The mapping of disease genes to specific loci has received a great deal of attention in the last decade, and many advances in therapeutics have resulted. Here we review family-based and population-based methods for association analysis. We define the factors that determine statistical power and show how study design and analysis should be designed to maximize the probability of localizing disease genes.
Derek Gordon, Stephen J. Finch
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A Review of the Genetics of Hypertension with a Focus on Gene-Environment Interactions
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A review of current approaches to identifying human genes involved in myopia
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Computing Power and Sample Size for Case-Control Association Studies with Copy Number Polymorphism: Application of Mixture-Based Likelihood Ratio Test
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2010 | |
The Genetics and Development of Scoliosis
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Testing for linkage and association across the dihydrolipoyl dehydrogenase gene region with Alzheimer's disease in three sample populations.
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