Go to
JCI Insight
Abstract
Cell death by apoptosis or necrosis is often important in the etiology and treatment of disease. Since mitochondria play important roles in cell death pathways, these organelles are potentially prime targets for therapeutic intervention. Here we discuss the mechanisms through which mitochondria participate in the cell death process and also survey some of the pharmacological approaches that target mitochondria in various ways.
Authors
Lisa Bouchier-Hayes, Lydia Lartigue, Donald D. Newmeyer
Options:
View larger image
(or click on image)
Download as PowerPoint
Summary of the literature concerning various compounds that act on mitochondria and their experimental or clinical stages of development
Copyright © 2024 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)