Endothelial cell culture: beginnings of modern vascular biology
Ralph L. Nachman, Eric A. Jaffe
Ralph L. Nachman, Eric A. Jaffe
Published October 15, 2004
Citation Information: J Clin Invest. 2004;114(8):1037-1040. https://doi.org/10.1172/JCI23284.
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Retrospectives

Endothelial cell culture: beginnings of modern vascular biology

Abstract

Endothelial cells derived from human umbilical veins were first successfully cultured in vitro in 1973. Weibel-Palade bodies and the von Willebrand factor antigen were used as morphological, immunohistochemical, and functional markers to unequivocally identify the cells. These landmark studies helped initiate the growth of modern vascular biology.

Authors

Ralph L. Nachman, Eric A. Jaffe

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Cumulative citations to “endothelium” in the biomedical literature over ...
Cumulative citations to “endothelium” in the biomedical literature over 4 decades (according to the ISI Web of Science database). The explosive phase started in the early 1990s, coinciding with the growing interest in angiogenesis.