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Citations to this article

Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency
Min Chen, … , William Jou, Lee S. Weinstein
Min Chen, … , William Jou, Lee S. Weinstein
Published November 1, 2005
Citation Information: J Clin Invest. 2005;115(11):3217-3227. https://doi.org/10.1172/JCI24196.
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Research Article Metabolism Article has an altmetric score of 6

Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gsα deficiency

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Abstract

The G protein Gsα is essential for hormone-stimulated cAMP generation and is an important metabolic regulator. We investigated the role of liver Gs-signaling pathways by developing mice with liver-specific Gsα deficiency (LGsKO mice). LGsKO mice had increased liver weight and glycogen content and reduced adiposity, whereas survival, body weight, food intake, and metabolic rates at ambient temperature were unaffected. LGsKO mice had increased glucose tolerance with both increased glucose-stimulated insulin secretion and increased insulin sensitivity in liver and muscle. Fed LGsKO mice were hypoglycemic and hypoinsulinemic, with low expression of hepatic gluconeogenic enzymes and PPARγ coactivator–1. However, LGsKO mice maintained normal fasting glucose and insulin levels, probably due to prolonged breakdown of glycogen stores and possibly increased extrahepatic gluconeogenesis. Lipid metabolism was unaffected in fed LGsKO mice, but fasted LGsKO mice had increased lipogenic and reduced lipid oxidation gene expression in liver and increased serum triglyceride and FFA levels. LGsKO mice had very high serum glucagon and glucagon-like peptide–1 levels and pancreatic α cell hyperplasia, probably secondary to hepatic glucagon resistance and/or chronic hypoglycemia. Our results define novel roles for hepatic Gs-signaling pathways in glucose and lipid regulation, which may prove useful in designing new therapeutic targets for diabetes and obesity.

Authors

Min Chen, Oksana Gavrilova, Wei-Qin Zhao, Annie Nguyen, Javier Lorenzo, Laura Shen, Lisa Nackers, Stephanie Pack, William Jou, Lee S. Weinstein

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Total
Citations: 3 5 4 6 7 3 8 4 6 3 7 10 3 5 7 2 6 3 3 95
Citation information
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Citations to this article in year 2019 (8)

Title and authors Publication Year
Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
Andras Iring, Young-June Jin, Julian Albarran-Juarez, Mauro Siragusa, ShengPeng Wang, Peter T. Dancs, Akiko Nakayama, Sarah Tonack, Min Chen, Carsten Künne, Anna M. Sokol, Stefan Günther, Alfredo Martínez, Ingrid Fleming, Nina Wettschureck, Johannes Graumann, Lee S. Weinstein, Stefan Offermanns
Journal of Clinical Investigation 2019
Glucagon lowers glycemia when beta-cells are active
Megan E Capozzi, Jacob B. Wait, Jepchumba Koech, Andrew N. Gordon, Reilly W Coch, Berit Svendsen, Brian Finan, David A D'Alessio, Jonathan E Campbell
JCI Insight 2019
Smooth muscle-specific Gsα deletion exaggerates angiotensin II-induced abdominal aortic aneurysm formation in mice in vivo
X Qin, L He, M Tian, P Hu, J Yang, H Lu, W Chen, X Jiang, C Zhang, J Gao, M Chen, LS Weinstein, Y Zhang, W Zhang
Journal of Molecular and Cellular Cardiology 2019
Gsα deficiency in the dorsomedial hypothalamus leads to obesity, hyperphagia, and reduced thermogenesis associated with impaired leptin signaling
M Chen, EA Wilson, Z Cui, H Sun, YB Shrestha, B Podyma, CH Le, B Naglieri, K Pacak, O Gavrilova, LS Weinstein
Molecular Metabolism 2019
A Primary Role for α-Cells as Amino Acid Sensors
ED Dean
Diabetes 2019
Elevated expression of GNAS promotes breast cancer cell proliferation and migration via the PI3K/AKT/Snail1/E-cadherin axis
X Jin, L Zhu, Z Cui, J Tang, M Xie, G Ren
Clinical and Translational Oncology 2019
β-Cell Fate in Human Insulin Resistance and Type 2 Diabetes: A Perspective on Islet Plasticity
T Mezza, F Cinti, CM Cefalo, A Pontecorvi, RN Kulkarni, A Giaccari
Diabetes 2019
Impaired amygdala-based learning and decreased anxiety in a murine model of pseudohypoparathyroidism type 1A
AH Shoemaker, KC Paffenroth, N Bingham, FE Harrison
Behavioural Brain Research 2019

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