgião, FC Ferreira, JM Cabral, CL da Silva |
Biotechnology Reports | 2014 |
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Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein
M Bender, JN Thon, AJ Ehrlicher, S Wu, L Mazutis, E Deschmann, M Sola-Visner, JE Italiano, JH Hartwig |
Blood | 2014 |
|
Serotonin Enhances Megakaryopoiesis and Proplatelet Formation via p-Erk1/2 and F-Actin Reorganization: Serotonin Enhances Megakaryopoiesis
JY Ye, EY Liang, YS Cheng, GC Chan, Y Ding, F Meng, MH Ng, BH Chong, Q Lian, M Yang |
Stem Cells | 2014 |
|
Gray platelet syndrome: proinflammatory megakaryocytes and -granule loss cause myelofibrosis and confer metastasis resistance in mice
JA Guerrero, C Bennett, L der Weyden, H McKinney, M Chin, P Nurden, Z McIntyre, EL Cambridge, J Estabel, H Wardle-Jones, AO Speak, WN Erber, A Rendon, WH Ouwehand, C Ghevaert |
Blood | 2014 |
|
Ex Vivo production of platelets from stem cells
MP Avanzi, WB Mitchell |
British Journal of Haematology | 2014 |
|
Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytes
S Stritt, I Thielmann, S Dütting, D Stegner, B Nieswandt |
Journal of Thrombosis and Haemostasis | 2014 |
|
Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect
M Bender, S Stritt, P Nurden, JM van Eeuwijk, B Zieger, K Kentouche, H Schulze, H Morbach, D Stegner, K Heinze, S Dütting, S Gupta, W Witke, H Falet, A Fischer, JH Hartwig, B Nieswandt |
Nature Communications | 2014 |
|
A novel point mutation in the β1-tubulin gene in asymptomatic macrothrombocytopenic Norfolk and Cairn Terriers
ME Gelain, W Bertazzolo, G Tutino, E Pogliani, F Cian, MK Boudreaux |
Veterinary Clinical Pathology | 2014 |
|
Differential proteomics study of platelets in asymptomatic constitutional macrothrombocytopenia: altered levels of cytoskeletal proteins
S Karmakar, S Saha, D Banerjee, A Chakrabarti |
European Journal of Haematology | 2014 |
|
Platelet bioreactor-on-a-chip
Jonathan N Thon, Linas Mazutis, Stephen Wu, Joanna L Sylman, Allen Ehrlicher, Kellie R Machlus, Qiang Feng, Shijiang Lu, Robert Lanza, Keith B Neeves, David A Weitz, Joseph E Italiano Jr |
Blood | 2014 |
|
Humanized Mice for HIV Research
LY Poluektova, JV Garcia, Y Koyanagi, MG Manz, AM Tager |
2014 | |
|
CAMT-iPS Cells Exhibiting Defective MPL Signaling Dysregulate Megakaryopoiesis and Erythropoiesis
Shinji Hirata, Naoya Takayama, Ryoko Jono-Onishi, Hiroshi Endo, Sou Nakamura, Takeaki Dohda, Masanori Nishi, Yuhei Hamasaki, Ei-ichi Ishii, Shin Kaneko, Makoto Otsu, Hiromitsu Nakauchi, Shinji Kunishima, Koji Eto |
Journal of Clinical Investigation | 2013 |
|
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Y Chen, J Aardema, S Kale, ZL Whichard, A Awomolo, E Blanchard, B Chang, DR Myers, L Ju, R Tran, D Reece, H Christensen, S Boukour, N Debili, TS Strom, D Rawlings, FX Vázquez, GA Voth, C Zhu, WH Kahr, WA Lam, SJ Corey |
Blood | 2013 |
|
Suppressive Effects of Anthrax Lethal Toxin on Megakaryopoiesis
PK Chen, HH Chang, GL Lin, TP Wang, YL Lai, TK Lin, MC Hsieh, JH Kau, HH Huang, HL Hsu, CY Liao, DS Sun, K Freson |
PloS one | 2013 |
|
Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis
S Badalucco, CA di Buduo, R Campanelli, I Pallotta, P Catarsi, V Rosti, DL Kaplan, G Barosi, M Massa, A Balduini |
Haematologica | 2013 |
|
Handbook of Stem Cells
M Amit, J Itskovitz-Eldor |
Handbook of Stem Cells | 2013 |
|
The incredible journey: From megakaryocyte development to platelet formation
KR Machlus, JE Italiano |
The Journal of Cell Biology | 2013 |
|
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects
K Shameer, JC Denny, K Ding, H Jouni, DR Crosslin, M Andrade, CG Chute, P Peissig, JA Pacheco, R Li, L Bastarache, AN Kho, MD Ritchie, DR Masys, RL Chisholm, EB Larson, CA McCarty, DM Roden, GP Jarvik, IJ Kullo |
Human Genetics | 2013 |
|
Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice
WH Kahr, RW Lo, L Li, FG Pluthero, H Christensen, R Ni, N Vaezzadeh, CE Hawkins, AS Weyrich, JD Paola, C Landolt-Marticorena, PL Gross |
Blood | 2013 |
|
RAD001-mediated STAT3 upregulation and megakaryocytic differentiation:
YC Su, SC Li, HY Peng, YH Ho, LJ Chen, HF Liao |
Thrombosis and Haemostasis | 2013 |
|
Quality in Laboratory Hemostasis and Thrombosis: Kitchen/Quality
M Johnston |
Quality in Laboratory Hemostasis and Thrombosis: Kitchen/Quality | 2013 |
|
MicroRNAs in platelet physiology and pathology:
S Dangwal, T Thum |
Hämostaseologie | 2013 |
|
Stochastic mechano-chemical kinetics of molecular motors: A multidisciplinary enterprise from a physicist’s perspective
D Chowdhury |
Physics Reports | 2013 |
|
Unraveling modulators of platelet reactivity in cardiovascular patients using omics strategies: Towards a network biology paradigm
A Zufferey, M Ibberson, JL Reny, I Xenarios, JC Sanchez, P Fontana |
Translational Proteomics | 2013 |
|
Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside
VR Deutsch, A Tomer |
British Journal of Haematology | 2013 |
|
Cardiac Regeneration using Stem Cells
F Hattori |
Cardiac Regeneration using Stem Cells | 2013 |
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Changes in megakaryocytes in cases of thrombocytopenia: bone marrow aspiration and biopsy analysis
TS Bhasin, S Sharma, M Manjari, R Mannan, V Kansal, M Chandey, S Piplani |
Journal of Clinical and Diagnostic Research : JCDR | 2013 |
|
Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42
I Pleines, S Dutting, D Cherpokova, A Eckly, I Meyer, M Morowski, G Krohne, H Schulze, C Gachet, N Debili, C Brakebusch, B Nieswandt |
Blood | 2013 |
|
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c
LC Edelstein, LM Simon, RT Montoya, M Holinstat, ES Chen, A Bergeron, X Kong, S Nagalla, N Mohandas, DE Cohen, J Dong, C Shaw, PF Bray |
Nature Medicine | 2013 |
|
New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer
L Clancy, JE Freedman |
Journal of Thrombosis and Thrombolysis | 2013 |
|
Discoidin domain receptor 1 protein is a novel modulator of megakaryocyte-collagen interactions
V Abbonante, C Gruppi, D Rubel, O Gross, R Moratti, A Balduini |
The Journal of biological chemistry | 2013 |
|
Mégacaryopoïèse : régulation de la production plaquettaire par la thrombopoïétine
W Vainchenker, R Besancenot, F Favale |
Bulletin de l'Académie nationale de médecine | 2013 |
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Visualizing developmentally programmed endoreplication in mammals using ubiquitin oscillators
A Sakaue-Sawano, T Hoshida, M Yo, R Takahashi, K Ohtawa, T Arai, E Takahashi, S Noda, H Miyoshi, A Miyawaki |
Development (Cambridge, England) | 2013 |
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Full reconstitution of human platelets in humanized mice after macrophage depletion
Z Hu, YG Yang |
Blood | 2012 |
|
Antiplatelet Agents
P Gresele, GV Born, C Patrono, CP Page |
2012 | |
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A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
L Zhang, M Orban, M Lorenz, V Barocke, D Braun, N Urtz, C Schulz, ML Bruhl, A Tirniceriu, F Gaertner, RL Proia, T Graf, SS Bolz, E Montanez, M Prinz, A Muller, L Baumgarten, A Billich, M Sixt, R Fassler, UH von Andrian, T Junt, S Massberg |
Journal of Experimental Medicine | 2012 |
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Megakaryocytes promote hepatoepithelial liver cell development in E11.5 mouse embryos by cell-to-cell contact and by vascular endothelial growth factor A signaling
N Serrano, I Cortegano, C Ruiz, M Alía, B Andrés, MT Rejas, MA Marcos, ML Gaspar |
Hepatology | 2012 |
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Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis
AJ Begonja, S Gambaryan, H Schulze, S Patel-Hett, JE Italiano, JH Hartwig, U Walter |
Experimental Hematology | 2012 |
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Pluripotent stem cells reveal the developmental biology of human megakaryocytes and provide a source of platelets for clinical application
N Takayama, K Eto |
Cellular and Molecular Life Sciences | 2012 |
|
Platelet mRNA: the meaning behind the message
JW Rowley, H Schwertz, AS Weyrich |
Current Opinion in Hematology | 2012 |
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The origin and function of platelet glycosyltransferases
HH Wandall, V Rumjantseva, AL Sorensen, S Patel-Hett, EC Josefsson, EP Bennett, JE Italiano, H Clausen, JH Hartwig, KM Hoffmeister |
Blood | 2012 |
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SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models
R Meng, Y Wang, Y Yao, Z Zhang, DC Harper, HF Heijnen, A Sitaram, W Li, G Raposo, MJ Weiss, M Poncz, MS Marks |
Blood | 2012 |
|
Blood platelet production and morphology
A Malara, A Balduini |
Thrombosis Research | 2012 |
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The genomic and proteomic blueprint of mouse megakaryocytes derived from embryonic stem cells : Genomic and proteomic blueprint of ES-MKs
V Merico, M Zuccotti, D Carpi, D Baev, F Mulas, L Sacchi, R Bellazzi, R Pastorelli, CA Redi, R Moratti, S Garagna, A Balduini |
Journal of Thrombosis and Haemostasis | 2012 |
|
Proteomics applied to the study of platelet-related diseases: Aiding the discovery of novel platelet biomarkers and drug targets
AF Parguiña, I Rosa, Á García |
Journal of Proteomics | 2012 |
|
BAR proteins in cancer and blood disorders
Y Chen, J Aardema, A Misra, SJ Corey |
International journal of biochemistry and molecular biology | 2012 |
|
HDAC6 controls the kinetics of platelet activation
K Sadoul, J Wang, B Diagouraga, AL Vitte, T Buchou, T Rossini, B Polack, X Xi, P Matthias, S Khochbin |
Blood | 2012 |
|
Canonical Wnt signaling in megakaryocytes regulates proplatelet formation
IC Macaulay, JN Thon, MR Tijssen, BM Steele, BT MacDonald, G Meade, P Burns, A Rendon, V Salunkhe, RP Murphy, C Bennett, NA Watkins, X He, DJ Fitzgerald, JE Italiano, PB Maguire |
Blood | 2012 |
|
Generation of platelet progeny
H Schwertz, AS Weyrich |
ISBT Science Series | 2012 |
|
MicroRNAs in platelet biogenesis and function:
S Dangwal, T Thum |
Thrombosis and Haemostasis | 2012 |
|
BDNF, produced by a TPO-stimulated megakaryocytic cell line, regulates autocrine proliferation
S Tamura, A Nagasawa, Y Masuda, T Tsunematsu, K Hayasaka, K Matsuno, C Shimizu, Y Ozaki, T Moriyama |
Biochemical and Biophysical Research Communications | 2012 |
|
Recent advances in platelet proteomics
MD Michele, CV Geet, K Freson |
Expert Review of Proteomics | 2012 |
|
2-(Trimethylammonium)ethyl ( R )-3-methoxy-3-oxo-2-stearamidopropyl phosphate promotes megakaryocytic differentiation of myeloid leukaemia cells and primary human CD34 + haematopoietic stem cells: ( R )-TEMOSPho induces megakaryocytic differentiation
JK Limb, D Song, M Jeon, SY Han, G Han, GJ Jhon, YS Bae, J Kim |
Journal of Tissue Engineering and Regenerative Medicine | 2012 |
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The VPS33B-binding protein VPS16B is required in megakaryocyte and platelet α-granule biogenesis
D Urban, L Li, H Christensen, FG Pluthero, SZ Chen, M Puhacz, PM Garg, KK Lanka, JJ Cummings, H Kramer, JD Wasmuth, J Parkinson, WH Kahr |
Blood | 2012 |
|
Myelofibrosis: molecular and cell biological aspects
H Kreipe, G Büsche, O Bock, K Hussein |
Fibrogenesis & Tissue Repair | 2012 |
|
Panobinostat (LBH589)-induced acetylation of tubulin impairs megakaryocyte maturation and platelet formation
C Iancu-Rubin, D Gajzer, G Mosoyan, F Feller, J Mascarenhas, R Hoffman |
Experimental Hematology | 2012 |
|
Aspirin-Induced Microscopic Surface Changes Stimulate Thrombopoiesis in Rat Megakaryocytes
I Kazama, Y Maruyama, S Nakamichi |
Clinical and Applied Thrombosis/Hemostasis | 2012 |
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Antiplatelet and Anticoagulation Therapy
A Ferro, DA Garcia |
2012 | |
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Alzheimer disease and platelets: how’s that relevant
S Catricala, M Torti, G Ricevuti |
Immunity & Ageing | 2012 |
|
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
A Vieira-de-Abreu, RA Campbell, AS Weyrich, GA Zimmerman |
Seminars in Immunopathology | 2011 |
|
Historical Perspective and Future Directions in Platelet Research
BS Coller |
Journal of Thrombosis and Haemostasis | 2011 |
|
Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice
SJ Lu, F Li, H Yin, Q Feng, EA Kimbrel, E Hahm, JN Thon, W Wang, JE Italiano, J Cho, R Lanza |
Cell Research | 2011 |
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Three-Dimensional System for theIn VitroStudy of Megakaryocytes and Functional Platelet Production Using Silk-Based Vascular Tubes
I Pallotta, M Lovett, DL Kaplan, A Balduini |
Tissue Engineering Part C: Methods | 2011 |
|
Megakaryocytes derived from patients with the classical form of Bernard-Soulier syndrome show no ability to extend proplatelets in vitro
A Balduini, A Malara, CL Balduini, P Noris |
Platelets | 2011 |
|
In vitro megakaryocyte differentiation and proplatelet formation in Ph-negative classical myeloproliferative neoplasms: distinct patterns in the different clinical phenotypes
A Balduini, S Badalucco, MT Pugliano, D Baev, AD Silvestri, M Cattaneo, V Rosti, G Barosi |
PloS one | 2011 |
|
Dasatinib enhances megakaryocyte differentiation but inhibits platelet formation
A Mazharian, C Ghevaert, L Zhang, S Massberg, SP Watson |
Blood | 2011 |
|
Covalently immobilized glycosaminoglycans enhance megakaryocyte progenitor expansion and platelet release
V Kishore, JF Eliason, HW Matthew |
Journal of Biomedical Materials Research Part A | 2011 |
|
Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration
JC Kostyak, MU Naik, UP Naik |
Blood | 2011 |
|
Mutations responsible for MYH9-related thrombocytopenia impair SDF-1-driven migration of megakaryoblastic cells :
A Pecci, V Bozzi, E Panza, S Barozzi, C Gruppi, M Seri, CL Balduini |
Thrombosis and Haemostasis | 2011 |
|
A copper–hydrogen peroxide redox system induces dityrosine cross-links and chemokine oligomerisation
HJ MacGregor, Y Kato, LJ Marshall, TG Nevell, JK Shute |
Cytokine | 2011 |
|
Platelet proteomics
A Zufferey, P Fontana, JL Reny, S Nolli, JC Sanchez |
Mass Spectrometry Reviews | 2011 |
|
Compensatory Thrombopoietin Production from the Liver and Bone Marrow Stimulates Thrombopoiesis of Living Rat Megakaryocytes in Chronic Renal Failure
I Kazama, Y Endo, H Toyama, Y Ejima, S Kurosawa, Y Murata, M Matsubara, Y Maruyama |
Nephron Extra | 2011 |
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Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events
L Cecchetti, ND Tolley, N Michetti, L Bury, AS Weyrich, P Gresele |
Blood | 2011 |
|
Regulatory effects of TLR2 on megakaryocytic cell function
LM Beaulieu, E Lin, KM Morin, K Tanriverdi, JE Freedman |
Blood | 2011 |
|
Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets
EC Josefsson, C James, KJ Henley, MA Debrincat, KL Rogers, MR Dowling, MJ White, EA Kruse, RM Lane, S Ellis, P Nurden, KD Mason, LA O'Reilly, AW Roberts, D Metcalf, DC Huang, BT Kile |
Journal of Experimental Medicine | 2011 |
|
Fibronectin promotes proplatelet formation in the human megakaryocytic cell line UT-7/TPO
T Kawaguchi, R Hatano, K Yamaguchi, K Nawa, R Hashimoto, H Yokota |
Cell Biology International | 2011 |
|
Cell Therapy for Blood Substitutes
SJ Lu, Q Feng, F Li, EA Kimbrel, R Lanza |
Principles of Regenerative Medicine | 2011 |
|
Investigation of interaction of human platelet membrane components with anticoagulant drugs Abciximab and Eptifibatide
E Gorodkiewicz, A Sankiewicz, ZA Figaszewski |
Folia Histochemica et Cytobiologica | 2011 |
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Proteomics investigation of human platelets in healthy donors and cystic fibrosis patients by shotgun nUPLC-MSE and 2DE: a comparative study
L Pieroni, F Finamore, M Ronci, D Mattoscio, V Marzano, SL Mortera, S Quattrucci, G Federici, M Romano, A Urbani |
Molecular BioSystems | 2011 |
|
Production of functional platelet-like particles by the megakaryoblastic DAMI cell line provides a model for platelet biogenesis
PR Lev, NP Goette, AC Glembotsky, RP Laguens, PM Meckert, JP Salim, PG Heller, RG Pozner, RF Marta, FC Molinas |
Platelets | 2011 |
|
Enhanced generation of megakaryocytes from umbilical cord blood-derived CD34+ cells expanded in the presence of two nutraceuticals, docosahexanoic acid and arachidonic acid, as supplements to the cytokine-containing medium
NF Siddiqui, NC Shabrani, VP Kale, LS Limaye |
Cytotherapy | 2011 |
|
Principles of Regenerative Medicine
S Gavrilov, VE Papaioannou, DW Landry |
Principles of Regenerative Medicine | 2011 |
|
Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling
RG Pozner, AE Ure, CJ de Giusti, LP D'Atri, JE Italiano, O Torres, V Romanowski, M Schattner, RM Gómez |
PLoS pathogens | 2010 |
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Global analysis of the rat and human platelet proteome - the molecular blueprint for illustrating multi-functional platelets and cross-species function evolution
Y Yu, T Leng, D Yun, N Liu, J Yao, Y Dai, P Yang, X Chen |
PROTEOMICS | 2010 |
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Serum response factor is an essential transcription factor in megakaryocytic maturation
S Halene, Y Gao, K Hahn, S Massaro, JE Italiano, V Schulz, S Lin, GM Kupfer, DS Krause |
Blood | 2010 |
|
Platelets as delivery systems for disease treatments
Q Shi, RR Montgomery |
Advanced Drug Delivery Reviews | 2010 |
|
ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing
M Bender, A Eckly, JH Hartwig, M Elvers, I Pleines, S Gupta, G Krohne, E Jeanclos, A Gohla, C Gurniak, C Gachet, W Witke, B Nieswandt |
Blood | 2010 |
|
Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells
N Takayama, S Nishimura, S Nakamura, T Shimizu, R Ohnishi, H Endo, T Yamaguchi, M Otsu, K Nishimura, M Nakanishi, A Sawaguchi, R Nagai, K Takahashi, S Yamanaka, H Nakauchi, K Eto |
Journal of Experimental Medicine | 2010 |
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The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation
S Séverin, C Ghevaert, A Mazharian |
Journal of Thrombosis and Haemostasis | 2010 |
|
De novo protein synthesis in mature platelets: a consideration for transfusion medicine
P Schubert, DV Devine |
Vox Sanguinis | 2010 |
|
Thrombopoietic agents
R Stasi, J Bosworth, E Rhodes, MS Shannon, F Willis, EC Gordon-Smith |
Blood Reviews | 2010 |
|
Association between fibrinogen plasma levels and platelet counts in an outpatient population and in patients with coronary heart disease
G Aliberti, M Proietta, I Pulignano, FD Porto, A Tammeo, M Trappolini |
Blood Coagulation & Fibrinolysis | 2010 |
|
Contributions of TRAIL-mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia
L Yang, L Wang, C Zhao, X Zhu, Y Hou, P Jun, M Hou |
Blood | 2010 |
|
Postgraduate Haematology
PM Mannucci, F Peyvandi, R Palla |
Postgraduate Haematology | 2010 |
|
Anucleate platelets generate progeny
H Schwertz, S Köster, WH Kahr, N Michetti, BF Kraemer, DA Weitz, RC Blaylock, LW Kraiss, A Greinacher, GA Zimmerman, AS Weyrich |
Blood | 2010 |
|
A structural basis for the inhibition of collagen-stimulated platelet function by quercetin and structurally related flavonoids
B Wright, LA Moraes, CF Kemp, W Mullen, A Crozier, JA Lovegrove, JM Gibbins |
British Journal of Pharmacology | 2010 |
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Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A
A Malara, C Gruppi, P Rebuzzini, L Visai, C Perotti, R Moratti, C Balduini, ME Tira, A Balduini |
Blood | 2010 |
|
Critical role of Src-Syk-PLC 2 signaling in megakaryocyte migration and thrombopoiesis
A Mazharian, SG Thomas, TS Dhanjal, CD Buckley, SP Watson |
Blood | 2010 |
|
Megakaryocytes muscle in
W Tong |
Blood | 2010 |
|
Aberrant proplatelet formation in chronic myeloproliferative neoplasms
M Muth, G Büsche, O Bock, K Hussein, H Kreipe |
Leukemia Research | 2010 |
|
How has proteomics informed transfusion biology so far?
G Liumbruno, A D’Alessandro, G Grazzini, L Zolla |
Critical Reviews in Oncology/Hematology | 2010 |
|
Cells in Dengue Virus Infection In Vivo
S Noisakran, N Onlamoon, P Songprakhon, HM Hsiao, K Chokephaibulkit, GC Perng |
Advances in Virology | 2010 |
|
Hemostatic Safety and Antithrombotic Efficacy of Moderate Platelet Count Reduction by Thrombopoietin Inhibition in Primates
EI Tucker, UM Marzec, MA Berny, S Hurst, S Bunting, OJ McCarty, A Gruber, SR Hanson |
Science Translational Medicine | 2010 |
|
Gegenwärtige Modelle der Thrombozytopoese
H Schulze |
Der Pathologe | 2010 |
|
Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine-1-phosphate receptor S1P4
S Golfier, S Kondo, T Schulze, T Takeuchi, G Vassileva, AH Achtman, MH Gräler, SJ Abbondanzo, M Wiekowski, E Kremmer, Y Endo, SA Lira, KB Bacon, M Lipp |
The FASEB Journal | 2010 |
|
Mathematical model of the coagulation in the bone–dental implant interface
JC Vanegas-Acosta, NS P., DA Garzón-Alvarado |
Computers in Biology and Medicine | 2010 |
|
PLATELETS: Iron Fortified?
CM Rubin |
Pediatric Hematology-Oncology | 2010 |
|
Blood-related proteomics
G Liumbruno, A D'Alessandro, G Grazzini, L Zolla |
Journal of Proteomics | 2010 |
|
The oestrogen receptor GPER is expressed in human haematopoietic stem cells but not in mature megakaryocytes
CD Vito, S Bergante, A Balduini, A Rastoldo, A Bagarotti, N Surico, A Bertoni, F Sinigaglia |
British Journal of Haematology | 2010 |
|
Proteomics meets blood banking: Identification of protein targets for the improvement of platelet quality
P Schubert, DV Devine |
Journal of Proteomics | 2010 |
|
Unique structure of the M loop region of β1-tubulin may contribute to size variability of platelets in the family Felidae: Feline platelet size variability and β1-tubulin
MK Boudreaux, CD Osborne, AC Herre, ER Rivera, EA Spangler |
Veterinary Clinical Pathology | 2010 |
|
Phase I Study of Trastuzumab-DM1, an HER2 Antibody-Drug Conjugate, Given Every 3 Weeks to Patients With HER2-Positive Metastatic Breast Cancer
IE Krop, M Beeram, S Modi, SF Jones, SN Holden, W Yu, S Girish, J Tibbitts, JH Yi, MX Sliwkowski, F Jacobson, SG Lutzker, HA Burris |
Journal of Clinical Oncology | 2010 |
|
Shaping of terminal megakaryocyte differentiation and proplatelet development by sphingosine‐1‐phosphate receptor S1P 4
S Golfier, S Kondo, T Schulze, T Takeuchi, G Vassileva, AH Achtman, MH Gräler, SJ Abbondanzo, M Wiekowski, E Kremmer, Y Endo, SA Lira, KB Bacon, M Lipp |
The FASEB Journal | 2010 |
|
Dynamic upregulation of human platelet production by high shear rates
Claire Dunois-Lardé, Claude Capron, Serge Fichelson, Thomas Bauer, Elisabeth Cramer-Bordé, Dominique Baruch |
Blood | 2009 |
|
The thrombotic potential of oral pathogens
SW Kerrigan, D Cox |
Journal of Oral Microbiology | 2009 |
|
Platelet–bacterial interactions
SW Kerrigan, D Cox |
Cellular and Molecular Life Sciences | 2009 |
|
Platelet α-granules: Basic biology and clinical correlates
P Blair, R Flaumenhaft |
Blood Reviews | 2009 |
|
Megakaryocyte-derived microparticles: direct visualization and distinction from platelet-derived microparticles
R Flaumenhaft, JR Dilks, J Richardson, E Alden, SR Patel-Hett, E Battinelli, GL Klement, M Sola-Visner, JE Italiano |
Blood | 2009 |
|
Proplatelet formation in heterozygous Bernard-Soulier syndrome type Bolzano
A Balduini, A Malara, A Pecci, S Badalucco, V Bozzi, I Pallotta, P Noris, M Torti, CL Balduini |
Journal of Thrombosis and Haemostasis | 2009 |
|
New insights into the mechanisms of nonimmune thrombocytopenia in neonates
M Sola-Visner, H Sallmon, R Brown |
Seminars in Perinatology | 2009 |
|
15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis
JJ O'Brien, CJ Baglole, TM Garcia-Bates, N Blumberg, CW Francis, RP Phipps |
Journal of Thrombosis and Haemostasis | 2009 |
|
Bone marrow osteoblastic niche: a new model to study physiological regulation of megakaryopoiesis
I Pallotta, M Lovett, W Rice, DL Kaplan, A Balduini |
PloS one | 2009 |
|
The evolution of platelet-directed pharmacotherapy
RC Becker, S Smyth |
Journal of Thrombosis and Haemostasis | 2009 |
|
Anagrelide: 20 years later
A Emadi, JL Spivak |
Expert Review of Anticancer Therapy | 2009 |
|
MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9
L Gilles, D Bluteau, S Boukour, Y Chang, Y Zhang, T Robert, P Dessen, N Debili, OA Bernard, W Vainchenker, H Raslova |
Blood | 2009 |
|
Getting in shape with RanBP10
R Flaumenhaft |
Blood | 2009 |
|
Overexpression of the partially activated α IIb β 3 D723H integrin salt bridge mutant downregulates RhoA activity and induces microtubule-dependent proplatelet-like extensions in Chinese hamster ovary cells
E Schaffner-Reckinger, A Salsmann, N Debili, J Bellis, JD Mey, W Vainchenker, WH Ouwehand, N Kieffer |
Journal of Thrombosis and Haemostasis | 2009 |
|
Regulation of Down Syndrome Critical Region 1 expression by Nuclear Factor of Activated T cells in megakaryocytes
S Kyttälä, I Habermann, T Minami, G Ehninger, A Kiani |
British Journal of Haematology | 2009 |
|
The platelet storage lesion
M Shrivastava |
Transfusion and Apheresis Science | 2009 |
|
Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs
L Oevermann, J Scheitz, K Starke, K Köck, T Kiefer, G Dölken, J Nießen, A Greinacher, W Siegmund, M Zygmunt, HK Kroemer, G Jedlitschky, CA Ritter |
International Journal of Cancer | 2009 |
|
The thrombotic potential of oral pathogens
SW Kerrigan, D Cox |
Journal of Oral Microbiology | 2009 |
|
Molecular Basis of Hematopoiesis
A Wickrema, B Kee |
2009 | |
|
Ran on tracks – cytoplasmic roles for a nuclear regulator
D Yudin, M Fainzilber |
Journal of cell science | 2009 |
|
Amicus or adversary: platelets in lung biology, acute injury, and inflammation
FA Bozza, AM Shah, AS Weyrich, GA Zimmerman |
American journal of respiratory cell and molecular biology | 2008 |
|
Platelets: Developmental biology, physiology, and translatable platforms for preclinical investigation and drug development
NS Kleiman, JE Freedman, PB Tracy, BC Furie, PF Bray, SV Rao, DR Phillips, RF Storey, CP Rusconi, PA French, SR Steinhubl, RC Becker |
Platelets | 2008 |
|
Fundamental and Clinical Cardiology Series
PD Stein |
Cardiovascular Disease in the Elderly | 2008 |
|
A nonsynonymous SNP in the ITGB3 gene disrupts the conserved membrane-proximal cytoplasmic salt bridge in the IIb 3 integrin and cosegregates dominantly with abnormal proplatelet formation and macrothrombocytopenia
C Ghevaert, A Salsmann, NA Watkins, E Schaffner-Reckinger, A Rankin, SF Garner, J Stephens, GA Smith, N Debili, W Vainchenker, PG de Groot, JA Huntington, M Laffan, N Kieffer, WH Ouwehand |
Blood | 2008 |
|
Inherited traits affecting platelet function
II Salles, HB Feys, BF Iserbyt, SF de Meyer, K Vanhoorelbeke, H Deckmyn |
Blood Reviews | 2008 |
|
Dynamin 3 participates in the growth and development of megakaryocytes
JA Reems, W Wang, K Tsubata, N Abdurrahman, B Sundell, MR Tijssen, E der Schoot, FD Summa, S Patel-Hett, J Italiano, DM Gilligan |
Experimental Hematology | 2008 |
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15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes
JJ O'Brien, SL Spinelli, J Tober, N Blumberg, CW Francis, MB Taubman, J Palis, KE Seweryniak, JM Gertz, RP Phipps |
Blood | 2008 |
|
Platelet Storage Lesion: A New Understanding From a Proteomic Perspective
JN Thon, P Schubert, DV Devine |
Transfusion Medicine Reviews | 2008 |
|
Generation of functional platelets from human embryonic stem cells in vitro via ES-sacs, VEGF-promoted structures that concentrate hematopoietic progenitors
N Takayama, H Nishikii, J Usui, H Tsukui, A Sawaguchi, T Hiroyama, K Eto, H Nakauchi |
Blood | 2008 |
|
Impact of chicken thrombopoietin and its receptor c-Mpl on hematopoietic cell development
P Bartunek, V Karafiat, J Bartunkova, P Pajer, M Dvorakova, J Kralova, M Zenke, M Dvorak |
Experimental Hematology | 2008 |
|
Platelet production by megakaryocytes: protoplatelet theory justifies cytoplasmic fragmentation model
G Kosaki |
International Journal of Hematology | 2008 |
|
Production plaquettaire : régulation cellulaire et moléculaire
E Cramer-Bordé |
EMC - Hematologie | 2008 |
|
A murine model for human immune thrombocytopenic purpura and comparative analysis of multiple gene expression in bone marrow and spleen
H Wei, X Ding, J Ren, K Liu, P Tan, D Li, RZ Ma |
Journal of Genetics and Genomics | 2008 |
|
Transfusion therapy by blood platelets derived from embryonic stem cells or induced pluripotent stem cells
K Eto, H Nakauchi |
Drug Delivery System | 2008 |
|
Transfusion using blood platelets derived from embryonic stem cells and induced pluripotent stem cells
K ETO |
Japanese Journal of Thrombosis and Hemostasis | 2008 |
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Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes
A Balduini, I Pallotta, A Malara, P Lova, A Pecci, G Viarengo, CL Balduini, M Torti |
Journal of Thrombosis and Haemostasis | 2008 |
|
Historical review: megakaryopoiesis and thrombopoiesis
K Kaushansky |
Blood | 2007 |
|
The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects
SL Spinelli, JJ O'Brien, S Bancos, GM Lehmann, DL Springer, N Blumberg, CW Francis, MB Taubman, RP Phipps |
PPAR Research | 2007 |
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Translation of glycoprotein IIIa in stored blood platelets
JN Thon, DV Devine |
Transfusion | 2007 |
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CD8+T cells suppress autologous megakaryocyte apoptosis in idiopathic thrombocytopenic purpura
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British Journal of Haematology | 2007 |
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SO Ciurea, R Hoffman |
Seminars in Hematology | 2007 |
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Effects of garlic on platelet biochemistry and physiology
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Molecular Nutrition & Food Research | 2007 |
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Programmed Anuclear Cell Death Delimits Platelet Life Span
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Cell | 2007 |
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Prostaglandins & Other Lipid Mediators | 2007 |
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British Journal of Haematology | 2007 |
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European Journal of Pharmacology | 2007 |
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Experimental Cell Research | 2007 |
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Radiation Research | 2007 |
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Modeling of Biological Materials
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Platelets and Tissue Remodeling: Extending the Role of the Blood Clotting System
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Endocrinology | 2007 |
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Expression analysis of nuclear factor of activated T cells (NFAT) during myeloid differentiation of CD34+ cells: regulation of Fas ligand gene expression in megakaryocytes
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Experimental Hematology | 2007 |
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A review of inherited platelet disorders with guidelines for their management on behalf of the UKHCDO
PH Bolton-Maggs, EA Chalmers, PW Collins, P Harrison, S Kitchen, RJ Liesner, A Minford, AD Mumford, LA Parapia, DJ Perry, SP Watson, JT Wilde, MD Williams |
British Journal of Haematology | 2006 |
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Leukemia | 2006 |
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Clinical Approaches Involving Thrombopoietin to Shorten the Period of Thrombocytopenia After High-Dose Chemotherapy
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Transfusion Medicine Reviews | 2006 |
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Decreased platelet expression of myosin regulatory light chain polypeptide (MYL9) and other genes with platelet dysfunction and CBFA2/RUNX1 mutation: insights from platelet expression profiling
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Journal of Thrombosis and Haemostasis | 2006 |
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Trends in Cell Biology | 2006 |
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A product of their environment: Do megakaryocytes rely on extracellular cues for proplatelet formation?
MK Larson, SP Watson |
Platelets | 2006 |
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Did dinosaurs have megakaryocytes? New ideas about platelets and their progenitors
LF Brass |
Journal of Clinical Investigation | 2005 |
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Transfusion Clinique et Biologique | 2018 |
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Platelets and Megakaryocytes: Volume 4, Advanced Protocols and Perspectives
JM Gibbins, M Mahaut-Smith |
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Overexpression of Short Variant Form of New Kelch Family Protein Leads to Erythroid and Megakaryocyte Dysplasia by Targeting Megakaryocyte–Erythroid Progenitors
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DNA and Cell Biology | 2018 |
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Detection of abundant megakaryocytes in pulmonary artery blood in lung cancer patients using a microfluidic platform
H Dejima, H Nakanishi, H Kuroda, M Yoshimura, N Sakakura, N Ueda, Y Ohta, R Tanaka, S Mori, T Yoshida, T Hida, N Sawabata, Y Yatabe, Y Sakao |
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Regulation of differentiation of MEG01 to megakaryocytes and platelet-like particles by Valproic acid through Notch3 mediated actin polymerization
A Dhenge, R Kuhikar, V Kale, L Limaye |
Platelets | 2018 |
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Platelets in cancer development and diagnosis
A Contursi, R Grande, M Dovizio, A Bruno, R Fullone, P Patrignani |
Biochemical Society Transactions | 2018 |
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Megakaryocyte contribution to bone marrow fibrosis: many arrows in the quiver
A Malara, V Abbonante, M Zingariello, AR Migliaccio, A Balduini |
Mediterranean journal of hematology and infectious diseases | 2017 |
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Turbidimetry on Human Washed Platelets: The Effect of the Pannexin1-inhibitor Brilliant Blue FCF on Collagen-induced Aggregation
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Journal of visualized experiments : JoVE | 2017 |
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Mechanism of platelet production from megakaryocytes-role of proplatelet formation-
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Japanese Journal of Thrombosis and Hemostasis | 2006 |
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