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Citations to this article

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
Rajesh K. Thimmulappa, … , Thomas W. Kensler, Shyam Biswal
Rajesh K. Thimmulappa, … , Thomas W. Kensler, Shyam Biswal
Published April 3, 2006
Citation Information: J Clin Invest. 2006;116(4):984-995. https://doi.org/10.1172/JCI25790.
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Research Article Article has an altmetric score of 7

Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis

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Abstract

Host genetic factors that regulate innate immunity determine susceptibility to sepsis. Disruption of nuclear factor-erythroid 2–related factor 2 (Nrf2), a basic leucine zipper transcription factor that regulates redox balance and stress response, dramatically increased the mortality of mice in response to endotoxin- and cecal ligation and puncture–induced septic shock. LPS as well as TNF-α stimulus resulted in greater lung inflammation in Nrf2-deficient mice. Temporal analysis of pulmonary global gene expression after LPS challenge revealed augmented expression of large numbers of proinflammatory genes associated with the innate immune response at as early as 30 minutes in lungs of Nrf2-deficient mice, indicating severe immune dysregulation. The expression profile indicated that Nrf2 has a global influence on both MyD88-dependent and -independent signaling. Nrf2-deficient mouse embryonic fibroblasts showed greater activation of NF-κB and interferon regulatory factor 3 in response to LPS and polyinosinic-polycytidylic acid [poly(I:C)] stimulus, corroborating the effect of Nrf2 on MyD88-dependent and -independent signaling. Nrf2’s regulation of cellular glutathione and other antioxidants is critical for optimal NF-κB activation in response to LPS and TNF-α. Our study reveals Nrf2 as a novel modifier gene of sepsis that determines survival by mounting an appropriate innate immune response.

Authors

Rajesh K. Thimmulappa, Hannah Lee, Tirumalai Rangasamy, Sekhar P. Reddy, Masayuki Yamamoto, Thomas W. Kensler, Shyam Biswal

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Oxidative medicine and cellular longevity 2022
Stressed erythrophagocytosis induces immunosuppression during sepsis through heme-mediated STAT1 dysregulation
Tolani F. Olonisakin, Tomeka L. Suber, Shekina Gonzalez-Ferrer, Zeyu Xiong, Hernán F. Peñaloza, Rick van der Geest, Yuting Xiong, David O. Osei-Hwedieh, Jesus Tejero, Matthew R. Rosengart, Wendy M. Mars, Daria Van Tyne, Andreas Perlegas, Samuel Brashears, Daniel B. Kim-Shapiro, Mark T. Gladwin, Michael A. Bachman, Eldad A. Hod, Claudette St. Croix, Yulia Y. Tyurina, Valerian E. Kagan, Rama K. Mallampalli, Anuradha Ray, Prabir Ray, Janet S. Lee
Journal of Clinical Investigation 2021
ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression
X Ouyang, E Becker, NB Bone, MS Johnson, J Craver, WX Zong, VM Darley-Usmar, JW Zmijewski, J Zhang
Laboratory Investigation 2021
Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy
S Bono, M Feligioni, M Corbo
Molecular Neurodegeneration 2021
Contribution of the Nrf2 Pathway on Oxidative Damage and Mitochondrial Failure in Parkinson and Alzheimer’s Disease
FV Tejo, RA Quintanilla
Antioxidants 2021
Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
I Choi, H Son, JH Baek
Life Sciences 2021
Metabolic Changes and Oxidative Stress in Diabetic Kidney Disease
M Sakashita, T Tanaka, R Inagi
Antioxidants 2021
Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19
RK Thimmulappa, KK Mudnakudu-Nagaraju, C Shivamallu, KJ Subramaniam, A Radhakrishnan, S Bhojraj, G Kuppusamy
Heliyon 2021
Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury
H Amatullah, T Maron-Gutierrez, Y Shan, S Gupta, JN Tsoporis, AK Varkouhi, AP Monteiro, X He, J Yin, JC Marshall, PR Rocco, H Zhang, WM Kuebler, CC dos Santos
Redox Biology 2021
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Y Lei, CG Martinez, S Torres-Odio, SL Bell, CE Birdwell, JD Bryant, CW Tong, RO Watson, LC West, AP West
Science Advances 2021
Antiviral, immunomodulatory, and anticoagulant effects of quercetin and its derivatives: Potential role in prevention and management of COVID-19
SH Manjunath, RK Thimmulappa
Journal of Pharmaceutical Analysis 2021
Redox regulation of immunity and the role of small molecular weight thiols
P Ghezzi
Redox Biology 2021
Ozone therapy for the treatment of COVID-19 pneumonia: A scoping review
M Izadi, L Cegolon, M Javanbakht, A Sarafzadeh, H Abolghasemi, G Alishiri, S Zhao, B Einollahi, M Kashaki, N Jonaidi-Jafari, M Asadi, R Jafari, S Fathi, H Nikoueinejad, M Ebrahimi, S Imanizadeh, AH Ghazale
International Immunopharmacology 2021
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization
M Kieler, M Hofmann, G Schabbauer
The FEBS journal 2021
Targeting oxidative stress in disease: promise and limitations of antioxidant therapy
HJ Forman, H Zhang
Nature Reviews Drug Discovery 2021
Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils
KM Amirova, PA Dimitrova, AS Marchev, SV Krustanova, SD Simova, KI Alipieva, MI Georgiev
International journal of molecular sciences 2021
A polygenic-score-based approach for identification of gene-drug interactions stratifying breast cancer risk
AR Marderstein, S Kulm, C Peng, R Tamimi, AG Clark, O Elemento
The American Journal of Human Genetics 2021
Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway
T Heurtaux, M Kirchmeyer, E Koncina, P Felten, L Richart, OU Huarte, H Schohn, M Mittelbronn
Cellular and Molecular Neurobiology 2021
Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD
S Oh, T Tsujimoto, B Kim, F Uchida, H Suzuki, S Iizumi, T Isobe, T Sakae, K Tanaka, J Shoda
2021
Nrf2 Regulates Anti-Inflammatory A20 Deubiquitinase Induction by LPS in Macrophages in Contextual Manner
HR Potteti, LK Venkareddy, PM Noone, A Ankireddy, CR Tamatam, D Mehta, C Tiruppathi, SP Reddy
Antioxidants 2021
Transcription Factors Interplay Orchestrates the Immune-Metabolic Response of Leishmania Infected Macrophages
H Bichiou, C Bouabid, I Rabhi, L Guizani-Tabbane
Frontiers in Cellular and Infection Microbiology 2021
Divulging the Intricacies of Crosstalk Between NF-Kb and Nrf2-Keap1 Pathway in Neurological Complications of COVID-19
R Bhandari, G Khanna, D Kaushik, A Kuhad
Molecular Neurobiology 2021
Reactive Oxygen Species in Macrophages: Sources and Targets
M Canton, R Sánchez-Rodríguez, I Spera, FC Venegas, M Favia, A Viola, A Castegna
Frontiers in immunology 2021
The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism
M Reverte, RO Eren, B Jha, C Desponds, T Snäkä, F Prevel, N Isorce, LF Lye, KL Owens, UG Lopes, SM Beverley, N Fasel, S Stäger
PLoS pathogens 2021
Influence of Ce3+ Substitution on Antimicrobial and Antibiofilm Properties of ZnCexFe2−xO4 Nanoparticles (X = 0.0, 0.02, 0.04, 0.06, and 0.08) Conjugated with Ebselen and Its Role Subsidised with γ-Radiation in Mitigating Human TNBC and Colorectal Adenocarcinoma Proliferation In Vitro
MK Abdel-Rafei, NM Thabet, MI Maksoud, MA Elkodous, G Kawamura, A Matsuda, AH Ashour, AI El-Batal, GS El-Sayyad
International journal of molecular sciences 2021
Auranofin-Mediated NRF2 Induction Attenuates Interleukin 1 Beta Expression in Alveolar Macrophages
SB Wall, R Li, B Butler, AR Burg, HM Tse, JL Larson-Casey, AB Carter, CJ Wright, LK Rogers, TE Tipple
Antioxidants 2021
The antioxidant role of STAT3 in methylmercury-induced toxicity in mouse hypothalamic neuronal GT1-7 cell line
B Ferrer, H Suresh, A Santamaria, JB Rocha, AB Bowman, M Aschner
Free radical biology & medicine 2021
Wogonin alleviates liver injury in sepsis through Nrf2‐mediated NF‐κB signalling suppression
JM Dai, WN Guo, YZ Tan, KW Niu, JJ Zhang, CL Liu, XM Yang, KS Tao, ZN Chen, JY Dai
Journal of Cellular and Molecular Medicine 2021
Phenylethanoid Glycosides From Callicarpa kwangtungensis Chun Attenuate TNF-α-Induced Cell Damage by Inhibiting NF-κB Pathway and Enhancing Nrf2 Pathway in A549 Cells
JN Zheng, JY Zhuo, J Nie, YL Liu, BY Chen, AZ Wu, YC Li
Frontiers in pharmacology 2021
Reactive Oxygen Species: Not Omnipresent but Important in Many Locations
M Herb, A Gluschko, M Schramm
Frontiers in Cell and Developmental Biology 2021
Tribbles pseudokinase NIPI-3 regulates intestinal immunity in Caenorhabditis elegans by controlling SKN-1/Nrf activity
C Wu, O Karakuzu, DA Garsin
Cell Reports 2021
Crocetin Exerts Its Anti-inflammatory Property in LPS-Induced RAW264.7 Cells Potentially via Modulation on the Crosstalk between MEK1/JNK/NF-κB/iNOS Pathway and Nrf2/HO-1 Pathway
YL Wen, Z He, DX Hou, S Qin, A Ciobica
Oxidative Medicine & Cellular Longevity 2021
Role of Nrf2 in Synaptic Plasticity and Memory in Alzheimer’s Disease
DA Davies, A Adlimoghaddam, BC Albensi
Cells 2021
Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling
Y Fu, J Jia
Frontiers in neuroscience 2021
Pneumolysin Is Responsible for Differential Gene Expression and Modifications in the Epigenetic Landscape of Primary Monocyte Derived Macrophages
J Cole, A Angyal, RD Emes, TJ Mitchell, MJ Dickman, DH Dockrell
Frontiers in immunology 2021
Virus Infection Induces Keap1 Binding to Cytokine Genes, Which Recruits NF-κB p50 and G9a-GLP and Represses Cytokine Transcription
VE Burns, TK Kerppola
Journal of immunology (Baltimore, Md. : 1950) 2021
Prohibitin‐1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis
TA Mattox, C Psaltis, K Weihbrecht, J Robidoux, B KilburgBasnyat, MP Murphy, KM Gowdy, EJ Anderson
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease 2021
Nrf2 for cardiac protection: pharmacological options against oxidative stress
QM Chen
Trends in Pharmacological Sciences 2021
Spinal Nrf2 translocation may inhibit neuronal NF‐κB activation and alleviate allodynia in a rat model of bone cancer pain
J Fu, C Ni, HD Ni, LS Xu, QL He, H Pan, DD Huang, YB Sun, G Luo, MJ Liu, M Yao
Journal of Neurochemistry 2021
Functions of ROS in Macrophages and Antimicrobial Immunity
M Herb, M Schramm
Antioxidants 2021
Redox Homeostasis in Poultry: Regulatory Roles of NF-κB
PF Surai, II Kochish, MT Kidd
Antioxidants 2021
Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation
W Shan, X Liao, Y Tang, J Liu
Experimental and therapeutic medicine 2021
Impact of Cigarette Smoking on the Expression of Oxidative Stress-Related Genes in Cumulus Cells Retrieved from Healthy Women Undergoing IVF
F Konstantinidou, MC Budani, A Sarra, L Stuppia, GM Tiboni, V Gatta
International journal of molecular sciences 2021
Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic Pathways
A Gandhirajan, S Roychowdhury, V Vachharajani
Antioxidants 2021
Escherichia coli and Staphylococcus aureus Differentially Regulate Nrf2 Pathway in Bovine Mammary Epithelial Cells: Relation to Distinct Innate Immune Response.
Ying YT, Yang J, Tan X, Liu R, Zhuang Y, Xu JX, Ren WJ
Cells 2021
The Potential Role of Curcumin in Modulating the Master Antioxidant Pathway in Diabetic Hypoxia-Induced Complications
Ghareghomi S, Rahban M, Moosavi-Movahedi Z, Habibi-Rezaei M, Saso L, Moosavi-Movahedi AA
Molecules (Basel, Switzerland) 2021
Geniposide Attenuates Hyperglycemia-Induced Oxidative Stress and Inflammation by Activating the Nrf2 Signaling Pathway in Experimental Diabetic Retinopathy
Tu Y, Li L, Zhu L, Guo Y, Du S, Zhang Y, Wang Z, Zhang Y, Zhu M
Oxidative medicine and cellular longevity 2021
Profiling Transcription Initiation in Peripheral Leukocytes Reveals Severity-Associated Cis-Regulatory Elements in Critical COVID-19
Lam MT, Duttke SH, Odish MF, Le HD, Hansen EA, Nguyen CT, Trescott S, Kim R, Deota S, Chang MW, Patel A, Hepokoski M, Alotaibi M, Rolfsen M, Perofsky K, Warden AS, Foley J, Ramirez SI, Dan JM, Abbott RK, Crotty S, Crotty Alexander LE, Malhotra A, Panda S, Benner CW, Coufal NG
2021
Macrophage nuclear factor erythroid 2‐related factor 2 deficiency promotes innate immune activation by tissue inhibitor of metalloproteinase 3–mediated RhoA/ROCK pathway in the ischemic liver
Rao J, Qiu J, Ni M, Wang H, Wang P, Zhang L, Wang Z, Liu M, Cheng F, Wang X, Lu L
Hepatology 2021
Hemolysis transforms liver macrophages into anti-inflammatory erythrophagocytes
Marc Pfefferlé, Giada Ingoglia, Christian A. Schaer, Ayla Yalamanoglu, Raphael M. Buzzi, Irina L. Dubach, Ge Tan, Emilio Y. López-​Cano, Nadja Schulthess, Kerstin Hansen, Rok Humar, Dominik J. Schaer, Florence Vallelian
Journal of Clinical Investigation 2020
Unveiling the Role of Inflammation and Oxidative Stress on Age-Related Cardiovascular Diseases
AJ de Almeida, MS de Almeida Rezende, SH Dantas, S de Lima Silva, JC de Oliveira, F de Lourdes Assunção Araújo de Azevedo, RM Alves, GM de Menezes, PF dos Santos, TA Gonçalves, VB Schini-Kerth, IA de Medeiros
Oxidative medicine and cellular longevity 2020
Alternative methanogenesis - Methanogenic potential of organosulfur administration
P Varga, N Vida, P Hartmann, A Szabó, Á Mohácsi, G Szabó, M Boros, E Tuboly, JE Wells
PloS one 2020
H 2 S attenuates oxidative stress via Nrf2/NF-κB signaling to regulate restenosis after percutaneous transluminal angioplasty
K Ling, W Zhou, Y Guo, G Hu, J Chu, F Xie, Y Li, W Wang
Experimental biology and medicine (Maywood, N.J.) 2020
Itaconate prevents abdominal aortic aneurysm formation through inhibiting inflammation via activation of Nrf2
H Song, T Xu, X Feng, Y Lai, Y Yang, H Zheng, X He, G Wei, W Liao, Y Liao, L Zhong, J Bin
EBioMedicine 2020
Classically activated mouse macrophages produce methylglyoxal that induces a TLR4‐ and RAGE‐independent proinflammatory response
D Prantner, S Nallar, K Richard, D Spiegel, KD Collins, SN Vogel
Journal of leukocyte biology 2020
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
S Saha, B Buttari, E Panieri, E Profumo, L Saso
Molecules (Basel, Switzerland) 2020
The α2 Na+/K+-ATPase isoform mediates LPS-induced neuroinflammation
JA Leite, TJ Isaksen, A Heuck, C Scavone, K Lykke-Hartmann
Scientific Reports 2020

Primary Amine Modified Gold Nanodots Regulate Macrophage Function and Antioxidant Response: Potential Therapeutics Targeting of Nrf2


YH Luo, HJ Cheng, FY Tsai, TC Tsou, SY Lin, P Lin
International Journal of Nanomedicine 2020
Immune‐Responsive Gene 1/Itaconate Activates Nuclear Factor Erythroid 2–Related Factor 2 in Hepatocytes to Protect Against Liver Ischemia–Reperfusion Injury
Z Yi, M Deng, MJ Scott, G Fu, PA Loughran, Z Lei, S Li, P Sun, C Yang, W Li, H Xu, F Huang, TR Billiar
Hepatology 2020
Sikyungbanha-Tang Suppressing Acute Lung Injury in Mice Is Related to the Activation of Nrf2 and TNFAIP3
KH Kim, S Ahn, R Won, JJ Lee, TH Kim, JI Kim, JY Choi, M Joo
Evidence-Based Complementary and Alternative Medicine 2020
The methanol extract of Guettarda speciosa Linn. Ameliorates acute lung injury in mice
KH Kim, JY Lee, S Ahn, R Won, SJ Kim, SI Jeong, JJ Lee, JI Kim, JY Choi, M Joo
2020
The Transcriptomic Response of the Murine Thyroid Gland to Iodide Overload and the Role of the Nrf2 Antioxidant System
DV Chartoumpekis, PG Ziros, I Georgakopoulos-Soares, AA Smith, AC Marques, M Ibberson, PA Kopp, I Habeos, IP Trougakos, NK Khoo, GP Sykiotis
Antioxidants 2020
NRF2 Is an Upstream Regulator of MYC-Mediated Osteoclastogenesis and Pathological Bone Erosion
PS Park, SH Mun, SL Zeng, H Kim, S Bae, KH Park-Min
Cells 2020
Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity
I Gopallawa, RJ Lee
World journal of biological chemistry 2020
SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
D Olagnier, E Farahani, J Thyrsted, J Blay-Cadanet, A Herengt, M Idorn, A Hait, B Hernaez, A Knudsen, MB Iversen, M Schilling, SE Jørgensen, M Thomsen, LS Reinert, M Lappe, HD Hoang, VH Gilchrist, AL Hansen, R Ottosen, CG Nielsen, C Møller, D van der Horst, S Peri, S Balachandran, J Huang, M Jakobsen, EB Svenningsen, TB Poulsen, L Bartsch, AL Thielke, Y Luo, T Alain, J Rehwinkel, A Alcamí, J Hiscott, T Mogensen, SR Paludan, CK Holm
Nature Communications 2020
Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodegeneration in an Amyloid-β-Induced Mouse Model
K Saeed, SA Shah, R Ullah, SI Alam, JS Park, S Saleem, MH Jo, MW Kim, JR Hahm, MO Kim, VM Mendoza-Núñez
Oxidative Medicine & Cellular Longevity 2020
Nrf2—A Molecular Target for Sepsis Patients in Critical Care
S Gunne, U Heinicke, MJ Parnham, V Laux, K Zacharowski, A von Knethen
Biomolecules 2020
Oxidative Stress Product, 4-Hydroxy-2-Nonenal, Induces the Release of Tissue Factor-Positive Microvesicles From Perivascular Cells Into Circulation
SA Ansari, S Keshava, UR Pendurthi, LV Rao
Arteriosclerosis, thrombosis, and vascular biology 2020
Targeting Cytokine Release Through the Differential Modulation of Nrf2 and NF-κB Pathways by Electrophilic/Non-Electrophilic Compounds
F Fagiani, M Catanzaro, E Buoso, F Basagni, DD Marino, S Raniolo, M Amadio, EH Frost, E Corsini, M Racchi, T Fulop, S Govoni, M Rosini, C Lanni
Frontiers in pharmacology 2020
Evaluation of IL-17D in Host Immunity to Group A Streptococcus Infection
A Washington, N Varki, JA Valderrama, V Nizet, JD Bui
Journal of immunology (Baltimore, Md. : 1950) 2020
NRF2 as a regulator of cell metabolism and inflammation in cancer
F He, L Antonucci, M Karin
Carcinogenesis 2020
NF‐E2–Related Factor 2 Regulates Interferon Receptor Expression and Alters Macrophage Polarization in Lupus
S Han, H Zhuang, PY Lee, M Li, L Yang, PA Nigrovic, WH Reeves
Arthritis & Rheumatology 2020
Reciprocal interference between the NRF2 and LPS signaling pathways on the immune‐metabolic phenotype of peritoneal macrophages
F Mornata, G Pepe, C Sfogliarini, E Brunialti, G Rovati, M Locati, A Maggi, E Vegeto
Pharmacology Research & Perspectives 2020
Lactobacillus reuteri DSM 17938 and ATCC PTA 5289 ameliorates chemotherapy-induced oral mucositis
N Gupta, J Ferreira, CH Hong, KS Tan
Scientific Reports 2020
The myeloid type I interferon response to myocardial infarction begins in bone marrow and is regulated by Nrf2-activated macrophages
DM Calcagno, RP Ng, A Toomu, C Zhang, K Huang, AD Aguirre, R Weissleder, LB Daniels, Z Fu, KR King
Science Immunology 2020
Pathogenic Mechanisms of Myeloma Bone Disease and Possible Roles for NRF2
CH Yen, CM Hsu, SY Hsiao, HH Hsiao
International journal of molecular sciences 2020
Electrophilic Nrf2 activators and itaconate inhibit inflammation at low dose and promote IL-1β production and inflammatory apoptosis at high dose
J Muri, H Wolleb, P Broz, EM Carreira, M Kopf
Redox Biology 2020
A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis
Y Chen, JW Evankovich, TB Lear, F Tuncer, JR Kennerdell, DP Camarco, MS Shishido, Y Liu, BB Chen
Redox Biology 2020
Flavonoids Activation of the Transcription Factor Nrf2 as a Hypothesis Approach for the Prevention and Modulation of SARS-CoV-2 Infection Severity
P Mendonca, KF Soliman
Antioxidants 2020

Methyl Jasmonate Protects Microglial Cells Against β-Amyloid-Induced Oxidative Stress and Inflammation via Nrf2-Dependent HO-1 Pathway


H Li, L Lv, C Wu, J Qi, B Shi
Neuropsychiatric Disease and Treatment 2020
Effects of Mycoplasmas on the Host Cell Signaling Pathways
SN Borchsenius, IE Vishnyakov, OA Chernova, VM Chernov, NA Barlev
Pathogens 2020
Protective Role of Nrf2 in Renal Disease
M Guerrero-Hue, S Rayego-Mateos, C Vázquez-Carballo, A Palomino-Antolín, C García-Caballero, L Opazo-Rios, JL Morgado-Pascual, C Herencia, S Mas, A Ortiz, A Rubio-Navarro, J Egea, JM Villalba, J Egido, JA Moreno
Antioxidants 2020
Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells
RE Kim, CY Shin, SH Han, KJ Kwon
International journal of molecular sciences 2020
PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling
Y An, H Zhang, S Huang, G Pei
Frontiers in immunology 2020
Mycoplasma hyopneumoniae J elicits an antioxidant response and decreases the expression of ciliary genes in infected swine epithelial cells
SG Mucha, MG Ferrarini, C Moraga, AD Genova, L Guyon, F Tardy, S Rome, MF Sagot, A Zaha
Scientific Reports 2020
Itaconate: A Metabolite Regulates Inflammation Response and Oxidative Stress
R Li, P Zhang, Y Wang, K Tao
Oxidative medicine and cellular longevity 2020
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
L Torrente, N Prieto-Farigua, A Falzone, CM Elkins, DA Boothman, EB Haura, GM DeNicola
Redox Biology 2020
Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
T Cordes, A Lucas, AS Divakaruni, AN Murphy, P Cabrales, CM Metallo
Molecular Metabolism 2020
High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro
L Torrente, G Maan, AO Rezig, J Quinn, A Jackson, A Grilli, L Casares, Y Zhang, E Kulesskiy, J Saarela, S Bicciato, J Edwards, AT Dinkova-Kostova, L de la Vega
Biomolecules 2020
NRF2, a Transcription Factor for Stress Response and Beyond
F He, X Ru, T Wen
International journal of molecular sciences 2020
Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction
LC Pomatto, T Dill, B Carboneau, S Levan, J Kato, EM Mercken, KJ Pearson, M Bernier, R de Cabo
Free radical biology & medicine 2020
Pyrocatechol, a component of coffee, suppresses LPS-induced inflammatory responses by inhibiting NF-κB and activating Nrf2
M Funakoshi-Tago, Y Nonaka, K Tago, M Takeda, Y Ishihara, A Sakai, M Matsutaka, K Kobata, H Tamura
Scientific Reports 2020
Redox regulation of immunometabolism
J Muri, M Kopf
Nature Reviews Immunology 2020
Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Hispolon in Mice, Through Regulating the TLR4/PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 Pathways, and Suppressing Oxidative Stress-Mediated ER Stress-Induced Apoptosis and Autophagy
CY Huang, JS Deng, WC Huang, WP Jiang, GJ Huang
Nutrients 2020
Roles of Nrf2 in Protecting the Kidney from Oxidative Damage
M Nezu, N Suzuki
International journal of molecular sciences 2020
Mechanisms and therapeutic implications of RTA 408, an activator of Nrf2, in subarachnoid hemorrhage–induced delayed cerebral vasospasm and secondary brain injury
TH Tsai, SH Lin, CH Wu, YC Tsai, SF Yang, CL Lin, J Ai
PloS one 2020
Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation
A Nakano-Kobayashi, A Fukumoto, A Morizane, DT Nguyen, TM Le, K Hashida, T Hosoya, R Takahashi, J Takahashi, O Hori, M Hagiwara
Science Advances 2020
Tanshinone IIA pretreatment promotes cell survival in human lung epithelial cells under hypoxia via AP-1-Nrf2 transcription factor
S Yadav, M Singh, SN Singh, B Kumar
Cell Stress and Chaperones 2020
Nrf2-dependent and -independent effects of tBHQ in activated murine B cells
JK Bursley, CE Rockwell
Food and Chemical Toxicology 2020
Targeting Transcription Factor Nrf2 (Nuclear Factor Erythroid 2-Related Factor 2) for the Intervention of Vascular Cognitive Impairment and Dementia
T Yang, F Zhang
Arteriosclerosis, thrombosis, and vascular biology 2020
Melatonin alleviates sepsis-induced heart injury through activating the Nrf2 pathway and inhibiting the NLRP3 inflammasome
I Rahim, RK Sayed, M Fernández-Ortiz, P Aranda-Martínez, A Guerra-Librero, J Fernández-Martínez, I Rusanova, G Escames, B Djerdjouri, D Acuña-Castroviejo
Naunyn-Schmiedeberg's Archives of Pharmacology 2020
Cyanidin Chloride Induces Apoptosis by Inhibiting NF-κB Signaling through Activation of Nrf2 in Colorectal Cancer Cells
DY Lee, SM Yun, MY Song, K Jung, EH Kim
Antioxidants 2020
Environmental pollutants and the immune response
T Suzuki, T Hidaka, Y Kumagai, M Yamamoto
Nature Immunology 2020
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice
CM Tamatam, NM Reddy, HR Potteti, A Ankireddy, PM Noone, M Yamamoto, TW Kensler, SP Reddy
Scientific Reports 2020
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
SD Naidu, AT Dinkova-Kostova
Open Biology 2020
The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract
Y Kong, KJ Olejar, SL On, V Chelikani
Antioxidants 2020
hPMSCs protects against d-galactose-induced oxidative damage of CD4+ T cells through activating Akt-mediated Nrf2 antioxidant signaling
Y Xiong, Y Wang, J Zhang, N Zhao, H Zhang, A Zhang, D Zhao, Z Yu, Y Yin, L Song, Y Xiong, X Luan
Stem Cell Research & Therapy 2020
Stress Memory of Recurrent Environmental Challenges in Marine Invasive Species: Ciona robusta as a Case Study.
Li H, Huang X, Zhan A
Frontiers in physiology 2020
Clinically-approved CFTR modulators rescue Nrf2 dysfunction in cystic fibrosis airway epithelia
Dana C. Borcherding, Matthew Siefert, Songbai Lin, John J. Brewington, Hesham Sadek, John Clancy, Scott Plafker, Assem Ziady
Journal of Clinical Investigation 2019
Dimethyl fumarate abrogates dust mite‐induced allergic asthma by altering dendritic cell function
AK Jaiswal, M Sandey, A Suryawanshi, RC Cattley, A Mishra
Immunity, Inflammation and Disease 2019
Differential Effects of Human SP-A1 and SP-A2 on the BAL Proteome and Signaling Pathways in Response to Klebsiella pneumoniae and Ozone Exposure
G Wang, TM Umstead, S Hu, AN Mikerov, DS Phelps, J Floros
Frontiers in immunology 2019
HYCO-3, a dual CO-releaser/Nrf2 activator, reduces tissue inflammation in mice challenged with lipopolysaccharide
R Motterlini, A Nikam, S Manin, A Ollivier, JL Wilson, S Djouadi, L Muchova, T Martens, M Rivard, R Foresti
Redox Biology 2019
Modulating NRF2 in Disease: Timing Is Everything
M Dodson, MR de la Vega, AB Cholanians, CJ Schmidlin, E Chapman, DD Zhang
Annual Review of Pharmacology and Toxicology 2019
Magnesium lithospermate B protects the endothelium from inflammation-induced dysfunction through activation of Nrf2 pathway
F Gao, J Li, , H Li, Y Liu, Y Wang, L Xuan
Acta Pharmacologica Sinica 2019
Nrf2 in cancers: A double‐edged sword
S Wu, H Lu, Y Bai
Cancer Medicine 2019
Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway
L Sheng, B Lu, H Chen, Y Du, C Chen, W Cai, Y Yang, X Tian, Z Huang, W Chi, S Lin, G Yan, W Yin
Marine drugs 2019
Effects of propofol combined with remifentanil anesthesia on the NO, endothelin and inflammatory cytokines in the plasma of patients with liver cirrhosis during the perioperative period
Y Wang, R Qiu, G Kong, J Liu
Experimental and therapeutic medicine 2019
Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation
C Yarana, H Thompson, L Chaiswing, DA Butterfield, H Weiss, S Bondada, S Alhakeem, S Sukati, DK Clair
Redox Biology 2019
Machine learning approach yields epigenetic biomarkers of food allergy: A novel 13-gene signature to diagnose clinical reactivity
A Alag, J Tost
PloS one 2019
miR‑148 family members are putative biomarkers for sepsis
L Dong, H Li, S Zhang, G Yang
Molecular medicine reports 2019
The Role of Nrf2 in the Antioxidant Cellular Response to Medical Ozone Exposure
M Galiè, V Covi, G Tabaracci, M Malatesta
International journal of molecular sciences 2019
Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice
C Gunderstofte, MB Iversen, S Peri, A Thielke, S Balachandran, CK Holm, D Olagnier
Frontiers in immunology 2019
p-Coumaric acid protects cardiac function against lipopolysaccharide-induced acute lung injury by attenuation of oxidative stress
Maryam Kheiry, Mahin Dianat, Mohammad Badavi, Seyyed Ali Mard, Vahid Bayati
Iranian Journal of Basic Medical Sciences 2019
Nitrated fatty acids: from diet to disease
NK Khoo, FJ Schopfer
Current Opinion in Physiology 2019
N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway
R Fusco, M Scuto, M Cordaro, R DAmico, E Gugliandolo, R Siracusa, AF Peritore, R Crupi, D Impellizzeri, S Cuzzocrea, RD Paola
International journal of molecular sciences 2019
Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease
CA Houghton
Oxidative medicine and cellular longevity 2019
Myricetin Abrogates Cisplatin-Induced Oxidative Stress, Inflammatory Response, and Goblet Cell Disintegration in Colon of Wistar Rats
MU Rehman, IA Rather
Plants 2019
miR‑195 promotes LPS‑mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a
T Yuan, L Zhang, S Yao, SY Deng, JQ Liu
International journal of molecular medicine 2019
Nrf2 dysfunction and impaired cellular resilience to oxidative stressors in the aged vasculature: from increased cellular senescence to the pathogenesis of age-related vascular diseases
Z Ungvari, S Tarantini, Á Nyúl-Tóth, T Kiss, A Yabluchanskiy, T Csipo, P Balasubramanian, A Lipecz, Z Benyo, A Csiszar
GeroScience 2019
p-Coumaric Acid Attenuates Lipopolysaccharide-Induced Lung Inflammation in Rats by Scavenging ROS Production: an In Vivo and In Vitro Study
M Kheiry, M Dianat, M Badavi, SA Mard, V Bayati
Inflammation 2019
Maggot Extracts Alleviate Inflammation and Oxidative Stress in Acute Experimental Colitis via the Activation of Nrf2
R Wang, Y Luo, Y Lu, D Wang, T Wang, W Pu, Y Wang
Oxidative medicine and cellular longevity 2019
Piceatannol protects against cisplatin nephrotoxicity via activation of Nrf2/HO-1 pathway and hindering NF-κB inflammatory cascade
SA Wahdan, SS Azab, DA Elsherbiny, E El-Demerdash
Naunyn-Schmiedeberg's Archives of Pharmacology 2019
Andrographolide sodium bisulfate attenuates UV‑induced photo‑damage by activating the keap1/Nrf2 pathway and downregulating the NF‑κB pathway in HaCaT keratinocytes
ML Wang, QY Zhong, BQ Lin, YH Liu, YF Huang, Y Chen, J Yuan, ZR Su, J Zhan
International journal of molecular medicine 2019
Oxidative Stress Mechanisms in the Pathogenesis of Environmental Lung Diseases
Thimmulappa RK, Chattopadhyay I, Rajasekaran S
2019
HEK293 Cells Overexpressing Nuclear Factor E2-Related Factor-2 Improve Expression of Recombinant Coagulation Factor VII.
Abbasi-Malati Z, Amiri F, Mohammadipour M, Roudkenar MH
Molecular Biotechnology 2019
Cyclic Stretch Negatively Regulates IL-1β Secretion Through the Inhibition of NLRP3 Inflammasome Activation by Attenuating the AMP Kinase Pathway
K Maruyama, Y Sakisaka, M Suto, H Tada, T Nakamura, S Yamada, E Nemoto
Frontiers in physiology 2018
Interleukin-17D and Nrf2 mediate initial innate immune cell recruitment and restrict MCMV infection
R Seelige, R Saddawi-Konefka, NM Adams, G Picarda, JC Sun, CA Benedict, JD Bui
Scientific Reports 2018
The Role of Mitophagy in Innate Immunity
I Gkikas, K Palikaras, N Tavernarakis
Frontiers in immunology 2018
NF-κB in oxidative stress
K Lingappan
Current Opinion in Toxicology 2018
Bone marrow-derived mesenchymal stem cells ameliorate liver injury in a rat model of sepsis by activating Nrf2 signaling
SA Selim, SA El-Baset, AA Kattaia, EM Askar, EA Elkader
Histochemistry and Cell Biology 2018
Clinical significance of the detection of procalcitonin and C-reactive protein in the intensive care unit
Q Li, X Gong
Experimental and therapeutic medicine 2018
Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2
JO Early, D Menon, CA Wyse, MP Cervantes-Silva, Z Zaslona, RG Carroll, EM Palsson-McDermott, S Angiari, DG Ryan, SE Corcoran, G Timmons, SS Geiger, DJ Fitzpatrick, D OConnell, RJ Xavier, K Hokamp, LA ONeill, AM Curtis
Proceedings of the National Academy of Sciences 2018
NRF2 and the Hallmarks of Cancer
MR de la Vega, E Chapman, DD Zhang
Cancer Cell 2018
Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy
Z Jiang, L Bo, Y Meng, C Wang, T Chen, C Wang, X Yu, X Deng
Cell Death and Disease 2018
Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside
R Velagapudi, A El-Bakoush, OA Olajide
Molecular Neurobiology 2018
Protective Role of Nuclear Factor Erythroid 2-Related Factor 2 Against Respiratory Syncytial Virus and Human Metapneumovirus Infections
T Ivanciuc, E Sbrana, A Casola, RP Garofalo
Frontiers in immunology 2018
Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model
S Yamada, M Kimura, Y Saito, H Saito
Journal of Clinical Biochemistry and Nutrition 2018
Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus
VT Mihaylova, Y Kong, O Fedorova, L Sharma, CS Cruz, AM Pyle, A Iwasaki, EF Foxman
Cell Reports 2018
Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming
D Olagnier, AM Brandtoft, C Gunderstofte, NL Villadsen, C Krapp, AL Thielke, A Laustsen, S Peri, AL Hansen, L Bonefeld, J Thyrsted, V Bruun, MB Iversen, L Lin, VM Artegoitia, C Su, L Yang, R Lin, S Balachandran, Y Luo, M Nyegaard, B Marrero, R Goldbach-Mansky, M Motwani, DG Ryan, KA Fitzgerald, LA ONeill, AK Hollensen, CK Damgaard, F v. de Paoli, HC Bertram, MR Jakobsen, TB Poulsen, CK Holm
Nature Communications 2018
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, MP Jedrychowski, AS Costa, M Higgins, E Hams, J Szpyt, MC Runtsch, MS King, JF McGouran, R Fischer, BM Kessler, AF McGettrick, MM Hughes, RG Carroll, LM Booty, EV Knatko, PJ Meakin, ML Ashford, LK Modis, G Brunori, DC Sévin, PG Fallon, ST Caldwell, ER Kunji, ET Chouchani, C Frezza, AT Dinkova-Kostova, RC Hartley, MP Murphy, LA ONeill
Nature 2018
2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease
M Cordaro, R Siracusa, R Crupi, D Impellizzeri, AF Peritore, R DAmico, E Gugliandolo, RD Paola, S Cuzzocrea
Molecular Neurobiology 2018
The role of oxidative stress in anxiety disorder: cause or consequence?
A das Graças Fedoce, F Ferreira, RG Bota, V Bonet-Costa, PY Sun, KJ Davies
Free Radical Research 2018
Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
DB Graham, GJ Jasso, A Mok, G Goel, AC Ng, R Kolde, M Varma, JG Doench, DE Root, CB Clish, SA Carr, RJ Xavier
Cell Reports 2018
Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis
D Zhao, MG Badur, J Luebeck, JH Magaña, A Birmingham, R Sasik, CS Ahn, T Ideker, CM Metallo, P Mali
Molecular Cell 2018
Electrophilic fatty acid nitroalkenes regulate Nrf2 and NF-κB signaling:A medicinal chemistry investigation of structure-function relationships
NK Khoo, L Li, SR Salvatore, FJ Schopfer, BA Freeman
Scientific Reports 2018
C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape
SD Naidu, A Muramatsu, R Saito, S Asami, T Honda, T Hosoya, K Itoh, M Yamamoto, T Suzuki, AT Dinkova-Kostova
Scientific Reports 2018
Differential Regulation of NF- κ B and Nrf2 by Bojungikki-Tang Is Associated with Suppressing Lung Inflammation
SR Park, KH Kim, MJ Kwun, JY Lee, R Won, CW Han, JY Choi, M Joo
Evidence-Based Complementary and Alternative Medicine 2018
Identification of potential genes and miRNAs associated with sepsis based on microarray analysis
Y Li, F Zhang, Y Cong, Y Zhao
Molecular medicine reports 2018
Differential effects of the Nrf2 activators tBHQ and CDDO-Im on the early events of T cell activation
JW Zagorski, AE Turley, RA Freeborn, KR VanDenBerg, HE Dover, BR Kardell, KT Liby, CE Rockwell
Biochemical Pharmacology 2018
Resveratrol ameliorates sepsis‑induced acute kidney injury in a pediatric rat model via Nrf2 signaling pathway
Y Wang, F Feng, M Liu, J Xue, H Huang
Experimental and therapeutic medicine 2018
Bioinformatics analysis to screen for critical genes between survived and non‑survived patients with sepsis
Y Wu, L Zhang, Y Zhang, Y Zhen, S Liu
Molecular medicine reports 2018
The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease
YF Zhao, QZ, JF Zhang, ZY Lou, HB Zu, ZG Wang, WC Zeng, KY, BG Xiao
Aging and disease 2018
NRF2 Is One of the Players Involved in Bone Marrow Mediated Drug Resistance in Multiple Myeloma
CH Yen, HH Hsiao
International journal of molecular sciences 2018
Transcriptional Regulation by Nrf2
C Tonelli, II Chio, DA Tuveson
Antioxidants & Redox Signaling 2018
Glucosamine improves survival in a mouse model of sepsis and attenuates sepsis-induced lung injury and inflammation
JS Hwang, KH Kim, J Park, SM Kim, H Cho, Y Lee, IO Han
The Journal of biological chemistry 2018
Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding
M Kanamoto, Y Tsuchiya, Y Nakao, T Suzuki, H Motohashi, M Yamamoto, H Kamata, W Hu
PloS one 2018
Glucose negatively affects Nrf2/SKN-1-mediated innate immunity in C. elegans
L Li, Y Chen, C Chenzhao, S Fu, Q Xu, J Zhao
Aging 2018
Deletion of both p62 and Nrf2 spontaneously results in the development of nonalcoholic steatohepatitis
K AKIYAMA, E WARABI, K OKADA, T YANAGAWA, T ISHII, K KOSE, K TOKUSHIGE, K ISHIGE, Y MIZOKAMI, K YAMAGATA, K ONIZAWA, S ARIIZUMI, M YAMAMOTO, J SHODA
Experimental Animals 2017
Unravelling the networks dictating host resistance versus tolerance during pulmonary infections
I Meunier, E Kaufmann, J Downey, M Divangahi
Cell and Tissue Research 2017
MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury
W Xu, F Li, Z Liu, Z Xu, B Sun, J Cao, Y Liu
Oncotarget 2017
Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart
P Jakobs, V Serbulea, N Leitinger, A Eckers, J Haendeler
Antioxidants & Redox Signaling 2017
The role of declining adaptive homeostasis in ageing: Ageing decline in adaptive homeostasis
LC Pomatto, KJ Davies
The Journal of Physiology 2017
Nrf2 regulates gene-environment interactions in an animal model of intrauterine inflammation: Implications for preterm birth and prematurity
TE Sussan, K Sudini, CC Talbot, X Wang, M Wills-Karp, I Burd, S Biswal
Scientific Reports 2017
Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF-κB inactivation
X Xu, X Zhang, Y Zhang, L Yang, Y Liu, S Huang, L Lu, L Kong, Z Li, Q Guo, L Zhao
Scientific Reports 2017
Disease tolerance and immunity in host protection against infection
MP Soares, L Teixeira, LF Moita
Nature Reviews Immunology 2017
Role of microRNAs in sepsis
SM Kingsley, BV Bhat
Inflammation Research 2017
Anti-inflammatory effects of H2S during acute bacterial infection: a review
F Benedetti, S Curreli, S Krishnan, S Davinelli, F Cocchi, G Scapagnini, RC Gallo, D Zella
Journal of Translational Medicine 2017
Differential regulation of innate immune cytokine production through pharmacological activation of Nuclear Factor-Erythroid-2-Related Factor 2 (NRF2) in burn patient immune cells and monocytes
TK Eitas, W Stepp, L Sjeklocha, C Long, C Riley, J Callahan, Y Sanchez, P Gough, L Knowlin, D Duin, S Ortiz-Pujols, S Jones, R Maile, Z Hong, S Berger, B Cairns, P Proost
PloS one 2017
Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion
X Xu, L Zhang, X Ye, Q Hao, T Zhang, G Cui, M Yu
Inflammation Research 2017
Suppressed ubiquitination of Nrf2 by p47 phox contributes to Nrf2 activation
KH Kim, RT Sadikot, JY Lee, HS Jeong, YK Oh, TS Blackwell, M Joo
Free radical biology & medicine 2017
N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2
J Mildenberger, I Johansson, I Sergin, E Kjøbli, JK Damås, B Razani, TH Flo, G Bjørkøy
Autophagy 2017
Activating de novo mutations in NFE2L2 encoding NRF2 cause a multisystem disorder
P Huppke, S Weissbach, JA Church, R Schnur, M Krusen, S Dreha-Kulaczewski, WN Kühn-Velten, A Wolf, B Huppke, F Millan, A Begtrup, F Almusafri, H Thiele, J Altmüller, P Nürnberg, M Müller, J Gärtner
Nature Communications 2017
Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2
KR VanDenBerg, RA Freeborn, S Liu, RC Kennedy, JW Zagorski, CE Rockwell, P Bobé
PloS one 2017
Nrf2-Dependent and -Independent Effects of tert -Butylhydroquinone, CDDO-Im, and H 2 O 2 in Human Jurkat T Cells as Determined by CRISPR/Cas9 Gene Editing
JW Zagorski, TP Maser, KT Liby, CE Rockwell
The Journal of pharmacology and experimental therapeutics 2017
Protective effects of sulforaphane on di-n-butylphthalate-induced testicular oxidative stress injury in male mice offsprings via activating Nrf2/ARE pathway
Z Qin, J Tang, P Han, X Jiang, C Yang, R Li, M Tang, B Shen, W Wang, C Qin, W Zhang
Oncotarget 2017
Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting I κ B α /NF κ B and Enhancing Nrf2/HO-1
H Liao, J Zhu, H Feng, J Ni, N Zhang, S Chen, H Liu, Z Yang, W Deng, QZ Tang
Oxidative medicine and cellular longevity 2017
Nrf2, the Master Regulator of Anti-Oxidative Responses
S Vomund, A Schäfer, M Parnham, B Brüne, A Knethen
International journal of molecular sciences 2017
The Role of Cyclo(His-Pro) in Neurodegeneration
S Grottelli, I Ferrari, G Pietrini, M Peirce, A Minelli, I Bellezza
International journal of molecular sciences 2016
Sulforaphane Protects Pancreatic Acinar Cell Injury by Modulating Nrf2-Mediated Oxidative Stress and NLRP3 Inflammatory Pathway
Z Dong, H Shang, YQ Chen, LL Pan, M Bhatia, J Sun
Oxidative medicine and cellular longevity 2016
Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet
SF Xia, GW Le, P Wang, YY Qiu, YY Jiang, X Tang
Nutrients 2016
Protective role of nuclear factor erythroid�2-related factor�2 in the hemorrhagic shock-induced inflammatory response
H Zhao, S Hao, H Xu, L Ma, Z Zhang, Y Ni, L Yu
International journal of molecular medicine 2016
Macrophages and Iron Metabolism
MP Soares, I Hamza
Immunity 2016
Mucosal Interactions between Genetics, Diet, and Microbiome in Inflammatory Bowel Disease
A Basson, A Trotter, A Rodriguez-Palacios, F Cominelli
Frontiers in immunology 2016
Dimethyl fumarate treatment induces adaptive and innate immune modulation independent of Nrf2
U Schulze-Topphoff, M Varrin-Doyer, K Pekarek, CM Spencer, A Shetty, SA Sagan, BA Cree, RA Sobel, BT Wipke, L Steinman, RH Scannevin, SS Zamvil
Proceedings of the National Academy of Sciences 2016
Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice
JC Gomez, H Dang, JR Martin, CM Doerschuk
Journal of immunology (Baltimore, Md. : 1950) 2016
Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways
C Nunes, N Teixeira, D Serra, V Freitas, L Almeida, J Laranjinha
Toxicology Research 2016
Adipose-derived mesenchymal stem cells promote the survival of fat grafts via crosstalk between the Nrf2 and TLR4 pathways
X Chen, L Yan, Z Guo, Z Chen, Y Chen, M Li, C Huang, X Zhang, L Chen
Cell Death and Disease 2016
Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis
SM Swamy, NS Rajasekaran, VJ Thannickal
The American Journal of Pathology 2016
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
EH Kobayashi, T Suzuki, R Funayama, T Nagashima, M Hayashi, H Sekine, N Tanaka, T Moriguchi, H Motohashi, K Nakayama, M Yamamoto
Nature Communications 2016
Green tea extract provides extensive Nrf2-independent protection against lipid accumulation and NFκB pro- inflammatory responses during nonalcoholic steatohepatitis in mice fed a high-fat diet
J Li, TN Sapper, E Mah, S Rudraiah, KE Schill, C Chitchumroonchokchai, MV Moller, JD McDonald, PR Rohrer, JE Manautou, RS Bruno
Molecular Nutrition & Food Research 2016
TrxR1 inhibition overcomes both hypoxia-induced and acquired bortezomib resistance in multiple myeloma through NF-кβ inhibition
PV Raninga, GD Trapani, S Vuckovic, KF Tonissen
Cell cycle (Georgetown, Tex.) 2016
Nuclear Factor E2-Related Factor-2 Negatively Regulates NLRP3 Inflammasome Activity by Inhibiting Reactive Oxygen Species-Induced NLRP3 Priming
X Liu, X Zhang, Y Ding, W Zhou, L Tao, P Lu, Y Wang, R Hu
Antioxidants & Redox Signaling 2016
Anti-TNF certolizumab pegol induces antioxidant response in human monocytes via reverse signaling
JF Boyer, M Baron, A Constantin, Y Degboé, A Cantagrel, JL Davignon
Arthritis Research & Therapy 2016
Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury
T Ashino, M Yamamoto, S Numazawa
Scientific Reports 2016
Nrf2 plays a pivotal role in protection against burn trauma–induced intestinal injury and death
Z Chen, Y Zhang, L Ma, Y Ni, H Zhao
Oncotarget 2016
A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity
HC Lok, S Sahni, PJ Jansson, Z Kovacevic, CL Hawkins, DR Richardson
The Journal of biological chemistry 2016
Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway
P Kong, G Chen, A Jiang, Y Wang, C Song, J Zhuang, C Xi, G Wang, Y Ji, J Yan
Oncotarget 2016
The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the Kras G12D ;Pdx1-Cre (KC) mouse model of pancreatic cancer
AS Leal, MB Sporn, PA Pioli, KT Liby
Carcinogenesis 2016
Nrf2 exerts cell-autonomous antifibrotic effects: compromised function in systemic sclerosis and therapeutic rescue with a novel heterocyclic chalcone derivative.
Wei J, Zhu H, Lord G, Bhattachayya M, Jones BM, Allaway G, Biswal SS, Korman B, Marangoni RG, Tourtellotte WG, Varga J
Translational research : the journal of laboratory and clinical medicine 2016
Association of Nrf2 with airway pathogenesis: lessons learned from genetic mouse models
HY Cho, SR Kleeberger
Archives of Toxicology 2015
Dietary Glucosinolates Sulforaphane, Phenethyl Isothiocyanate, Indole-3-Carbinol/3,3′-Diindolylmethane: Antioxidative Stress/Inflammation, Nrf2, Epigenetics/Epigenomics and In Vivo Cancer Chemopreventive Efficacy
F Fuentes, X Paredes-Gonzalez, AN Kong
Current Pharmacology Reports 2015
Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
C Qu, B Li, Y Lai, H Li, A Windust, LJ Hofseth, M Nagarkatti, P Nagarkatti, XL Wang, D Tang, JS Janicki, X Tian, T Cui
Journal of Ethnopharmacology 2015
Mechanisms of Interferon-γ Production by Neutrophils and Its Function during Streptococcus pneumoniae Pneumonia
JC Gomez, M Yamada, JR Martin, H Dang, WJ Brickey, W Bergmeier, MC Dinauer, CM Doerschuk
American journal of respiratory cell and molecular biology 2015
Exposure to Diesel Exhaust Particle Extracts (DEPe) Impairs Some Polarization Markers and Functions of Human Macrophages through Activation of AhR and Nrf2
M Jaguin, O Fardel, V Lecureur, CJ Baglole
PloS one 2015
3-(3-Pyridylmethylidene)-2-indolinone Reduces the Severity of Colonic Injury in a Murine Model of Experimental Colitis
KP Wang, C Zhang, SG Zhang, ED Liu, L Dong, XZ Kong, P Cao, CP Hu, K Zhao, YQ Zhan, XM Dong, CH Ge, M Yu, H Chen, L Wang, XM Yang, CY Li
Oxidative medicine and cellular longevity 2015
Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function
TE Sussan, S Gajghate, S Chatterjee, P Mandke, S McCormick, K Sudini, S Kumar, PN Breysse, GB Diette, VK Sidhaye, S Biswal
American journal of physiology. Lung cellular and molecular physiology 2015
Discovery of direct inhibitors of Keap1–Nrf2 protein–protein interaction as potential therapeutic and preventive agents
DA Abed, M Goldstein, H Albanyan, H Jin, L Hu
Acta Pharmaceutica Sinica B 2015
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues and energy status, and pathways through which it attenuates degenerative disease
LE Tebay, H Robertson, ST Durant, SR Vitale, TM Penning, AT Dinkova-Kostova, JD Hayes
Free radical biology & medicine 2015
The complexity of the Nrf2 pathway: Beyond the antioxidant response
Y Huang, W Li, Z Su, AN Kong
The Journal of Nutritional Biochemistry 2015
Sulforaphane reduces lipopolysaccharide-induced proinflammatory markers in hippocampus and liver but does not improve sickness behavior
BE Townsend, RW Johnson
Nutritional Neuroscience 2015
The Nrf2 activator tBHQ inhibits T cell activation of primary human CD4 T cells
AE Turley, JW Zagorski, CE Rockwell
Cytokine 2015
Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio
M Itsumi, S Inoue, AJ Elia, K Murakami, M Sasaki, EF Lind, D Brenner, IS Harris, II Chio, S Afzal, RA Cairns, DW Cescon, AR Elford, J Ye, PA Lang, WY Li, A Wakeham, GS Duncan, J Haight, A You-Ten, B Snow, K Yamamoto, PS Ohashi, TW Mak
Cell Death and Differentiation 2015
RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity
BL Probst, I Trevino, L McCauley, R Bumeister, I Dulubova, WC Wigley, DA Ferguson
PloS one 2015
Phospholipid oxidation generates potent anti-inflammatory lipid mediators that mimic structurally related pro-resolving eicosanoids by activating Nrf2
P Bretscher, J Egger, A Shamshiev, M Trotzmuller, H Kofeler, EM Carreira, M Kopf, S Freigang
EMBO Molecular Medicine 2015
Nrf2 regulates PU.1 expression and activity in the alveolar macrophage
BS Staitieh, X Fan, W Neveu, DM Guidot
American journal of physiology. Lung cellular and molecular physiology 2015
Dimethyl fumarate confers neuroprotection by casein kinase 2 phosphorylation of Nrf2 in murine intracerebral hemorrhage
LO Iniaghe, PR Krafft, DW Klebe, EK Omogbai, JH Zhang, J Tang
Neurobiology of Disease 2015
Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation
SY Qin, RH Du, SS Yin, XF Liu, GL Xu, W Cao
Inflammation Research 2015
Whole-Body In Vivo Monitoring of Inflammatory Diseases Exploiting Human Interleukin 6-Luciferase Transgenic Mice
M Hayashi, J Takai, L Yu, H Motohashi, T Moriguchi, M Yamamoto
Molecular and cellular biology 2015
Differential expression of the Nrf2-linked genes in pediatric septic shock
JR Grunwell, SL Weiss, NZ Cvijanovich, GL Allen, NJ Thomas, RJ Freishtat, N Anas, K Meyer, PA Checchia, TP Shanley, MT Bigham, J Fitzgerald, K Howard, E Frank, K Harmon, HR Wong
Critical Care 2015
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2,3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, Erythroid 2-Like 2 Antioxidant Pathway
SY Min, M Yan, SB Kim, S Ravikumar, SR Kwon, K Vanarsa, HY Kim, LS Davis, C Mohan
Journal of Inflammation 2015
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
JD Wardyn, AH Ponsford, CM Sanderson
Biochemical Society Transactions 2015
Nrf2 as a master regulator of tissue damage control and disease tolerance to infection
MP Soares, AM Ribeiro
Biochemical Society Transactions 2015
Antioxidant therapy for treatment of inflammatory bowel disease: does it work?
FA Moura, KQ de Andrade, JC Santos, OR Araújo, MO Goulart
Redox Biology 2015
Electroacupuncture Ameliorates Acute Renal Injury in Lipopolysaccharide-Stimulated Rabbits via Induction of HO-1 through the PI3K/Akt/Nrf2 Pathways
J Yu, J Shi, Y Zhang, L Gong, S Dong, X Cao, L Wu, L Wu, B Bussolati
PloS one 2015
Phytoestrogens modulate hepcidin expression by Nrf2: Implications for dietary control of iron absorption
HK Bayele, S Balesaria, SK Srai
Free radical biology & medicine 2015
Neutrophilic Lung Inflammation Suppressed by Picroside II Is Associated with TGF- β Signaling
S Noh, KS Ahn, SR Oh, KH Kim, M Joo
Evidence-Based Complementary and Alternative Medicine 2015
Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation
JH Park, J Choi, E Ju, A Pae, K Park
Molecules (Basel, Switzerland) 2015
Effect of Redox Modulating NRF2 Activators on Chronic Kidney Disease
B Choi, KS Kang, MK Kwak
Molecules (Basel, Switzerland) 2014
Redox Control of Microglial Function: Molecular Mechanisms and Functional Significance
AI Rojo, G McBean, M Cindric, J Egea, MG López, P Rada, N Zarkovic, A Cuadrado
Antioxidants & Redox Signaling 2014
Curcumin Protects against Cadmium-Induced Vascular Dysfunction, Hypertension and Tissue Cadmium Accumulation in Mice
U Kukongviriyapan, P Pannangpetch, V Kukongviriyapan, W Donpunha, K Sompamit, P Surawattanawan
Nutrients 2014
Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man
A Jais, E Einwallner, O Sharif, K Gossens, TT Lu, SM Soyal, D Medgyesi, D Neureiter, J Paier-Pourani, K Dalgaard, JC Duvigneau, J Lindroos-Christensen, TC Zapf, S Amann, S Saluzzo, F Jantscher, P Stiedl, J Todoric, R Martins, H Oberkofler, S Müller, C Hauser-Kronberger, L Kenner, E Casanova, H Sutterlüty-Fall, M Bilban, K Miller, AV Kozlov, F Krempler, S Knapp, CN Lumeng, W Patsch, O Wagner, JA Pospisilik, H Esterbauer
Cell 2014
Keap1 inhibition attenuates glomerulosclerosis
Y Miyazaki, A Shimizu, I Pastan, K Taguchi, E Naganuma, T Suzuki, T Hosoya, T Yokoo, A Saito, T Miyata, M Yamamoto, T Matsusaka
Nephrology Dialysis Transplantation 2014
Protective effect of nuclear factor E2-related factor 2 on inflammatory cytokine response to brominated diphenyl ether-47 in the HTR-8/SVneo human first trimester extravillous trophoblast cell line
HR Park, R Loch-Caruso
Toxicology and Applied Pharmacology 2014
Suppression of lung inflammation in an LPS-induced acute lung injury model by the fruit hull of Gleditsia sinensis
K Kim, M Kwun, C Han, KT Ha, JY Choi, M Joo
BMC complementary and alternative medicine 2014
Nuclear Factor E2-related Factor-2 (Nrf2) Is Required for NLRP3 and AIM2 Inflammasome Activation
C Zhao, DD Gillette, X Li, Z Zhang, H Wen
The Journal of biological chemistry 2014
Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells
L Wang, N Kondo, M Cano, K Ebrahimi, T Yoshida, BP Barnett, S Biswal, JT Handa
Free radical biology & medicine 2014
Hydrogen Gas Presents a Promising Therapeutic Strategy for Sepsis
K Xie, L Liu, Y Yu, G Wang
BioMed Research International 2014
Nrf2 Activation Protects the Liver From Ischemia/Reperfusion Injury in Mice:
K Kudoh, H Uchinami, M Yoshioka, E Seki, Y Yamamoto
Annals of Surgery 2014
Nrf2 Protects Against TWEAK-mediated Skeletal Muscle Wasting
O Al-Sawaf, A Fragoulis, C Rosen, YW Kan, TT Sönmez, T Pufe, CJ Wruck
Scientific Reports 2014
Molecular mechanisms of lipopolysaccharide-mediated inhibition of glutathione synthesis in mice
ML Tomasi, M Ryoo, H Yang, AI Ara, KS Ko, SC Lu
Free radical biology & medicine 2014
ROS Function in Redox Signaling and Oxidative Stress
M Schieber, NS Chandel
Current Biology 2014
Desoxyrhapontigenin up-regulates Nrf2-mediated heme oxygenase-1 expression in macrophages and inflammatory lung injury
RJ Choi, M Cheng, YS Kim
Redox Biology 2014
Glutathione Protects Brain Endothelial Cells from Hydrogen Peroxide-Induced Oxidative Stress by Increasing Nrf2 Expression
J Song, SM Kang, WT Lee, KA Park, KM Lee, JE Lee
Experimental Neurobiology 2014
Genetic silencing of Nrf2 enhances X-ROS in dysferlin-deficient muscle
P Kombairaju, JP Kerr, JA Roche, SJ Pratt, RM Lovering, TE Sussan, JH Kim, G Shi, S Biswal, CW Ward
Frontiers in physiology 2014
Toxic effects of maternal zearalenone exposure on intestinal oxidative stress, barrier function, immunological and morphological changes in rats
M Liu, R Gao, Q Meng, Y Zhang, C Bi, A Shan
PloS one 2014
Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of cecal ligation and puncture
C Coletta, K Módis, G Oláh, A Brunyánszki, DS Herzig, ER Sherwood, Z Ungvári, C Szabo
Critical Care 2014
A novel compound VSC2 has anti-inflammatory and antioxidant properties in microglia and in Parkinson's disease animal model: VSC2 is anti-inflammatory and neuroprotective
JA Lee, JH Kim, SY Woo, HJ Son, SH Han, BK Jang, JW Choi, DJ Kim, KD Park, O Hwang
British Journal of Pharmacology 2014
The Effect of Ex Vivo CDDO-Me Activation on Nuclear Factor Erythroid 2–Related Factor 2 Pathway in White Blood Cells From Patients With Septic Shock:
S Noel, L Zheng, A Navas-Acien, RJ Fuchs
Shock 2014
Anti-inflammatory effects of curcumin in experimental spinal cord injury in rats.
Jin W, Wang J, Zhu T, Yuan B, Ni H, Jiang J, Wang H, Liang W
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014
Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells.
Hwang YJ, Song J, Kim HR, Hwang KA
BMB Reports 2014
Water-soluble phenol TS-13 combats acute but not chronic inflammation.
Menshchikova E, Tkachev V, Lemza A, Sharkova T, Kandalintseva N, Vavilin V, Safronova O, Zenkov N
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2014
Melatonin suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway
U Kilic, E Kilic, Z Tuzcu, M Tuzcu, IH Ozercan, O Yilmaz, F Sahin, K Sahin
Nutrition & Metabolism 2013
Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis
AA Gupte, CJ Lyon, WA Hsueh
Current Diabetes Reports 2013
Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats
Z Liu, M Zhao, Q Zheng, H Zhao, W Hou, S Bai
Acta Pharmacologica Sinica 2013
The glutathione peroxidase 1-protein tyrosine phosphatase 1B-protein phosphatase 2A axis. A key determinant of airway inflammation and alveolar destruction
P Geraghty, AA Hardigan, AM Wallace, O Mirochnitchenko, J Thankachen, L Arellanos, V Thompson, JM D'Armiento, RF Foronjy
American journal of respiratory cell and molecular biology 2013
Neutrophils in oral paracoccidioidomycosis and the involvement of Nrf2
VC Araújo, AP Demasi, AB Soares, F Passador-Santos, MH Napimoga, EF Martinez, NS Freitas, NS Araújo
PloS one 2013
Therapeutic Effect of Chung-Pae, an Experimental Herbal Formula, on Acute Lung Inflammation Is Associated with Suppression of NF- κ B and Activation of Nrf2
KH Kim, DH Kim, N Jeong, KI Kim, YH Kim, M Lee, JY Choi, HJ Jung, SK Jung, M Joo
Evidence-Based Complementary and Alternative Medicine 2013
Therapeutic Effect of the Tuber of Alisma orientale on Lipopolysaccharide-Induced Acute Lung Injury
KH Kim, MJ Kwun, JY Choi, KS Ahn, SR Oh, YG Lee, JW Christman, RT Sadikot, CW Han, M Joo
Evidence-Based Complementary and Alternative Medicine 2013
Retinal microenvironment imbalance in dry age-related macular degeneration: a mini-review
BP Barnett, JT Handa
Gerontology 2013
INFLAMMATORY BOWEL DISEASE: MECHANISMS, REDOX CONSIDERATIONS AND THERAPEUTIC TARGETS
F Biasi, G Leonarduzzi, PI Oteiza, G Poli
Antioxidants & Redox Signaling 2013
Bach2 maintains T cells in a naive state by suppressing effector memory-related genes
S Tsukumo, M Unno, A Muto, A Takeuchi, K Kometani, T Kurosaki, K Igarashi, T Saito
Proceedings of the National Academy of Sciences 2013
MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice
JD Belcher, M Young, C Chen, J Nguyen, K Burhop, P Tran, GM Vercellotti
Blood 2013
The Nrf2 Activator, tBHQ, Differentially Affects Early Events Following Stimulation of Jurkat Cells
JW Zagorski, AE Turley, HE Dover, KR VanDenBerg, JR Compton, CE Rockwell
Toxicological Sciences 2013
Health promoting effects of brassica-derived phytochemicals: from chemopreventive and anti-inflammatory activities to epigenetic regulation
AE Wagner, AM Terschluesen, G Rimbach
Oxidative Medicine & Cellular Longevity 2013
Insight into the intermolecular recognition mechanism between Keap1 and IKKβ combining homology modelling, protein-protein docking, molecular dynamics simulations and virtual alanine mutation
ZY Jiang, HX Chu, MY Xi, TT Yang, JM Jia, JJ Huang, XK Guo, XJ Zhang, QD You, HP Sun
PloS one 2013
Roles nrf2 plays in myeloid cells and related disorders
E Kobayashi, T Suzuki, M Yamamoto
Oxidative Medicine & Cellular Longevity 2013
Nuclear factor-erythroid 2 (NF-E2) p45-related factor-2 (Nrf2) modulates dendritic cell immune function through regulation of p38 MAPK-cAMP-responsive element binding protein/activating transcription factor 1 signaling
LM Al-Huseini, HX Yeang, S Sethu, N Alhumeed, JM Hamdam, Y Tingle, L Djouhri, N Kitteringham, BK Park, CE Goldring, JG Sathish
The Journal of biological chemistry 2013
Hepatic gene expression profiling in Nrf2 knockout mice after long-term high-fat diet-induced obesity
DV Chartoumpekis, PG Ziros, A Zaravinos, RP Iskrenova, AI Psyrogiannis, VE Kyriazopoulou, GP Sykiotis, IG Habeos
Oxidative Medicine & Cellular Longevity 2013
Adaptive redox response of mesenchymal stromal cells to stimulation with lipopolysaccharide inflammagen: mechanisms of remodeling of tissue barriers in sepsis
NV Gorbunov, BR Garrison, DP McDaniel, M Zhai, PJ Liao, D Nurmemet, JG Kiang
Oxidative Medicine & Cellular Longevity 2013
Mycoplasma fermentans MALP-2 induces heme oxygenase-1 expression via mitogen-activated protein kinases and Nrf2 pathways to modulate cyclooxygenase 2 expression in human monocytes
X Ma, X You, Y Zeng, J He, L Liu, Z Deng, C Jiang, H Wu, C Zhu, M Yu, Y Wu
Clinical and vaccine immunology : CVI 2013
Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy.
Gill AJ, Kolson DL
Critical reviews in immunology 2013
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium
SM Plafker, GB O'Mealey, LI Szweda
International review of cell and molecular biology 2012
Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome
P Xue, Y Hou, Y Chen, B Yang, J Fu, H Zheng, K Yarborough, CG Woods, D Liu, M Yamamoto, Q Zhang, ME Andersen, J Pi
Diabetes 2012
PPARγ and Oxidative Stress: Con(β) Catenating NRF2 and FOXO
S Polvani, M Tarocchi, A Galli
PPAR Research 2012
Antioxidants in Kidney Diseases: The Impact of Bardoxolone Methyl
J Rojas-Rivera, A Ortiz, J Egido
International Journal of Nephrology 2012
Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease
KT Liby, MB Sporn
Pharmacological reviews 2012
Natural Products in Cancer Prevention and Therapy
JM Pezzuto, N Suh
Natural Products in Cancer Prevention and Therapy 2012
Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance
AK Meher, PR Sharma, VA Lira, M Yamamoto, TW Kensler, Z Yan, N Leitinger
Free radical biology & medicine 2012
Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB
JH Lyu, KH Kim, HW Kim, SI Cho, KT Ha, JY Choi, CW Han, HS Jeong, HK Lee, KS Ahn, SR Oh, RT Sadikot, JW Christman, M Joo
Journal of Ethnopharmacology 2012
Protective Effect of the Fruit Hull of Gleditsia sinensis on LPS-Induced Acute Lung Injury Is Associated with Nrf2 Activation
JY Choi, MJ Kwun, KH Kim, JH Lyu, CW Han, HS Jeong, KT Ha, HJ Jung, BJ Lee, RT Sadikot, JW Christman, SK Jung, M Joo
Evidence-based complementary and alternative medicine : eCAM 2012
Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2
Q Ma, X He
Pharmacological reviews 2012
Targeted Deletion of Nrf2 Impairs Lung Development and Oxidant Injury in Neonatal Mice
HY Cho, B Houten, X Wang, L Miller-DeGraff, J Fostel, W Gladwell, L Perrow, V Panduri, L Kobzik, M Yamamoto, DA Bell, SR Kleeberger
Antioxidants & Redox Signaling 2012
NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease
AJ Sandford, D Malhotra, HM Boezen, M Siedlinski, DS Postma, V Wong, L Akhabir, JQ He, JE Connett, NR Anthonisen, PD Paré, S Biswal
Physiological genomics 2012
How does the macula protect itself from oxidative stress?
JT Handa
Molecular Aspects of Medicine 2012
The Absence of Nrf2 Enhances NF-κB-Dependent Inflammation following Scratch Injury in Mouse Primary Cultured Astrocytes
H Pan, H Wang, X Wang, L Zhu, L Mao
Mediators of Inflammation 2012
Emerging roles for multipotent, bone marrow-derived stromal cells in host defense
JJ Auletta, RJ Deans, AM Bartholomew
Blood 2012
A Role for SKN-1/Nrf in Pathogen Resistance and Immunosenescence in Caenorhabditis elegans
D Papp, P Csermely, C Sőti
PLoS pathogens 2012
Neuroimmune endocrine effects of antidepressants
M Antonioli, J Rybka, LA Carvalho
Neuropsychiatric Disease and Treatment 2012
Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells*
HX Yeang, JM Hamdam, LM Al-Huseini, S Sethu, L Djouhri, J Walsh, N Kitteringham, BK Park, CE Goldring, JG Sathish
The Journal of biological chemistry 2012
Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice
J Athale, A Ulrich, NC MacGarvey, RR Bartz, KE Welty-Wolf, HB Suliman, CA Piantadosi
Free radical biology & medicine 2012
Aging Exacerbates Microvascular Endothelial Damage Induced by Circulating Factors Present in the Serum of Septic Patients
Z Tucsek, T Gautam, WE Sonntag, P Toth, H Saito, R Salomao, C Szabo, A Csiszar, Z Ungvari
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2012
Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from Lethal Staphylococcus aureus Sepsis
NC MacGarvey, HB Suliman, RR Bartz, P Fu, CM Withers, KE Welty-Wolf, CA Piantadosi
American journal of respiratory and critical care medicine 2012
The Tobacco Smoke Component, Acrolein, Suppresses Innate Macrophage Responses by Direct Alkylation of c-Jun N-Terminal Kinase
M Hristova, PC Spiess, DI Kasahara, MJ Randall, B Deng, A der Vliet
American journal of respiratory cell and molecular biology 2012
Mechanisms of Oxidative Damage in Multiple Sclerosis and Neurodegenerative Diseases: Therapeutic Modulation via Fumaric Acid Esters
DH Lee, R Gold, RA Linker
International journal of molecular sciences 2012
Disruption of Type-I IFN pathway ameliorates preservation damage in mouse orthotopic liver transplantation via HO-1 dependent mechanism
XD Shen, B Ke, H Ji, F Gao, MC Freitas, WW Chang, C Lee, Y Zhai, RW Busuttil, JW Kupiec-Weglinski
American Journal of Transplantation 2012
Oxidant-induced cell death and Nrf2-dependent antioxidative response are controlled by Fra-1/AP-1
M Vaz, N Machireddy, A Irving, HR Potteti, K Chevalier, D Kalvakolanu, SP Reddy
Molecular and cellular biology 2012
GLUTATHIONE SYNTHESIS
SC Lu
Biochimica et Biophysica Acta 2012
Th2 Skewing by Activation of Nrf2 in CD4 + T Cells
CE Rockwell, M Zhang, PE Fields, CD Klaassen
Journal of immunology (Baltimore, Md. : 1950) 2012
The endoplasmic reticulum: a sensor of cellular stress that modulates immune responses.
Martinon F
Microbes and Infection 2012
The anti-inflammatory effect of melatonin on methamphetamine-induced proinflammatory mediators in human neuroblastoma dopamine SH-SY5Y cell lines.
Permpoonputtana K, Govitrapong P
Neurotoxicity Research 2012
Inhibition of nuclear factor erythroid 2-related factor 2 exacerbates HIV-1 gp120-induced oxidative and inflammatory response: role in HIV associated neurocognitive disorder.
Reddy PV, Agudelo M, Atluri VS, Nair MP
Neurochemical Research 2012
Down-regulation of Glutathione S-transferase Pi in Asthma Contributes to Enhanced Oxidative Stress
KT Schroer, AM Gibson, U Sivaprasad, SA Bass, MB Ericksen, M Wills-Karp, T Lecras, AM Fitzpatrick, LA Brown, KF Stringer, GK Hershey
Journal of Allergy and Clinical Immunology 2011
Endoplasmic Reticulum Stress and the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease
CL Gentile, M Frye, MJ Pagliassotti
Antioxidants & Redox Signaling 2011
Targeting Nrf2 Signaling Improves Bacterial Clearance by Alveolar Macrophages in Patients with COPD and in a Mouse Model
CJ Harvey, RK Thimmulappa, S Sethi, X Kong, L Yarmus, RH Brown, D Feller-Kopman, R Wise, S Biswal
Science Translational Medicine 2011
The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels
AA Merchant, A Singh, W Matsui, S Biswal
Blood 2011
Sustained Activation of Nuclear Erythroid 2-Related Factor 2/Antioxidant Response Element Signaling Promotes Reductive Stress in the Human Mutant Protein Aggregation Cardiomyopathy in Mice
NS Rajasekaran, S Varadharaj, GD Khanderao, CJ Davidson, S Kannan, MA Firpo, JL Zweier, IJ Benjamin
Antioxidants & Redox Signaling 2011
Nrf2 Regulates Chronic Lung Inflammation and B-Cell Responses to Nontypeable Haemophilus influenzae
AA Lugade, RR Vethanayagam, M Nasirikenari, PN Bogner, BH Segal, Y Thanavala
American journal of respiratory cell and molecular biology 2011
Dietary flavonoids are neuroprotective through Nrf2-coordinated induction of endogenous cytoprotective proteins
CC Leonardo, S Doré
Nutritional Neuroscience 2011
Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis
X Kong, R Thimmulappa, F Craciun, C Harvey, A Singh, P Kombairaju, SP Reddy, D Remick, S Biswal
American journal of respiratory and critical care medicine 2011
Role of Nrf2 in Host Defense against Influenza Virus in Cigarette Smoke-Exposed Mice
Y Yageta, Y Ishii, Y Morishima, H Masuko, S Ano, T Yamadori, K Itoh, K Takeuchi, M Yamamoto, N Hizawa
Journal of virology 2011
NF-E2–Related Factor 2 Promotes Atherosclerosis by Effects on Plasma Lipoproteins and Cholesterol Transport That Overshadow Antioxidant Protection
B Barajas, N Che, F Yin, A Rowshanrad, LD Orozco, KW Gong, X Wang, LW Castellani, K Reue, AJ Lusis, JA Araujo
Arteriosclerosis, thrombosis, and vascular biology 2011
Role of glutathione in immunity and inflammation in the lung
P Ghezzi
International journal of general medicine 2011
Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system
M Gao, A Singh, K Macri, C Reynolds, V Singhal, S Biswal, EW Spannhake
Respiratory Research 2011
The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria
PN Mimche, D Taramelli, L Vivas
Malaria Journal 2011
Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation
K Fujita, D Maeda, Q Xiao, SM Srinivasula
Proceedings of the National Academy of Sciences 2011
Nrf2, a PPARγ Alternative Pathway to Promote CD36 Expression on Inflammatory Macrophages: Implication for Malaria
D Olagnier, RA Lavergne, E Meunier, L Lefèvre, C Dardenne, A Aubouy, F Benoit-Vical, B Ryffel, A Coste, A Berry, B Pipy
PLoS pathogens 2011
Bench-to-bedside review: Sepsis - from the redox point of view
MÉ Andrades, A Morina, S Spasić, I Spasojević
Critical Care 2011
Depletion of Nrf2 enhances inflammation induced by oxyhemoglobin in cultured mice astrocytes.
Pan H, Wang H, Zhu L, Mao L, Qiao L, Su X
Neurochemical Research 2011
NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice
BH Segal, W Han, JJ Bushey, M Joo, Z Bhatti, J Feminella, CG Dennis, RR Vethanayagam, FE Yull, M Capitano, PK Wallace, H Minderman, JW Christman, MB Sporn, J Chan, DC Vinh, SM Holland, LR Romani, SL Gaffen, ML Freeman, TS Blackwell, A Gaggar
PloS one 2010
Regulation of innate immune responses by autophagy-related proteins
T Saitoh, S Akira
The Journal of Cell Biology 2010
When NRF2 Talks, Who's Listening?
N Wakabayashi, SL Slocum, JJ Skoko, S Shin, TW Kensler
Antioxidants & Redox Signaling 2010
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
D Malhotra, E Portales-Casamar, A Singh, S Srivastava, D Arenillas, C Happel, C Shyr, N Wakabayashi, TW Kensler, WW Wasserman, S Biswal
Nucleic Acids Research 2010
NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice
X Kong, R Thimmulappa, P Kombairaju, S Biswal
Journal of immunology (Baltimore, Md. : 1950) 2010
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function
J Pi, Q Zhang, J Fu, CG Woods, Y Hou, BE Corkey, S Collins, ME Andersen
Toxicology and Applied Pharmacology 2010
Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2
S Bancos, CJ Baglole, I Rahman, RP Phipps
Cellular Immunology 2010
Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice
HY Cho, W Gladwell, X Wang, B Chorley, D Bell, SP Reddy, SR Kleeberger
American journal of respiratory and critical care medicine 2010
Effects of tert-butylhydroquinone on intestinal inflammatory response and apoptosis following traumatic brain injury in mice
W Jin, H Ni, Y Dai, H Wang, T Lu, J Wu, J Jiang, W Liang
Mediators of Inflammation 2010
Disruption of Nrf2 enhances the upregulation of nuclear factor-kappaB activity, tumor necrosis factor-α, and matrix metalloproteinase-9 after spinal cord injury in mice
L Mao, H Wang, L Qiao, X Wang
Mediators of Inflammation 2010
Nrf2, a Guardian of Healthspan and Gatekeeper of Species Longevity
KN Lewis, J Mele, JD Hayes, R Buffenstein
Integrative and Comparative Biology 2010
The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge
JJ Auletta, JL Alabran, BG Kim, CJ Meyer, JJ Letterio
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010
Early-age-related changes in proteostasis augment immunopathogenesis of sepsis and acute lung injury
M Bodas, T Min, N Vij
PloS one 2010
Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease
B Jürgens, D Fuchs, J Reichenbach, A Heitger
Clinical Immunology 2010
Comparative airway inflammatory response of normal volunteers to ozone and lipopolysaccharide challenge
ML Hernandez, B Harris, JC Lay, PA Bromberg, D Diaz-Sanchez, RB Devlin, SR Kleeberger, NE Alexis, DB Peden
Inhalation Toxicology 2010
Ionizing radiation activates the Nrf2 antioxidant response
JT McDonald, K Kim, AJ Norris, E Vlashi, TM Phillips, C Lagadec, LD Donna, J Ratikan, H Szelag, L Hlatky, WH McBride
Cancer research 2010
The nrf1 and nrf2 balance in oxidative stress regulation and androgen signaling in prostate cancer cells
MA Schultz, AB Abdel-Mageed, D Mondal
Cancers 2010
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2009
Regenerative stromal cell therapy in allogeneic hematopoietic stem cell transplantation: current impact and future directions
JJ Auletta, KR Cooke, LA Solchaga, RJ Deans, W Hof
Biology of Blood and Marrow Transplantation 2009
Nrf2 is a critical modulator of the innate immune response in a model of uveitis
N Nagai, RK Thimmulappa, M Cano, M Fujihara, K Izumi-Nagai, X Kong, MB Sporn, TW Kensler, S Biswal, JT Handa
Free radical biology & medicine 2009
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid
E Kansanen, HK Jyrkkänen, OL Volger, H Leinonen, AM Kivelä, SK Häkkinen, SR Woodcock, FJ Schopfer, AJ Horrevoets, S Ylä-Herttuala, BA Freeman, AL Levonen
The Journal of biological chemistry 2009
Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injury
W Jin, H Wang, W Yan, L Xu, X Wang, X Zhao, X Yang, G Chen, Y Ji
Mediators of Inflammation 2009
Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress
CJ Harvey, RK Thimmulappa, A Singh, DJ Blake, G Ling, N Wakabayashi, J Fujii, A Myers, S Biswal
Free radical biology & medicine 2009
Nuclear Erythroid 2 p45-Related Factor 2 Inhibits the Maturation of Murine Dendritic Cells by Ragweed Extract
T Rangasamy, MA Williams, S Bauer, MA Trush, J Emo, SN Georas, S Biswal
American journal of respiratory cell and molecular biology 2009
Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration
M Cano, R Thimmalappula, M Fujihara, N Nagai, M Sporn, AL Wang, AH Neufeld, S Biswal, JT Handa
Vision research 2009
Coordinate Control of Expression of Nrf2-Modulated Genes in the Human Small Airway Epithelium Is Highly Responsive to Cigarette Smoking
RH Hübner, JD Schwartz, BP De, B Ferris, L Omberg, JG Mezey, NR Hackett, RG Crystal
Molecular Medicine 2009
The Role of Nrf2 in Cellular Innate Immune Response to Inflammatory Injury
JY Kim, YJ Surh
Toxicological Research 2009
Regulation of glutathione synthesis
SC Lu
Molecular Aspects of Medicine 2009
Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation
U Garbin, AF Pasini, C Stranieri, M Cominacini, A Pasini, S Manfro, F Lugoboni, C Mozzini, GC Guidi, G Faccini, L Cominacini
PloS one 2009
The absence of the pro-antioxidant transcription factor Nrf2 exacerbates experimental autoimmune encephalomyelitis
DA Johnson, S Amirahmadi, C Ward, Z Fabry, JA Johnson
Toxicological sciences : an official journal of the Society of Toxicology 2009
Cell stiffness, contractile stress and the role of extracellular matrix
SS An, J Kim, K Ahn, X Trepat, KJ Drake, S Kumar, G Ling, C Purington, T Rangasamy, TW Kensler, W Mitzner, JJ Fredberg, S Biswal
Biochemical and Biophysical Research Communications 2009
The Nrf2–ARE cytoprotective pathway in astrocytes
MR Vargas, JA Johnson
Expert Reviews in Molecular Medicine 2009
Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease
HY Cho, F Imani, L Miller-DeGraff, D Walters, GA Melendi, M Yamamoto, FP Polack, SR Kleeberger
American journal of respiratory and critical care medicine 2008
Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice
TE Sussan, J Jun, R Thimmulappa, D Bedja, M Antero, KL Gabrielson, VY Polotsky, S Biswal
PloS one 2008
Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles
H Liu, AT Dinkova-Kostova, P Talalay
Proceedings of the National Academy of Sciences 2008
Network inference algorithms elucidate Nrf2 regulation of mouse lung oxidative stress
RC Taylor, G Acquaah-Mensah, M Singhal, D Malhotra, S Biswal
PLoS computational biology 2008
Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1
D Malhotra, R Thimmulappa, A Navas-Acien, A Sandford, M Elliott, A Singh, L Chen, X Zhuang, J Hogg, P Pare, RM Tuder, S Biswal
American journal of respiratory and critical care medicine 2008
Cellular Stress Response: A Novel Target for Chemoprevention and Nutritional Neuroprotection in Aging, Neurodegenerative Disorders and Longevity
V Calabrese, C Cornelius, C Mancuso, G Pennisi, S Calafato, F Bellia, TE Bates, AM Stella, T Schapira, AT Kostova, E Rizzarelli
Neurochemical Research 2008
Increased susceptibility of Nrf2 knockout mice to colitis-associated colorectal cancer
TO Khor, MT Huang, A Prawan, Y Liu, X Hao, S Yu, WK Cheung, JY Chan, BS Reddy, CS Yang, AN Kong
Cancer prevention research (Philadelphia, Pa.) 2008
Proteomic analysis of brain protein expression levels in NF-kappabeta p50 -/- homozygous knockout mice
JB Owen, WO Opii, C Ramassamy, WM Pierce, DA Butterfield
Brain Research 2008
Genetic or Pharmacologic Amplification of Nrf2 Signaling Inhibits Acute Inflammatory Liver Injury in Mice
WO Osburn, MS Yates, PD Dolan, S Chen, KT Liby, MB Sporn, K Taguchi, M Yamamoto, TW Kensler
Toxicological Sciences 2008
Epigallocatechin activates haem oxygenase-1 expression via protein kinase Cdelta and Nrf2
RM Ogborne, SA Rushworth, MA O'Connell
Biochemical and Biophysical Research Communications 2008
Dysregulation of mitochondrial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure
K Fredriksson, I Tjäder, P Keller, N Petrovic, B Ahlman, C Schéele, J Wernerman, JA Timmons, O Rooyackers
PloS one 2008
Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells
HJ Kim, B Barajas, M Wang, AE Nel
Journal of Allergy and Clinical Immunology 2008
Synergistic effect of combination of phenethyl isothiocyanate and sulforaphane or curcumin and sulforaphane in the inhibition of inflammation.
Cheung KL, Khor TO, Kong AN
Pharmaceutical Research 2008
Lipopolysaccharide-induced expression of NAD(P)H:quinone oxidoreductase 1 and heme oxygenase-1 protects against excessive inflammatory responses in human monocytes.
Rushworth SA, MacEwan DJ, O'Connell MA
Journal of immunology (Baltimore, Md. : 1950) 2008
Disruption of the Transcription Factor Nrf2 Promotes Pro-Oxidative Dendritic Cells That Stimulate Th2-Like Immunoresponsiveness upon Activation by Ambient Particulate Matter
Williams MA, Rangasamy T, Bauer SM, Killedar S, Karp M, Kensler TW, Yamamoto M, Breysse P, Biswal S, Georas SN
Journal of immunology (Baltimore, Md. : 1950) 2008
Genetic and pharmacologic evidence links oxidative stress to ventilator-induced lung injury in mice
S Papaiahgari, A Yerrapureddy, SR Reddy, NM Reddy, JM Dodd-O, MT Crow, DN Grigoryev, K Barnes, RM Tuder, M Yamamoto, TW Kensler, S Biswal, W Mitzner, PM Hassoun, SP Reddy
American journal of respiratory and critical care medicine 2007
Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults
WO Osburn, TW Kensler
Mutation research 2007
Preclinical evaluation of targeting the Nrf2 pathway by triterpenoids (CDDO-Im and CDDO-Me) for protection from LPS-induced inflammatory response and reactive oxygen species in human peripheral blood mononuclear cells and neutrophils
RK Thimmulappa, RJ Fuchs, D Malhotra, C Scollick, K Traore, JH Bream, MA Trush, KT Liby, MB Sporn, TW Kensler, S Biswal
Antioxidants & Redox Signaling 2007
Deficiency in Nrf2-GSH signaling impairs type II cell growth and enhances sensitivity to oxidants
NM Reddy, SR Kleeberger, HY Cho, M Yamamoto, TW Kensler, S Biswal, SP Reddy
American journal of respiratory cell and molecular biology 2007
Selective and Nonselective Packaging of Cellular RNAs in Retrovirus Particles
SJ Rulli, CS Hibbert, J Mirro, T Pederson, S Biswal, A Rein
Journal of virology 2007
Sepsis: redox mechanisms and therapeutic opportunities
S Biswal, DG Remick
Antioxidants & Redox Signaling 2007
Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
CS Yang, DS Lee, CH Song, SJ An, S Li, JM Kim, CS Kim, DG Yoo, BH Jeon, HY Yang, TH Lee, ZW Lee, J El-Benna, DY Yu, EK Jo
Journal of Experimental Medicine 2007
Dysregulated Immune Profiles for Skin and Dendritic Cells Are Associated with Increased Host Susceptibility to Haemophilus ducreyi Infection in Human Volunteers
TL Humphreys, L Li, X Li, DM Janowicz, KR Fortney, Q Zhao, W Li, J McClintick, BP Katz, DS Wilkes, HJ Edenberg, SM Spinola
Infection and immunity 2007
Induction of cystine/glutamate transporter in bacterial lipopolysaccharide induced endotoxemia in mice
K Taguchi, M Tamba, S Bannai, H Sato
Journal of Inflammation 2007
Role of lung maintenance program in the heterogeneity of lung destruction in emphysema
RM Tuder, T Yoshida, I Fijalkowka, S Biswal, I Petrache
Proceedings of the American Thoracic Society 2006
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
RK Thimmulappa, C Scollick, K Traore, M Yates, MA Trush, KT Liby, MB Sporn, M Yamamoto, TW Kensler, S Biswal
Biochemical and Biophysical Research Communications 2006
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
A Singh, V Misra, RK Thimmulappa, H Lee, S Ames, MO Hoque, JG Herman, SB Baylin, D Sidransky, E Gabrielson, MV Brock, S Biswal
PLoS Medicine 2006
Nrf2 regulates an adaptive response protecting against oxidative damage following diquat-mediated formation of superoxide anion
WO Osburn, N Wakabayashi, V Misra, T Nilles, S Biswal, MA Trush, TW Kensler
Archives of Biochemistry and Biophysics 2006
Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2
A Singh, T Rangasamy, RK Thimmulappa, H Lee, WO Osburn, R Brigelius-Flohé, TW Kensler, M Yamamoto, S Biswal
American journal of respiratory cell and molecular biology 2006
Oxidative stress in sepsis: a redox redux
JK Kolls
Journal of Clinical Investigation 2006

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