The legacy of Homer W. Smith: mechanistic insights into renal physiology
L. Gabriel Navar
L. Gabriel Navar
Published October 15, 2004
Citation Information: J Clin Invest. 2004;114(8):1048-1050. https://doi.org/10.1172/JCI23150.
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Retrospectives

The legacy of Homer W. Smith: mechanistic insights into renal physiology

Abstract

In 1945, Homer W. Smith published an article in the JCI that clearly demonstrated that para-aminohippuric acid is the most suitable agent for the evaluation of renal plasma flow in both humans and dogs; in addition, the paper provided detailed methodology that is still in use today. This paper is but one of many outstanding works performed by Smith and his colleagues that clearly established the clearance technique as a powerful noninvasive approach to gain mechanistic insights into intrarenal function.

Authors

L. Gabriel Navar

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Figure 1

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James A. Shannon, Robert Berliner, and Homer W. Smith (center) prior to ...
James A. Shannon, Robert Berliner, and Homer W. Smith (center) prior to Smith’s lecture on April 26, 1960 (NIH, Bethesda, Maryland, USA). Image courtesy of the National Library of Medicine.