Since the first successful transplantation of umbilical cord blood in 1988, cord blood has become an important source of hematopoietic stem and progenitor cells for the treatment of blood and genetic disorders. Significant progress has been accompanied by challenges for scientists, ethicists, and health policy makers. With the recent recognition of the need for a national system for the collection, banking, distribution, and use of cord blood and the increasing focus on cord blood as an alternative to embryos as a source of tissue for regenerative medicine, cord blood has garnered significant attention. We review the development of cord blood banking and transplantation and then discuss the scientific and ethical issues influencing both established and investigational practices surrounding cord blood collection, banking, and use.
Joanne Kurtzberg, Anne Drapkin Lyerly, Jeremy Sugarman
Title and authors | Publication | Year |
---|---|---|
Perinatal Tissue-Derived Stem Cells: An Emerging Therapeutic Strategy for Challenging Neurodegenerative Diseases.
Bruno A, Milillo C, Anaclerio F, Buccolini C, Dell'Elice A, Angilletta I, Gatta M, Ballerini P, Antonucci I |
International journal of molecular sciences | 2024 |
Converging frontiers in cancer treatment: the role of nanomaterials, mesenchymal stem cells, and microbial agents—challenges and limitations
Afkhami H, Yarahmadi A, Bostani S, Yarian N, Haddad MS, Lesani SS, Aghaei SS, Zolfaghari MR |
Discover Oncology | 2024 |
Stem Cells: A Historical Review about Biological, Religious, and Ethical Issues
IA Charitos, A Ballini, S Cantore, M Boccellino, MD Domenico, E Borsani, R Nocini, MD Cosola, L Santacroce, L Bottalico, M Mascitti |
Stem Cells International | 2021 |
Decreased Mortality in 1-Year Survivors of Umbilical Cord Blood Transplant vs. Matched Related or Matched Unrelated Donor Transplant in Patients with Hematologic Malignancies
L Bohannon, H Tang, K Page, Y Ren, SH Jung, A Artica, A Britt, P Islam, S Siamakpour-Reihani, V Giri, M Lew, M Kelly, T Choi, C Gasparetto, G Long, R Lopez, D Rizzieri, S Sarantopoulos, N Chao, M Horwitz, A Sung |
2021 | |
Awareness and practice of cord blood donation by pregnant women in Lagos Nigeria: Practice implication for future cord blood transplantation in Nigeria
SO John-Olabode, KS Okunade, IO Ajie, G Olorunfemi, OA Oyedeji |
Annals of African Medicine | 2021 |
Cell sources proposed for nucleus pulposus regeneration
Williams RJ, Tryfonidou MA, Snuggs JW, Le Maitre CL |
2021 | |
Real‐time ethics engagement in biomedical research: Ethics from bench to bedside
J Sugarman, AL Bredenoord |
EMBO reports | 2020 |
Harnessing the anti-inflammatory properties of stem cells for transplant therapy in hemorrhagic stroke
S Corey, B Bonsack, M Heyck, A Shear, N Sadanandan, H Zhang, CV Borlongan |
2020 | |
Perinatal Stem Cells: Biology, Manufacturing and Translational Medicine
ZC Han, TA Takahashi, Z Han, Z Li |
2019 | |
Bladder regeneration through stem cell therapy
J Smolar, M Horst, T Sulser, D Eberli |
Expert Opinion on Biological Therapy | 2018 |
Stem Cell Therapy for Abrogating Stroke-Induced Neuroinflammation and Relevant Secondary Cell Death Mechanisms
C Stonesifer, S Corey, S Ghanekar, Z Diamandis, SA Acosta, CV Borlongan |
Progress in Neurobiology | 2017 |
Cell-based therapeutic strategies for replacement and preservation in retinal degenerative diseases
MK Jones, B Lu, S Girman, S Wang |
Progress in Retinal and Eye Research | 2017 |
Donor Selection for Allogenic Hemopoietic Stem Cell Transplantation: Clinical and Ethical Considerations
I Riezzo, N Pascale, RL Russa, A Liso, M Salerno, E Turillazzi |
Stem Cells International | 2017 |
Effect of Maternal Obesity on Maternal-Fetal Transfer of Preoperative Cefazolin at Cesarean Section
SM Groff, W Fallatah, S Yang, J Murphy, C Crutchfield, M Marzinke, J Kurtzberg, CK Lee, I Burd, A Farzin |
The Journal of Pediatric Pharmacology and Therapeutics : JPPT | 2017 |
The role of policies and networks in development of cord blood usage in China
HC Chang |
Regenerative Medicine | 2017 |
Banking Umbilical Cord Blood (UCB) Stem Cells: Awareness, Attitude and Expectations of Potential Donors from One of the Largest Potential Repository (India)
D Pandey, S Kaur, A Kamath, LV Pereira |
PloS one | 2016 |
The private, the public and the hybrid in umbilical cord blood banking – a global perspective
M Sleeboom-Faulkener, HC Chang |
New Genetics and Society | 2016 |
Stem Cells in Regenerative Medicine: Science, regulation and business strategies
HM Lazarus, SL Gerson |
Stem Cells in Regenerative Medicine: Science, regulation and business strategies | 2016 |
Umbilical cord blood donation: public or private?
KK Ballen, F Verter, J Kurtzberg |
Bone Marrow Transplantation | 2015 |
Stem Cell Biology and Tissue Engineering in Dental Sciences
PJ Brooks, SG Gong |
Stem Cell Biology and Tissue Engineering in Dental Sciences | 2015 |
Human Umbilical Cord Blood Cells Ameliorate Motor Deficits in Rabbits in a Cerebral Palsy Model
A Drobyshevsky, CM Cotten, Z Shi, K Luo, R Jiang, M Derrick, ET Tracy, T Gentry, RN Goldberg, J Kurtzberg, S Tan |
Developmental Neuroscience | 2015 |
Developing Educational Resources to Advance Umbilical Cord Blood Banking and Research: A Canadian Perspective
CP Beak, SB Chargé, R Isasi, BM Knoppers |
Journal of Obstetrics and Gynaecology Canada | 2015 |
Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy
CM Cotten, AP Murtha, RN Goldberg, CA Grotegut, PB Smith, RF Goldstein, KA Fisher, KE Gustafson, B Waters-Pick, GK Swamy, B Rattray, S Tan, J Kurtzberg |
The Journal of Pediatrics | 2014 |
Transplantation of umbilical cord-derived mesenchymal stem cells into the striata of R6/2 mice: behavioral and neuropathological analysis
KD Fink, J Rossignol, AT Crane, KK Davis, MC Bombard, AM Bavar, S Clerc, SA Lowrance, C Song, L Lescaudron, GL Dunbar |
Stem Cell Research & Therapy | 2013 |
US public cord blood banking practices: recruitment, donation, and the timing of consent
SM Broder, RS Ponsaran, AJ Goldenberg |
Transfusion | 2012 |
Towards a Richer Debate on Tissue Engineering: A Consideration on the Basis of NEST-Ethics
AJ Oerlemans, ME van Hoek, E van Leeuwen, S van der Burg, WJ Dekkers |
Science and Engineering Ethics | 2012 |
Handbook of Clinical Neurology
T Ashizawa, PS Sarkar |
Muscular Dystrophies | 2011 |
Gimme shelter: the immune system during pregnancy
A Munoz-Suano, AB Hamilton, AG Betz |
Immunological Reviews | 2011 |
The Placenta
C Wright, CP Sibley |
The Placenta | 2011 |
Fetal adnexa derived stem cells from domestic animal: progress and perspectives
F Cremonesi, B Corradetti, AL Consiglio |
Theriogenology | 2011 |
The current status of umbilical cord blood collection in Japanese medical centers: Survey of obstetricians
N Tada, S Hinotsu, H Urushihara, F Kita, S Kai, TA Takahashi, S Kato, M Takanashi, K Ito, H Sawai, T Maekawa, S Kosugi, K Kawakami |
Transfusion and Apheresis Science | 2011 |
Translational Stem Cell Research
K Hug, G Hermerén |
2011 | |
“Good Mothering” or “Good Citizenship”?: Conflicting Values in Choosing Whether to Donate or Store Umbilical Cord Blood
M Porter, IH Kerridge, CF Jordens |
Journal of Bioethical Inquiry | 2011 |
Perinatal Stem Cells
RR Taghizadeh, JL Sherley |
Perinatal Stem Cells | 2010 |
A great lack of knowledge regarding umbilical cord blood banking among pregnant women in Berlin, Germany
PE Palten, JW Dudenhausen |
Journal of Perinatal Medicine | 2010 |
Educating patients about the value of umbilical cord blood donation:
PL Skabla, B McGadney-Douglas, J Hampton |
Journal of the American Academy of Physician Assistants | 2010 |
Cord blood banking in France: Reorganising the national network
G Katz, A Mills |
Transfusion and Apheresis Science | 2010 |
Stem Cell Source and Outcome After Hematopoietic Stem Cell Transplantation (HSCT) in Children and Adolescents with Acute Leukemia
C Peters, JM Cornish, SH Parikh, J Kurtzberg |
Pediatric Clinics of North America | 2010 |
An Efficient Approach to Isolation and Characterization of Pre- and Postnatal Umbilical Cord Lining Stem Cells for Clinical Applications
R Gonzalez, L Griparic, M Umana, K Burgee, V Vargas, R Nasrallah, F Silva, A Patel |
Cell Transplantation | 2010 |
Cord blood banking: a historical perspective
C Navarrete, M Contreras |
British Journal of Haematology | 2009 |
Update on umbilical cord blood transplantation
J Kurtzberg |
Current Opinion in Pediatrics | 2009 |
A strategy of splitting individual high volume cord blood units into two half subunits prior to processing increases the recovery of cells and facilitates ex vivo expansion of the infused haematopoietic progenitor cells in adults
AC Papassavas, V Gioka, T Chatzistamatiou, T Kokkinos, I Anagnostakis, G Gecka, I Redoukas, G Paterakis, C Stavropoulos-Giokas |
International Journal of Laboratory Hematology | 2008 |
Ethical Aspects of Tissue Engineering: A Review
RB de Vries, A Oerlemans, L Trommelmans, K Dierickx, B Gordijn |
Tissue Engineering Part B: Reviews | 2008 |
Banking on cord blood stem cells
MJ Sullivan |
Nature Reviews Cancer | 2008 |
Human Stem Cell Ethics: Beyond the Embryo
J Sugarman |
Cell Stem Cell | 2008 |
Frontiers of Cord Blood Science
P Stubblefield, N Bhattacharya |
2008 | |
International perspectives on the ethics and regulation of human cell and tissue transplantation
A Schulz-Baldes, N Biller-Andorno, AM Capron |
Bulletin of the World Health Organization | 2007 |
Problems in Umbilical Cord Blood Collection
C Troeger, S Meyer-Monard, A Tichelli, G Manegold, D Pauli, D Surbek, W Holzgreve, N Bürki |
Transfusion Medicine and Hemotherapy | 2007 |
Analysis of Hematopoietic Cell Transplants Using Plasma-Depleted Cord Blood Products That Are Not Red Blood Cell Reduced
R Chow, A Nademanee, J Rosenthal, C Karanes, TH Jaing, ML Graham, E Tsukahara, B Wang, D Gjertson, P Tan, S Forman, LD Petz |
Biology of Blood and Marrow Transplantation | 2007 |
Ethics and Stem Cell Therapeutics for Cardiovascular Disease
J Sugarman |
Progress in Cardiovascular Diseases | 2007 |
Understanding Umbilical Cord Blood Banking
L Kharaboyan, BM Knoppers, D Avard, J Nisker |
Women s Health Issues | 2007 |
Review Article: Stem Cells in Human Reproduction
CE Gargett |
Reproductive sciences (Thousand Oaks, Calif.) | 2007 |
Clinically relevant expansion of hematopoietic stem cells with conserved function in a single-use, closed-system bioprocess
GJ Madlambayan, I Rogers, KA Purpura, C Ito, M Yu, D Kirouac, RF Casper, PW Zandstra |
Biology of Blood and Marrow Transplantation | 2006 |
The Ethics of Cord Blood Banking in Light of Ownership, Informed Consent, and Solidarity
E Salvaterra, L Lecchi, S Gobbi, P Rebulla |
Cell Preservation Technology | 2006 |
Stem cells in the umbilical cord
ML Weiss, DL Troyer |
Stem Cell Reviews and Reports | 2006 |
Banking and transplantation of umbilical cord blood in Guangzhou, China
JY Wu, C Liao, ZP Xu, JS Chen, SL Gu, YN Huang, Y Li, XW Tang, X Yang, PH Tang, KS Tsang |
Cytotherapy | 2006 |
Umbilical cord blood banking options and the prenatal patient: An obstetrician's perspective
JH Perlow |
Stem Cell Reviews and Reports | 2006 |