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Citations to this article

Activation of Notch1 signaling is required for β-catenin–mediated human primary melanoma progression
Klara Balint, … , Meenhard Herlyn, Zhao-Jun Liu
Klara Balint, … , Meenhard Herlyn, Zhao-Jun Liu
Published November 1, 2005
Citation Information: J Clin Invest. 2005;115(11):3166-3176. https://doi.org/10.1172/JCI25001.
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Research Article Oncology Article has an altmetric score of 3

Activation of Notch1 signaling is required for β-catenin–mediated human primary melanoma progression

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Abstract

Notch is a highly conserved transmembrane receptor that determines cell fate. Notch signaling denotes cleavage of the Notch intracellular domain, its translocation to the nucleus, and subsequent activation of target gene transcription. Involvement of Notch signaling in several cancers is well known, but its role in melanoma remains poorly characterized. Here we show that the Notch1 pathway is activated in human melanoma. Blocking Notch signaling suppressed whereas constitutive activation of the Notch1 pathway enhanced primary melanoma cell growth both in vitro and in vivo yet had little effect on metastatic melanoma cells. Activation of Notch1 signaling enabled primary melanoma cells to gain metastatic capability. Furthermore, the oncogenic effect of Notch1 on primary melanoma cells was mediated by β-catenin, which was upregulated following Notch1 activation. Inhibiting β-catenin expression reversed Notch1-enhanced tumor growth and metastasis. Our data therefore suggest a β-catenin–dependent, stage-specific role for Notch1 signaling in promoting the progression of primary melanoma.

Authors

Klara Balint, Min Xiao, Chelsea C. Pinnix, Akinobu Soma, Imre Veres, Istvan Juhasz, Eric J. Brown, Anthony J. Capobianco, Meenhard Herlyn, Zhao-Jun Liu

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Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 Total
Citations: 2 4 5 2 12 12 6 5 10 11 11 16 9 14 5 6 11 9 5 1 156
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Citations to this article in year 2021 (12)

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Signal Transduction and Targeted Therapy 2021
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H Luo, C Ma
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Stem Cell Therapy for Burns: Story so Far
NA Kareem, A Aijaz, MG Jeschke
Biologics : targets & therapy 2021
Aetiology and Pathogenesis of Cutaneous Melanoma: Current Concepts and Advances
S Strashilov, A Yordanov
International journal of molecular sciences 2021
Converting melanoma-associated fibroblasts into a tumor-suppressive phenotype by increasing intracellular Notch1 pathway activity
H Shao, M Moller, L Cai, R Prokupets, C Yang, C Costa, K Yu, N Le, ZJ Liu, SV Pizzo
PloS one 2021
Increased Expression of VANGL1 is Predictive of Lymph Node Metastasis in Colorectal Cancer: Results from a 20-Gene Expression Signature
N Peyravian, S Nobili, Z Pezeshkian, M Olfatifar, A Moradi, K Baghaei, F Anaraki, K Nazari, HA Aghdaei, MR Zali, E Mini, EN Mojarad
Journal of Personalized Medicine 2021
Adipose mesenchymal stem cells combined with platelet-rich plasma accelerate diabetic wound healing by modulating the Notch pathway
N Ebrahim, AA Dessouky, O Mostafa, A Hassouna, MM Yousef, Y Seleem, EA Gebaly, MM Allam, AS Farid, BA Saffaf, D Sabry, A Nawar, AA Shoulah, AH Khalil, SF Abdalla, M El-Sherbiny, NM Elsherbiny, RF Salim
Stem Cell Research & Therapy 2021
Gender-Dependent Specificities in Cutaneous Melanoma Predisposition, Risk Factors, Somatic Mutations, Prognostic and Predictive Factors: A Systematic Review
O DEcclesiis, S Caini, C Martinoli, S Raimondi, C Gaiaschi, G Tosti, P Queirolo, C Veneri, C Saieva, S Gandini, S Chiocca
International journal of environmental research and public health 2021
Comprehensive molecular profiling of UV-induced metastatic melanoma in Nme1/Nme2-deficient mice reveals novel markers of survival in human patients
MK Leonard, GS Puts, N Pamidimukkala, G Adhikary, Y Xu, E Kwok, Y Jin, D Snyder, N Matsangos, M Novak, A Mahurkar, AC Shetty, RM Slominski, EC Fabo, FP Noonan, CP Day, M Rigi, AT Slominski, MG Webb, DW Craig, G Merlino, RL Eckert, JD Carpten, Z Manojlovic, DM Kaetzel
Oncogene 2021
Biology and Treatment Advances in Cutaneous Squamous Cell Carcinoma
AA Thai, AM Lim, BJ Solomon, D Rischin
Cancers 2021
Clinical Features and Prognostic Significance of NOTCH1 Mutations in Diffuse Large B-Cell Lymphoma
Li Z, Yu F, Ye W, Mao L, Huang J, Shao Y, Yan J, Yu W, Jin J, Wang J
Frontiers in Oncology 2021
NUMB as a Therapeutic Target for Melanoma
Hristova DM, Fukumoto T, Takemori C, Gao L, Hua X, Wang JX, Li L, Beqiri M, Watters A, Vultur A, Gimie Y, Rebecca V, Samarkina A, Jimbo H, Nishigori C, Zhang J, Cheng C, Wei Z, Somasundaram R, Fukunaga-Kalabis M, Herlyn M
Journal of Investigative Dermatology 2021

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