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Citations to this article

Homeostatic control of immunity by TCR peptide–specific Tregs
Vipin Kumar
Vipin Kumar
Published November 1, 2004
Citation Information: J Clin Invest. 2004;114(9):1222-1226. https://doi.org/10.1172/JCI23166.
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Review Series

Homeostatic control of immunity by TCR peptide–specific Tregs

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Abstract

Regulation of the immune response is a multifaceted process involving lymphocytes that function to maintain both self tolerance as well as homeostasis following productive immunity against microbes. There are 2 broad categories of Tregs that function in different immunological settings depending upon the context of antigen exposure and the nature of the inflammatory response. During massive inflammatory conditions such as microbial exposure in the gut or tissue transplantation, regulatory CD4+CD25+ Tregs broadly suppress priming and/or expansion of polyclonal autoreactive responses nonspecifically. In other immune settings where initially a limited repertoire of antigen-reactive T cells is activated and expanded, TCR-specific negative feedback mechanisms are able to achieve a fine homeostatic balance. Here I will describe experimental evidence for the existence of a Treg population specific for determinants that are derived from the TCR and are expressed by expanding myelin basic protein–reactive T cells mediating experimental autoimmune encephalomyelitis, an animal prototype for multiple sclerosis. These mechanisms ensure induction of effective but appropriately limited responses against foreign antigens while preventing autoreactivity from inflicting escalating damage. In contrast to CD25+ Tregs, which are most efficient at suppressing priming or activation, these specific Tregs are most efficient in controlling T cells following their activation.

Authors

Vipin Kumar

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Total citations by year

Year: 2021 2019 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 1974 Total
Citations: 2 1 1 5 3 4 4 4 5 8 7 6 14 7 1 1 73
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2008 (7)

Title and authors Publication Year
Revival of CD8+ Treg–mediated suppression
TR Smith, V Kumar
Trends in Immunology 2008
CD8+ regulatory T cells—A distinct T-cell lineage or a transient T-cell phenotype?
EM Aandahl, KM Torgersen, K Taskén
Human Immunology 2008
Involvement of IL-2 in homeostasis of regulatory T cells: the IL-2 cycle
S Yarkoni, A Kaminitz, Y Sagiv, I Yaniv, N Askenasy
BioEssays 2008
Regulatory T Cells and Clinical Application
S Jiang
2008
Preservation of FoxP3+ Regulatory T Cells in the Peripheral Blood of Human Immunodeficiency Virus Type 1-Infected Elite Suppressors Correlates with Low CD4+ T-Cell Activation
AJ Chase, HC Yang, H Zhang, JN Blankson, RF Siliciano
Journal of virology 2008
TGF-β Inhibits IL-2 Production and Promotes Cell Cycle Arrest in TCR-Activated Effector/Memory T Cells in the Presence of Sustained TCR Signal Transduction
L Das, AD Levine
Journal of immunology (Baltimore, Md. : 1950) 2008
Immunodominance in the TCR Repertoire of αTCR Peptide-Specific CD4 + Treg Population That Controls Experimental Autoimmune Encephalomyelitis
LT Madakamutil, I Maricic, EE Sercarz, V Kumar
Journal of immunology (Baltimore, Md. : 1950) 2008

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