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Citations to this article

Factors affecting statistical power in the detection of genetic association
Derek Gordon, Stephen J. Finch
Derek Gordon, Stephen J. Finch
Published June 1, 2005
Citation Information: J Clin Invest. 2005;115(6):1408-1418. https://doi.org/10.1172/JCI24756.
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Factors affecting statistical power in the detection of genetic association

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Abstract

The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.

Authors

Derek Gordon, Stephen J. Finch

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Total citations by year

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