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Citations to this article

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
Steven D. Crowley, … , Thu H. Le, Thomas M. Coffman
Steven D. Crowley, … , Thu H. Le, Thomas M. Coffman
Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):1092-1099. https://doi.org/10.1172/JCI23378.
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Article Cardiology Article has an altmetric score of 1

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

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Abstract

Angiotensin II, acting through type 1 angiotensin (AT1) receptors, has potent effects that alter renal excretory mechanisms. Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the renin-angiotensin system (RAS). However, since AT1 receptors are ubiquitously expressed, precisely dissecting their physiological actions in individual tissue compartments including the kidney with conventional pharmacological or gene targeting experiments has been difficult. Here, we used a cross-transplantation strategy and AT1A receptor–deficient mice to demonstrate distinct and virtually equivalent contributions of AT1 receptor actions in the kidney and in extrarenal tissues to determining the level of blood pressure. We demonstrate that regulation of blood pressure by extrarenal AT1A receptors cannot be explained by altered aldosterone generation, which suggests that AT1 receptor actions in systemic tissues such as the vascular and/or the central nervous systems make nonredundant contributions to blood pressure regulation. We also show that interruption of the AT1 receptor–mediated short-loop feedback in the kidney is not sufficient to explain the marked stimulation of renin production induced by global AT1 receptor deficiency or by receptor blockade. Instead, the renin response seems to be primarily determined by renal baroreceptor mechanisms triggered by reduced blood pressure. Thus, the regulation of blood pressure by the RAS is mediated by AT1 receptors both within and outside the kidney.

Authors

Steven D. Crowley, Susan B. Gurley, Michael I. Oliverio, A. Kathy Pazmino, Robert Griffiths, Patrick J. Flannery, Robert F. Spurney, Hyung-Suk Kim, Oliver Smithies, Thu H. Le, Thomas M. Coffman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 4 3 10 15 9 4 12 8 12 8 12 7 14 16 14 7 9 6 5 1 177
Citation information
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Citations to this article in year 2013 (7)

Title and authors Publication Year
Proximal nephron
JL Zhuo, XC Li
Comprehensive Physiology 2013
New frontiers in the intrarenal Renin-Angiotensin system: a critical review of classical and new paradigms
JL Zhuo, FM Ferrao, Y Zheng, XC Li
Frontiers in Endocrinology 2013
Role of angiotensin AT(2) receptors in natriuresis: Intrarenal mechanisms and therapeutic potential
RM Carey, SH Padia
Clinical and experimental pharmacology & physiology 2013
Disturbed acid-base transport: an emerging cause of hypertension
E Boedtkjer, C Aalkjaer
Frontiers in physiology 2013
Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice
XC Li, JL Zhuo
American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 2013
Smooth muscle-selective CPI-17 expression increases vascular smooth muscle contraction and blood pressure
W Su, Z Xie, S Liu, LE Calderon, Z Guo, MC Gong
American journal of physiology. Heart and circulatory physiology 2013
Angiotensin II blockade and renal protection.
Kobori H, Mori H, Masaki T, Nishiyama A
Current pharmaceutical design 2013

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