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Citations to this article

Absence of ghrelin protects against early-onset obesity
Katherine E. Wortley, … , Michael O. Thorner, Mark W. Sleeman
Katherine E. Wortley, … , Michael O. Thorner, Mark W. Sleeman
Published December 1, 2005
Citation Information: J Clin Invest. 2005;115(12):3573-3578. https://doi.org/10.1172/JCI26003.
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Research Article Metabolism Article has an altmetric score of 6

Absence of ghrelin protects against early-onset obesity

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Abstract

The gut peptide ghrelin, the endogenous ligand for the growth hormone secretagogue receptor, has been implicated not only in the regulation of pituitary growth hormone (GH) secretion but in a number of endocrine and nonendocrine functions, including appetitive behavior and carbohydrate substrate utilization. Nevertheless, recent genetic studies have failed to show any significant defects in GH levels, food intake, or body weight in adult ghrelin-deficient (Ghrl−/−) mice. Here we demonstrate that male Ghrl−/− mice are protected from the rapid weight gain induced by early exposure to a high-fat diet 3 weeks after weaning (6 weeks of age). This reduced weight gain was associated with decreased adiposity and increased energy expenditure and locomotor activity as the animals aged. Despite the absence of ghrelin, these Ghrl−/− mice showed a paradoxical preservation of the GH/IGF-1 axis, similar to that reported in lean compared with obese humans. These findings suggest an important role for endogenous ghrelin in the metabolic adaptation to nutrient availability.

Authors

Katherine E. Wortley, Juan-Pablo del Rincon, Jane D. Murray, Karen Garcia, Keiji Iida, Michael O. Thorner, Mark W. Sleeman

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Total citations by year

Year: 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 4 3 5 5 3 5 3 5 5 5 6 10 13 10 7 5 13 7 6 2 122
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (10)

Title and authors Publication Year
Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance
PB de Morentin, CR González, AK Saha, L Martins, C Diéguez, A Vidal-Puig, M Tena-Sempere, M López
Reviews in Endocrine and Metabolic Disorders 2011
Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure
BC de Jonghe, MR Hayes, R Banno, KP Skibicka, DJ Zimmer, KA Bowen, TM Leichner, AL Alhadeff, SE Kanoski, NE Cyr, EA Nillni, HJ Grill, KK Bence
American journal of physiology. Endocrinology and metabolism 2011
Ablations of Ghrelin and Ghrelin Receptor Exhibit Differential Metabolic Phenotypes and Thermogenic Capacity during Aging
X Ma, L Lin, G Qin, X Lu, M Fiorotto, VD Dixit, Y Sun, K Stadler
PloS one 2011
Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps
Y Qi, KA Longo, DJ Giuliana, S Gagne, T McDonagh, E Govek, A Nolan, C Zou, K Morgan, J Hixon, JO Saunders, PS Distefano, BJ Geddes
BMC Physiology 2011
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice
RG Albarran-Zeckler, Y Sun, RG Smith
Peptides 2011
Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain
M Perello, MM Scott, I Sakata, CE Lee, JC Chuang, S Osborne-Lawrence, SA Rovinsky, JK Elmquist, JM Zigman
The Journal of Comparative Neurology 2011
Effect of ghrelin receptor antagonist on meal patterns in cholecystokinin type 1 receptor null mice
J Lee, E Martin, G Paulino, G Lartigue, HE Raybould
Physiology & Behavior 2011
Neuroprotective Actions of Ghrelin and Growth Hormone Secretagogues
LM Frago, E Baquedano, J Argente, JA Chowen
Frontiers in molecular neuroscience 2011
Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice
JS Zakhari, EP Zorrilla, B Zhou, AV Mayorov, KD Janda
Molecular Pharmaceutics 2011
Synthesis and in vivo evaluation of (S)-6-(4-fluorophenoxy)-3-((1-[11C]methylpiperidin-3-yl)methyl)-2-o-tolylquinazolin-4(3H)-one, a potential PET tracer for growth hormone secretagogue receptor (GHSR)
R Potter, AG Horti, HT Ravert, DP Holt, P Finley, U Scheffel, RF Dannals, RL Wahl
Bioorganic & Medicinal Chemistry 2011

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