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Citations to this article

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system
Steven D. Crowley, … , Thu H. Le, Thomas M. Coffman
Steven D. Crowley, … , Thu H. Le, Thomas M. Coffman
Published April 1, 2005
Citation Information: J Clin Invest. 2005;115(4):1092-1099. https://doi.org/10.1172/JCI23378.
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Article Cardiology Article has an altmetric score of 1

Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system

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Abstract

Angiotensin II, acting through type 1 angiotensin (AT1) receptors, has potent effects that alter renal excretory mechanisms. Control of sodium excretion by the kidney has been suggested to be the critical mechanism for blood pressure regulation by the renin-angiotensin system (RAS). However, since AT1 receptors are ubiquitously expressed, precisely dissecting their physiological actions in individual tissue compartments including the kidney with conventional pharmacological or gene targeting experiments has been difficult. Here, we used a cross-transplantation strategy and AT1A receptor–deficient mice to demonstrate distinct and virtually equivalent contributions of AT1 receptor actions in the kidney and in extrarenal tissues to determining the level of blood pressure. We demonstrate that regulation of blood pressure by extrarenal AT1A receptors cannot be explained by altered aldosterone generation, which suggests that AT1 receptor actions in systemic tissues such as the vascular and/or the central nervous systems make nonredundant contributions to blood pressure regulation. We also show that interruption of the AT1 receptor–mediated short-loop feedback in the kidney is not sufficient to explain the marked stimulation of renin production induced by global AT1 receptor deficiency or by receptor blockade. Instead, the renin response seems to be primarily determined by renal baroreceptor mechanisms triggered by reduced blood pressure. Thus, the regulation of blood pressure by the RAS is mediated by AT1 receptors both within and outside the kidney.

Authors

Steven D. Crowley, Susan B. Gurley, Michael I. Oliverio, A. Kathy Pazmino, Robert Griffiths, Patrick J. Flannery, Robert F. Spurney, Hyung-Suk Kim, Oliver Smithies, Thu H. Le, Thomas M. Coffman

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Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Total
Citations: 1 4 3 10 15 9 4 12 8 12 8 12 7 14 16 14 7 9 6 5 1 177
Citation information
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Citations to this article in year 2007 (6)

Title and authors Publication Year
Gain-of-function mutant of Angiotensin II AT1A Receptor causes Hypertension and Cardiovascular Fibrosis in Mice
Sandrine BILLET, Sabine BARDIN, Sonia VERP, Véronique BAUDRIE, Annie MICHAUD, Sophie CONCHON, Martine MUFFAT-JOLY, Brigitte ESCOUBET, Evelyne SOUIL, Ghislaine HAMARD, Kenneth E. BERNSTEIN, Jean Marie GASC, Jean-Luc ELGHOZI, Pierre CORVOL & Eric CLAUSER
Journal of Clinical Investigation 2007
Anti-hypertensive Effects of Selective Prostaglandin E2 EP1 Receptor Targeting
Youfei Guan, Yahua Zhang, Zhonghua Qi, Guangrui Yang, Dou Dou=, Yuansheng Gao, Jing Wu, Lihong Chen, Xiaoyan Zhang, Linda S. Davis, Mingfeng Wei, Xuefeng Fan, Monica Carmosino, Chuanming Hao, John D. Imig, Richard M. Breyer, Matthew D. Breyer
Journal of Clinical Investigation 2007
In hypertension, the kidney rules
SD Crowley, TM Coffman
Current Hypertension Reports 2007
Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus
HR Salzler, R Griffiths, P Ruiz, L Chi, C Frey, DA Marchuk, HA Rockman, TH Le
Kidney International 2007
Development of an AT2-deficient proximal tubule cell line for transport studies
PG Woost, RJ Kolb, CH Chang, M Finesilver, T Inagami, U Hopfer
In vitro cellular & developmental biology. Animal 2007
Renovascular hypertension in 2007: where are we now?
Textor SC
Current Cardiology Reports 2007

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