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Lars Bertram, Rudolph E. Tanzi
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1449-1457. https://doi.org/10.1172/JCI24761.
Citation Information: J Clin Invest. 2005;115(6):1449-1457. https://doi.org/10.1172/JCI24761.
Abstract
Gene defects play a major role in the pathogenesis of degenerative disorders of the nervous system. In fact, it has been the very knowledge gained from genetic studies that has allowed the elucidation of the molecular mechanisms underlying the etiology and pathogenesis of many neurodegenerative disorders. In this review, we discuss the current status of genetic epidemiology of the most common neurodegenerative diseases: Alzheimer disease, Parkinson disease, Lewy body dementia, frontotemporal dementia, amyotrophic lateral sclerosis, Huntington disease, and prion diseases, with a particular focus on similarities and differences among these syndromes.
Authors
Lars Bertram, Rudolph E. Tanzi
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Citation information
Citations to this article (443)
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Dose-Dependent Neuroprotective Effect of Standardized Bee Venom Phospholipase A2 Against MPTP-Induced Parkinson’s Disease in Mice
KH Kim, SY Lee, J Shin, JT Hwang, HN Jeon, H Bae |
Frontiers in aging neuroscience | 2019 |
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Comparison of the Protective Effects of Bee Venom Extracts with Varying PLA2 Compositions in a Mouse Model of Parkinson’s Disease
KH Kim, M Kim, J Lee, HN Jeon, SH Kim, H Bae |
Toxins | 2019 |
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Characteristics and advantages of adeno-associated virus vector-mediated gene therapy for neurodegenerative diseases
Y Qu, Y Liu, AF Noor, J Tran, R Li |
NEURAL REGEN RES | 2019 |
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Emerging Developments in Targeting Proteotoxicity in Neurodegenerative Diseases
L McAlary, SS Plotkin, NR Cashman |
CNS Drugs | 2019 |
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Molecular mechanisms of proteinopathies across neurodegenerative disease: a review
AP Marsh |
2019 | |
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Viral Induced Oxidative and Inflammatory Response in Alzheimer’s Disease Pathogenesis with Identification of Potential Drug Candidates: A Systematic Review using Systems Biology Approach
P Talwar, R Gupta, S Kushwaha, R Agarwal, L Saso, S Kukreti, R Kukreti |
Current neuropharmacology | 2019 |
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Automated high-content phenotyping from the first larval stage till the onset of adulthood of the nematode Caenorhabditis elegans
HB Atakan, M Cornaglia, L Mouchiroud, J Auwerx, MA Gijs |
Lab on a Chip | 2019 |
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Tau and mTOR: The Hotspots for Multifarious Diseases in Alzheimer's Development
Z Mueed, P Tandon, SK Maurya, R Deval, MA Kamal, NK Poddar |
Frontiers in neuroscience | 2019 |
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Calcium-Binding Proteins in the Nervous System during Hibernation: Neuroprotective Strategies in Hypometabolic Conditions?
G Gattoni, G Bernocchi |
International journal of molecular sciences | 2019 |
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Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments
Sales, Prandi, Castro, Leal, Cunha, Kuca, Ramalho |
International journal of molecular sciences | 2019 |
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Calcium-responsive transactivator (CREST) toxicity is rescued by loss of PBP1/ATXN2 function in a novel yeast proteinopathy model and in transgenic flies
S Park, SK Park, N Watanabe, T Hashimoto, T Iwatsubo, TA Shelkovnikova, SW Liebman, TR Serio |
PLoS genetics | 2019 |
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Postural Instability in Parkinson’s Disease: A Review
B Palakurthi, SP Burugupally |
Brain Sciences | 2019 |
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Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes
CD Gottlieb, AC Thompson, A Ordureau, JW Harper, RR Kopito |
The Journal of biological chemistry | 2019 |
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The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy
JL Yang, YR Yang, SD Chen |
Life Sciences | 2019 |
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Dendritic spines: Revisiting the physiological role
SB Chidambaram, AG Rathipriya, SR Bolla, A Bhat, B Ray, AM Mahalakshmi, T Manivasagam, AJ Thenmozhi, MM Essa, GJ Guillemin, R Chandra, MK Sakharkar |
Progress in neuro-psychopharmacology & biological psychiatry | 2019 |
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In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device
JH Choi, M Santhosh, JW Choi |
MICROMACHINES-BASEL | 2019 |
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Benefits of curcumin in brain disorders
A Bhat, AM Mahalakshmi, B Ray, S Tuladhar, TA Hediyal, E Manthiannem, J Padamati, R Chandra, SB Chidambaram, MK Sakharkar |
BioFactors (Oxford, England) | 2019 |
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A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders
J Geng, J Zhang, F Yao, X Liu, J Liu, Y Huang |
Aging clinical and experimental research | 2019 |
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Copy Number Variants in miR-138 as a Potential Risk Factor for Early-Onset Alzheimer’s Disease
E Boscher, T Husson, O Quenez, A Laquerrière, F Marguet, K Cassinari, D Wallon, O Martinaud, C Charbonnier, G Nicolas, JF Deleuze, A Boland, M Lathrop, T Frébourg, D Campion, SS Hébert, A Rovelet-Lecrux |
Journal of Alzheimer's disease : JAD | 2019 |
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Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease
A Martinez, N Lopez, C Gonzalez, C Hetz |
Biology of the Cell | 2019 |
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Prevention and Treatment of Alzheimer’s Disease: Biological Mechanisms of Exercise
H McGurran, JM Glenn, EN Madero, NT Bott, M Barbera |
Journal of Alzheimer's disease : JAD | 2019 |
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Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies
PG Renani, F Taheri, D Rostami, N Farahani, H Abdolkarimi, E Abdollahi, E Taghizadeh, SM Hayat |
Journal of Cellular Physiology | 2019 |
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In vitro cell evaluation of curcumin-loaded PCL/F68 nanoparticles for potential application in neuronal diseases
ML Prado-Audelo, JJ Magaña, BA Mejía-Contreras, FV Borbolla-Jiménez, DM Giraldo-Gomez, MC Piña-Barba, D Quintanar-Guerrero, G Leyva-Gómez |
Journal of drug delivery science and technology | 2019 |
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CRISPR/Cas: An intriguing genomic editing tool with prospects in treating neurodegenerative diseases
S Rahman, M Datta, J Kim, AT Jan |
Seminars in Cell & Developmental Biology | 2019 |
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P5 eHealth: An Agenda for the Health Technologies of the Future
G Pravettoni, S Triberti |
2019 | |
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The DNA, RNA, and Histone Methylomes
S Jurga, J Barciszewski |
2019 | |
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Gene Therapy Strategies to Restore ER Proteostasis in Disease
V Valenzuela, KL Jackson, SP Sardi, C Hetz |
Molecular Therapy | 2018 |
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Protein production is an early biomarker for RNA-targeted therapies
WK Self, KM Schoch, J Alex, N Barthélemy, JG Bollinger, C Sato, T Cole, HB Kordasiewicz, E Swayze, RJ Bateman, TM Miller |
Annals of Clinical and Translational Neurology | 2018 |
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Salivary biomarkers for the diagnosis and monitoring of neurological diseases
R Farah, H Haraty, Z Salame, Y Fares, DM Ojcius, NS Sadier |
Biomedical journal | 2018 |
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VDAC1, mitochondrial dysfunction, and Alzheimer's disease
V Shoshan-Barmatz, E Nahon-Crystal, A Shteinfer-Kuzmine, R Gupta |
Pharmacological research : the official journal of the Italian Pharmacological Society | 2018 |
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Pacific Ciguatoxin Induces Excitotoxicity and Neurodegeneration in the Motor Cortex Via Caspase 3 Activation: Implication for Irreversible Motor Deficit
P Asthana, N Zhang, G Kumar, VB Chine, KK Singh, YL Mak, LL Chan, PK Lam, CH Ma |
Molecular Neurobiology | 2018 |
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Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease
G Mercado, V Castillo, P Soto, N López, JM Axten, SP Sardi, JJ Hoozemans, C Hetz |
Neurobiology of Disease | 2018 |
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Manganese-Enhanced Magnetic Resonance Imaging: Overview and Central Nervous System Applications With a Focus on Neurodegeneration
RA Cloyd, SA Koren, JF Abisambra |
Frontiers in aging neuroscience | 2018 |
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Emergence of breath testing as a new non-invasive diagnostic modality for neurodegenerative diseases
NS Subramaniam, CS Bawden, H Waldvogel, RM Faull, GS Howarth, RG Snell |
Brain Research | 2018 |
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The Relation Between Brain Amyloid Deposition, Cortical Atrophy, and Plasma Biomarkers in Amnesic Mild Cognitive Impairment and Alzheimer’s Disease
LY Fan, KY Tzen, YF Chen, TF Chen, YM Lai, RF Yen, YY Huang, CY Shiue, SY Yang, MJ Chiu |
Frontiers in aging neuroscience | 2018 |
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A Possible Role for Platelet-Activating Factor Receptor in Amyotrophic Lateral Sclerosis Treatment
MR Briones, AM Snyder, RC Ferreira, EB Neely, JR Connor, JR Broach |
Frontiers in neurology | 2018 |
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Herpes Simplex Virus Vectors for Gene Transfer to the Central Nervous System
S Artusi, Y Miyagawa, W Goins, J Cohen, J Glorioso |
Diseases | 2018 |
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From a Highly Disordered to a Metastable State: Uncovering Insights of α-Synuclein
Y Cote, P Delarue, HA Scheraga, P Senet, GG Maisuradze |
ACS Chemical Neuroscience | 2018 |
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HMGB1 promotes the starvation-induced autophagic degradation of α-synuclein in SH-SY5Y cells Atg 5-dependently
Y Guan, Y Li, G Zhao, Y Li |
Life Sciences | 2018 |
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Genetic Modifiers in Neurodegeneration
N Jain, AS Chen-Plotkin |
Current Genetic Medicine Reports | 2018 |
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Amyloid-β interrupts canonical Sonic hedgehog signaling by distorting primary cilia structure
AG Vorobyeva, AJ Saunders |
Cilia | 2018 |
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Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study
S Thordardottir, E Rodriguez-Vieitez, O Almkvist, D Ferreira, L Saint-Aubert, A Kinhult-Ståhlbom, H Thonberg, M Schöll, E Westman, A Wall, M Eriksdotter, H Zetterberg, K Blennow, A Nordberg, C Graff |
Alzheimer's research & therapy | 2018 |
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Inhaled Xenon Washout as a Biomarker of Alzheimer’s Disease
F Hane, T Li, JA Plata, A Hassan, K Granberg, M Albert |
Diagnostics | 2018 |
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miR-494-3p modulates the progression of in vitro and in vivo Parkinson’s disease models by targeting SIRT3
L Geng, T Zhang, W Liu, Y Chen |
Neuroscience Letters | 2018 |
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Detecting neurodegenerative disorders from web search signals
RW White, PM Doraiswamy, E Horvitz |
2018 | |
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Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model
C Griñán-Ferré, R Corpas, D Puigoriol-Illamola, V Palomera-Ávalos, C Sanfeliu, M Pallàs, G Perry, J Avila, M Tabaton, X Zhu |
Journal of Alzheimer's disease : JAD | 2018 |
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Codon Usage Pattern of Genes Involved in Central Nervous System
A Uddin, S Chakraborty |
Molecular Neurobiology | 2018 |
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Association of Parkinson Disease Induction with Cardiac Upregulation of Apoptotic Mediators P53 and Active Caspase-3: An Immunohistochemistry Study
NS Erekat, MD Al-Jarrah |
Medical Science Monitor Basic Research | 2018 |
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Advances in the discovery of genetic risk factors for complex forms of neurodegenerative disorders: contemporary approaches, success, challenges and prospects
S Kumar, N Yadav, S Pandey, BK Thelma |
Journal of Genetics | 2018 |
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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Y Will, JA Dykens |
2018 | |
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Psychological Support for Health Professionals: An Interpretative Phenomenological Analysis
E Volpato, PI Banfi, C Valota, F Pagnini |
Frontiers in psychology | 2018 |
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Treating Speech Movement Hypokinesia in Parkinson's Disease: Does Movement Size Matter?
E Kearney, B Haworth, J Scholl, P Faloutsos, M Baljko, Y Yunusova |
Journal of speech, language, and hearing research : JSLHR | 2018 |
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Cellular and Molecular Aspects of Parkinson Treatment: Future Therapeutic Perspectives
K Jamebozorgi, E Taghizadeh, D Rostami, H Pormasoumi, GE Barreto, SM Hayat, A Sahebkar |
Molecular Neurobiology | 2018 |
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Current and novel polymeric biomaterials for neural tissue engineering
R Boni, A Ali, A Shavandi, AN Clarkson |
Journal of Biomedical Science | 2018 |
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Shared mechanisms among neurodegenerative diseases: from genetic factors to gene networks
D Arneson, Y Zhang, X Yang, M Narayanan |
Journal of Genetics | 2018 |
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Protein aggregation in cell biology: An aggregomics perspective of health and disease
D Cox, C Raeburn, X Sui, DM Hatters |
Seminars in Cell & Developmental Biology | 2018 |
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Yeast as a model to study protein misfolding in aged cells
SE Gregorio, ML Duennwald |
FEMS Yeast Research | 2018 |
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Protein Misfolding Diseases: Methods and Protocols
CM Gomes |
2018 | |
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Neuroprotective effects of antioxidants in the management of neurodegenerative disorders: A literature review: PANAHI et al
Y Panahi, SM Rajaee, TP Johnston, A Sahebkar |
Journal of Cellular Biochemistry | 2018 |
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Therapeutic trial design for frontotemporal dementia and related disorders
P Desmarais, JD Rohrer, QD Nguyen, N Herrmann, DT Stuss, AE Lang, AL Boxer, BC Dickerson, H Rosen, JC van Swieten, LH Meeter, B Borroni, MC Tartaglia, HH Feldman, SE Black, M Masellis |
Journal of neurology, neurosurgery, and psychiatry | 2018 |
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ER stress and the unfolded protein response in neurodegeneration
C Hetz, S Saxena |
Nature Reviews Neurology | 2017 |
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Voltage-gated Sodium Channels: Structure, Function and Channelopathies
M Chahine |
2017 | |
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Voltage-gated Sodium Channels: Structure, Function and Channelopathies
M Chahine |
2017 | |
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Voltage-gated Sodium Channels: Structure, Function and Channelopathies
M Chahine |
2017 | |
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Voltage-gated Sodium Channels: Structure, Function and Channelopathies
M Chahine |
2017 | |
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Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology
J Guo, J Cheng, BJ North, W Wei |
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer | 2017 |
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E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration
A Upadhyay, V Joshi, A Amanullah, R Mishra, N Arora, A Prasad, A Mishra |
Frontiers in molecular neuroscience | 2017 |
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Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments
P Maiti, J Manna, GL Dunbar |
Translational Neurodegeneration | 2017 |
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Angewandte Ethik in der Neuromedizin
P Weydt |
Angewandte Ethik in der Neuromedizin | 2017 |
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Extracts from two ubiquitous Mediterranean plants ameliorate cellular and animal models of neurodegenerative proteinopathies
M Briffa, S Ghio, J Neuner, AJ Gauci, R Cacciottolo, C Marchal, M Caruana, C Cullin, N Vassallo, RJ Cauchi |
Neuroscience Letters | 2017 |
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Coping With Caregiver Burnout When Caring for a Person With Neurodegenerative Disease: A Guide for Caregivers
S Krishnan, MK York, D Backus, PC Heyn |
Archives of Physical Medicine and Rehabilitation | 2017 |
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Necroptosis in amyotrophic lateral sclerosis and other neurological disorders
JR Morrice, CY Gregory-Evans, CA Shaw |
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 |
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Image-Based Multilevel Biomechanical Modeling for Fall-Induced Hip Fracture
Y Luo |
Image-Based Multilevel Biomechanical Modeling for Fall-Induced Hip Fracture | 2017 |
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A role of P-glycoprotein in neurology
IV Chernykh, AV Shchulkin, EN Yakusheva, NM Popova |
ZH NEVROL PSIKHIATR | 2017 |
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Angiogenin Prevents Progranulin A9D Mutation-Induced Neuronal-Like Cell Apoptosis Through Cleaving tRNAs into tiRNAs
S Li, Y Chen, D Sun, R Bai, X Gao, Y Yang, J Sheng, Z Xu |
Molecular Neurobiology | 2017 |
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Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration
P Singh, PS Hanson, CM Morris |
Parkinson's Disease | 2017 |
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Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans
YA Wang, JE Kammenga, SC Harvey |
Human genomics | 2017 |
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Recent Progress in Alzheimer’s Disease Research, Part 1: Pathology
FT Hane, BY Lee, Z Leonenko |
Journal of Alzheimer's disease : JAD | 2017 |
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The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention
Y Huang, N Todd, A Thathiah |
Current Opinion in Pharmacology | 2017 |
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Secretory carrier membrane protein 5 is an autophagy inhibitor that promotes the secretion of α-synuclein via exosome
Y Yang, M Qin, P Bao, W Xu, J Xu, V Trajkovic |
PloS one | 2017 |
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Significance of long chain polyunsaturated fatty acids in human health
R Zárate, N Jaber-Vazdekis, N Tejera, JA Pérez, C Rodríguez |
Clinical and Translational Medicine | 2017 |
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3D brain Organoids derived from pluripotent stem cells: promising experimental models for brain development and neurodegenerative disorders
CT Lee, RM Bendriem, WW Wu, RF Shen |
Journal of Biomedical Science | 2017 |
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Toxicity and infectivity: insights from de novo prion formation
BT Wisniewski, J Sharma, ER Legan, E Paulson, SJ Merrill, AL Manogaran |
Current Genetics | 2017 |
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Imaging of neuronal tissues by x-ray diffraction and x-ray fluorescence microscopy: evaluation of contrast and biomarkers for neurodegenerative diseases
E Carboni, JD Nicolas, M Töpperwien, C Stadelmann-Nessler, P Lingor, T Salditt |
Biomedical Optics Express | 2017 |
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Nutrition in Neurologic Disorders
EM Arsava |
Nutrition in Neurologic Disorders | 2017 |
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Tenuigenin inhibits LPS-induced inflammatory responses in microglia via activating the Nrf2-mediated HO-1 signaling pathway
X Wang, M Li, Y Cao, J Wang, H Zhang, X Zhou, Q Li, L Wang |
European Journal of Pharmacology | 2017 |
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Yeast models of Parkinson’s disease-associated molecular pathologies
S Tenreiro, V Franssens, J Winderickx, TF Outeiro |
Current Opinion in Genetics & Development | 2017 |
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The impact of obesity on neurodegenerative diseases
JN Mazon, AH de Mello, GK Ferreira, GT Rezin |
Life Sciences | 2017 |
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Glutamine promotes Hsp70 and inhibits α-Synuclein accumulation in pheochromocytoma PC12 cells
H Wang, C Tang, Z Jiang, X Zhou, J Chen, M Na, H Shen, Z Lin |
Experimental and therapeutic medicine | 2017 |
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Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease
MV Fernández, JH Kim, JP Budde, K Black, A Medvedeva, B Saef, Y Deming, J Del-Aguila, L Ibañez, U Dube, O Harari, J Norton, R Chasse, JC Morris, A Goate, C Cruchaga, AJ Myers |
PLoS genetics | 2017 |
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Neurodegenerative Diseases
P Beart, M Robinson, M Rattray, NJ Maragakis |
Neurodegenerative Diseases | 2017 |
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A Powerful Approach to Estimating Annotation-Stratified Genetic Covariance via GWAS Summary Statistics
Q Lu, B Li, D Ou, M Erlendsdottir, RL Powles, T Jiang, Y Hu, D Chang, C Jin, W Dai, Q He, Z Liu, S Mukherjee, PK Crane, H Zhao |
The American Journal of Human Genetics | 2017 |
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CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons
X Qing, J Walter, J Jarazo, J Arias-Fuenzalida, AL Hillje, JC Schwamborn |
Stem Cell Research | 2017 |
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Proteostasis disturbance in amyotrophic lateral sclerosis
DB Medinas, V Valenzuela, C Hetz |
Human Molecular Genetics | 2017 |
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Multivalent interacting glycodendrimer to prevent amyloid-peptide fibril formation induced by Cu(II): A multidisciplinary approach
A Janaszewska, B Klajnert-Maculewicz, M Marcinkowska, P Duchnowicz, D Appelhans, G Grasso, MA Deriu, A Danani, M Cangiotti, MF Ottaviani |
Nano research | 2017 |
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Genetic analysis of SNCA gene polymorphisms in Parkinson’s disease in an Iranian population
M Rahimi, M Akbari, J Jamshidi, A Tafakhori, B Emamalizadeh, H Darvish |
Basal Ganglia | 2017 |
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Research advances in the treatment of Alzheimer's disease with polysaccharides from traditional Chinese medicine
Q LIU, SC WANG, K DING |
Chinese Journal of Natural Medicines | 2017 |
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Apo E4 Alleles and Impaired Olfaction as Predictors of Alzheimer’s Disease
MM Misiak, MM Hipolito, HW Ressom, TO Obisesan, KF Manaye, EA Nwulia |
2017 | |
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ŞİZOFRENİ VE BİPOLAR BOZUKLUKLAR İLE ENFEKSİYON HASTALIKLARI ARASINDAKİ İLİŞKİNİN ARAŞTIRILMASI
C ÖNLEN |
2017 | |
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CPG-based circuitry for controlling musculoskeletal model of human locomotor system
A Shachykov, P Henaff, A Shachykov, A Popov, A Shulyak |
2017 | |
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Immune-mediated processes in neurodegeneration: where do we stand?
M Fakhoury |
Journal of Neurology | 2016 |
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The role of magnetic resonance imaging in the diagnosis of Parkinson's disease: a review
AM Al-Radaideh, EM Rababah |
Clinical Imaging | 2016 |
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Association between MDR1 gene polymorphisms and Parkinson's disease in Asian and Caucasian populations: a meta-analysis
SS Ahmed, RS Husain, S Kumar, V Ramakrishnan |
Journal of the Neurological Sciences | 2016 |
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Neuroprotective effects of Paeonia Lactiflora extract against cell death of dopaminergic SH-SY5Y cells is mediated by epigenetic modulation
G Lee, JC Joo, BY Choi, AM Lindroth, SJ Park, YJ Park |
BMC complementary and alternative medicine | 2016 |
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Use of PEGylated Immunoliposomes to Deliver Dopamine Across the Blood-Brain Barrier in a Rat Model of Parkinson's Disease
YS Kang, HJ Jung, JS Oh, DY Song |
CNS Neuroscience & Therapeutics | 2016 |
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Novel Selective Butyrylcholinesterase Inhibitors Incorporating Antioxidant Functionalities as Potential Bimodal Therapeutics for Alzheimer’s Disease
M Jones, J Wang, S Harmon, B Kling, J Heilmann, J Gilmer |
Molecules (Basel, Switzerland) | 2016 |
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A systems biology-led insight into the role of the proteome in neurodegenerative diseases
M Fasano, C Monti, T Alberio |
Expert Review of Proteomics | 2016 |
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Improving drug delivery technology for treating neurodegenerative diseases
YE Choonara, P Kumar, G Modi, V Pillay |
Expert Opinion on Drug Delivery | 2016 |
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Brain Disorders Due to Lysosomal Dysfunction
A Fraldi, AD Klein, DL Medina, C Settembre |
Annual Review of Neuroscience | 2016 |
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Genetics of psychosis of Alzheimer disease
C Shah, MA DeMichele-Sweet, RA Sweet |
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics | 2016 |
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Histone H3 acetylation in the postmortem Parkinson’s disease primary motor cortex
KG Gebremedhin, DJ Rademacher |
Neuroscience Letters | 2016 |
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Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase
N Otsuki, T Homma, H Fujiwara, K Kaneko, Y Hozumi, M Shichiri, M Takashima, J Ito, T Konno, T Kurahashi, Y Yoshida, K Goto, S Fujii, J Fujii |
Regulatory Toxicology and Pharmacology | 2016 |
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Amyloid–β peptides time-dependent structural modifications: AFM and voltammetric characterization
TA Enache, AM Chiorcea-Paquim, AM Oliveira-Brett |
Analytica Chimica Acta | 2016 |
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Red Light Treatment in an Axotomy Model of Neurodegeneration
K Beirne, M Rozanowska, M Votruba |
Photochemistry and Photobiology | 2016 |
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Copy Number Variants in Alzheimer’s Disease
D Cuccaro, EV de Marco, R Cittadella, S Cavallaro, D Campion |
Journal of Alzheimer's disease : JAD | 2016 |
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Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease
KG Coupland, WS Kim, GM Halliday, M Hallupp, C Dobson-Stone, JB Kwok, P Lewis |
PloS one | 2016 |
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Geniposide Protects Primary Cortical Neurons against Oligomeric Aβ1-42-Induced Neurotoxicity through a Mitochondrial Pathway
C Zhao, C Lv, H Li, S Du, X Liu, Z Li, W Xin, W Zhang, B Zhivotovsky |
PloS one | 2016 |
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Neurodegeneration in a Drosophila model of adrenoleukodystrophy: the roles of the Bubblegum and Double bubble acyl-CoA synthetases
A Sivachenko, HB Gordon, SS Kimball, EJ Gavin, JL Bonkowsky, A Letsou |
Disease models & mechanisms | 2016 |
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A bi-objective network design approach for discovering functional modules linking Golgi apparatus fragmentation and neuronal death
E Álvarez-Miranda, H Farhan, M Luipersbeck, M Sinnl |
Annals of Operations Research | 2016 |
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Enteral feeding in neurological disorders
T Stavroulakis, CJ McDermott |
Practical Neurology | 2016 |
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Association of rs1801582 and rs1801334 PARK2 Polymorphisms with risk of Parkinson's disease: A case-control study in South India and Meta-Analysis
V Ramakrishnan, TA Alphonsa, RS Husain, SS Ahmed, K Subramaniyan, S Kumar |
Meta Gene | 2016 |
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Genes of susceptibility to early neurodegenerative changes in the rat retina and brain: analysis by means of congenic strains
EE Korbolina, AA Zhdankina, AZ Fursova, OS Kozhevnikova, NG Kolosova |
BMC genetics | 2016 |
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Pridopidine activates neuroprotective pathways impaired in Huntington Disease
M Geva, R Kusko, H Soares, KD Fowler, T Birnberg, S Barash, AM -Wagner, T Fine, A Lysaght, B Weiner, Y Cha, S Kolitz, F Towfic, A Orbach, R Laufer, B Zeskind, I Grossman, MR Hayden |
Human Molecular Genetics | 2016 |
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Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease
J TCW, AM Goate |
Cold Spring Harbor Perspectives in Medicine | 2016 |
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Genetics of psychosis of Alzheimer disease
C Shah, MA DeMichele-Sweet, RA Sweet |
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics | 2016 |
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Copy Number Variants in Alzheimer’s Disease
D Cuccaro, EV de Marco, R Cittadella, S Cavallaro, D Campion |
Journal of Alzheimer's disease : JAD | 2016 |
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Computational identification and analysis of neurodegenerative disease associated protein kinases in hominid genomes
S Jayapalan, D Subramanian, J Natarajan |
Genes & Diseases | 2016 |
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Pathophysiological Role of Peroxynitrite Induced DNA Damage in Human Diseases: A Special Focus on Poly(ADP-ribose) Polymerase (PARP)
B Islam, S Habib, P Ahmad, S Allarakha, Moinuddin, A Ali |
Indian Journal of Clinical Biochemistry | 2015 |
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Protein aggregation and neurodegeneration in prototypical neurodegenerative diseases: Examples of amyloidopathies, tauopathies and synucleinopathies
M Bourdenx, NS Koulakiotis, D Sanoudou, E Bezard, B Dehay, A Tsarbopoulos |
Progress in Neurobiology | 2015 |
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Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
J Hu, CC Liu, XF Chen, Y Zhang, H Xu, G Bu |
Molecular Neurodegeneration | 2015 |
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Systems biology of neurodegenerative diseases
LB Wood, AR Winslow, SD Strasser |
Integrative Biology | 2015 |
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Pseudocatalytic Antiaggregation Activity of Antibodies: Immunoglobulins can Influence α-Synuclein Aggregation at Substoichiometric Concentrations
L Breydo, D Morgan, VN Uversky |
Molecular Neurobiology | 2015 |
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Role of 5-hydroxymethylcytosine in neurodegeneration
SI Sherwani, HA Khan |
Gene | 2015 |
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Fast Flow Microfluidics and Single-Molecule Fluorescence for the Rapid Characterization of α-Synuclein Oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, MD Serra, TP Knowles, CM Dobson, D Klenerman |
Analytical Chemistry | 2015 |
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Early onset of cognitive impairment is associated with altered synaptic plasticity and enhanced hippocampal GluA1 expression in a mouse model of depression
M Gross, A Sheinin, E Nesher, T Tikhonov, D Baranes, A Pinhasov, I Michaelevski |
Neurobiology of Aging | 2015 |
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Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?
NS de Groot, MT Burgas |
Cellular and Molecular Life Sciences | 2015 |
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Serine phosphorylation and arginine methylation at the crossroads to neurodegeneration
M Basso, M Pennuto |
Experimental Neurology | 2015 |
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Gene panels and primers for next generation sequencing studies on neurodegenerative disorders
VV Giau, SS An, E Bagyinszky, SY Kim |
Molecular & Cellular Toxicology | 2015 |
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Molecular regulation of dendritic spine dynamics and their potential impact on synaptic plasticity and neurological diseases
P Maiti, J Manna, G Ilavazhagan, J Rossignol, GL Dunbar |
Neuroscience & Biobehavioral Reviews | 2015 |
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Preclinical Evidence for a Role of the Nicotinic Cholinergic System in Parkinson’s Disease
XA Perez |
Neuropsychology Review | 2015 |
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Leerboek metabolisme
FC Schuit |
2015 | |
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A platelet protein biochip rapidly detects an Alzheimer’s disease-specific phenotype
M Veitinger, R Oehler, E Umlauf, R Baumgartner, G Schmidt, C Gerner, R Babeluk, J Attems, G Mitulovic, E Rappold, J Lamont, M Zellner |
Acta Neuropathologica | 2014 |
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Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology
BX Wong, YH Hung, AI Bush, JA Duce |
Frontiers in aging neuroscience | 2014 |
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Neuronal cellular responses to extremely low frequency electromagnetic field exposure: implications regarding oxidative stress and neurodegeneration
M Reale, MA Kamal, A Patruno, E Costantini, C D'Angelo, M Pesce, NH Greig |
PloS one | 2014 |
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Targeted Suppression of Chaperone-Mediated Autophagy by miR-320a Promotes α-Synuclein Aggregation
G Li, H Yang, D Zhu, H Huang, G Liu, P Lun |
International journal of molecular sciences | 2014 |
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Expression of A2V-mutated Aβ in Caenorhabditis elegans results in oligomer formation and toxicity
L Diomede, GD Fede, M Romeo, R Bagnati, R Ghidoni, F Fiordaliso, M Salio, A Rossi, M Catania, A Paterlini, L Benussi, A Bastone, M Stravalaci, M Gobbi, F Tagliavini, M Salmona |
Neurobiology of Disease | 2014 |
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The genetics of Alzheimer's disease
E Bagyinszky, YC Youn, SS An, SY Kim |
Clinical Interventions in Aging | 2014 |
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A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress
N Chaudhari, P Talwar, A Parimisetty, CL d'Hellencourt, P Ravanan |
Frontiers in cellular neuroscience | 2014 |
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miR-16-1 promotes the aberrant α-synuclein accumulation in parkinson disease via targeting heat shock protein 70
Z Zhang, Y Cheng |
The Scientific World JOURNAL | 2014 |
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Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species
PB Campos, BS Paulsen, SK Rehen |
Frontiers in aging neuroscience | 2014 |
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Epigenetic Features Induced by Ischemia-Hypoxia in Cultured Rat Astrocytes
Q Yang, X Wu, J Sun, J Cui, L Li |
Molecular Neurobiology | 2014 |
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Examining the Relationship between Head Trauma and Neurodegenerative Disease: A Review of Epidemiology, Pathology and Neuroimaging Techniques
MH Hall |
Journal of Alzheimer's disease & Parkinsonism | 2014 |
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Testing synthetic amyloid-β aggregation inhibitor using single molecule atomic force spectroscopy
FT Hane, BY Lee, A Petoyan, A Rauk, Z Leonenko |
Biosensors and Bioelectronics | 2014 |
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Guard of Delinquency? A Role of Microglia in Inflammatory Neurodegenerative Diseases of the CNS
W Wu, J Shao, H Lu, J Xu, A Zhu, W Fang, G Hui |
Cell Biochemistry and Biophysics | 2014 |
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Neurodegenerative disorders: Dysregulation of a carefully maintained balance?
C Swart, W Haylett, C Kinnear, G Johnson, S Bardien, B Loos |
Experimental Gerontology | 2014 |
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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
D Heras-Sandoval, JM Pérez-Rojas, J Hernández-Damián, J Pedraza-Chaverri |
Cellular Signalling | 2014 |
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Neuronal Cellular Responses to Extremely Low Frequency Electromagnetic Field Exposure: Implications Regarding Oxidative Stress and Neurodegeneration
M Reale, MA Kamal, A Patruno, E Costantini, C D'Angelo, M Pesce, NH Greig, BK Harvey |
PloS one | 2014 |
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Drug Delivery System
KK Jain |
Drug Delivery System | 2014 |
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Drug Delivery System
KK Jain |
Drug Delivery System | 2014 |
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A Review of Quality of Life after Predictive Testing for and Earlier Identification of Neurodegenerative Diseases
JS Paulsen, M Nance, JI Kim, NE Carlozzi, PK Panegyres, C Erwin, A Goh, E McCusker, JK Williams |
Progress in Neurobiology | 2013 |
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Genetic susceptibility testing for neurodegenerative diseases: Ethical and practice issues
JS Roberts, WR Uhlmann |
Progress in Neurobiology | 2013 |
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Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain
X Wu, J Sun, L Li |
Neuroscience Bulletin | 2013 |
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Is AD a homogeneous nosologic entity? Yes
P Martinez-Martin |
Journal of Neural Transmission | 2013 |
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Emery and Rimoin's Principles and Practice of Medical Genetics
DC Wallace, MT Lott, V Procaccio |
Emery and Rimoin's Principles and Practice of Medical Genetics | 2013 |
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Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
H Martiskainen, A Haapasalo, KM Kurkinen, J Pihlajamäki, H Soininen, M Hiltunen |
Expert Opinion on Therapeutic Targets | 2013 |
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Proteinopathies, a core concept for understanding and ultimately treating degenerative disorders?
TA Bayer |
European Neuropsychopharmacology | 2013 |
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CYP46A1 intron-2T/C polymorphism and Alzheimer's disease: an updated meta-analysis of 16 studies including 3960 cases and 3828 controls
M Li, W Wang, Y Li, L Wang, X Shen, Z Tang |
Neuroscience Letters | 2013 |
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Protein misfolding in the late-onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis: Protein Misfolding in Neurodegeneration
VK Mulligan, A Chakrabartty |
Proteins: Structure, Function, and Bioinformatics | 2013 |
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Metabolic Syndrome and Neurological Disorders: Farooqui/Metabolic
AA Farooqui, T Farooqui |
Metabolic Syndrome and Neurological Disorders: Farooqui/Metabolic | 2013 |
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DNA methylation of the MAPT gene in Parkinson's disease cohorts and modulation by vitamin E In Vitro: MAPT METHYLATION AND VITAMIN E IN PD
KG Coupland, GD Mellick, PA Silburn, K Mather, NJ Armstrong, PS Sachdev, H Brodaty, Y Huang, GM Halliday, M Hallupp, WS Kim, C Dobson-Stone, JB Kwok |
Movement disorders : official journal of the Movement Disorder Society | 2013 |
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Protective Effect of Paeoniflorin on Aβ25–35-Induced SH-SY5Y Cell Injury by Preventing Mitochondrial Dysfunction
K Wang, L Zhu, X Zhu, K Zhang, B Huang, J Zhang, Y Zhang, L Zhu, B Zhou, F Zhou |
Cellular and Molecular Neurobiology | 2013 |
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Twenty-Five Years of Progress: The View from NIMH and NINDS
TR Insel, SC Landis |
Neuron | 2013 |
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Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo
C Scaramuzzino, J Monaghan, C Milioto, NA Lanson, A Maltare, T Aggarwal, I Casci, FO Fackelmayer, M Pennuto, UB Pandey |
PloS one | 2013 |
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Cu(2+) affects amyloid-β (1-42) aggregation by increasing peptide-peptide binding forces
F Hane, G Tran, SJ Attwood, Z Leonenko |
PloS one | 2013 |
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Bewegung zur Prävention von Demenz: Ergebnisse der evidenzbasierten Bewegungsintervention – GESTALT
A Streber, K Abu-Omar, A Wolff, A Rütten |
Prävention und Gesundheitsförderung | 2013 |
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Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer's disease, Parkinson's disease, and related disorders
VK Ramanan, AJ Saykin |
American journal of neurodegenerative disease | 2013 |
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Pathways to neurodegeneration: mechanistic insights from GWAS in Alzheimer’s disease, Parkinson’s disease, and related disorders
VK Ramanan, AJ Saykin |
American journal of neurodegenerative disease | 2013 |
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Cu2+ Affects Amyloid-β (1–42) Aggregation by Increasing Peptide-Peptide Binding Forces
F Hane, G Tran, SJ Attwood, Z Leonenko, I Sokolov |
PloS one | 2013 |
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Protein Arginine Methyltransferase 1 and 8 Interact with FUS to Modify Its Sub-Cellular Distribution and Toxicity In Vitro and In Vivo
C Scaramuzzino, J Monaghan, C Milioto, NA Lanson, A Maltare, T Aggarwal, I Casci, FO Fackelmayer, M Pennuto, UB Pandey, DE Rincon-Limas |
PloS one | 2013 |
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Omics for Personalized Medicine
D Barh, D Dhawan, NK Ganguly |
2013 | |
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Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis
M Maulik, D Westaway, JH Jhamandas, S Kar |
Molecular Neurobiology | 2012 |
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Human induced pluripotent stem cells and neurodegenerative disease : prospects for novel therapies
YW Jung, E Hysolli, KY Kim, Y Tanaka, IH Park |
Current Opinion in Neurology | 2012 |
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Interaction between pathogenic proteins in neurodegenerative disorders
KA Jellinger, BO Popescu |
Journal of Cellular and Molecular Medicine | 2012 |
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The Effects of SIRT1 on Alzheimer's Disease Models
G Donmez |
International Journal of Alzheimer's Disease | 2012 |
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Neurodegeneration in Alzheimer Disease: Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
M Nizzari, S Thellung, A Corsaro, V Villa, A Pagano, C Porcile, C Russo, T Florio |
Journal of Toxicology | 2012 |
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New Insights in the Amyloid-Beta Interaction with Mitochondria
C Spuch, S Ortolano, C Navarro |
Journal of Aging Research | 2012 |
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The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia
L Moll, M Schubert |
Current Gerontology and Geriatrics Research | 2012 |
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Alzheimer’s Disease: A Clinical Practice-Oriented Review
L Alves, AS Correia, R Miguel, P Alegria, P Bugalho |
Frontiers in neurology | 2012 |
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Whole genome expression profile in neuroblastoma cells exposed to 1-methyl-4-phenylpyridine
E Mazzio, KF Soliman |
NeuroToxicology | 2012 |
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Lessons from Tau-Deficient Mice
YD Ke, AK Suchowerska, J der Hoven, DM de Silva, CW Wu, J Eersel, A Ittner, LM Ittner |
International Journal of Alzheimer's Disease | 2012 |
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Genetics of Neurodegenerative Diseases
CM Lill, RE Tanzi, L Bertram |
Basic Neurochemistry | 2012 |
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Leucine-rich repeat kinase 2 and alternative splicing in Parkinson's disease
DA Elliott, WS Kim, S Gorissen, GM Halliday, JB Kwok |
Movement Disorders | 2012 |
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Cochrane Database of Systematic Reviews: Protocols
JJ Ho, AS Adnan, Z Darus, NZ Ismail, HV Rostenberghe, JJ Ho |
Cochrane Database of Systematic Reviews: Protocols | 2012 |
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To Know or Not to Know: An Update of the Literature on the Psychological and Behavioral Impact of Genetic Testing for Alzheimer Disease Risk
B Rahman, B Meiser, P Sachdev, K Barlow-Stewart, M Otlowski, E Zilliacus, P Schofield |
Genetic Testing and Molecular Biomarkers | 2012 |
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Selective degeneration of septal and hippocampal GABAergic neurons in a mouse model of amyloidosis and tauopathy
D Loreth, L Ozmen, FG Revel, F Knoflach, P Wetzel, M Frotscher, F Metzger, O Kretz |
Neurobiology of Disease | 2012 |
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Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study
AS Fleisher, K Chen, YT Quiroz, LJ Jakimovich, MG Gomez, CM Langois, JB Langbaum, N Ayutyanont, A Roontiva, P Thiyyagura, W Lee, H Mo, L Lopez, S Moreno, N Acosta-Baena, M Giraldo, G Garcia, RA Reiman, MJ Huentelman, KS Kosik, PN Tariot, F Lopera, EM Reiman |
The Lancet Neurology | 2012 |
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RNA-Seq and human complex diseases: recent accomplishments and future perspectives
V Costa, M Aprile, R Esposito, A Ciccodicola |
European Journal of Human Genetics | 2012 |
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Bioinorganic Chemistry of Alzheimer’s Disease
KP Kepp |
Chemical Reviews | 2012 |
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Non-coding RNA in Neurodegeneration
A Ciccodicola, MR Ambrosio, M Scarpato, V Costa |
Current Translational Geriatrics and Gerontology Reports | 2012 |
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Genetics of Alzheimer’s Disease
ME Vilatela, ML López, PY Gómez |
Archives of Medical Research | 2012 |
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Cortical beta amyloid protein triggers an immune response, but no synaptic changes in the APPswe/PS1dE9 Alzheimer's disease mouse model
KT Wirz, K Bossers, A Stargardt, W Kamphuis, DF Swaab, EM Hol, J Verhaagen |
Neurobiology of Aging | 2012 |
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Individuals at risk for Alzheimer's disease show differential patterns of ERP brain activation during odor identification
CD Morgan, C Murphy |
Behavioral and Brain Functions | 2012 |
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The Genetics of Alzheimer Disease
RE Tanzi |
Cold Spring Harbor Perspectives in Medicine | 2012 |
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Home care program for patients at high risk of hospitalization
Stuart Levine, Bernard A Steinman, Karol Attaway, Tyler Jung, Susan Enguidanos |
The American journal of managed care | 2012 |
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The importance of integrating basic and clinical research towards the development of new therapies for Huntington’s disease
Ignacio Munoz-Sanjuan, gillain bates |
Journal of Clinical Investigation | 2011 |
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Behavioral Neurogenetics
JF Cryan, A Reif |
Behavioral Neurogenetics | 2011 |
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Behavioral Neurogenetics
JF Cryan, A Reif |
Behavioral Neurogenetics | 2011 |
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Behavioral Neurogenetics
JF Cryan, A Reif |
Behavioral Neurogenetics | 2011 |
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Behavioral Neurogenetics
JF Cryan, A Reif |
Behavioral Neurogenetics | 2011 |
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Behavioral Neurogenetics
JF Cryan, A Reif |
Behavioral Neurogenetics | 2011 |
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Interaction between α-Synuclein and Other Proteins in Neurodegenerative Disorders
KA Jellinger |
TheScientificWorldJournal | 2011 |
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Encyclopedia of Environmental Health
FP Perera, SC Edwards |
Encyclopedia of Environmental Health | 2011 |
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The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease
EA Mazzio, F Close, KF Soliman |
International journal of molecular sciences | 2011 |
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Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria
J Miklossy |
Journal of Neuroinflammation | 2011 |
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Mitochondrial transcription factor A (TFAM) polymorphisms and risk of late-onset Alzheimer's disease in Han Chinese
Q Zhang, JT Yu, P Wang, W Chen, ZC Wu, H Jiang, L Tan |
Brain Research | 2011 |
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Emerging roles of pathogens in Alzheimer disease
J Miklossy |
Expert Reviews in Molecular Medicine | 2011 |
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Molecular Neuroimaging of the Dementias : From Scientific Insights to Clinical Applications
BC Dickerson |
The Handbook of Alzheimer s Disease and Other Dementias Budson/The Handbook of Alzheimer s Disease and Other Dementias | 2011 |
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Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease)
C Spuch, C Navarro |
Journal of drug delivery | 2011 |
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Connecting the Bench with the Bedside : Translating Life Science Discoveries to Disease Treatments and Vice Versa
YW Webster, ER Dow, MJ Palakal |
Systemic Approaches in Bioinformatics and Computational Systems Biology Recent Advances | 2011 |
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What monozygotic twins discordant for phenotype illustrate about mechanisms influencing genetic forms of neurodegeneration
ME Ketelaar, RM Hofstra, MR Hayden |
Clinical Genetics | 2011 |
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Associations of gene sequence variation and serum levels of C-reactive protein and Interleukin-6 with Alzheimer’s disease and dementia
UK Eriksson, NL Pedersen, CA Reynolds, MG Hong, JA Prince, M Gatz, PW Dickman, AM Bennet |
Journal of Alzheimer's disease : JAD | 2011 |
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Extended Kindred With Recessive Late-Onset Alzheimer Disease Maps to Locus 8p22-p21.2 : A Genome-wide Linkage Analysis
M Baron, E Gomez-Tortosa, Z Bochdanovits, I Gobernado, A Rabano, DG Munoz, P Heutink, A Jimenez-Escrig |
Alzheimer Disease & Associated Disorders | 2011 |
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How does the genetic assassin select its neuronal target?
JC Stevens, EM Fisher, S Mead |
Mammalian Genome | 2011 |
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Alzheimer’s Genetics in the GWAS Era: A Continuing Story of ‘Replications and Refutations’
L Bertram |
Current Neurology and Neuroscience Reports | 2011 |
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Brief update on different roles of tau in neurodegeneration
A Ittner, YD Ke, J Eersel, A Gladbach, J Götz, LM Ittner |
IUBMB Life | 2011 |
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Epigenetics in neurodegeneration: A new layer of complexity
SC Marques, CR Oliveira, CM Pereira, TF Outeiro |
Progress in Neuro-Psychopharmacology and Biological Psychiatry | 2011 |
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Clinical Recognition and Management of Amyotrophic Lateral Sclerosis: The Nurse's Role
K Clarke, T Levine |
Journal of Neuroscience Nursing | 2011 |
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Diagnosis of Alzheimer's disease in Brazil: Supplementary exams
P Caramelli, AL Teixeira, CA Buchpiguel, HW Lee, JA Livramento, LL Fernandez, R Anghinah |
Dementia & Neuropsychologia | 2011 |
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Studies on Experimental Models
S Basu, L Wiklund |
2011 | |
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Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors
Goldman JS, Hahn SE, Catania JW, LaRusse-Eckert S, Butson MB, Rumbaugh M, Strecker MN, Roberts JS, Burke W, Mayeux R, Bird T |
Genetics in Medicine | 2011 |
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γ-Secretase Modulators as Potential Disease Modifying Anti-Alzheimer’s Drugs
D Oehlrich, DJ Berthelot, HJ Gijsen |
Journal of Medicinal Chemistry | 2010 |
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Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
K Iijima, A Gatt, K Iijima-Ando |
Human Molecular Genetics | 2010 |
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Alzheimer's disease: diagnostics, prognostics and the road to prevention
I Grossman, MW Lutz, DG Crenshaw, AM Saunders, DK Burns, AD Roses |
The EPMA Journal | 2010 |
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Amyloid precursor protein and tau transgenic models of Alzheimer's disease: insights from the past and directions for the future
N Sahara, J Lewis |
Future Neurology | 2010 |
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Genetics and biology of Alzheimer's disease and frontotemporal lobar degeneration
D Galimberti, E Scarpini |
International journal of clinical and experimental medicine | 2010 |
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Role of epigenetics in Alzheimer’s and Parkinson’s disease
JB Kwok |
Epigenomics | 2010 |
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Complement receptor 1 polymorphisms and risk of late-onset Alzheimer's disease
Q Zhang, JT Yu, QX Zhu, W Zhang, ZC Wu, D Miao, L Tan |
Brain Research | 2010 |
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Transgenic animal models of neurodegeneration based on human genetic studies
BK Harvey, CT Richie, BJ Hoffer, M Airavaara |
Journal of neural transmission (Vienna, Austria : 1996) | 2010 |
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NATURE VERSUS NURTURE: DEATH OF A DOGMA, AND THE ROAD AHEAD
BJ Traynor, AB Singleton |
Neuron | 2010 |
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Investigations in Old Age Psychiatry
S Merve, RC Baldwin |
Principles and Practice of Geriatric Psychiatry Abou-Saleh/Principles and Practice of Geriatric Psychiatry | 2010 |
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Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
LM Ittner, J Götz |
Nature Reviews Neuroscience | 2010 |
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Amyloid precursor protein and tau transgenic models of Alzheimer’s disease: insights from the past and directions for the future
N Sahara, J Lewis |
Future Neurology | 2010 |
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An update on clinical proteomics in Alzheimer’s research
MA Korolainen, TA Nyman, T Aittokallio, T Pirttilä |
Journal of Neurochemistry | 2010 |
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Genetic predisposition in dementia
H Yamagata |
Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics | 2010 |
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Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
K Bossers, KT Wirz, GF Meerhoff, AH Essing, JW van Dongen, P Houba, CG Kruse, J Verhaagen, DF Swaab |
Brain | 2010 |
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Pathogenic TARDBP Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: Disease-Associated Pathways
SJ Barmada, S Finkbeiner |
Reviews in the Neurosciences | 2010 |
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Disease onset in familial and sporadic primary progressive multiple sclerosis
M Koch, Y Zhao, I Yee, C Guimond, E Kingwell, P Rieckmann, D Sadovnick, H Tremlett |
Multiple sclerosis (Houndmills, Basingstoke, England) | 2010 |
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Metabolisme
FC Schuit |
2010 | |
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Bringing SOD1 into the fold
S Barmada, S Finkbeiner |
Nature Neuroscience | 2010 |
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Pulmonary surfactant: an immunological perspective
ZC Chroneos, Z Sever-Chroneos, VL Shepherd |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | 2009 |
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Transgenic Drosophila models of Alzheimer's disease and tauopathies
K Iijima-Ando, K Iijima |
Brain structure & function | 2009 |
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The importance of NAD in multiple sclerosis
WT Penberthy, I Tsunoda |
Current pharmaceutical design | 2009 |
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Genetic aspects of Alzheimer disease
J Williamson, J Goldman, KS Marder |
The Neurologist | 2009 |
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Emerging role of microRNAs in diagnosis and treatment of various diseases including ovarian cancer
PP Shah, LE Hutchinson, SS Kakar |
Journal of Ovarian Research | 2009 |
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Fine mapping of gene regions regulating neurodegeneration
M Swanberg, K Harnesk, M Ström, M Diez, O Lidman, F Piehl |
PloS one | 2009 |
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Lack of association between PRNP 1368 polymorphism and Alzheimer's disease or vascular dementia
BH Jeong, KH Lee, YJ Lee, YJ Kim, EK Choi, YH Kim, YS Cho, RI Carp, YS Kim |
BMC Medical Genetics | 2009 |
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A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis
GD Fede, M Catania, M Morbin, G Rossi, S Suardi, G Mazzoleni, M Merlin, AR Giovagnoli, S Prioni, A Erbetta, C Falcone, M Gobbi, L Colombo, A Bastone, M Beeg, C Manzoni, B Francescucci, A Spagnoli, L Cantù, ED Favero, E Levy, M Salmona, F Tagliavini |
Science (New York, N.Y.) | 2009 |
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Die Alzheimer-Demenz: von der Pathologie zu therapeutischen Ansätzen
R Jakob-Roetne, H Jacobsen |
Angewandte Chemie | 2009 |
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Alzheimer's Disease: From Pathology to Therapeutic Approaches
R Jakob-Roetne, H Jacobsen |
Angewandte Chemie International Edition | 2009 |
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Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin
DF Fischer, R Dijk, P Tijn, B Hobo, MC Verhage, RC van der Schors, KW Li, J Minnen, EM Hol, FW van Leeuwen |
Neurobiology of Aging | 2009 |
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Inflammation and susceptibility to neurodegeneration: The use of unbiased genetics to decipher critical regulatory pathways
F Piehl, T Olsson |
Neuroscience | 2009 |
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Cortical and Hippocampal Neurons from Truncated Tau Transgenic Rat Express Multiple Markers of Neurodegeneration
P Filipcik, M Cente, G Krajciova, I Vanicky, M Novak |
Cellular and Molecular Neurobiology | 2009 |
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Progressive language impairments: Definitions, diagnoses, and prognoses
K Croot |
Aphasiology | 2009 |
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Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin
B Ray, DK Lahiri |
Current Opinion in Pharmacology | 2009 |
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Nursing Advocacy in a Post-Genomic Age
R Hamilton |
Nursing Clinics of North America | 2009 |
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Prevention of common neurodegenerative disorders in the elderly
L Fratiglioni, C Qiu |
Experimental Gerontology | 2009 |
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Aggregation of neurodegenerative disease in ALS kindreds
BA Fallis, O Hardiman |
Amyotrophic Lateral Sclerosis | 2009 |
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Handbook of Behavior Genetics
YK Kim |
2009 | |
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fMRI Techniques and Protocols
M Filippi |
2009 | |
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Apolipoprotein E isoform-specific disruption of Alzheimer's amyloid beta-peptide clearance from brain
Rashid Deane, Abhay Sagare, Katie Hamm, Margaret Parisi, Steven Lane, Mary Beth Finn, David M. Holtzman, Berislav V. Zlokovic |
Journal of Clinical Investigation | 2008 |
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Modeling brain dynamics using computational neurogenetic approach
L Benuskova, N Kasabov |
Cognitive neurodynamics | 2008 |
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The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer's disease
JH Lee, S Barral, C Reitz |
Current Neurology and Neuroscience Reports | 2008 |
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The Sp1/Egr1-tandem Repeat Polymorphism in the 5-Lipoxygenase Gene Promoter is not Associated With Late Onset Alzheimer Disease
V Alvarez, P González, AI Corao, M Menéndez, CH Lahoz, C Martínez, M Calatayud, B Morales, E Coto |
Alzheimer Disease & Associated Disorders | 2008 |
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Animal models of Alzheimer's disease and frontotemporal dementia
J Götz, LM Ittner |
Nature Reviews Neuroscience | 2008 |
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Parenchymal and vascular Aβ-deposition and its effects on the degeneration of neurons and cognition in Alzheimer's disease
DR Thal, WS Griffin, H Braak |
Journal of Cellular and Molecular Medicine | 2008 |
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Double stranded RNA activated EIF2 α kinase (EIF2AK2; PKR) is associated with Alzheimer's disease
MJ Bullido, A Martínez-García, R Tenorio, I Sastre, DG Muñoz, A Frank, F Valdivieso |
Neurobiology of Aging | 2008 |
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Familial risks for amyotrophic lateral sclerosis and autoimmune diseases
K Hemminki, X Li, J Sundquist, K Sundquist |
neurogenetics | 2008 |
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Increased severity over generations of Charcot-Marie-Tooth disease type 1A
I Steiner, M Gotkine, B Steiner-Birmanns, I Biran, S Silverstein, D Abeliovich, Z Argov, I Wirguin |
Journal of Neurology | 2008 |
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A phenotype for genetic studies of successful cognitive aging
JM Silverman, M Schnaider-Beeri, HT Grossman, J Schmeidler, JY Wang, RC Lally |
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics | 2008 |
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Familial risks for common diseases: Etiologic clues and guidance to gene identification
K Hemminki, X Li, K Sundquist, J Sundquist |
Mutation Research/Reviews in Mutation Research | 2008 |
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The neuronal sortilin-related receptor gene SORL1 and late-onset Alzheimer’s disease
JH Lee, S Barral, C Reitz |
Current Neurology and Neuroscience Reports | 2008 |
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Nitric oxide and peroxynitrite in health and disease
P Pacher, JS Beckman, L Liaudet |
Physiological reviews | 2007 |
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Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
D Krewski, RA Yokel, E Nieboer, D Borchelt, J Cohen, J Harry, S Kacew, J Lindsay, AM Mahfouz, V Rondeau |
Journal of Toxicology and Environmental Health, Part B | 2007 |
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Familial risks for nerve, nerve root and plexus disorders in siblings based on hospitalisations in Sweden
K Hemminki, X Li, K Sundquist |
Journal of epidemiology and community health | 2007 |
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A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population
F Liu, A Arias-Vásquez, K Sleegers, YS Aulchenko, M Kayser, P Sanchez-Juan, BJ Feng, AM Bertoli-Avella, J Swieten, TI Axenovich, P Heutink, C Broeckhoven, BA Oostra, CM van Duijn |
The American Journal of Human Genetics | 2007 |
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In vivo imaging of brain lesions with [11C]CLINME, a new PET radioligand of peripheral benzodiazepine receptors
H Boutin, F Chauveau, C Thominiaux, B Kuhnast, MC Grégoire, S Jan, R Trebossen, F Dollé, B Tavitian, F Mattner, A Katsifis |
Glia | 2007 |
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The LDLR locus in alzheimer's disease: A family-based study and meta-analysis of case-control data
L Bertram, M Hsiao, MB McQueen, M Parkinson, K Mullin, D Blacker, RE Tanzi |
Neurobiology of Aging | 2007 |
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A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers
MJ Bullido, A Martínez-García, MJ Artiga, J Aldudo, I Sastre, P Gil, F Coria, DG Muñoz, V Hachinski, A Frank, F Valdivieso |
Neurobiology of Aging | 2007 |
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Myocyte enhancing factor-2A in Alzheimer's disease: Genetic analysis and association with MEF2A-polymorphisms
P Gonzalez, V Alvarez, M Menendez, C Lahoz, C Martinez, A Corao, M Calatayud, J Pena, M Garciacastro, E Coto |
Neuroscience Letters | 2007 |
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Averting Dementia of the Alzheimer's Type in Women: Can Counselors Help?
KZ Douthit |
Adultspan Journal | 2007 |
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Oxidative Stress and Neurodegenerative Disorders
K Christou, KI Gourgoulianis |
Oxidative Stress and Neurodegenerative Disorders | 2007 |
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Effects of Acute Exposure to Aluminum on Cognition in Humans
DW Molloy, TI Standish, E Nieboer, JD Turnbull, SD Smith, S Dubois |
Journal of Toxicology and Environmental Health, Part A | 2007 |
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Localizations of endogenous APP/APP-Proteolytic products are consistent with microtubular transport
G Zitnik, L Wang, GM Martin, Q Hu |
Journal of Molecular Neuroscience | 2007 |
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Statins, Neuromuscular Degenerative Disease and an Amyotrophic Lateral Sclerosis-Like Syndrome: An Analysis of Individual Case Safety Reports from Vigibase
IR Edwards, K Star, A Kiuru |
Drug Safety | 2007 |
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High familial risks for cerebral palsy implicate partial heritable aetiology
K Hemminki, X Li, K Sundquist, J Sundquist |
Paediatric and Perinatal Epidemiology | 2007 |
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Management and Analysis of Genomic Functional and Phenotypic Controlled Annotations to Support Biomedical Investigation and Practice
M Masseroli |
IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society | 2007 |
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Alzheimer’s disease and Helicobacter pylori infection: Defective immune regulation and apoptosis as proposed common links
J Kountouras, E Gavalas, C Zavos, C Stergiopoulos, D Chatzopoulos, N Kapetanakis, D Gisakis |
Medical Hypotheses | 2007 |
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Associations between VHL genotype and clinical phenotype in familial von Hippel?Lindau disease
JS Huang, CJ Huang, SK Chen, CC Chien, CW Chen, CM Lin |
European Journal of Clinical Investigation | 2007 |
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FOOTBALL INCREASES THE RISK FOR LOU GEHRIG'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS 1
EL Abel |
Perceptual and Motor Skills | 2007 |
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Association between Vitamin D Receptor Gene Polymorphism and Alzheimer's Disease
D Gezen-Ak, E Dursun, T Ertan, H Hanagasi, H Gürvit, M Emre, E Eker, M Öztürk, F Engin, S Yilmazer |
The Tohoku Journal of Experimental Medicine | 2007 |
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The potential role of epigenomic dysregulation in complex human disease
E Hatchwell, JM Greally |
Trends in Genetics | 2007 |
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Genetic heterogeneity of Alzheimer's disease: Complexity and advances
JC Lambert, P Amouyel |
Psychoneuroendocrinology | 2007 |
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Advancing translational research with the Semantic Web
A Ruttenberg, T Clark, W Bug, M Samwald, O Bodenreider, H Chen, D Doherty, K Forsberg, Y Gao, V Kashyap, J Kinoshita, J Luciano, MS Marshall, C Ogbuji, J Rees, S Stephens, GT Wong, E Wu, D Zaccagnini, T Hongsermeier, E Neumann, I Herman, KH Cheung |
BMC bioinformatics | 2007 |
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Epidemiology of Parkinson's disease
Kasten M, Chade A, Tanner CM |
Handbook of Clinical Neurology | 2007 |
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Sorting through the Cell Biology of Alzheimer's Disease: Intracellular Pathways to Pathogenesis
SA Small, S Gandy |
Neuron | 2006 |
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Genetic Epidemiology of Alzheimer Disease
R Mayeux |
Alzheimer Disease & Associated Disorders | 2006 |
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Pharmacogenetics of alkylator-associated acute myeloid leukemia
E Knoche, HL McLeod, TA Graubert |
Pharmacogenomics | 2006 |
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Association of DSC1, a gene modulated by adrenergic stimulation, with Alzheimer's disease
MC Ramos, R Tenorio, A Martínez-García, I Sastre, E Vilella-Cuadrada, A Frank, M Rosich-Estragó, F Valdivieso, MJ Bullido |
Neuroscience Letters | 2006 |
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Einstellung zu genetischen Untersuchungen auf Alzheimer-Demenz
F Illes, T Bernhardt, K Prell, C Rietz, G Rudinger, L Frölich, W Maier, M Rietschel |
Zeitschrift für Gerontologie und Geriatrie | 2006 |
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The search for disease-modifying drugs for neurodegenerative disorders
SC Lenzken, M Racchi, A Lucchelli, S Govoni |
Future Neurology | 2006 |
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2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases
EA Sheta, SH Appel, IL Goldknopf |
Expert Review of Proteomics | 2006 |
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In vivo modulation of the Parkinsonian phenotype by Nrf2
NC Burton, TW Kensler, TR Guilarte |
NeuroToxicology | 2006 |
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Familial Risks for Main Neurological Diseases in Siblings Based on Hospitalizations in Sweden
K Hemminki, K Sundquist, X Li |
Twin Research and Human Genetics | 2006 |
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beta-Amyloid Accumulation Impairs Multivesicular Body Sorting by Inhibiting the Ubiquitin-Proteasome System
CG Almeida |
The Journal of neuroscience : the official journal of the Society for Neuroscience | 2006 |
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Neurobiologie psychischer Störungen
H Förstl, M Hautzinger, G Roth |
2006 | |
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The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations.
Sharma M, Mueller JC, Zimprich A, Lichtner P, Hofer A, Leitner P, Maass S, Berg D, Dürr A, Bonifati V, De Michele G, Oostra B, Brice A, Wood NW, Muller-Myhsok B, Gasser T |
Journal of medical genetics | 2006 |
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Mapping the new frontier: complex genetic disorders
R Mayeux |
Journal of Clinical Investigation | 2005 |
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Microarray Analysis of VEGF-C Responsive Genes in Human Lymphatic Endothelial Cells
C Yong, EA Bridenbaugh, DC Zawieja, MA Swartz |
Lymphatic Research and Biology | 2005 |
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International Review of Neurobiology
ZT Bloomgarden |
International review of neurobiology | 2005 |
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The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease
Z Nagy |
Journal of Cellular and Molecular Medicine | 2005 |
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Lewy Body Dementia
S Goldfein, CD Qualls |
Perspectives on Gerontology | 2005 |
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Alzheimer’s Disease
DS Vohora, LC Mishra |
Scientific Basis for Ayurvedic Therapies | 2003 |
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