JCI - Citations to Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells.

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Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells.

T J Kelley, M L Drumm

T J Kelley, M L Drumm

Published September 15, 1998
Citation Information: J Clin Invest. 1998;102(6):1200-1207. https://doi.org/10.1172/JCI2357.

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Citations to this article (197)

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S-Nitrosoglutathione Reduces the Density of Staphylococcus aureus Biofilms Established on Human Airway Epithelial Cells. Wolf A, Tabasi M, Zacharek M, Martin G, Hershenson MB, Meyerhoff ME, Sajjan U	ACS Omega	2022
2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function M Wang, AG Gauthier, TP Kennedy, H Wang, UK Velagapudi, TT Talele, M Lin, J Wu, LA Daley, X Yang, V Patel, SS Mun, CR Ashby, LL Mantell	Molecular Medicine	2021
Regulation of B cell functions by S-nitrosoglutathione in the EAE model J Kim, SM Islam, F Qiao, AK Singh, M Khan, J Won, I Singh	Redox Biology	2021
Correlation between nasal nitric oxide and its metabolites, RANTES, IL-5 in allergic rhinitis T Zheng, SM Jung, HJ Kang, HG Kim, JH Chung, JH Jeong		2021
Current evidence on the effect of highly effective CFTR modulation on interleukin-8 in cystic fibrosis M Williamson, M Casey, C Gabillard-Lefort, A Alharbi, YQ Teo, NG McElvaney, E Reeves	Expert Review of Respiratory Medicine	2021
Nitrosylation of Tissue Transglutaminase enhances fibroblast migration and regulates MMP activation I Kurt-Celep, K AN, M Griffin, D Telci	Matrix biology : journal of the International Society for Matrix Biology	2021
Comparative transcriptome analysis unveils the adaptative mechanisms of Scedosporium apiospermum to the microenvironment encountered in the lungs of patients with cystic fibrosis P Vandeputte, TD de Bernonville, YL Govic, SL Gal, G Nevez, N Papon, JP Bouchara	Computational and Structural Biotechnology Journal	2020
Targeting the phosphoinositide-3-kinase/protein kinase B pathway in airway innate immunity I Gopallawa, RJ Lee	World journal of biological chemistry	2020
Targeting the Heme Oxygenase 1/Carbon Monoxide Pathway to Resolve Lung Hyper-Inflammation and Restore a Regulated Immune Response in Cystic Fibrosis CD Pietro, HH Öz, TS Murray, EM Bruscia	Frontiers in pharmacology	2020
Cyclic compression increases F508 Del CFTR expression in ciliated human airway epithelium N Marozkina, J Bosch, C Cotton, L Smith, J Seckler, K Zaman, S Rehman, A Periasamy, H Gaston, G Altawallbeh, M Davis, DR Jones, R Schilz, SH Randell, B Gaston	American journal of physiology. Lung cellular and molecular physiology	2019
From Genetics to Precision Therapy: Finding a Path through the Scientific Valley of Death R Gupta, B Gaston	American journal of respiratory cell and molecular biology	2019
New Vascular Insights into Premature Aging Charles Lowenstein, John Allen Bennett	Journal of Clinical Investigation	2018
Oxidative and endoplasmic reticulum stress in respiratory disease AC Chen, L Burr, MA McGuckin	IBMS BoneKEy	2018
Immunomodulatory Cell Therapy to Target Cystic Fibrosis Inflammation O Khoury, C Barrios, V Ortega, A Atala, SV Murphy	American journal of respiratory cell and molecular biology	2018
Nontuberculous Mycobacterial Disease: A Comprehensive Approach to Diagnosis and Management DE Griffith		2018
Linaclotide improves gastrointestinal transit in cystic fibrosis mice by inhibiting sodium/hydrogen exchanger 3 DR McHugh, CU Cotton, FJ Moss, M Vitko, DM Valerio, TJ Kelley, S Hao, A Jafri, ML Drumm, WF Boron, RC Stern, K McBennett, CA Hodges	AJP Gastrointestinal and Liver Physiology	2018
L-Arginine in Clinical Nutrition NJ Tripolt, H Sourij	L-Arginine in Clinical Nutrition	2017
Nasal nitric oxide in allergic rhinitis in children and its relationship to severity and treatment P Wang, G Wang, W Ge, L Tang, J Zhang, X Ni	Allergy Asthma & Clinical Immunology	2017
Exhaled and nasal nitric oxide in relation to lung function, blood cell counts and disease characteristics in cystic fibrosis C Krantz, C Janson, A Hollsing, K Alving, A Malinovschi	Journal of Breath Research	2017
Progress in Understanding Cystic Fibrosis D Sriramulu	Progress in Understanding Cystic Fibrosis	2017
Lessons From Unilateral Loss of Cilia: Early Nasal Nitric Oxide Gas Mixing and the Role of Sinus Patency in Determining Nasal Nitric Oxide K Rodriguez, B Gaston, J Wasman, N Marozkina	Clinical Medicine Insights: Ear, Nose and Throat	2017
Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus JA Bartlett, S Ramachandran, CL Wohlford-Lenane, CK Barker, AA Pezzulo, J Zabner, MJ Welsh, DK Meyerholz, DA Stoltz, PB McCray	American journal of respiratory and critical care medicine	2016
Innate and Adaptive Immunity in Cystic Fibrosis EM Bruscia, TL Bonfield	Clinics in Chest Medicine	2016
Asymmetric dimethylarginine and related metabolites in exhaled breath condensate of children with cystic fibrosis: Exhaled ADMA in cystic fibrosis F Lucca, LD Dalt, M Ros, A Gucciardi, P Pirillo, M Naturale, G Perilongo, G Giordano, E Baraldi	The Clinical Respiratory Journal	2016
Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy AM Cantin, D Hartl, MW Konstan, JF Chmiel	Journal of Cystic Fibrosis	2015
Short-chain fatty acids affect cystic fibrosis airway inflammation and bacterial growth P Ghorbani, P Santhakumar, Q Hu, P Djiadeu, TM Wolever, N Palaniyar, H Grasemann	The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology	2015
Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis H Grasemann, T Gonska, J Avolio, M Klingel, E Tullis, F Ratjen	Journal of Cystic Fibrosis	2015
Reduced EPAC1 Activity Leads to Slowed Microtubule Polymerization in Cystic Fibrosis Epithelial Cells SM Rymut, T Ivy, DA Corey, CU Cotton, JD Burgess, TJ Kelley	American journal of respiratory cell and molecular biology	2015
Concentration of fractional excretion of nitric oxide (FENO): A potential airway biomarker of restored CFTR function K Kotha, RD Szczesniak, AP Naren, MC Fenchel, LL Duan, GL McPhail, JP Clancy	Journal of Cystic Fibrosis	2015
Optimizing aerosolization of a high-dose L-Arginine powder for pulmonary delivery S Lakio, DA Morton, AP Ralph, P Lambert	Asian Journal of Pharmaceutical Sciences	2015
Application of nitric oxide measurements in clinical conditions beyond asthma A Malinovschi, D Ludviksdottir, E Tufvesson, G Rolla, L Bjermer, K Alving, Z Diamant	European Clinical Respiratory Journal	2015
Nitric oxide production by polymorphonuclear leucocytes in infected cystic fibrosis sputum consumes oxygen: NO production by PMNs in infected CF sputum M Kolpen, T Bjarnsholt, C Moser, CR Hansen, LF Rickelt, M Kühl, C Hempel, T Pressler, N Høiby, PØ Jensen	Clinical & Experimental Immunology	2014
Lung arginase expression and activity is increased in cystic fibrosis mouse models T Jaecklin, J Duerr, H Huang, M Rafii, CE Bear, F Ratjen, P Pencharz, BP Kavanagh, MA Mall, H Grasemann	Journal of applied physiology	2014
Diagnostic Tests in Pediatric Pulmonology SD Davis, E Eber, AC Koumbourlis		2014
Current concepts: host–pathogen interactions in cystic fibrosis airways disease Tang AC, Turvey SE, Alves MP, Regamey N, Tümmler B, Hartl D	European Respiratory Review	2014
Ventilatory pattern and energy expenditure are altered in cystic fibrosis mice RJ Darrah, IR Bederman, AL Mitchell, CA Hodges, CK Campanaro, ML Drumm, FJ Jacono	Journal of Cystic Fibrosis	2013
γ-Glutamyltransferase catabolism of S-nitrosoglutathione modulates IL-8 expression in cystic fibrosis bronchial epithelial cells A Corti, G Bergamini, M Menegazzi, S Piaggi, E Bramanti, I Scataglini, S Cianchetti, P Paggiaro, P Melotti, A Pompella	Free radical biology & medicine	2013
Modulation of ENaC, CFTR, and iNOS expression in bronchial epithelial cells after stimulation with Staphylococcus epidermidis (94B080) and Staphylococcus aureus (90B083) R Hussain, I Oliynyk, GM Roomans, M Björkqvist	APMIS	2013
Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis A Ramkissoon, AM Shapiro, MM Loniewska, PG Wells	Molecular Basis of Oxidative Stress: Chemistry, Mechanisms, and Disease Pathogenesis	2013
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Gasotransmitters: Novel Regulators of Epithelial Na+ Transport? M Althaus	Frontiers in physiology	2012
Update on exhaled nitric oxide in pulmonary disease N Spitale, N Popat, A McIvor	Expert Review of Respiratory Medicine	2012
A phase I clinical study of inhaled nitric oxide in healthy adults C Miller, M Miller, B McMullin, G Regev, L Serghides, K Kain, J Road, Y Av-Gay	Journal of Cystic Fibrosis	2012
L-ornithine derived polyamines in cystic fibrosis airways H Grasemann, D Shehnaz, M Enomoto, M Leadley, J Belik, F Ratjen	PloS one	2012
Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis AR Hauser, M Jain, M Bar-Meir, SA McColley	Clinical microbiology reviews	2011
An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (F e NO ) for Clinical Applications RA Dweik, PB Boggs, SC Erzurum, CG Irvin, MW Leigh, JO Lundberg, AC Olin, AL Plummer, DR Taylor	American journal of respiratory and critical care medicine	2011
Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions D Lorentzen, L Durairaj, AA Pezzulo, Y Nakano, J Launspach, DA Stoltz, G Zamba, PB McCray, J Zabner, MJ Welsh, WM Nauseef, B Bánfi	Free radical biology & medicine	2011
Nitric Oxide: A Promising Methodological Approach in Airway Diseases G Sahin, L Klimek, J Mullol, K Hörmann, LE Walther, O Pfaar	International Archives of Allergy and Immunology	2011
P. aeruginosa drives CXCL8 synthesis via redundant toll-like receptors and NADPH oxidase in CFTR∆F508 airway epithelial cells L Roussel, G Martel, J Bérubé, S Rousseau	Journal of Cystic Fibrosis	2011
Nitric Oxide Inhibits Highly Selective Sodium Channels and the Na + /K + -ATPase in H441 Cells M Althaus, A Pichl, WG Clauss, W Seeger, M Fronius, RE Morty	American journal of respiratory cell and molecular biology	2011
Asymmetric Dimethylarginine Contributes to Airway Nitric Oxide Deficiency in Patients with Cystic Fibrosis H Grasemann, S Al-Saleh, JA Scott, D Shehnaz, A Mehl, R Amin, M Rafii, P Pencharz, J Belik, F Ratjen	American journal of respiratory and critical care medicine	2011
Myeloperoxidase-dependent oxidative metabolism of nitric oxide in the cystic fibrosis airway AL Chapman, BM Morrissey, VT Vasu, MM Juarez, JS Houghton, CS Li, CE Cross, JP Eiserich	Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society	2010
Low levels of exhaled nitric oxide are associated with impaired lung function in cystic fibrosis C Keen, P Gustafsson, A Lindblad, G Wennergren, AC Olin	Pediatric Pulmonology	2010
PREDICTION OF NOSOCOMIAL INFECTION ACQUISITION IN VENTILATED PATIENTS BY NASAL NITRIC OXIDE JM Tadié, L Trinquart, C Jannière-Nartey, E Guerot, B Louis, JY Fagon, JL Diehl, C Delclaux	Shock	2010
Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa J Bérubé, L Roussel, L Nattagh, S Rousseau	The Journal of biological chemistry	2010
NADPH-Diaphorase Activity and NO Synthase Expression in the Olfactory Epithelium of the Bovine S Wenisch, S Arnhold	Anatomia, Histologia, Embryologia	2010
AMPK Agonists Ameliorate Sodium and Fluid Transport and Inflammation in Cystic Fibrosis Airway Epithelial Cells MM Myerburg, JD King, NM Oyster, AC Fitch, A Magill, CJ Baty, SC Watkins, JK Kolls, JM Pilewski, KR Hallows	American journal of respiratory cell and molecular biology	2010
Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Enhances Activation of p38 and ERK MAPKs, Increasing Interleukin-6 Synthesis in Airway Epithelial Cells Exposed to Pseudomonas aeruginosa J Bérubé, L Roussel, L Nattagh, S Rousseau	The Journal of biological chemistry	2010
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells MM Myerburg, JD King, NM Oyster, AC Fitch, A Magill, CJ Baty, SC Watkins, JK Kolls, JM Pilewski, KR Hallows	American journal of respiratory cell and molecular biology	2009
Bugs, Biofilms, and Resistance in Cystic Fibrosis JC Davies	Respiratory Care	2009
Increased TG2 expression can result in induction of transforming growth factor beta1, causing increased synthesis and deposition of matrix proteins, which can be regulated by nitric oxide D Telci, RJ Collighan, H Basaga, M Griffin	The Journal of biological chemistry	2009
Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells A Chambellan, R Leahy, W Xu, PJ Cruickshank, A Janocha, K Szabo, SB Cannady, SA Comhair, SC Erzurum	Nitric Oxide	2009
Exhaled nitric oxide measurements in the first 2 years of life: methodological issues, clinical and epidemiological applications C Gabriele, FM de Benedictis, JC de Jongste	Italian Journal of Pediatrics	2009
The role of inhaled corticosteroids in the management of cystic fibrosis KR Ross, JF Chmiel, MW Konstan	Paediatric Drugs	2009
Immunological mechanisms behind the cystic fibrosis-ABPA link D Hartl	Medical Mycology	2009
Extended Nitric Oxide Measurements in Exhaled Air of Cystic Fibrosis and Healthy Adults M Hofer, L Mueller, T Rechsteiner, C Benden, A Boehler	Lung	2009
The Role of Inhaled Corticosteroids in the Management of Cystic Fibrosis KR Ross, JF Chmiel, MW Konstan	Pediatric Drugs	2009
Oral bacteria – The missing link to ambiguous findings of exhaled nitrogen oxides in cystic fibrosis W Zetterquist, H Marteus, P Kalm-Stephens, E Näs, L Nordvall, M Johannesson, K Alving	Respiratory Medicine	2009
Increased TG2 Expression Can Result in Induction of Transforming Growth Factor β1, Causing Increased Synthesis and Deposition of Matrix Proteins, Which Can Be Regulated by Nitric Oxide D Telci, RJ Collighan, H Basaga, M Griffin	The Journal of biological chemistry	2009
Flagellum-Mediated Biofilm Defense Mechanisms of Pseudomonas aeruginosa against Host-Derived Lactoferrin JG Leid, M Kerr, C Selgado, C Johnson, G Moreno, A Smith, ME Shirtliff, GA O'Toole, EK Cope	Infection and immunity	2009
AMPK agonists ameliorate sodium and fluid transport and inflammation in cystic fibrosis airway epithelial cells. Myerburg MM, King JD Jr, Oyster NM, Fitch AC, Magill A, Baty CJ, Watkins SC, Kolls JK, Pilewski JM, Hallows KR	American journal of respiratory cell and molecular biology	2009
Anti-inflammatory Therapies for Cystic Fibrosis-Related Lung Disease DP Nichols, MW Konstan, JF Chmiel	Clinical Reviews in Allergy & Immunology	2008
cAMP-mediated regulation of cholesterol accumulation in cystic fibrosis and Niemann-Pick type C cells ME Manson, DA Corey, NM White, TJ Kelley	American journal of physiology. Lung cellular and molecular physiology	2008
IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells K Chibana, JB Trudeau, AT Mustovitch, H Hu, J Zhao, S Balzar, HW Chu, SE Wenzel	Clinical & Experimental Allergy	2008
Biomarkers in exhaled breath condensate indicate presence and severity of cystic fibrosis in children CM Robroeks, PP Rosias, D Vliet, Q Jöbsis, JB Yntema, HJ Brackel, JG Damoiseaux, GM Hartog, WK Wodzig, E Dompeling	Pediatric Allergy and Immunology	2008
Posttranslational Activation of Endothelial Nitric Oxide Synthase Attenuates Carbon Tetrachloride-Induced Hepatotoxicity in Newborn Rats H Liu, C Subramony, M Nowicki	Pediatric Research	2008
Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite K Govindaraju, J Shan, K Levesque, SN Hussain, WS Powell, DH Eidelman	Nitric Oxide	2008
Assessment and monitoring of cystic fibrosis lung disease in infants and young children CL Ren	Expert Review of Respiratory Medicine	2008
Animal models of chronic lung infection with Pseudomonas aeruginosa : useful tools for cystic fibrosis studies I Kukavica-Ibrulj, RC Levesque	Laboratory Animals	2008
cAMP-mediated regulation of cholesterol accumulation in cystic fibrosis and Niemann-Pick type C cells ME Manson, DA Corey, NM White, TJ Kelley	American journal of physiology. Lung cellular and molecular physiology	2008
Hypersusceptibility to Pseudomonas aeruginosa Exotoxin A Due to Elevated Furin in Cystic Fibrosis Respiratory Epithelial Cells Wojciech Ornatowski, Jens F. Poschet, Elizabeth Perkett, Jennifer L. Taylor-Cousar, and Vojo Deretic	Journal of Clinical Investigation	2007
Pharmacological modulation of cGMP levels by phosphodiesterase 5 inhibitors as a therapeutic strategy for treatment of respiratory pathology in cystic fibrosis JF Poschet, GS Timmins, JL Taylor-Cousar, W Ornatowski, J Fazio, E Perkett, KR Wilson, HD Yu, HR de Jonge, V Deretic	American journal of physiology. Lung cellular and molecular physiology	2007
Chronic Inflammation in the Cystic Fibrosis Lung: Alterations in Inter- and Intracellular Signaling D Nichols, J Chmiel, M Berger	Clinical Reviews in Allergy & Immunology	2007
Infections in Chronic Lung Diseases GI Parameswaran, TF Murphy	Infectious Disease Clinics of North America	2007
What have we learned from mouse models for cystic fibrosis? I Carvalho-Oliveira, BJ Scholte, D Penque	Expert Review of Molecular Diagnostics	2007
Assessment of airway inflammation with exhaled NO measurement E Hatziagorou, J Tsanakas	Hippokratia	2007
Inflammation and Anti-Inflammatory Therapies for Cystic Fibrosis JF Chmiel, MW Konstan	Clinics in Chest Medicine	2007
Proteomic biomarker discovery for the monogenic disease cystic fibrosis D Penque	Expert Review of Proteomics	2007
Exhaled nitric oxide in childhood asthma: a review MW Pijnenburg, JC de Jongste	Clinical & Experimental Allergy	2007
Airway nitric oxide output is reduced in bronchiectasis SC Foley, NO Hopkins, MX Fitzgerald, SC Donnelly, P McLoughlin	Respiratory Medicine	2007
Cystic Fibrosis Mouse Models C Guilbault, Z Saeed, GP Downey, D Radzioch	American journal of respiratory cell and molecular biology	2007
Nitrosative stress inhibits production of the virulence factor alginate in mucoid Pseudomonas aeruginosa SR Wood, AM Firoved, W Ornatowski, T Mai, V Deretic, GS Timmins	Free Radical Research	2007
Evidence that CFTR is expressed in rat tracheal smooth muscle cells and contributes to bronchodilation C Vandebrouck, P Melin, C Norez, R Robert, C Guibert, Y Mettey, F Becq	Respiratory Research	2006
Emerging drugs for the treatment of sepsis J Aboab, O Nardi, D Lipiner, T Sharshar, D Annane	Expert Opinion on Emerging Drugs	2006
Exhaled nitric oxide measurements: clinical application and interpretation DR Taylor, MW Pijnenburg, AD Smith, JC de Jongste	Thorax	2006
Endosomal hyperacidification in cystic fibrosis is due to defective nitric oxide-cylic GMP signalling cascade JF Poschet, JA Fazio, GS Timmins, W Ornatowski, E Perkett, M Delgado, V Deretic	EMBO reports	2006
S-nitrosothiol signaling in respiratory biology B Gaston, D Singel, A Doctor, JS Stamler	American journal of respiratory and critical care medicine	2006
Inducible NO synthase expression is low in airway epithelium from young children with cystic fibrosis A Moeller, F Horak, C Lane, D Knight, A Kicic, S Brennan, P Franklin, J Terpolilli, JH Wildhaber, SM Stick	Thorax	2006
Respiratory syncytial virus infection in a murine model of cystic fibrosis GN Colasurdo, JJ Fullmer, O Elidemir, C Atkins, AM Khan, JM Stark	Journal of Medical Virology	2006
Inhaled l -Arginine Improves Exhaled Nitric Oxide and Pulmonary Function in Patients with Cystic Fibrosis H Grasemann, F Kurtz, F Ratjen	American journal of respiratory and critical care medicine	2006
Interaction between enteric epithelial cells and Peyer's patch lymphocytes in response to Shigella lipopolysaccharide: effect on nitric oxide and IL-6 release J Chen, CP Ng, DK Rowlands, PH Xu, JY Gao, YW Chung, HC Chan	World journal of gastroenterology : WJG	2006
Interaction between enteric epithelial cells and Peyer’s patch lymphocytes in response to Shigella lipopolysaccharide: Effect on nitric oxide and IL-6 release J Chen, CP Ng, DK Rowlands, PH Xu, JY Gao, YW Chung, HC Chan	World journal of gastroenterology : WJG	2006
Innate immune response in CF airway epithelia: hyperinflammatory? TE Machen	American journal of physiology. Cell physiology	2006
Distinct pattern of lung gene expression in the Cftr -KO mice developing spontaneous lung disease compared with their littermate controls C Guilbault, JP Novak, P Martin, ML Boghdady, Z Saeed, MC Guiot, TJ Hudson, D Radzioch	Physiological genomics	2006
Up-regulation of AMP-activated Kinase by Dysfunctional Cystic Fibrosis Transmembrane Conductance Regulator in Cystic Fibrosis Airway Epithelial Cells Mitigates Excessive Inflammation KR Hallows, AC Fitch, CA Richardson, PR Reynolds, JP Clancy, PC Dagher, LA Witters, JK Kolls, JM Pilewski	The Journal of biological chemistry	2006
S -Nitrosylating Agents: A Novel Class of Compounds That Increase Cystic Fibrosis Transmembrane Conductance Regulator Expression and Maturation in Epithelial Cells K Zaman, S Carraro, J Doherty, EM Henderson, E Lendermon, L Liu, G Verghese, M Zigler, M Ross, E Park, LA Palmer, A Doctor, JS Stamler, B Gaston	Molecular pharmacology	2006
Role of epithelial nitric oxide in airway viral infection W Xu, S Zheng, RA Dweik, SC Erzurum	Free radical biology & medicine	2006
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Study of Aerosolized Interferon Gamma-1b in Patients With Mild to Moderate Cystic Fibrosis Lung Disease RB Moss, N Mayer-Hamblett, J Wagener, C Daines, K Hale, R Ahrens, RL Gibson, P Anderson, G Retsch-Bogart, SZ Nasr, I Noth, D Waltz, P Zeitlin, B Ramsey, K Starko	Pediatric Pulmonology	2005
Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis JC Ojoo, SA Mulrennan, JA Kastelik, AH Morice, AE Redington	Thorax	2005
Origin of nitrite and nitrate in nasal and exhaled breath condensate and relation to nitric oxide formation H Marteus, DC Törnberg, E Weitzberg, U Schedin, K Alving	Thorax	2005
Nitric oxide in cystic fibrosis KM de Groot, CK van der Ent	Journal of Cystic Fibrosis	2005
Reduced exhaled NO is related to impaired nasal potential difference in patients with cystic fibrosis J Texereau, I Fajac, D Hubert, J Coste, DJ Dusser, T Bienvenu, J Dall'Ava-Santucci, AT Dinh-Xuan	Vascular Pharmacology	2005
Biofilms, Infection, and Antimicrobial Therapy A Smiley, D Hassett	Biofilms, Infection, and Antimicrobial Therapy	2005
Increased Arginase Activity in Cystic Fibrosis Airways H Grasemann, R Schwiertz, S Matthiesen, K Racké, F Ratjen	American journal of respiratory and critical care medicine	2005
A Pilot Study of the Effect of Inhaled Buffered Reduced Glutathione on the Clinical Status of Patients With Cystic Fibrosis C Bishop, VM Hudson, SC Hilton, C Wilde	Chest	2005
NO pathway in CF and non-CF children JL Wooldridge, GH Deutsch, MK Sontag, I Osberg, DR Chase, PE Silkoff, JS Wagener, SH Abman, FJ Accurso	Pediatric Pulmonology	2004
Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1 K Zaman, LA Palmer, A Doctor, JF Hunt, B Gaston	Biochemical Journal	2004
Dornase alpha and exhaled NO in cystic fibrosis H Grasemann, H Lax, JW Treseler, AA Colin	Pediatric Pulmonology	2004
Animal models of cystic fibrosis BJ Scholte, DJ Davidson, M Wilke, HR de Jonge	Journal of Cystic Fibrosis	2004
Impaired nitric oxide synthase-2 signaling pathway in cystic fibrosis airway epithelium S Zheng, W Xu, S Bose, AK Banerjee, SJ Haque, SC Erzurum	American journal of physiology. Lung cellular and molecular physiology	2004
Microarray Analysis and Functional Characterization of the Nitrosative Stress Response in Nonmucoid and Mucoid Pseudomonas aeruginosa AM Firoved, SR Wood, W Ornatowski, V Deretic, GS Timmins	Journal of bacteriology	2004
Effects of nitric oxide on Pseudomonas aeruginosa infection of epithelial cells from a human respiratory cell line derived from a patient with cystic fibrosis KE Darling, TJ Evans	Infection and immunity	2003
Cystic Fibrosis in Adults: Current and Future Management Strategies BM Morrissey, BC Schock, GP Marelich, CE Cross	Clinical Reviews in Allergy & Immunology	2003
Non-viral gene transfer therapy for cystic fibrosis AG Ziady, PB Davis, MW Konstan	Expert Opinion on Biological Therapy	2003
S-nitrosylation in health and disease MW Foster, TJ McMahon, JS Stamler	Trends in Molecular Medicine	2003
State of the art: why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? JF Chmiel, PB Davis	Respiratory Research	2003
Noninvasive biomarkers of airway inflammation in cystic fibrosis SD Sagel	Current Opinion in Pulmonary Medicine	2003
Oxidative Stress and Disease: Significance or Triviality? B Morrissey, A der Vliet, J Eiserich, C Cross	Oxidative Stress and Disease: Significance or Triviality?	2003
Rhinitis and asthma: Evidence for respiratory system integration A Togias	Journal of Allergy and Clinical Immunology	2003
Seeking Modifier Genes in Cystic Fibrosis FJ Accurso, MK Sontag	American journal of respiratory and critical care medicine	2003
Endothelial Nitric Oxide Synthase Variants in Cystic Fibrosis Lung Disease H Grasemann, KS Gravesande, R Büscher, N Knauer, ES Silverman, LJ Palmer, JM Drazen, F Ratjen	American journal of respiratory and critical care medicine	2003
Human Rhinovirus Selectively Modulates Membranous and Soluble Forms of Its Intercellular Adhesion Molecule–1 (ICAM-1) Receptor to Promote Epithelial Cell Infectivity SC Whiteman, A Bianco, RA Knight, MA Spiteri	The Journal of biological chemistry	2003
Statin-mediated correction of STAT1 signaling and inducible nitric oxide synthase expression in cystic fibrosis epithelial cells NE Kreiselmeier, NC Kraynack, DA Corey, TJ Kelley	American journal of physiology. Lung cellular and molecular physiology	2003
Functional evidence of CFTR gene transfer in nasal epithelium of cystic fibrosis mice in vivo following luminal application of DNA complexes targeted to the serpin-enzyme complex receptor AG Ziady, TJ Kelley, E Milliken, T Ferkol, PB Davis	Molecular Therapy	2002
Nitric oxide in respiratory diseases BJ Nevin, KJ Broadley	Pharmacology & Therapeutics	2002
Hyperacidification in cystic fibrosis: links with lung disease and new prospects for treatment J Poschet, E Perkett, V Deretic	Trends in Molecular Medicine	2002
Pharmacological approaches for the discovery and development of new anti-inflammatory agents for the treatment of cystic fibrosis MW Konstan, PB Davis	Advanced Drug Delivery Reviews	2002
Nasal Nitric Oxide Levels in Cystic Fibrosis Patients Are Associated with a Neuronal NO Synthase (NOS1) Gene Polymorphism H Grasemann, KS Gravesande, S Gärtig, M Kirsch, R Büscher, JM Drazen, F Ratjen	Nitric Oxide	2002
S-Nitrosoglutathione induces functional ΔF508-CFTR in airway epithelial cells C Andersson, B Gaston, GM Roomans	Biochemical and Biophysical Research Communications	2002
Pseudomonas aeruginosa in cystic fibrosis: pathogenesis and persistence JC Davies	Paediatric Respiratory Reviews	2002
The role of endogenous and exogenous nitric oxide on airway function RJ Martin, MJ Mhanna, MA Haxhiu	Seminars in Perinatology	2002
Nitric oxide and protein nitration in the cystic fibrosis airway BM Morrissey, K Schilling, JV Weil, PE Silkoff, DM Rodman	Archives of Biochemistry and Biophysics	2002
Expression and Regulation of Inducible Nitric Oxide Synthase from Human Primary Airway Epithelial Cells LE Donnelly, PJ Barnes	American journal of respiratory cell and molecular biology	2002
Flow-independent Nitric Oxide Exchange Parameters in Cystic Fibrosis HW Shin, CM Rose-Gottron, RS Sufi, F Perez, DM Cooper, AF Wilson, SC George	American journal of respiratory and critical care medicine	2002
Analysis of Expired Air for Oxidation Products P Paredi, SA Kharitonov, PJ Barnes	American journal of respiratory and critical care medicine	2002
Acute Effects of Aerosolized S -Nitrosoglutathione in Cystic Fibrosis AH Snyder, ME McPherson, JF Hunt, M Johnson, JS Stamler, B Gaston	American journal of respiratory and critical care medicine	2002
Airway nitric oxide in Duchenne muscular dystrophy V Straub, F Ratjen, H Amthor, T Voit, H Grasemann	The Journal of Pediatrics	2002
Exhaled and Sputum Nitric Oxide in Bronchiectasis KW Tsang, R Leung, PC Fung, SL Chan, GL Tipoe, GC Ooi, WK Lam	Chest	2002
Gene expression in Peyronie's disease NF Gonzalez-Cadavid, TR Magee, M Ferrini, A Qian, D Vernet, J Rajfer	International Journal of Impotence Research	2002
Mechanisms of NOS2 regulation by Rho GTPase signaling in airway epithelial cells NC Kraynack, DA Corey, HL Elmer, TJ Kelley	American journal of physiology. Lung cellular and molecular physiology	2002
Persistent and aggressive bacteria in the lungs of cystic fibrosis children CA Hart, C Winstanley	British Medical Bulletin	2002
Nitric Oxide Deficiency Contributes to Impairment of Airway Relaxation in Cystic Fibrosis Mice MJ Mhanna, T Ferkol, RJ Martin, IA Dreshaj, AM van Heeckeren, TJ Kelley, MA Haxhiu	American journal of respiratory cell and molecular biology	2001
Molecular basis for defective glycosylation and Pseudomonas pathogenesis in cystic fibrosis lung JF Poschet, JC Boucher, L Tatterson, J Skidmore, RW van Dyke, V Deretic	Proceedings of the National Academy of Sciences	2001
Rethinking cystic fibrosis pathology: the critical role of abnormal reduced glutathione (GSH) transport caused by CFTR mutation VM Hudson	Free radical biology & medicine	2001
Mouse models of cystic fibrosis DJ Davidson, M Rolfe	Trends in Genetics	2001
Modifier genes and variation in cystic fibrosis ML Drumm	Respiratory Research	2001
Biology of respiratory epithelial cells: Role in defense against infections AM Cantin	Pediatric Pulmonology	2001
Increased Nitrosothiols in Exhaled Breath Condensate in Inflammatory Airway Diseases M Corradi, P Montuschi, LE Donnelly, A Pesci, SA Kharitonov, PJ Barnes	American journal of respiratory and critical care medicine	2001
Reduced Smad3 Protein Expression and Altered Transforming Growth Factor- β 1–Mediated Signaling in Cystic Fibrosis Epithelial Cells TJ Kelley, HL Elmer, DA Corey	American journal of respiratory cell and molecular biology	2001
Exhaled Markers of Pulmonary Disease SA Kharitonov, PJ Barnes	American journal of respiratory and critical care medicine	2001
In vitro resistance of Burkholderia cepacia complex isolates to reactive oxygen species in relation to catalase and superoxide dismutase production MA Valvano, MD Lefebre	Microbiology	2001
Regulation of anion secretion by nitric oxide in human airway epithelial cells M Duszyk	American journal of physiology. Lung cellular and molecular physiology	2001
Cystische Fibrose D Reinhardt, M Götz, R Kraemer, MH Schöni		2001
Purinergic and Pyrimidinergic Signalling II MP Abbracchio, M Williams		2001
In vivo alterations of interferon regulatory factor-1 and protein inhibitor of activated Stat-1 protein levels in cystic fibrosis epithelium Thomas J. Kelley, Heather L. Elmer	Journal of Clinical Investigation	2000
Mouse models of chronic lung infection withPseudomonas Aeruginosa: Models for the study of cystic fibrosis PK Stotland, D Radzioch, MM Stevenson	Pediatric Pulmonology	2000
Neutrophils enhance expression of inducible nitric oxide synthase in human normal but not cystic fibrosis bronchial epithelial cells QH Meng, JM Polak, AJ Edgar, MR Chacon, TJ Evans, DC Gruenert, AE Bishop	The Journal of Pathology	2000
Elevation of nitrotyrosine and nitrate concentrations in cystic fibrosis sputum KL Jones, AH Hegab, BC Hillman, KL Simpson, PA Jinkins, MB Grisham, MW Owens, E Sato, RA Robbins	Pediatric Pulmonology	2000
Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis P Montuschi, SA Kharitonov, G Ciabattoni, M Corradi, L Rensen, DM Geddes, ME Hodson, PJ Barnes	Thorax	2000
Increase in exhaled carbon monoxide during exacerbations of cystic fibrosis JD Antuni, SA Kharitonov, D Hughes, ME Hodson, PJ Barnes	Thorax	2000
Airway inflammation and ion channel abnormalities in cystic fibrosis J Shute	Clinical & Experimental Allergy	2000
Phagocyte oxidants and nitric oxide in cystic fibrosis: new therapeutic targets? A der Vliet, CE Cross	Current Opinion in Pulmonary Medicine	2000
Impairment of Airway Mucociliary Transport in Patients with Sinobronchial Syndrome: Role of Nitric Oxide J Tamaoki, M Taira, K Nishimura, J Nakata, A Nagai	Journal of Aerosol Medicine	2000
Phagocyte oxidants and nitric oxide in cystic fibrosis: new therapeutic targets?: A der Vliet, CE Cross	Current Opinion in Pulmonary Medicine	2000
Oxidants, nitrosants, and the lung A der Vliet, CE Cross	The American Journal of Medicine	2000
Pseudomonas aeruginosa Induction of Apoptosis in Respiratory Epithelial Cells: Analysis of the Effects of Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction and Bacterial Virulence Factors S Rajan, G Cacalano, R Bryan, AJ Ratner, CU Sontich, A Heerckeren, P Davis, A Prince	American journal of respiratory cell and molecular biology	2000
Myeloperoxidase and protein oxidation in cystic fibrosis D Torre, G Ferrario, F Speranza, A Orani, GP Fiori, C Zeroli	American journal of physiology. Lung cellular and molecular physiology	2000
Cystic Fibrosis Transmembrane Conductance Regulator–Dependent Regulation of Epithelial Inducible Nitric Oxide Synthase Expression WK Steagall, HL Elmer, KG Brady, TJ Kelley	American journal of respiratory cell and molecular biology	2000
Airway Nitric Oxide Levels in Cystic Fibrosis Patients Are Related to a Polymorphism in the Neuronal Nitric Oxide Synthase Gene H Grasemann, N Knauer, R Büscher, K Hübner, JM Drazen, F Ratjen	American journal of respiratory and critical care medicine	2000
Yet Another Role for the Cystic Fibrosis Transmembrane Conductance Regulator JH Widdicombe	American journal of respiratory cell and molecular biology	2000
Exhaled Ethane Is Elevated in Cystic Fibrosis and Correlates with Carbon Monoxide Levels and Airway Obstruction P Paredi, SA Kharitonov, D Leak, PL Shah, D Cramer, ME Hodson, PJ Barnes	American journal of respiratory and critical care medicine	2000
Reduced Nasal Nitric Oxide in Diffuse Panbronchiolitis H Nakano, H Ide, M Imada, S Osanai, T Takahashi, K Kikuchi, J Iwamoto	American journal of respiratory and critical care medicine	2000
Nitric oxide: a pro-inflammatory mediator in lung disease? A der Vliet, JP Eiserich, CE Cross	Respiratory Research	2000
The role of nitric oxide in the regulation of ion channels in airway epithelium: Implications for diseases of the lung M Duszyk, MW Radomski	Free Radical Research	2000
Function and Composition of Pulmonary Surfactant and Surfactant-Derived Fatty Acid Profiles Are Altered in Young Adults With Cystic Fibrosis KC Meyer, A Sharma, R Brown, M Weatherly, FR Moya, J Lewandoski, JJ Zimmerman	Chest	2000
Nasal and Exhaled Nitric Oxide Is Reduced in Adult Patients With Cystic Fibrosis and Does Not Correlate With Cystic Fibrosis Genotype SR Thomas, SA Kharitonov, SF Scott, ME Hodson, PJ Barnes	Chest	2000
Third Place—Resident Basic Science Award 1999 Elevated Nitric Oxide Metabolite Levels in Chronic Sinusitis RJ Schlosser, WD Spotnitz, EJ Peters, K Fang, B Gaston, CW Gross	Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery	2000
Persistent Bacterial Infections JP Nataro, MJ Blaser, S Cunningham-Rundles		2000
Innate Lung Defenses and Compromised Pseudomonas aeruginosa Clearance in the Malnourished Mouse Model of Respiratory Infections in Cystic Fibrosis EI Tuomanen, H Yu, SZ Nasr, V Deretic	Infection and immunity	2000
Heme oxygenase-2 and nitric oxide synthase immunoreactivity of bovine olfactory receptor neurons and a comparison with the distribution of NADPH-diaphorase staining S Wenisch, C Andressen, A Derouiche, S Arnhold, K Addicks, R Leiser	The Histochemical Journal	2000
The innate immune system in cystic fibrosis lung disease R Bals, DJ Weiner, JM Wilson	Journal of Clinical Investigation	1999
Cystic fibrosis lung disease: The role of nitric oxide H Grasemann, F Ratjen	Pediatric Pulmonology	1999
Inflammation and CFTR: might neutrophils be the key in cystic fibrosis? V Witko-Sarsat, I Sermet-Gaudelus, G Lenoir, B Descamps-Latscha	Mediators of Inflammation	1999
Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis F Ratjen, S Gärtig, HG Wiesemann, H Grasemann	Respiratory Medicine	1999
Nitric oxide-mediated regulation of transepithelial sodium and chloride transport in murine nasal epithelium HL Elmer, KG Brady, ML Drumm, TJ Kelley	American journal of physiology. Lung cellular and molecular physiology	1999
Nitric oxide inhibits heterologous CFTR expression in polarized epithelial cells T Jilling, IY Haddad, SH Cheng, S Matalon	American journal of physiology. Lung cellular and molecular physiology	1999

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