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Citations to this article

Megakaryocyte biology and related disorders
Liyan Pang, … , Mitchell J. Weiss, Mortimer Poncz
Liyan Pang, … , Mitchell J. Weiss, Mortimer Poncz
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3332-3338. https://doi.org/10.1172/JCI26720.
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Review Series Article has an altmetric score of 9

Megakaryocyte biology and related disorders

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Abstract

Platelets, derived from megakaryocytes, have an essential role in thrombosis and hemostasis. Over the past 10 years, a great deal of new information has been obtained concerning the various aspects of hematopoiesis necessary to maintain a steady-state platelet level to support physiologic hemostasis. Here we discuss the differentiation of HSCs into megakaryocytes, with emphasis on the key cytokine signaling pathways and hematopoietic transcription factors. Recent insight into these processes elucidates the molecular bases of numerous acquired and inherited hematologic disorders. It is anticipated that the growing knowledge in these areas may be exploited for new therapeutic strategies to modulate both platelet numbers and their thrombogenicity.

Authors

Liyan Pang, Mitchell J. Weiss, Mortimer Poncz

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Total citations by year

Year: 2024 2023 2021 2020 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 4 2 3 4 2 4 2 2 1 4 2 3 4 3 2 2 1 1 46
Citation information
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Citations to this article (46)

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International journal of molecular sciences 2024
From Hematopoietic Stem Cells to Platelets: Unifying Differentiation Pathways Identified by Lineage Tracing Mouse Models
Manso BA, Rodriguez y Baena A, Forsberg EC
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The Role of TLR-2 in Lethal COVID-19 Disease Involving Medullary and Resident Lung Megakaryocyte Up-Regulation in the Microthrombosis Mechanism
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Khazali AS, Hadrawi WH, Ibrahim F, Othman S, Nor Rashid N
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He B, Wang C, Niu J, Wang F, Zhang Y, Gao Y, Yang Q
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Blood Advances 2023
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2021
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