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Citations to this article

IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy
Jun-Li Luo, … , Hideaki Kamata, Michael Karin
Jun-Li Luo, … , Hideaki Kamata, Michael Karin
Published October 3, 2005
Citation Information: J Clin Invest. 2005;115(10):2625-2632. https://doi.org/10.1172/JCI26322.
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Review Series Article has an altmetric score of 7

IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy

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Abstract

IκB kinase/NF-κB (IKK/NF-κB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-κB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-κB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin, use NF-κB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-κB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.

Authors

Jun-Li Luo, Hideaki Kamata, Michael Karin

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 4 18 21 25 25 18 25 9 20 13 20 19 18 10 13 21 30 23 15 9 1 357
Citation information
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Lp16-PSP, a Member of YjgF/YER057c/UK114 Protein Family Induces Apoptosis and p21WAF1/CIP1 Mediated G1 Cell Cycle Arrest in Human Acute Promyelocytic Leukemia (APL) HL-60 Cells
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International journal of molecular sciences 2017

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