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Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

Anne Angelillo-Scherrer, … , Bernhard Wehrle-Haller, Peter Carmeliet

Anne Angelillo-Scherrer, … , Bernhard Wehrle-Haller, Peter Carmeliet

Published February 1, 2005
Citation Information: J Clin Invest. 2005;115(2):237-246. https://doi.org/10.1172/JCI22079.

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Citations to this article (97)

Title and authors	Publication	Year
AXL signaling in cancer: from molecular insights to targeted therapies Yadav M, Sharma A, Patne K, Tabasum S, Suryavanshi J, Rawat L, Machaalani M, Eid M, Singh RP, Choueiri TK, Pal S, Sabarwal A	Signal Transduction and Targeted Therapy	2025
Gas6 induces AIM to suppress acute lung injury in mice by inhibiting NLRP3 inflammasome activation and inducing autophagy Jeong S, Yang K, Lee Y, Park JW, Park EM, Kang JL	Frontiers in Immunology	2025
Tumor-Extrinsic Axl Expression Shapes an Inflammatory Microenvironment Independent of Tumor Cell Promoting Axl Signaling in Hepatocellular Carcinoma Breitenecker K, Heiden D, Demmer T, Weber G, Primorac AM, Hedrich V, Ortmayr G, Gruenberger T, Starlinger P, Herndler-Brandstetter D, Barozzi I, Mikulits W	International journal of molecular sciences	2024
Modification of Gas6 Protein in the Brain by a Functional Endogenous Tissue Vitamin K Cycle. Aydin N, Ouliass B, Ferland G, Hafizi S	Cells	2024
Could Gas6/TAM Axis Provide Valuable Insights into the Pathogenesis of Systemic Sclerosis? Apostolo D, D\u2019Onghia D, Nerviani A, Ghirardi GM, Sola D, Perazzi M, Tonello S, Colangelo D, Sainaghi PP, Bellan M	Current issues in molecular biology	2024
Elevated Plasma Levels of Growth Arrest Specific 6 (Gas6) Protein in Severe Obesity: Implications for Adipose Tissue and Inflammation Sola D, Bellan M, Mai S, Minisini R, Perazzi M, Brunani A, Gentilli S, Sainaghi PP, Scacchi M, Marzullo P	Medical science monitor : international medical journal of experimental and clinical research	2024
Targeting MERTK on tumour cells and macrophages: a potential intervention for sporadic and NF2-related meningioma and schwannoma tumours. Dave F, Herrera K, Lockley A, van de Weijer LL, Henderson S, Sofela AA, Hook L, Adams CL, Ercolano E, Hilton DA, Maze EA, Kurian KM, Ammoun S, Hanemann CO	Oncogene	2024
The transcription factors NR5A1 and JUNB cooperate to activate the Axl promoter in mouse Sertoli cell lines. Diawara M, Martin LJ	Molecular biology reports	2024
Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. Gao L, He C, Yang A, Zhou H, Lu Q, Birge RB, Wu Y	Cell communication and signaling : CCS	2023
A Review: The Potential Involvement of Growth Arrest-Specific 6 and Its Receptors in the Pathogenesis of Lung Damage and in Coronavirus Disease 2019. Apostolo D, Ferreira LL, Di Tizio A, Ruaro B, Patrucco F, Bellan M	Microorganisms	2023
Therapeutic targeting of the functionally elusive TAM receptor family. Miao YR, Rankin EB, Giaccia AJ	Nature reviews. Drug discovery	2023
Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis J Mao, K Zhu, Z Long, H Zhang, B Xiao, , Y Wang, J Huang, J Liu, X Shi, H Jiang, T Lu, Y Wen, N Zhang, Q Meng, H Zhou, Z Ruan, J Wang, C Luo,	Advanced Science	2022
The role of phosphatidylserine on the membrane in immunity and blood coagulation J Wang, C Yu, J Zhuang, W Qi, J Jiang, X Liu, W Zhao, Y Cao, H Wu, J Qi, R Zhao	Biomarker Research	2022
AXL, along with PROS1, is overexpressed in papillary thyroid carcinoma and regulates its biological behaviour Wei M, Wang Y, Liu Y, Li D, He X	World journal of surgical oncology	2022
Immunothrombosis and the Role of Platelets in Venous Thromboembolic Diseases Heestermans M, Poenou G, Duchez AC, Hamzeh-Cognasse H, Bertoletti L, Cognasse F	International journal of molecular sciences	2022
Therapeutic Targeting of the Gas6/Axl Signaling Pathway in Cancer M Tanaka, DW Siemann	International journal of molecular sciences	2021
Gene variants of coagulation related proteins that interact with SARS-CoV-2 D Holcomb, A Alexaki, N Hernandez, R Hunt, K Laurie, J Kames, N Hamasaki-Katagiri, AA Komar, M DiCuccio, C Kimchi-Sarfaty, JM Briggs	PLoS computational biology	2021
G-749 Promotes Receptor Tyrosine Kinase TYRO3 Degradation and Induces Apoptosis in Both Colon Cancer Cell Lines and Xenograft Mouse Models HD Kim, EJ Park, EK Choi, SY Song, KL Hoe, DU Kim	Frontiers in pharmacology	2021
Intrinsic and Extrinsic Control of Hepatocellular Carcinoma by TAM Receptors V Hedrich, K Breitenecker, L Djerlek, G Ortmayr, W Mikulits	Cancers	2021
Targeting MERTK and AXL in EGFR Mutant Non-Small Cell Lung Cancer D Yan, HS Earp, D DeRyckere, DK Graham	Cancers	2021
Platelet protein S limits venous but not arterial thrombosis propensity by controlling coagulation in the thrombus S Calzavarini, R Prince-Eladnani, F Saller, L Bologna, L Burnier, AC Brisset, C Quarroz, MD Caro, V Ermolayev, Y Matsumura, JA Fernández, TM Hackeng, JH Griffin, A Angelillo-Scherrer	Blood	2020
Role of Vitamin K-Dependent Factors Protein S and GAS6 and TAM Receptors in SARS-CoV-2 Infection and COVID-19-Associated Immunothrombosis A Tutusaus, M Marí, JT Ortiz-Pérez, GA Nicolaes, A Morales, PG de Frutos	Cells	2020
New Insights into the Role of Tyro3, Axl, and Mer Receptors in Rheumatoid Arthritis S Pagani, M Bellan, D Mauro, LM Castello, GC Avanzi, MJ Lewis, PP Sainaghi, C Pitzalis, A Nerviani	Disease Markers	2020
Role of Gas6 and TAM Receptors in the Identification of Cardiopulmonary Involvement in Systemic Sclerosis and Scleroderma Spectrum Disorders M Bellan, A Dimagli, C Piccinino, A Giubertoni, A Ianniello, F Grimoldi, M Sguazzotti, A Nerviani, M Barini, A Carriero, C Smirne, ME Burlone, C Rigamonti, R Minisini, L Salmi, MN Barbaglia, LM Castello, D Sola, P Marino, GC Avanzi, M Pirisi, PP Sainaghi	Disease Markers	2020
Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting J Huang, X Li, X Shi, M Zhu, J Wang, S Huang, X Huang, H Wang, L Li, H Deng, Y Zhou, J Mao, Z Long, Z Ma, W Ye, J Pan, , J Jin	Journal of Hematology & Oncology	2019
TYRO3: A potential therapeutic target in cancer PL Hsu, J Jou, SJ Tsai	Experimental biology and medicine (Maywood, N.J.)	2019
A high Gas6 level in plasma predicts venous thromboembolism recurrence, major bleeding and mortality in the elderly: a prospective multicenter cohort study A Schnegg-Kaufmann, S Calzavarini, A Limacher, M Mean, M Righini, D Staub, JH Beer, B Frauchiger, J Osterwalder, N Kucher, CM Matter, M Husmann, M Banyai, M Aschwanden, L Mazzolai, O Hugli, M Nagler, M Daskalakis, N Rodondi, D Aujesky, A Angelillo-Scherrer	Journal of Thrombosis and Haemostasis	2019
AXL Is a Putative Tumor Suppressor and Dormancy Regulator in Prostate Cancer HD Axelrod, KC Valkenburg, SR Amend, JL Hicks, P Parsana, G Torga, AM DeMarzo, KJ Pienta	Molecular cancer research : MCR	2019
A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD M Furukawa, X Wang, H Ohkawara, M Fukatsu, L Alkebsi, H Takahashi, K Harada-Shirado, A Shichishima-Nakamura, S Kimura, K Ogawa, T Ikezoe	Blood Advances	2019
Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors Jung, Lee, Choi, Park, Kim, Kang	Cells	2019
Tumour-Secreted Protein S (ProS1) Activates a Tyro3-Erk Signalling Axis and Protects Cancer Cells from Apoptosis NA Kafri, S Hafizi	Cancers	2019
TAM Family Receptor Kinase Inhibition Reverses MDSC-Mediated Suppression and Augments Anti–PD-1 Therapy in Melanoma A Holtzhausen, W Harris, E Ubil, DM Hunter, J Zhao, Y Zhang, D Zhang, Q Liu, X Wang, DK Graham, SV Frye, HS Earp	Cancer immunology research	2019
Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation J Zhou, A Yang, Y Wang, F Chen, Z Zhao, V Davra, K Suzuki-Inoue, Y Ozaki, RB Birge, Q Lu, Y Wu	Cell Communication and Signaling	2018
Translational Implications of Platelets as Vascular First Responders RC Becker, T Sexton, SS Smyth	Circulation research	2018
The small-molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis BR Branchford, TJ Stalker, L Law, G Acevedo, S Sather, C Brzezinski, KM Wilson, K Minson, AB Lee-Sherick, P Davizon-Castillo, C Ng, W Zhang, KB Neeves, SR Lentz, X Wang, SV Frye, HS Earp, D DeRyckere, LF Brass, DK Graham, JA di Paola	Journal of Thrombosis and Haemostasis	2018
The role of TAM family receptors and ligands in the nervous system: From development to pathobiology B Shafit-Zagardo, RC Gruber, JC DuBois	Pharmacology & Therapeutics	2018
The search for new antithrombotic mechanisms and therapies that may spare hemostasis EF Plow, Y Wang, DI Simon	Blood	2018
GAS6/TAM Pathway Signaling in Hemostasis and Thrombosis LA Law, DK Graham, JD Paola, BR Branchford	Frontiers in Medicine	2018
Does Axl have potential as a therapeutic target in pancreatic cancer? W Du, RA Brekken	Expert Opinion on Therapeutic Targets	2018
The Dual Role of TAM Receptors in Autoimmune Diseases and Cancer: An Overview M Wium, J Paccez, L Zerbini	Cells	2018
The Emerging Role of TYRO3 as a Therapeutic Target in Cancer S Smart, E Vasileiadi, X Wang, D DeRyckere, D Graham	Cancers	2018
Dynamics of Axl Receptor Shedding in Hepatocellular Carcinoma and Its Implication for Theranostics E Holstein, M Binder, W Mikulits	International journal of molecular sciences	2018
Genome-Wide Association Study Links Receptor Tyrosine Kinase Inhibitor Sprouty 2 to Thrombocytopenia after Coronary Artery Bypass Surgery J Karhausen, W Qi, A Smeltz, YJ Li, S Shah, W Kraus, J Mathew, M Podgoreanu, M Kertai	Thrombosis and Haemostasis	2018
TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy YT Akalu, CV Rothlin, S Ghosh	Immunological Reviews	2017
Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα Y Wang, H Gao, C Shi, PW Erhardt, A Pavlovsky, DA Soloviev, K Bledzka, V Ustinov, L Zhu, J Qin, AD Munday, J Lopez, E Plow, DI Simon	Nature Communications	2017
The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia ( anx ) mutation DY Kim, J Yu, RK Mui, R Niibori, HB Taufique, R Aslam, JW Semple, SP Cordes	Disease models & mechanisms	2017
Role of Axl in T-Lymphocyte Survival in Salt-Dependent HypertensionHighlights SN Batchu, A Hughson, KM Wadosky, CN Morrell, DJ Fowell, VA Korshunov	Arteriosclerosis, thrombosis, and vascular biology	2016
Targeting the TAM Receptors in Leukemia M Huey, K Minson, H Earp, D DeRyckere, D Graham	Cancers	2016
The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy M Paolino, J Penninger	Cancers	2016
Study of Early Elevated Gas6 Plasma Level as a Predictor of Mortality in a Prospective Cohort of Patients with Sepsis G Stalder, YA Que, S Calzavarini, L Burnier, C Kosinski, P Ballabeni, T Roger, T Calandra, MA Duchosal, L Liaudet, P Eggimann, A Angelillo-Scherrer, PG de Frutos	PloS one	2016
The Receptor Tyrosine Kinase AXL in Cancer Progression E Rankin, A Giaccia	Cancers	2016
TAM receptors Tyro3 and Mer as novel targets in colorectal cancer R Schmitz, AF Valls, R Yerbes, S Richter, C Kahlert, S Loges, J Weitz, M Schneider, CR de Almodovar, A Ulrich, T Schmidt	Oncotarget	2016
TAM Receptor Signaling in Immune Homeostasis CV Rothlin, EA Carrera-Silva, L Bosurgi, S Ghosh	Annual Review of Immunology	2015
Elevated Serum Gas6 Is a Novel Prognostic Biomarker in Patients with Oral Squamous Cell Carcinoma T Jiang, G Liu, L Wang, H Liu, QY Wei	PloS one	2015
Regulation of phagocytosis by Rho GTPases Y Mao, SC Finnemann	Small GTPases	2015
The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity JJ Miner, BP Daniels, B Shrestha, JL Proenca-Modena, ED Lew, HM Lazear, MJ Gorman, G Lemke, RS Klein, MS Diamond	Nature Medicine	2015
Growth Arrest-Specific 6 (Gas6) and TAM Receptors in Mouse Platelets F Uras, B Küçük, ÖB Özakpınar, AM Demir	Turkish Journal of Hematology	2015
Platelet-Derived Myeloid Related Protein-14 (S100A9) Regulates Thrombosis Yunmei Wang, Chao Fang, Huiyun Gao, Matthew Bilodeau, Zijie Zhang, Kevin J. Croce, Shijian Liu, Toshifumi Morooka, Masashi Sakuma, Kohsuke Nakajima, Shuichi Yoneda, Can Shi, David Zidar, Patrick Andre, Gillian Stephens, Roy L. Silverstein, Nancy Hogg, Alvin Schmaier, Daniel Simon	Journal of Clinical Investigation	2014
The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer DK Graham, D DeRyckere, KD Davies, HS Earp	Nature Reviews Cancer	2014
A Systems Biology Approach to Blood SJ Corey, M Kimmel, JN Leonard	A Systems Biology Approach to Blood	2014
High glucose induces human endothelial dysfunction through an Axl-dependent mechanism CH Lee, YS Shieh, FC Hsiao, FC Kuo, CY Lin, CH Hsieh, YJ Hung	Cardiovascular Diabetology	2014
Role of Growth arrest-specific gene 6-Mer axis in multiple myeloma JS Waizenegger, I Ben-Batalla, N Weinhold, T Meissner, M Wroblewski, M Janning, K Riecken, M Binder, D Atanackovic, H Taipaleenmaeki, D Schewe, S Sawall, V Gensch, M Cubas-Cordova, A Seckinger, W Fiedler, E Hesse, N Kröger, B Fehse, D Hose, B Klein, MS Raab, K Pantel, C Bokemeyer, S Loges	Leukemia	2014
Axl as a mediator of cellular growth and survival Axelrod H, Pienta KJ	Oncotarget	2014
Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis W Zhang, AL McIver, MA Stashko, D DeRyckere, BR Branchford, D Hunter, D Kireev, MJ Miley, J Norris-Drouin, WM Stewart, M Lee, S Sather, Y Zhou, JA di Paola, M Machius, WP Janzen, HS Earp, DK Graham, SV Frye, X Wang	Journal of Medicinal Chemistry	2013
Biology of the TAM Receptors G Lemke	Cold Spring Harbor perspectives in biology	2013
Molecular Pathways: MERTK Signaling in Cancer CT Cummings, D DeRyckere, HS Earp, DK Graham	Clinical cancer research	2013
The TAM-family receptor Mer mediates production of HGF through the RhoA-dependent pathway in response to apoptotic cells HJ Park, JY Baen, YJ Lee, YH Choi, JL Kang, CH Heldin	Molecular biology of the cell	2012
Cross-Phosphorylation, Signaling and Proliferative Functions of the Tyro3 and Axl Receptors in Rat2 Cells JE Brown, M Krodel, M Pazos, C Lai, AL Prieto	PloS one	2012
Growth Arrest-Specific Gene 6 (gas6) and Vascular Hemostasis S Laurance, CA Lemarié, MD Blostein	Advances in Nutrition	2012
mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets SF Moore, RW Hunter, I Hers	The Journal of biological chemistry	2011
Macrophage–tumor crosstalk: role of TAMR tyrosine kinase receptors and of their ligands T Schmidt, I Ben-Batalla, A Schultze, S Loges	Cellular and Molecular Life Sciences	2011
Historical Perspective and Future Directions in Platelet Research BS Coller	Journal of Thrombosis and Haemostasis	2011
Elevated plasma gas6 levels are associated with venous thromboembolic disease MD Blostein, I Rajotte, DP Rao, CA Holcroft, SR Kahn	Journal of Thrombosis and Thrombolysis	2011
Axl-dependent signalling: a clinical update VA Korshunov	Clinical Science	2011
TAM receptors in leukemia: expression, signaling, and therapeutic implications. Brandão L, Migdall-Wilson J, Eisenman K, Graham DK	Critical Reviews in Oncogenesis	2011
Akt signaling in platelets and thrombosis DS Woulfe	Expert Review of Hematology	2010
Inhibition of Mer and Axl receptor tyrosine kinases in astrocytoma cells leads to increased apoptosis and improved chemosensitivity AK Keating, GK Kim, AE Jones, AM Donson, K Ware, JM Mulcahy, DB Salzberg, NK Foreman, X Liang, A Thorburn, DK Graham	Molecular cancer therapeutics	2010
Embryonic lethal coagulopathy and vascular dysgenesis in mice lacking Protein S Tal Burstyn-Cohen, Mary Jo Heeb, Greg Lemke	Journal of Clinical Investigation	2009
Pulmonary surfactant: an immunological perspective ZC Chroneos, Z Sever-Chroneos, VL Shepherd	Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology	2009
Endothelial cell specific adhesion molecule (ESAM) localizes to plateletâplatelet contacts and regulates thrombus formationin vivo TJ Stalker, J Wu, A Morgans, EA Traxler, L Wang, MS Chatterjee, D Lee, T Quertermous, RA Hall, DA Hammer, SL Diamond, LF Brass	Journal of Thrombosis and Haemostasis	2009
TAM receptors and the regulation of erythropoiesis in mice H Tang, S Chen, H Wang, H Wu, Q Lu, D Han	Haematologica	2009
Role of Gas6 in erythropoiesis and anemia Anne Angelillo-Scherrer, Laurent Burnier, Diether Lambrechts, Richard J. Fish, Marc Tjwa, Stéphane Plaisance, Rocco Sugamele, Maria DeMol, Eduardo Martinez-Soria, Patrick Maxwell, Greg Lemke, Stephen P. Goff, Glenn K. Matsushima, H. Shelton Earp, Marc Chanson, Désiré Collen, Shozo Izui, Marc Schapira, Edward M. Conway, Peter Carmeliet	Journal of Clinical Investigation	2008
Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in vivo Arunima Ghosh Wei Li Maria Febbraio Ricardo G. Espinola Keith R. McCrae Roy L. Silverstein	Journal of Clinical Investigation	2008
Future innovations in anti-platelet therapies NE Barrett, L Holbrook, S Jones, WJ Kaiser, LA Moraes, R Rana, T Sage, RG Stanley, KL Tucker, B Wright, JM Gibbins	British Journal of Pharmacology	2008
Immunobiology of the TAM receptors G Lemke, CV Rothlin	Nature Reviews Immunology	2008
RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase X Su, J Mi, J Yan, P Flevaris, Y Lu, H Liu, Z Ruan, X Wang, N Kieffer, S Chen, X Du, X Xi	Blood	2008
Growth arrest-specific gene 6 expression in human breast cancer OM Cormack, WY Chung, P Fitzpatrick, F Cooke, B Flynn, M Harrison, E Fox, E Gallagher, AM Goldrick, PA Dervan, AM Cann, MJ Kerin	British Journal of Cancer	2008
Advances in Cancer Research RM Linger, AK Keating, HS Earp, DK Graham	Advances in cancer research	2008
Axl and Tyro3 Modulate Female Reproduction by Influencing Gonadotropin-Releasing Hormone Neuron Survival and Migration A Pierce, B Bliesner, M Xu, S Nielsen-Preiss, G Lemke, S Tobet, ME Wierman	Molecular Endocrinology	2008
Localization and signaling of the receptor protein tyrosine kinase Tyro3 in cortical and hippocampal neurons AL Prieto, S O’Dell, B Varnum, C Lai	Neuroscience	2007
A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation S Sather, KD Kenyon, JB Lefkowitz, X Liang, BC Varnum, PM Henson, DK Graham	Blood	2006
Adaptation of a photochemical method to initiate recurrent platelet-mediated thrombosis in small animals K Przyklenk, P Whittaker	Lasers in Medical Science	2006
Tyro3 Family-Mediated Cell Entry of Ebola and Marburg Viruses M Shimojima, A Takada, H Ebihara, G Neumann, K Fujioka, T Irimura, S Jones, H Feldmann, Y Kawaoka	Journal of virology	2006
Structural basis for Gas6-Axl signalling T Sasaki, PG Knyazev, NJ Clout, Y Cheburkin, W Göhring, A Ullrich, R Timpl, E Hohenester	The EMBO Journal	2005
Minding the gaps to promote thrombus growth and stability LF Brass, L Zhu, TJ Stalker	Journal of Clinical Investigation	2005
Soluble Axl is generated by ADAM10-dependent cleavage and associates with Gas6 in mouse serum V Budagian, E Bulanova, Z Orinska, E Duitman, K Brandt, A Ludwig, D Hartmann, G Lemke, P Saftig, S Bulfone-Paus	Molecular and cellular biology	2005
Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets N Prévost, DS Woulfe, H Jiang, TJ Stalker, P Marchese, ZM Ruggeri, LF Brass	Proceedings of the National Academy of Sciences	2005

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