Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative interactions between clinical and basic scientists. Our understanding of the mechanisms that control the critical plateau and repolarization phases of the human ventricular action potential has been raised to new levels through these studies, which have clarified the manner in which both potassium and sodium channels regulate this critical period of electrical activity.
Arthur J. Moss, Robert S. Kass
Title and authors | Publication | Year |
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Exceptional Seizure-Like Presentation of Torsades De Pointes
Kanchan K, Mohamed A, Kumar P |
Cureus | 2025 |
Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death
Singh V, Wagner KT, Williams LG, Ryan JM, Keller KR, Mohnkern JD, Gardner RS, Dang LT, Ziobro JM, Wojcikiewicz RJ, Tucker NR, Auerbach DS |
Journal of Translational Medicine | 2025 |
Postpartum QT Prolongation in a Long QT Syndrome Type 1 Patient
Wiedenmann LC, Ehrlich JR, Goldenberg I |
Annals of Noninvasive Electrocardiology | 2025 |
Risk Prediction in Male Adolescents With Congenital Long QT Syndrome: Implications for Sex‐Specific Risk Stratification in Potassium Channel‐Mediated Long QT Syndrome
Bjelic M, Goldenberg I, Younis A, Chen AY, Huang DT, Yoruk A, Aktas MK, Rosero S, Cutter K, McNitt S, Sotoodehnia N, Kudenchuk PJ, Rea TD, Arking DE, Zareba W, Ackerman MJ, Goldenberg I |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2024 |
From genes to clinical management: A comprehensive review of long QT syndrome pathogenesis and treatment
Zhu W, Bian X, Lv J |
Heart Rhythm O2 | 2024 |
Computational analysis of long QT syndrome type 2 and the therapeutic effects of KCNQ1 antibodies.
Pan Z, Fu Q, Jiang H, Wei Z, Zhang S |
Digital health | 2024 |
Elucidation of ALG10B as a Novel Long QT Syndrome Susceptibility Gene
Zhou W, Ye D, Tester DJ, Bains S, Giudicessi JR, Haglund-Turnquist CM, Orland KM, January CT, Eckhardt LL, Maginot KR, Ackerman MJ |
Circulation. Genomic and precision medicine | 2023 |
Deciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Casis O, Echeazarra L, Sáenz-Díez B, Gallego M |
Journal of Physiology and Biochemistry | 2023 |
Cardiac Involvement in Classical Organic Acidurias: Clinical Profile and Outcome in a Pediatric Cohort
Passantino S, Chiellino S, Girolami F, Zampieri M, Calabri GB, Spaziani G, Bennati E, Porcedda G, Procopio E, Olivotto I, Favilli S |
Diagnostics | 2023 |
Low-voltage electrical injuries and the electrocardiogram: is a ‘normal’ electrocardiogram sufficient for safe discharge from care? A systematic review
Corrall S, Laws S, Rice A |
2023 | |
Polypharmacy, Gender Disparities, and Ethnic and Racial Predispositions in Long QT Syndrome: An In-Depth Review
Lima B, Razmjouei S, Bajwa MT, Shahzad Z, Shoewu OA, Ijaz O, Mange P, Khanal S, Gebregiorgis T |
Cureus | 2023 |
Identification of a novel pathogenic variant in KCNH2 in an Iranian family with long QT syndrome 2 by whole‐exome sequencing
Fazelifar AF, Pourirahim M, Masoumi T, Biglari A, Maleki M, Kalayinia S |
Journal of Arrhythmia | 2023 |
Downregulation of Vascular Hemeoxygenase-1 Leads to Vasculopathy in Systemic Sclerosis
R Ross, G Mavria, F Galdo, J Elies |
Frontiers in physiology | 2022 |
Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers
Comollo TW, Zou X, Zhang C, Kesters D, Hof T, Sampson KJ, Kass RS |
Channels | 2022 |
Gene mutations in comorbidity of epilepsy and arrhythmia.
Yu C, Deng XJ, Xu D |
Journal of Neurology | 2022 |
Engineered human cardiac tissues for modeling heart diseases
Min S, Cho SW |
BMB Reports | 2022 |
A calibrated functional patch-clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome
Jiang C, Richardson E, Farr J, Hill AP, Ullah R, Kroncke BM, Harrison SM, Thomson KL, Ingles J, Vandenberg JI, Ng CA |
The American Journal of Human Genetics | 2022 |
Determinants of trafficking, conduction, and disease within a K+ channel revealed through multiparametric deep mutational scanning
Coyote-Maestas W, Nedrud D, He Y, Schmidt D |
eLife | 2022 |
Risk Prediction in Women With Congenital Long QT Syndrome
Goldenberg I, Bos JM, Yoruk A, Chen AY, Lopes C, Huang DT, Kutyifa V, Younis A, Aktas MK, Z. Rosero S, McNitt S, Sotoodehnia N, Kudenchuk PJ, Rea TD, Arking DE, Scott CG, Briske KA, Sorensen K, J. Ackerman M, Zareba W |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease | 2021 |
Human‐induced pluripotent stem cell‐derived cardiomyocytes: Cardiovascular properties and metabolism and pharmacokinetics of deuterated mexiletine analogs
Gomez\u2010Galeno J, Okolotowicz K, Johnson M, McKeithan WL, Mercola M, Cashman JR |
Pharmacology Research & Perspectives | 2021 |
Specific protein kinase C isoform exerts chronic inhibition on the slowly activating delayed-rectifier potassium current by affecting channel trafficking
Gou X, Hu T, Gou Y, Li C, Yi M, Jia M |
Channels | 2021 |
A novel mutation in KCNH2 yields loss-of-function of hERG potassium channel in long QT syndrome 2.
Gu K, Qian D, Qin H, Cui C, Fernando WCHA, Wang D, Wang J, Cao K, Chen M |
2021 | |
Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome
KR Brewer, G Kuenze, CG Vanoye, AL George, J Meiler, CR Sanders |
Frontiers in pharmacology | 2020 |
Cardiac Complications of Propionic and Other Inherited Organic Acidemias
KC Park, S Krywawych, E Richard, LR Desviat, P Swietach |
Frontiers in Cardiovascular Medicine | 2020 |
Pseudo-colouring an ECG enables lay people to detect QT-interval prolongation regardless of heart rate
A Alahmadi, A Davies, M Vigo, C Jay, P Pławiak |
PloS one | 2020 |
Long QT and Silver Russell syndrome: First case report in a 9-year-old girl
Roses-Noguer F, Martinez-Villar M, Honti F, Edwards M, Till J, Morris-Rosendahl DJ |
HeartRhythm Case Reports | 2020 |
Gating and Regulation of KCNQ1 and KCNQ1 + KCNE1 Channel Complexes
Wang Y, Eldstrom J, Fedida D |
Frontiers in physiology | 2020 |
Protective role of cardiac-specific overexpression of caveolin-3 in cirrhotic cardiomyopathy
Kim SY, Kim KH, Schilling JM, Leem J, Dhanani M, Head BP, Roth DM, Zemljic-Harpf AE, Patel HH |
AJP Gastrointestinal and Liver Physiology | 2020 |
Heterogeneity of the action potential duration is required for sustained atrial fibrillation
Uma Mahesh Avula, Jeffrey Abrams, Alex Katchman, Sergey I. Zakharov, Sergey Mironov, Joseph Bayne, Daniel Roybal, Anirudh K Gorti, Lin Yang, Vivek Iyer, Marc Waase, Deepak Saluja, Edward Ciaccio, Hasan Garan, Andrew R. Marks, Steven O. Marx, Elaine Y. Wan |
JCI Insight | 2019 |
Cardiac function modulation depends on the A‐kinase anchoring protein complex
YR Zhu, XX Jiang, Y Zheng, J Xiong, D Wei, DM Zhang |
Journal of Cellular and Molecular Medicine | 2019 |
Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug-induced adverse events
Genova E, Cavion F, Lucafò M, Leo LD, Pelin M, Stocco G, Decorti G |
World journal of stem cells | 2019 |
Statin-specific inhibition of Rab-GTPase regulates cPKC-mediated IKs internalization
Ronzier E, Parks XX, Qudsi H, Lopes CM |
Scientific Reports | 2019 |
Characterization of a novel LQT3 variant with a selective efficacy of mexiletine treatment
Kim HJ, Kim BG, Park JE, Ki CS, Huh J, Youm JB, Kang JS, Cho H |
Scientific Reports | 2019 |
Effect of Ischemic Preconditioning and Postconditioning on Exosome-Rich Fraction microRNA Levels, in Relation with Electrophysiological Parameters and Ventricular Arrhythmia in Experimental Closed-Chest Reperfused Myocardial Infarction
Spannbauer A, Traxler D, Lukovic D, Zlabinger K, Winkler J, Gugerell A, Ferdinandy P, Hausenloy DJ, Pavo N, Emmert MY, Hoerstrup SP, Jakab A, Gyöngyösi M, Riesenhuber M |
International journal of molecular sciences | 2019 |
Development of a High-Throughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels
SA Kanner, A Jain, HM Colecraft |
Frontiers in physiology | 2018 |
Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia
Q Zhang, J Chen, Y Qin, J Wang, L Zhou |
Channels (Austin, Tex.) | 2018 |
Autonomic Regulation and Ventricular Arrhythmias
L Meng, K Shivkumar, O Ajijola |
Current Treatment Options in Cardiovascular Medicine | 2018 |
Abnormal Repolarization Duration During Everyday Emotional Arousal in Long QT Syndrome and Coronary Artery Disease
Lane RD, Reis HT, Hsu CH, Kern KB, Couderc JP, Moss AJ, Zareba W |
The American Journal of Medicine | 2018 |
Doxorubicin induces caspase-mediated proteolysis of KV7.1
Strigli A, Raab C, Hessler S, Huth T, Schuldt AJ, Alzheimer C, Friedrich T, Burridge PW, Luedde M, Schwake M |
Communications biology | 2018 |
Role of ion channels in heart failure and channelopathies
Rahm AK, Lugenbiel P, Schweizer PA, Katus HA, Thomas D |
Biophysical Reviews | 2018 |
Polymorphisms/Mutations in A-Kinase Anchoring Proteins (AKAPs): Role in the Cardiovascular System
Suryavanshi SV, Jadhav SM, McConnell BK |
Journal of Cardiovascular Development and Disease | 2018 |
The Impact of CRISPR/Cas9 Technology on Cardiac Research: From Disease Modelling to Therapeutic Approaches
BM Motta, PP Pramstaller, AA Hicks, A Rossini |
Stem Cells International | 2017 |
Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies
KO Brandão, VA Tabel, DE Atsma, CL Mummery, RP Davis |
Disease models & mechanisms | 2017 |
Modulation of the heart's electrical properties by the anticonvulsant drug retigabine
Rubi L, Kovar M, Zebedin-Brandl E, Koenig X, Dominguez-Rodriguez M, Todt H, Kubista H, Boehm S, Hilber K |
Toxicology and Applied Pharmacology | 2017 |
Computational design of membrane proteins using RosettaMembrane
Duran AM, Meiler J |
Protein science : a publication of the Protein Society | 2017 |
The Association between QT Interval Components and Sudden Cardiac Death: The Atherosclerosis Risk In Communities Study
O'Neal WT, Singleton MJ, Roberts JD, Tereshchenko LG, Sotoodehnia N, Chen LY, Marcus GM, Soliman EZ |
Circulation. Arrhythmia and electrophysiology | 2017 |
Trigger vs. Substrate: Multi-Dimensional Modulation of QT-Prolongation Associated Arrhythmic Dynamics by a hERG Channel Activator
Colman MA, Perez Alday EA, Holden AV, Benson AP |
Frontiers in physiology | 2017 |
The effects of zoledronic acid on ECG: a prospective study on patients with bone metastatic cancer
Demirtas D, Bilir C, Demirtas AO, Engin H |
Clinical Cases in Mineral and Bone Metabolism | 2017 |
A novel transgenic rabbit model with reduced repolarization reserve: long QT syndrome caused by a dominant-negative mutation of the KCNE1 gene: LQT5 transgenic rabbits
P Major, I Baczkó, L Hiripi, KE Odening, V Juhász, Z Kohajda, A Horváth, G Seprényi, M Kovács, L Virág, N Jost, J Prorok, B Ördög, Z Doleschall, S Nattel, A Varró, Z Bősze |
British Journal of Pharmacology | 2016 |
A CRISPR Path to Engineering New Genetic Mouse Models for Cardiovascular ResearchHighlights
JM Miano, QM Zhu, CJ Lowenstein |
Arteriosclerosis, thrombosis, and vascular biology | 2016 |
Phenotype guided characterization and molecular analysis of Indian patients with long QT syndromes
Vyas B, Puri RD, Namboodiri N, Saxena R, Nair M, Balakrishnan P, Jayakrishnan MP, Udyavar A, Kishore R, Verma IC |
Indian pacing and electrophysiology journal | 2016 |
An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval
Lorberbaum T, Sampson KJ, Woosley RL, Kass RS, Tatonetti NP |
Drug Safety | 2016 |
Association between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort
Mordukhovich I, Kloog I, Coull B, Koutrakis P, Vokonas P, Schwartz J |
Epidemiology (Cambridge, Mass.) | 2016 |
Aberrant sodium influx causes cardiomyopathy and atrial fibrillation in mice
Elaine Wan, Jeffrey Abrams, Richard Weinberg, Alex Katchman, Joseph Bayne, Sergey I. Zakharov, Lin Yang, John Morrow, Hasan Garan, Steven O. Marx |
Journal of Clinical Investigation | 2015 |
Long-QT-Syndrom: Historie, Genetik, klinische Symptome, Ursachen und Therapie
T Krönauer, P Friederich |
Der Anaesthesist | 2015 |
Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation
Chen L, Zhang Q, Qiu Y, Li Z, Chen Z, Jiang H, Li Y, Yang H |
Scientific Reports | 2015 |
Long QT Syndrome: How Effective Therapy in a Single Patient Favorably Influenced the Long-term Clinical Course and Genetic Understanding of this Hereditary Disorder
Lowengrub KM, Moss DR, Moss DA, Moss AJ |
Progress in Cardiovascular Diseases | 2015 |
The Long and the Short of It: Seizures Induce Cardiac Remodeling and Arrhythmia
Smith BN, Delisle BP |
Epilepsy Currents | 2015 |
Deletion of FoxO1 Leads to Shortening of QRS by Increasing Na+ Channel Activity through Enhanced Expression of both Cardiac NaV1.5 and β3 Subunit
B Cai, N Wang, W Mao, T You, Y Lu, X Li, B Ye, F Li, H Xu |
Journal of Molecular and Cellular Cardiology | 2014 |
Calcium Transients Closely Reflect Prolonged Action Potentials in iPSC Models of Inherited Cardiac Arrhythmia
CI Spencer, S Baba, K Nakamura, EA Hua, MA Sears, C Fu, J Zhang, S Balijepalli, K Tomoda, Y Hayashi, P Lizarraga, J Wojciak, MM Scheinman, K Aalto-Setälä, JC Makielski, CT January, KE Healy, TJ Kamp, S Yamanaka, BR Conklin |
Stem Cell Reports | 2014 |
LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms
Aromolaran AS, Subramanyam P, Chang DD, Kobertz WR, Colecraft HM |
Cardiovascular Research | 2014 |
KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps
Barro-Soria R, Rebolledo S, Liin SI, Perez ME, Sampson KJ, Kass RS, Larsson HP |
Nature Communications | 2014 |
Clinical profile of pediatric patients with long QT syndrome masquerading as seizures.
Thakkar B, Shukla A, Singh T, Shah S, Bohora S, Shah J, Madan T |
The Indian Journal of Pediatrics | 2014 |
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome
DS Auerbach, J Jones, BC Clawson, J Offord, GM Lenk, I Ogiwara, K Yamakawa, MH Meisler, JM Parent, LL Isom |
PloS one | 2013 |
Gene mutations in cardiac arrhythmias: a review of recent evidence in ion channelopathies
PY Hsiao, HC Tien, CP Lo, JM Juang, YH Wang, RJ Sung |
The Application of Clinical Genetics | 2013 |
Genomic biomarkers of SUDEP in brain and heart
E Glasscock |
Epilepsy & Behavior | 2013 |
Single Nucleotide Deletion Mutation of KCNH2 Gene is Responsible for LQT Syndrome in a 3-Generation Korean Family
Park JK, Oh YS, Choi JH, Yoon SK |
Journal of Korean Medical Science | 2013 |
Exome Sequencing and Systems Biology Converge to Identify Novel Mutations in the L-Type Calcium Channel, CACNA1C, Linked to Autosomal Dominant Long QT Syndrome
Boczek NJ, Best JM, Tester DJ, Giudicessi JR, Middha S, Evans JM, Kamp TJ, Ackerman MJ |
Circulation. Cardiovascular genetics | 2013 |
Mild Beckwith-Wiedemann and severe long-QT syndrome due to deletion of the imprinting center 2 on chromosome 11p
Gurrieri F, Zollino M, Oliva A, Pascali V, Orteschi D, Pietrobono R, Camporeale A, Coll Vidal M, Partemi S, Brugada R, Bellocci F, Neri G |
European Journal of Human Genetics | 2013 |
Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency
Sroubek J, Krishnan Y, McDonald TV |
The FASEB Journal | 2013 |
Leaky Channels Make Weak Muscles
Alfred L George, Jr. |
Journal of Clinical Investigation | 2012 |
Cardiac ion channelopathies and the sudden infant death syndrome
R Wilders |
ISRN Cardiology | 2012 |
Mouse Models of SCN5A-Related Cardiac Arrhythmias
M Derangeon, J Montnach, I Baró, F Charpentier |
Frontiers in physiology | 2012 |
Sudden cardiac death and inherited channelopathy: the basic electrophysiology of the myocyte and myocardium in ion channel disease
CA Martin, GD Matthews, CL Huang |
Heart (British Cardiac Society) | 2012 |
Induced pluripotent stem cells used to reveal drug actions in a long QT syndrome family with complex genetics
C Terrenoire, K Wang, KW Tung, WK Chung, RH Pass, JT Lu, JC Jean, A Omari, KJ Sampson, DN Kotton, G Keller, RS Kass |
The Journal of General Physiology | 2012 |
Induced Pluripotent Stem Cells as a Disease Modeling and Drug Screening Platform:
AD Ebert, P Liang, JC Wu |
Journal of Cardiovascular Pharmacology | 2012 |
The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias
R Ang, A Opel, A Tinker |
Frontiers in physiology | 2012 |
Anchoring proteins as regulators of signaling pathways
A Perino, A Ghigo, JD Scott, E Hirsch |
Circulation research | 2012 |
Prospective In Vitro Models of Channelopathies and Cardiomyopathies
Kawaguchi N, Hayama E, Furutani Y, Nakanishi T |
Stem Cells International | 2012 |
Role of the transient outward potassium current in the genesis of early afterdepolarizations in cardiac cells
Zhao Z, Xie Y, Wen H, Xiao D, Allen C, Fefelova N, Dun W, Boyden PA, Qu Z, Xie LH |
Cardiovascular Research | 2012 |
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels
Osteen JD, Barro-Soria R, Robey S, Sampson KJ, Kass RS, Larsson HP |
Proceedings of the National Academy of Sciences | 2012 |
Mutation and Gender Specific Risk in Type-2 Long QT Syndrome: Implications for Risk Stratification for Life-Threatening Cardiac Events in Patients with Long QT Syndrome
Migdalovich D, Moss AJ, Lopes CM, Costa J, Ouellet G, Barsheshet A, McNitt S, Polonsky S, Robinson JL, Zareba W, Ackerman MJ, Benhorin J, Kaufman ES, Platonov PG, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Goldenberg I |
Heart rhythm : the official journal of the Heart Rhythm Society | 2011 |
Risk for Life-Threatening Cardiac Events in Patients With Genotype-Confirmed Long-QT Syndrome and Normal-Range Corrected QT Intervals
Goldenberg I, Horr S, Moss AJ, Lopes CM, Barsheshet A, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Platonov PG, Priori SG, Qi M, Schwartz PJ, Shimizu W, Towbin JA, Vincent GM, Wilde AA, Zhang L |
Journal of the American College of Cardiology | 2011 |
Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers
Auerbach DS, Grzȩda KR, Furspan PB, Sato PY, Mironov S, Jalife J |
The Journal of Physiology | 2011 |
Ion Channel Mechanisms Related to Sudden Cardiac Death in Phenotype-Negative Long-QT Syndrome: Genotype-Phenotype Correlations of the KCNQ1(S349W) Mutation
Horr S, Goldenberg I, Moss AJ, O-Uchi J, Barsheshet A, Connelly H, Gray DA, Zareba W, Lopes CM |
Journal of Cardiovascular Electrophysiology | 2011 |
AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells
R Alzamora, F Gong, C Rondanino, JK Lee, C Smolak, NM Pastor-Soler, KR Hallows |
AJP Renal Physiology | 2010 |
Recent progress in congenital long QT syndrome
JT Lu, RS Kass |
Current Opinion in Cardiology | 2010 |
Molecular remodeling of ion channels, exchangers and pumps in atrial and ventricular myocytes in ischemic cardiomyopathy
N Gronich, A Kumar, Y Zhang, IR Efimov, NM Soldatov |
Channels (Austin, Tex.) | 2010 |
Absence of the Inhibitory G-Protein Gα i2 Predisposes to Ventricular Cardiac Arrhythmia
Z Zuberi, M Nobles, S Sebastian, A Dyson, SY Lim, R Breckenridge, L Birnbaumer, A Tinker |
Circulation. Arrhythmia and electrophysiology | 2010 |
A global in vivo Drosophila RNAi screen identifies NOT3 as a conserved regulator of heart function
Neely GG, Kuba K, Cammarato A, Isobe K, Amann S, Zhang L, Murata M, Elmén L, Gupta V, Arora S, Sarangi R, Dan D, Fujisawa S, Usami T, Xia CP, Keene AC, Alayari NN, Yamakawa H, Elling U, Berger C, Novatchkova M, Koglgruber R, Fukuda K, Nishina H, Isobe M, Pospisilik JA, Imai Y, Pfeufer A, Hicks AA, Pramstaller PP, Subramaniam S, Kimura A, Ocorr K, Bodmer R, Penninger JM |
Cell | 2010 |
Changes in Ventricular Repolarization Duration During Typical Daily Emotion in Patients With Long QT Syndrome
Lane RD, Zareba W, Reis HT, Peterson DR, Moss AJ |
Psychosomatic medicine | 2010 |
Spatial and temporal heterogeneities are localized to the right ventricular outflow tract in a heterozygotic Scn5a mouse model
Martin CA, Grace AA, Huang CL |
American journal of physiology. Heart and circulatory physiology | 2010 |
LQTS Gene LOVD Database
Zhang T, Moss A, Cong P, Pan M, Chang B, Zheng L, Fang Q, Zareba W, Robinson J, Lin C, Li Z, Wei J, Zeng Q, Qi M |
Human Mutation | 2010 |
Trigger-Specific Risk Factors and Response to Therapy in Type 2 Long QT Syndrome
Kim JA, Lopes CM, Moss AJ, McNitt S, Barsheshet A, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Towbin JA, Vincent M, Goldenberg I |
Heart rhythm : the official journal of the Heart Rhythm Society | 2010 |
Long QT syndrome provoked by induction of general anesthesia -A case report-
Kim HT, Lee JH, Park IB, Heo HE, Kim TY, Lee MJ |
Korean Journal of Anesthesiology | 2010 |
Characterization of a Binding Site for Anionic Phospholipids on KCNQ1
Thomas AM, Harmer SC, Khambra T, Tinker A |
The Journal of biological chemistry | 2010 |
KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate
Osteen JD, Gonzalez C, Sampson KJ, Iyer V, Rebolledo S, Larsson HP, Kass RS |
Proceedings of the National Academy of Sciences | 2010 |
The cardiac IKs channel, complex indeed
Osteen JD, Sampson KJ, Kass RS |
Proceedings of the National Academy of Sciences | 2010 |
Traffic-Related Air Pollution and QT Interval: Modification by Diabetes, Obesity, and Oxidative Stress Gene Polymorphisms in the Normative Aging Study
Baja ES, Schwartz JD, Wellenius GA, Coull BA, Zanobetti A, Vokonas PS, Suh HH |
Environmental Health Perspectives | 2010 |
Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
Mechanisms of disease pathogenesis in long QT syndrome type 5
SC Harmer, AJ Wilson, R Aldridge, A Tinker |
American journal of physiology. Cell physiology | 2009 |
Transfection of rat or mouse neurons by biolistics or electroporation
SD Dib-Hajj, JS Choi, LJ Macala, L Tyrrell, JA Black, TR Cummins, SG Waxman |
Nature Protocols | 2009 |
Familial long QT syndrome presented as ventricular tachycardia during anesthesia
Tran SM, Nobrega RQ, Kammerer WA, Quezado Z |
Pediatric Anesthesia | 2009 |
Genotype-Phenotype Aspects of Type-2 Long-QT Syndrome
Shimizu W, Moss AJ, Wilde AA, Towbin JA, Ackerman MJ, January CT, Tester DJ, Zareba W, Robinson JL, Qi M, Michael Vincent G, Kaufman ES, Hofman N, Noda T, Kamakura S, Miyamoto Y, Shah S, Amin V, Goldenberg I, Andrews ML, McNitt S |
Journal of the American College of Cardiology | 2009 |
The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3
Terrenoire C, Houslay MD, Baillie GS, Kass RS |
The Journal of biological chemistry | 2009 |
Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade
X Cheng, SD Dib-Hajj, L Tyrrell, SG Waxman |
Molecular Pain | 2008 |
Antiarrhythmic Benefits of Targeting the Na+/Ca2+ Exchanger Editorial Comment
Anumonwo J |
Heart rhythm : the official journal of the Heart Rhythm Society | 2008 |
A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope
Christé G, Thériault O, Chahine M, Millat G, Rodriguez-Lafrasse C, Rousson R, Deschênes I, Ficker E, Chevalier P |
Heart rhythm : the official journal of the Heart Rhythm Society | 2008 |
A novel and lethal de novo LQT-3 mutation in a newborn with distinct molecular pharmacology and therapeutic response
JR Bankston, M Yue, W Chung, M Spyres, RH Pass, E Silver, KJ Sampson, RS Kass |
PloS one | 2007 |
QTc and psychopharmacs: are there any differences between monotherapy and polytherapy
JC Sumić, V Barić, P Bilić, M Herceg, M Sisek-Sprem, V Jukić |
Annals of general psychiatry | 2007 |
Mutation of an A-kinase-anchoring protein causes long-QT syndrome
Chen L, Marquardt ML, Tester DJ, Sampson KJ, Ackerman MJ, Kass RS |
Proceedings of the National Academy of Sciences | 2007 |
Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts
Sabir IN, Li LM, Grace AA, Huang CL |
2007 | |
Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome
Sabir IN, Li LM, Jones VJ, Goddard CA, Grace AA, Huang CL |
2007 | |
Transient alterations in transmural repolarization gradients and arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts
Sabir IN, Killeen MJ, Goddard CA, Thomas G, Gray S, Grace AA, Huang CL |
The Journal of Physiology | 2007 |
Long and short QT syndrome
B Borchert, T Lawrenz, C Stellbrink |
Herzschrittmachertherapie + Elektrophysiologie | 2006 |
Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action
S Fredj, KJ Sampson, H Liu, RS Kass |
British Journal of Pharmacology | 2006 |
Altered Na+ Channels Promote Pause-Induced Spontaneous Diastolic Activity in Long QT Syndrome Type 3 Myocytes
S Fredj, N Lindegger, KJ Sampson, P Carmeliet, RS Kass |
Circulation research | 2006 |
[Ventricular tachycardia. Diagnostic spectrum and therapeutic measures].
Lewalter T, Schwab JO, Nickenig G |
Der Internist | 2006 |
[Molecular basis of primary electrical heart diseases]
E Zitron, EP Scholz, C Kiesecker, M Pirot, S Kathöfer, D Thomas, J Kiehn, HA Katus, R Becker, CA Karle |
Herzschrittmachertherapie + Elektrophysiologie | 2005 |
Genetics of acquired long QT syndrome
DM Roden, PC Viswanathan |
Journal of Clinical Investigation | 2005 |
The channelopathies: novel insights into molecular and genetic mechanisms of human disease
RS Kass |
Journal of Clinical Investigation | 2005 |
[Primary electrical heart disease in adulthood--electrophysiological findings and therapy].
Schimpf R, Kuschyk J, Veltmann C, Borggrefe M, Wolpert C |
Herzschrittmachertherapie & Elektrophysiologie | 2005 |