JCI - Citations to Inherited disorders of voltage-gated sodium channels

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Inherited disorders of voltage-gated sodium channels

Alfred L. George Jr.

Alfred L. George Jr.

Published August 1, 2005
Citation Information: J Clin Invest. 2005;115(8):1990-1999. https://doi.org/10.1172/JCI25505.

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Citations to this article (170)

Title and authors	Publication	Year
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Dilated cardiomyopathy: from genes and molecules to potential treatments. Wang X, Lang Z, Yan Z, Xu J, Zhang J, Jiao L, Zhang H	Molecular and cellular biochemistry	2025
Popeye domain containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5 Rinné S, Kiper AK, Jacob R, Ortiz-Bonnin B, Schindler RF, Fischer S, Komadowski M, De Martino E, Schäfer MK, Cornelius T, Fabritz L, Helker CS, Brand T, Decher N	iScience	2024
Eugenol and lidocaine inhibit voltage-gated Na+ channels from dorsal root ganglion neurons with different mechanisms Moreira-Junior L, Leal-Cardoso JH, Cassola AC, Carvalho-de-Souza JL	Frontiers in pharmacology	2024
Mapping structural distribution and gating-property impacts of disease-associated mutations in voltage-gated sodium channels. Akbari Ahangar A, Elhanafy E, Blanton H, Li J	iScience	2024
ELUCIDATING THE DIFFERENTIAL IMPACTS OF EQUIVALENT GATING-CHARGE MUTATIONS IN VOLTAGE-GATED SODIUM CHANNELS Elhanafy E, Ahangar AA, Roth R, Gamal El-Din TM, Bankston JR, Li J	bioRxiv	2024
Blockers of Skeletal Muscle Nav1.4 Channels: From Therapy of Myotonic Syndrome to Molecular Determinants of Pharmacological Action and Back De Bellis M, Boccanegra B, Cerchiara AG, Imbrici P, De Luca A	International journal of molecular sciences	2023
Mapping Structural Distribution and Gating-Property Impacts of Disease-Associated Missense Mutations in Voltage-Gated Sodium Channels Ahangar AA, Elhanafy E, Blanton H, Li J		2023
Coevolution with toxic prey produces functional trade-offs in sodium channels of predatory snakes del Carlo RE, Reimche JS, Moniz HA, Hague MT, Agarwal SR, Brodie ED III, Brodie ED Jr, Leblanc N, Feldman CR		2023
Sodium channel-inhibiting drugs and cancer-specific survival: a population-based study of electronic primary care data Fairhurst C, Doran T, Martin F, Watt I, Bland M, Brackenbury WJ	BMJ Open	2023
Targeting Ion Channels for Cancer Treatment: Current Progress and Future Challenges. Capatina AL, Lagos D, Brackenbury WJ	Reviews of Physiology, Biochemistry and Pharmacology	2022
The novel persistent sodium current inhibitor PRAX-562 has potent anticonvulsant activity with improved protective index relative to standard of care sodium channel blockers. Kahlig KM, Scott L, Hatch RJ, Griffin A, Martinez Botella G, Hughes ZA, Wittmann M	Epilepsia	2022
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Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy Nguyen HX, Wu T, Needs D, Zhang H, Perelli RM, DeLuca S, Yang R, Pan M, Landstrom AP, Henriquez C, Bursac N	Nature Communications	2022
Paclitaxel mitigates structural alterations and cardiac conduction system defects in a mouse model of Hutchinson–Gilford progeria syndrome Á Macías, JJ Díaz-Larrosa, Y Blanco, V Fanjul, C González-Gómez, P Gonzalo, MJ Andrés-Manzano, AM da Rocha, D Ponce-Balbuena, A Allan, D Filgueiras-Rama, J Jalife, V Andrés	Cardiovascular Research	2021
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Differential Effects of Modified Batrachotoxins on Voltage-gated Sodium Channel Fast and Slow Inactivation MacKenzie TM, Abderemane-Ali F, Garrison CE, Minor DL Jr, Bois JD	Cell Chemical Biology	2021
A novel wireless ECG system for prolonged monitoring of multiple zebrafish for heart disease and drug screening studies Le T, Zhang J, Nguyen AH, Trigo Torres RS, Vo K, Dutt N, Lee J, Ding Y, Xu X, Lau MP, Cao H	Biosensors & bioelectronics	2021
An open state of a voltage-gated sodium channel involving a π-helix and conserved pore-facing asparagine Choudhury K, Kasimova MA, McComas S, Howard RJ, Delemotte L	Biophysical Journal	2021
The Dragon’s Paralysing Spell: Evidence of Sodium and Calcium Ion Channel Binding Neurotoxins in Helodermatid and Varanid Lizard Venoms Dobson JS, Harris RJ, Zdenek CN, Huynh T, Hodgson WC, Bosmans F, Fourmy R, Violette A, Fry BG	Toxins	2021
Cryptic prokaryotic promoters explain instability of recombinant neuronal sodium channels in bacteria DeKeyser JM, Thompson CH, George AL Jr	The Journal of biological chemistry	2021
Biophysical Investigation of Sodium Channel Interaction with β-Subunit Variants Associated with Arrhythmias JP Llongueras, S Das, JD Waele, L Capulzini, A Sorgente, FV Petegem, F Bosmans		2020
Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain TN Vien, J Wang, LC Ng, E Cao, PG DeCaen	Proceedings of the National Academy of Sciences	2020
Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3 G Li, RL Woltz, C Wang, L Ren, P He, S Yu, X Liu, V Yarov-Yarovoy, D Hu, N Chiamvimonvat, L Wu	Frontiers in pharmacology	2020
Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels Leslie TK, Brückner L, Chawla S, Brackenbury WJ	Frontiers in pharmacology	2020
The Sodium Channel B4-Subunits are Dysregulated in Temporal Lobe Epilepsy Drug-Resistant Patients. Sheilabi MA, Takeshita LY, Sims EJ, Falciani F, Princivalle AP	International journal of molecular sciences	2020
Alternative splicing potentiates dysfunction of early-onset epileptic encephalopathy SCN2A variants. Thompson CH, Ben-Shalom R, Bender KJ, George AL	The Journal of General Physiology	2020
Voltage-dependent activation of Rac1 by Na(v) 1.5 channels promotes cell migration. Yang M, James AD, Suman R, Kasprowicz R, Nelson M, O'Toole PJ, Brackenbury WJ	Journal of Cellular Physiology	2019
Comparing human iPSC-cardiomyocytes versus HEK293T cells unveils disease-causing effects of Brugada mutation A735V of Na(V)1.5 sodium channels. de la Roche J, Angsutararux P, Kempf H, Janan M, Bolesani E, Thiemann S, Wojciechowski D, Coffee M, Franke A, Schwanke K, Leffler A, Luanpitpong S, Issaragrisil S, Fischer M, Zweigerdt R	Scientific Reports	2019
A Mixed Periodic Paralysis & Myotonia Mutant, P1158S, Imparts pH-Sensitivity in Skeletal Muscle Voltage-gated Sodium Channels MR Ghovanloo, M Abdelsayed, CH Peters, PC Ruben	Scientific Reports	2018
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Inhibitory effects of cannabidiol on voltage-dependent sodium currents. Ghovanloo MR, Shuart NG, Mezeyova J, Dean RA, Ruben PC, Goodchild SJ	The Journal of biological chemistry	2018
SCN5A mutation status increases the risk of major arrhythmic events in Asian populations with Brugada syndrome: systematic review and meta-analysis. Rattanawong P, Chenbhanich J, Mekraksakit P, Vutthikraivit W, Chongsathidkiet P, Limpruttidham N, Prasitlumkum N, Chung EH	Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc	2018
Progress in Understanding and Treating SCN2A-Mediated Disorders. Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ	Trends in Neurosciences	2018
Noninvasive extraction of microsecond-scale dynamics from human motor cortex. Koponen LM, Nieminen JO, Mutanen TP, Ilmoniemi RJ	Human Brain Mapping	2018
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors. Chernov-Rogan T, Li T, Lu G, Verschoof H, Khakh K, Jones SW, Beresini MH, Liu C, Ortwine DF, McKerrall SJ, Hackos DH, Sutherlin D, Cohen CJ, Chen J	Proceedings of the National Academy of Sciences	2018
Using voltage-sensor toxins and their molecular targets to investigate Na(V) 1.8 gating. Gilchrist J, Bosmans F	The Journal of Physiology	2018
Cellular Mechanism Underlying Insensitivity to Pain Associated with Nav1.9 Mutations Jianying Huang, Carlos Vanoye, Alison Cutts, Paul Goldberg, Sulayman Dib-Hajj, Charles Cohen, Stephen G Waxman, Alfred L. George, Jr.	Journal of Clinical Investigation	2017
Mutation E87Q of the β1-subunit impairs the maturation of the cardiac voltage-dependent sodium channel D Baroni, C Picco, O Moran	Scientific Reports	2017
Distribution and function of voltage-gated sodium channels in the nervous system J Wang, SW Ou, YJ Wang	Channels (Austin, Tex.)	2017
CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice CH Thompson, NA Hawkins, JA Kearney, AL George	Proceedings of the National Academy of Sciences	2017
Late sodium current associated cardiac electrophysiological and mechanical dysfunction S Yu, G Li, CL Huang, M Lei, L Wu	Pflügers Archiv - European Journal of Physiology	2017
Association of SCN1A gene polymorphism with antiepileptic drug responsiveness in the population of Thrace, Greece C Angelopoulou, S Veletza, I Heliopoulos, K Vadikolias, G Tripsianis, C Stathi, C Piperidou	Archives of Medical Science : AMS	2017
Genetic basis of pediatric epilepsy syndromes. Zhang D, Liu X, Deng X	Experimental and therapeutic medicine	2017
Small molecule modulation of voltage gated sodium channels. Carnevale V, Klein ML	Current Opinion in Structural Biology	2017
Structures of closed and open states of a voltage-gated sodium channel. Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA	Proceedings of the National Academy of Sciences	2017
Structure-based assessment of disease-related mutations in human voltage-gated sodium channels. Huang W, Liu M, Yan SF, Yan N	Protein & Cell	2017
Exome Sequencing Identifies Compound Heterozygous Mutations in SCN5A Associated with Congenital Complete Heart Block in the Thai Population C Thongnak, P Limprasert, D Tangviriyapaiboon, S Silvilairat, A Puangpetch, E Pasomsub, C Sukasem, W Chantratita	Disease Markers	2016
Spectrum and Prevalence of CALM1 -, CALM2 -, and CALM3 -Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE NJ Boczek, N Gomez-Hurtado, D Ye, ML Calvert, DJ Tester, DO Kryshtal, HS Hwang, CN Johnson, WJ Chazin, CG Loporcaro, M Shah, AL Papez, YR Lau, R Kanter, BC Knollmann, MJ Ackerman	Circulation. Cardiovascular genetics	2016
Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison G Loussouarn, D Sternberg, S Nicole, C Marionneau, FL Bouffant, G Toumaniantz, J Barc, OA Malak, V Fressart, Y Péréon, I Baró, F Charpentier	Frontiers in pharmacology	2016
Understanding Sodium Channel Function and Modulation Using Atomistic Simulations of Bacterial Channel Structures. Boiteux C, Allen TW	Current topics in membranes	2016
A Novel Striated Muscle-Specific Myosin-Blocking Drug for the Study of Neuromuscular Physiology. Heredia DJ, Schubert D, Maligireddy S, Hennig GW, Gould TW	Frontiers in cellular neuroscience	2016
Engineering prokaryotic channels for control of mammalian tissue excitability. Nguyen HX, Kirkton RD, Bursac N	Nature Communications	2016
Analysis of SCN5A Gene Variants in East Slovak Patients with Cardiomyopathy. Priganc M, Zigová M, Boroňová I, Bernasovská J, Dojčáková D, Szabadosová V, Mydlárová Blaščáková M, Tóthová I, Kmec J, Bernasovský I	Journal of Clinical Laboratory Analysis	2016
Dopaminergic Neurons Exhibit an Age-Dependent Decline in Electrophysiological Parameters in the MitoPark Mouse Model of Parkinson's Disease. Branch SY, Chen C, Sharma R, Lechleiter JD, Li S, Beckstead MJ	The Journal of neuroscience : the official journal of the Society for Neuroscience	2016
When all is lost…a severe myopathy with hypotonia from sodium channel mutations. Cannon SC	Brain : a journal of neurology	2016
Comprehensive Physiology SC Cannon	Comprehensive Physiology	2015
A rendezvous with the queen of ion channels: Three decades of ion channel research by David T. Yue and his Calcium Signals Laboratory IE Dick, WB Limpitikul, J Niu, R Banerjee, JB Issa, M Ben-Johny, PJ Adams, PW Kang, SR Lee, L Sang, W Yang, J Babich, M Zhang, H Bazazzi, NC Yue, GF Tomaselli	Channels (Austin, Tex.)	2015
Probing kinetic drug binding mechanism in voltage-gated sodium ion channel: open state versus inactive state blockers K Pal, G Gangopadhyay	Channels (Austin, Tex.)	2015
Target-Driven Evolution of Scorpion Toxins S Zhang, B Gao, S Zhu	Scientific Reports	2015
The hitchhiker’s guide to the voltage-gated sodium channel galaxy CA Ahern, J Payandeh, F Bosmans, B Chanda	The Journal of General Physiology	2015
Sodium channel-inhibiting drugs and survival of breast, colon and prostate cancer: a population-based study. Fairhurst C, Watt I, Martin F, Bland M, Brackenbury WJ	Scientific Reports	2015
Allosteric interactions between receptor site 3 and 4 of voltage-gated sodium channels: a novel perspective for the underlying mechanism of scorpion sting-induced pain. Feng YJ, Feng Q, Tao J, Zhao R, Ji YH		2015
Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo. Nelson M, Yang M, Millican-Slater R, Brackenbury WJ	Oncotarget	2015
Mutational analysis of SCN5A gene in long QT syndrome. Qureshi SF, Ali A, John P, Jadhav AP, Venkateshwari A, Rao H, Jayakrishnan MP, Narasimhan C, Shenthar J, Thangaraj K, Nallari P	Meta Gene	2015
Comparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine. Wang Y, Mi J, Lu K, Lu Y, Wang K	PloS one	2015
SCN4A variants and Brugada syndrome: phenotypic and genotypic overlap between cardiac and skeletal muscle sodium channelopathies. Bissay V, Van Malderen SC, Keymolen K, Lissens W, Peeters U, Daneels D, Jansen AC, Pappaert G, Brugada P, De Keyser J, Van Dooren S	European journal of human genetics : EJHG	2015
Distal spike initiation zone location estimation by morphological simulation of ionic current filtering demonstrated in a novel model of an identified Drosophila motoneuron. Günay C, Sieling FH, Dharmar L, Lin WH, Wolfram V, Marley R, Baines RA, Prinz AA	PLoS computational biology	2015
Towards a Unified Theory of Calmodulin Regulation (Calmodulation) of Voltage-Gated Calcium and Sodium Channels. Ben-Johny M, Dick IE, Sang L, Limpitikul WB, Kang PW, Niu J, Banerjee R, Yang W, Babich JS, Issa JB, Lee SR, Namkung H, Li J, Zhang M, Yang PS, Bazzazi H, Adams PJ, Joshi-Mukherjee R, Yue DN, Yue DT	Current molecular pharmacology	2015
Idiopathic generalized epilepsy and hypokalemic periodic paralysis in a family of South Indian descent. Subramanian M, Senthil N, Sujatha S	Case Reports in Neurological Medicine	2015
Benchmarking the stability of human detergent-solubilised voltage-gated sodium channels for structural studies using eel as a reference. Slowik D, Henderson R	Biochimica et Biophysica Acta	2015
A Common SCN5A Variant Is Associated with PR Interval and Atrial Fibrillation Among African Americans: rs7629265 and AF Risk L Ilkhanoff, DE Arking, RN Lemaitre, A Alonso, LY Chen, P Durda, SE Hesselson, KF Kerr, JW Magnani, GM Marcus, RB Schnabel, JG Smith, EZ Soliman, AP Reiner, N Sotoodehnia	Journal of Cardiovascular Electrophysiology	2014
Lecture Notes in Computer Science JM Jeff, K Brown-Gentry, R Goodloe, MD Ritchie, JC Denny, AN Kho, LL Armstrong, B McClellan, P Mayo, M Allen, H Jin, NB Gillani, N Schnetz-Boutaud, HH Dilks, MA Basford, JA Pacheco, GP Jarvik, RL Chisholm, DM Roden, MG Hayes, DC Crawford	Lecture Notes in Computer Science	2014
Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca2+ Regulation by Distinct Mechanisms G Yin, F Hassan, AR Haroun, LL Murphy, L Crotti, PJ Schwartz, AL George, J Satin	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease	2014
Decreased cardiac excitability secondary to reduction of sodium current may be a significant contributor to reduced contractility in a rat model of sepsis A Koesters, KL Engisch, MM Rich	Critical Care	2014
Gating-Pore Currents Demonstrate Selective and Specific Modulation of Individual Sodium Channel Voltage-Sensors by Biological Toxins Y Xiao, K Blumenthal, TR Cummins	Molecular pharmacology	2014
Global nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain J Gingras, S Smith, DJ Matson, D Johnson, K Nye, L Couture, E Feric, R Yin, BD Moyer, ML Peterson, JB Rottman, RJ Beiler, AB Malmberg, SI McDonough	PloS one	2014
Different inward and outward conduction mechanisms in NaVMs suggested by molecular dynamics simulations. Ke S, Timin EN, Stary-Weinzinger A	PLoS computational biology	2014
Conservation of Ca2+/calmodulin regulation across Na and Ca2+ channels. Ben-Johny M, Yang PS, Niu J, Yang W, Joshi-Mukherjee R, Yue DT	Cell	2014
Knock-in model of Dravet syndrome reveals a constitutive and conditional reduction in sodium current. Schutte RJ, Schutte SS, Algara J, Barragan EV, Gilligan J, Staber C, Savva YA, Smith MA, Reenan R, O'Dowd DK	Journal of neurophysiology	2014
Altered cardiac electrophysiology and SUDEP in a model of Dravet syndrome DS Auerbach, J Jones, BC Clawson, J Offord, GM Lenk, I Ogiwara, K Yamakawa, MH Meisler, JM Parent, LL Isom	PloS one	2013
Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects: Cardiac sodium channelopathy associated with SCN5A mutations CA Remme	The Journal of Physiology	2013
The arrhythmogenic consequences of increasing late INa in the cardiomyocyte JC Shryock, Y Song, S Rajamani, C Antzelevitch, L Belardinelli	Cardiovascular Research	2013
Functional modulation of voltage-dependent sodium channel expression by wild type and mutated C121W-β1 subunit D Baroni, R Barbieri, C Picco, O Moran	Journal of Bioenergetics and Biomembranes	2013
Crystallographic insights into sodium-channel modulation by the β4 subunit J Gilchrist, S Das, FV Petegem, F Bosmans	Proceedings of the National Academy of Sciences	2013
Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels C Pérez-Medina, N Patel, M Robson, MF Lythgoe, E Årstad	Bioorganic & Medicinal Chemistry Letters	2013
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Catterall WA, Spedding M, Peters JA, Harmar AJ	British Journal of Pharmacology	2013
A1180V of cardiac sodium channel gene (SCN5A): is it a risk factor for dilated cardiomyopathy or just a common variant in Han Chinese? Shen C, Xu L, Yang Z, Zou Y, Hu K, Fan Z, Ge J, Sun A	Disease Markers	2013
Catalysis of Na+ permeation in the bacterial sodium channel Na(V)Ab. Chakrabarti N, Ing C, Payandeh J, Zheng N, Catterall WA, Pomès R	Proceedings of the National Academy of Sciences	2013
Distribution and function of sodium channel subtypes in human atrial myocardium. Kaufmann SG, Westenbroek RE, Maass AH, Lange V, Renner A, Wischmeyer E, Bonz A, Muck J, Ertl G, Catterall WA, Scheuer T, Maier SKG	Journal of Molecular and Cellular Cardiology	2013
Persistent human cardiac Na+ currents in stably transfected mammalian cells: Robust expression and distinct open-channel selectivity among Class 1 antiarrhythmics. Wang GK, Russell G, Wang SY	Channels (Austin, Tex.)	2013
S1-S3 counter charges in the voltage sensor module of a mammalian sodium channel regulate fast inactivation. Groome JR, Winston V	The Journal of General Physiology	2013
Effects of the antianginal drug, ranolazine, on the brain sodium channel Na(V)1.2 and its modulation by extracellular protons. Peters CH, Sokolov S, Rajamani S, Ruben PC	British Journal of Pharmacology	2013
Lithium-induced sinus node dysfunction at therapeutic levels. Shetty RK, Vivek G, Parida A, Chetty S	BMJ case reports	2013
Genetic variation in T-box binding element functionally affects SCN5A/10A enhancer Malou van den Boogaard, Elaine Wong, Federico Tessadori, Martijn Bakker, Lisa Dreizehnter, Vincent Wakker, Connie Bezzina, Peter A.C. 't Hoen, Jeroen Bakkers, phil barnett, Vincent Christoffels	Journal of Clinical Investigation	2012
Leaky Channels Make Weak Muscles Alfred L George, Jr.	Journal of Clinical Investigation	2012
A Proton Leak Current through the Cardiac Sodium Channel Is Linked to Mixed Arrhythmia and the Dilated Cardiomyopathy Phenotype P Gosselin-Badaroudine, DI Keller, H Huang, V Pouliot, A Chatelier, S Osswald, M Brink, M Chahine	PloS one	2012
Regulation of cardiovascular cellular processes by S-nitrosylation IH Schulman, JM Hare	Biochimica et Biophysica Acta (BBA) - General Subjects	2012
Novel deletion mutation in the cardiac sodium channel inactivation gate causes long QT syndrome N Detta, G Frisso, A Zullo, B Sarubbi, C Cozzolino, E Romeo, DW Wang, R Calabrò, F Salvatore, AL George	International Journal of Cardiology	2012
Voltage-Gated Sodium Channels: Biophysics, Pharmacology, and Related Channelopathies E Savio-Galimberti, MH Gollob, D Darbar	Frontiers in pharmacology	2012
Nontruncating SCN1A mutations associated with severe myoclonic epilepsy of infancy impair cell surface expression CH Thompson, JC Porter, KM Kahlig, MA Daniels, AL George	The Journal of biological chemistry	2012
Influence of the SCN1A IVS5N + 5 G>A Polymorphism on Therapy with Carbamazepine for Epilepsy. Sterjev Z, Kiteva G, Cvetkovska E, Petrov I, Kuzmanovski I, Ribarska T, Nestorovska K, Matevska N, Trajkovik-Jolevska S, Dimovski A, Suturkova Lj		2012
State-Dependent Inhibition of Sodium Channels by Local Anesthetics: A 40-Year Evolution. Wang GK, Strichartz GR	Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology	2012
Molecular modeling, docking and ADMET studies towards development of novel Disopyramide analogs for potential inhibition of human voltage gated sodium channel proteins. Meraj K, Mahto MK, Christina NB, Desai N, Shahbazi S, Bhaskar M	Bioinformation	2012
Slowly inactivating component of Na+ current in peri-somatic region of hippocampal CA1 pyramidal neurons. Park YY, Johnston D, Gray R	Journal of neurophysiology	2012
Hinge-bending motions in the pore domain of a bacterial voltage-gated sodium channel. Barber AF, Carnevale V, Raju SG, Amaral C, Treptow W, Klein ML	Biochimica et Biophysica Acta	2012
Mechanism and molecular basis for the sodium channel subtype specificity of µ-conopeptide CnIIIC. Markgraf R, Leipold E, Schirmeyer J, Paolini-Bertrand M, Hartley O, Heinemann SH	British Journal of Pharmacology	2012
Perturbation of sodium channel structure by an inherited Long QT Syndrome mutation. Glaaser IW, Osteen JD, Puckerin A, Sampson KJ, Jin X, Kass RS	Nature Communications	2012
A mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia T Kubota, X Roca, T Kimura, Y Kokunai, I Nishino, S Sakoda, AR Krainer, MP Takahashi	Human Mutation	2011
Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel TC Atack, DM Stroud, H Watanabe, T Yang, L Hall, SB Hipkens, JS Lowe, B Leake, MA Magnuson, P Yang, DM Roden	Circulation research	2011
SCN5A Variation Is Associated With Electrocardiographic Traits in the Jackson Heart Study JM Jeff, K Brown-Gentry, SG Buxbaum, DF Sarpong, HA Taylor, AL George, DM Roden, DC Crawford	Circulation. Cardiovascular genetics	2011
Skeletal Muscle Na+ Channel Disorders D Simkin, S Bendahhou	Frontiers in pharmacology	2011
Open- and closed-state fast inactivation in sodium channels: Differential effects of a site-3 anemone toxin J Groome, F Lehmann-Horn, B Holzherr	Channels (Austin, Tex.)	2011
Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts. Davis GC, Kong Y, Paige M, Li Z, Merrick EC, Hansen T, Suy S, Wang K, Dakshanamurthy S, Cordova A, McManus OB, Williams BS, Chruszcz M, Minor W, Patel MK, Brown ML	Bioorganic & Medicinal Chemistry	2011
SCN1A splice variants exhibit divergent sensitivity to commonly used antiepileptic drugs. Thompson CH, Kahlig KM, George AL Jr	Epilepsia	2011
Increased persistent Na+ current contributes to seizure in the slamdance bang-sensitive Drosophila mutant. Marley R, Baines RA	Journal of neurophysiology	2011
Voltage-gated sodium channels are required for heart development in zebrafish SS Chopra, DM Stroud, H Watanabe, JS Bennett, CG Burns, KS Wells, T Yang, TP Zhong, DM Roden	Circulation research	2010
Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1.1 mutations KM Kahlig, I Lepist, K Leung, S Rajamani, AL George	British Journal of Pharmacology	2010
Transmembrane Segments Prevent Surface Expression of Sodium Channel Nav1.8 and Promote Calnexin-dependent Channel Degradation* Q Li, YY Su, H Wang, L Li, Q Wang, L Bao	The Journal of biological chemistry	2010
Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide. Desaphy JF, Dipalma A, Costanza T, Bruno C, Lentini G, Franchini C, George A, Conte Camerino D	British Journal of Pharmacology	2010
The outer vestibule of the Na+ channel-toxin receptor and modulator of permeation as well as gating. Cervenka R, Zarrabi T, Lukacs P, Todt H	Marine drugs	2010
Can robots patch-clamp as well as humans? Characterization of a novel sodium channel mutation. Estacion M, Choi JS, Eastman EM, Lin Z, Li Y, Tyrrell L, Yang Y, Dib-Hajj SD, Waxman SG	The Journal of Physiology	2010
Targeting voltage sensors in sodium channels with spider toxins. Bosmans F, Swartz KJ	Trends in Pharmacological Sciences	2010
Resurgent Sodium Currents are Increased in Inherited Neuronal and Muscle Channelopathies Brian Jarecki, Andrew Piekarz, James Jackson, II, Theodore Cummins	Journal of Clinical Investigation	2009
Sodium channels gone wild: resurgent current from neuronal and muscle channelopathies Stephen C. Cannon, Bruce Bean	Journal of Clinical Investigation	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Sodium channel mutations and arrhythmias Y Ruan, N Liu, SG Priori	Nature Reviews Cardiology	2009
Readthrough of nonsense mutation W822X in the SCN5A gene can effectively restore expression of cardiac Na+ channels S Teng, L Gao, V Paajanen, J Pu, Z Fan	Cardiovascular Research	2009
S-Nitrosylation of Cardiac Ion Channels DR Gonzalez, A Treuer, QA Sun, JS Stamler, JM Hare	Journal of Cardiovascular Pharmacology	2009
A double tyrosine motif in the cardiac sodium channel domain III-IV linker couples calcium-dependent calmodulin binding to inactivation gating MF Sarhan, FV Petegem, CA Ahern	The Journal of biological chemistry	2009
Cell Membrane Expression of Cardiac Sodium Channel Na v 1.5 Is Modulated by α-Actinin-2 Interaction R Ziane, H Huang, B Moghadaszadeh, AH Beggs, G Levesque, M Chahine	Biochemistry	2009
Distinct functional defect of three novel Brugada syndrome related cardiac sodium channel mutations CH Hsueh, WP Chen, JL Lin, CT Tsai, YB Liu, JM Juang, HM Tsao, MJ Su, LP Lai	Journal of Biomedical Science	2009
The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking LM Sharkey, X Cheng, V Drews, DA Buchner, JM Jones, MJ Justice, SG Waxman, SD Dib-Hajj, MH Meisler	The Journal of neuroscience : the official journal of the Society for Neuroscience	2009
Transfection of rat or mouse neurons by biolistics or electroporation SD Dib-Hajj, JS Choi, LJ Macala, L Tyrrell, JA Black, TR Cummins, SG Waxman	Nature Protocols	2009
Manipulating neuronal circuits with endogenous and recombinant cell-surface tethered modulators. Holford M, Auer S, Laqua M, Ibañez-Tallon I	Frontiers in molecular neuroscience	2009
Structural and regulatory evolution of cellular electrophysiological systems. Rosati B, McKinnon D	Evolution & Development	2009
Crystal structure of a fibroblast growth factor homologous factor (FHF) defines a conserved surface on FHFs for binding and modulation of voltage-gated sodium channels. Goetz R, Dover K, Laezza F, Shtraizent N, Huang X, Tchetchik D, Eliseenkova AV, Xu CF, Neubert TA, Ornitz DM, Goldfarb M, Mohammadi M	The Journal of biological chemistry	2009
Inherited Neuronal Ion Channelopathies: New Windows on Complex Neurological Diseases WA Catterall, S Dib-Hajj, MH Meisler, D Pietrobon	The Journal of neuroscience : the official journal of the Society for Neuroscience	2008
Voltage-gated Na+ channels: Potential for β subunits as therapeutic targets WJ Brackenbury, LL Isom	Expert Opinion on Therapeutic Targets	2008
Mutation of sodium channel SCN3A in a patient with cryptogenic pediatric partial epilepsy KD Holland, JA Kearney, TA Glauser, G Buck, M Keddache, JR Blankston, IW Glaaser, RS Kass, MH Meisler	Neuroscience Letters	2008
Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade X Cheng, SD Dib-Hajj, L Tyrrell, SG Waxman	Molecular Pain	2008
Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC	PLoS genetics	2008
DDESC: Dragon database for exploration of sodium channels in human. Sagar S, Kaur M, Dawe A, Seshadri SV, Christoffels A, Schaefer U, Radovanovic A, Bajic VB	BMC Genomics	2008
Deconstructing voltage sensor function and pharmacology in sodium channels. Bosmans F, Martin-Eauclaire MF, Swartz KJ	Nature	2008
The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Lindsay HA, Baines R, ffrench-Constant R, Lilley K, Jacobs HT, O'Dell KM	Genetics	2008
A case of appropriate inappropriate device therapy: hyperkalemia-induced ventricular oversensing. Oudit GY, Cameron D, Harris L	The Canadian journal of cardiology	2008
Mutations in sodium channel gene SCN9A cause a spectrum of human genetic pain disorders Joost P.H. Drenth1 and Stephen G. Waxman2	Journal of Clinical Investigation	2007
Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel LL Shang, AE Pfahnl, S Sanyal, Z Jiao, J Allen, K Banach, J Fahrenbach, D Weiss, WR Taylor, AM Zafari, SC Dudley	Circulation research	2007
Ribonucleoprotein assembly defects correlate with spinal muscular atrophy severity and preferentially affect a subset of spliceosomal snRNPs F Gabanella, ME Butchbach, L Saieva, C Carissimi, AH Burghes, L Pellizzoni	PloS one	2007
Lithium-induced sinus node disease at therapeutic concentrations: linking lithium-induced blockade of sodium channels to impaired pacemaker activity. Oudit GY, Korley V, Backx PH, Dorian P	The Canadian journal of cardiology	2007
Persistent sodium current and its role in epilepsy CE Stafstrom	Epilepsy currents / American Epilepsy Society	2007
Reduced Sodium Current in Purkinje Neurons from NaV1.1 Mutant Mice: Implications for Ataxia in Severe Myoclonic Epilepsy in Infancy F Kalume, FH Yu, RE Westenbroek, T Scheuer, WA Catterall	The Journal of neuroscience : the official journal of the Society for Neuroscience	2007
Modulatory Proteins Can Rescue a Trafficking Defective Epileptogenic Nav1.1 Na+ Channel Mutant R Rusconi, P Scalmani, RR Cassulini, G Giunti, A Gambardella, S Franceschetti, G Annesi, E Wanke, M Mantegazza	The Journal of neuroscience : the official journal of the Society for Neuroscience	2007
Nav1.1 Localizes to Axons of Parvalbumin-Positive Inhibitory Interneurons: A Circuit Basis for Epileptic Seizures in Mice Carrying an Scn1a Gene Mutation I Ogiwara, H Miyamoto, N Morita, N Atapour, E Mazaki, I Inoue, T Takeuchi, S Itohara, Y Yanagawa, K Obata, T Furuichi, TK Hensch, K Yamakawa	The Journal of neuroscience : the official journal of the Society for Neuroscience	2007
State- and use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Wang GK, Calderon J, Wang SY	Molecular pharmacology	2007
The roles of sodium channels in nociception: Implications for mechanisms of pain. Cummins TR, Sheets PL, Waxman SG	PAIN	2007
Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates. Chopra SS, Watanabe H, Zhong TP, Roden DM	BMC Evolutionary Biology	2007
A possible explanation for the paradox of hyperexcitability and epilepsy in "loss of function" voltage-gated sodium channel mutations. Mathews GC	Epilepsy Currents	2007
Functional anthology of intrinsic disorder. 3. Ligands, post-translational modifications, and diseases associated with intrinsically disordered proteins. Xie H, Vucetic S, Iakoucheva LM, Oldfield CJ, Dunker AK, Obradovic Z, Uversky VN	Journal of Proteome Research	2007
(What to do) when epilepsy gene mutations stop making sense. Cooper EC	Epilepsy Currents	2007
Temperature dependence of erythromelalgia mutation L858F in sodium channel Nav1.7. Han C, Lampert A, Rush AM, Dib-Hajj SD, Wang X, Yang Y, Waxman SG	Molecular Pain	2007
Effects in Neocortical Neurons of Mutations of the Nav1.2 Na+ Channel causing Benign Familial Neonatal-Infantile Seizures P Scalmani, R Rusconi, E Armatura, F Zara, G Avanzini, S Franceschetti, M Mantegazza	The Journal of neuroscience : the official journal of the Society for Neuroscience	2006
Impaired inactivation gate stabilization predicts increased persistent current for an epilepsy-associated SCN1A mutation. Kahlig KM, Misra SN, George AL Jr	The Journal of neuroscience : the official journal of the Society for Neuroscience	2006
Topochemical models for the prediction of voltage-gated sodium channel binding activity of hydantoins and related non-hydantoins. Gupta M, Madan AK	Journal of Molecular Modeling	2006
Single-channel properties of human NaV1.1 and mechanism of channel dysfunction in SCN1A-associated epilepsy. Vanoye CG, Lossin C, Rhodes TH, George AL Jr	The Journal of General Physiology	2006
The channelopathies: novel insights into molecular and genetic mechanisms of human disease RS Kass	Journal of Clinical Investigation	2005

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