Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Citations to this article

The emergence of Lyme disease
Allen C. Steere, … , Jenifer Coburn, Lisa Glickstein
Allen C. Steere, … , Jenifer Coburn, Lisa Glickstein
Published April 15, 2004
Citation Information: J Clin Invest. 2004;113(8):1093-1101. https://doi.org/10.1172/JCI21681.
View: Text | PDF
Review Series Article has an altmetric score of 39

The emergence of Lyme disease

  • Text
  • PDF
Abstract

Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern.

Authors

Allen C. Steere, Jenifer Coburn, Lisa Glickstein

×

Total citations by year

Year: 2025 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Total
Citations: 5 7 7 12 8 18 10 11 12 17 26 21 27 22 29 20 27 19 10 18 10 2 338
Citation information
This citation data is accumulated from CrossRef, which receives citation information from participating publishers, including this journal. Not all publishers participate in CrossRef, so this information is not comprehensive. Additionally, data may not reflect the most current citations to this article, and the data may differ from citation information available from other sources (for example, Google Scholar, Web of Science, and Scopus).

Citations to this article in year 2011 (29)

Title and authors Publication Year
Cyclic di-GMP is essential for the survival of the lyme disease spirochete in ticks
M He, Z Ouyang, B Troxell, H Xu, A Moh, J Piesman, MV Norgard, M Gomelsky, XF Yang
PLoS pathogens 2011
Borrelia burgdorferi BBA52 is a potential target for transmission blocking Lyme disease vaccine
M Kumar, S Kaur, T Kariu, X Yang, I Bossis, JF Anderson, U Pal
Vaccine 2011
The coenzyme A disulphide reductase of Borrelia burgdorferi is important for rapid growth throughout the enzootic cycle and essential for infection of the mammalian host
CH Eggers, MJ Caimano, RA Malizia, T Kariu, B Cusack, DC Desrosiers, KR Hazlett, A Claiborne, U Pal, JD Radolf
Molecular Microbiology 2011
Methods for rapid transfer and localization of lyme disease pathogens within the tick gut
T Kariu, AS Coleman, JF Anderson, U Pal
Journal of visualized experiments : JoVE 2011
A host-restricted viral vector for antigen-specific immunization against Lyme disease pathogen
S Xiao, M Kumar, X Yang, M Akkoyunlu, PL Collins, SK Samal, U Pal
Vaccine 2011
Allelic Variation of the Lyme Disease Spirochete Adhesin DbpA Influences Spirochetal Binding to Decorin, Dermatan Sulfate, and Mammalian Cells
VM Benoit, JR Fischer, YP Lin, N Parveen, JM Leong, JB Bliska
Infection and immunity 2011
Genetic Manipulation of Borrelia burgdorferi
JA Hyde, EH Weening, JT Skare
Current Protocols in Microbiology 2011
A Single-Domain FlgJ Contributes to Flagellar Hook and Filament Formation in the Lyme Disease Spirochete Borrelia burgdorferi
K Zhang, BA Tong, J Liu, C Li
Journal of bacteriology 2011
A Surface Enolase Participates in Borrelia burgdorferi-Plasminogen Interaction and Contributes to Pathogen Survival within Feeding Ticks
SV Nogueira, AA Smith, JH Qin, U Pal, BA McCormick
Infection and immunity 2011
Analysis of the HD-GYP Domain Cyclic Dimeric GMP Phosphodiesterase Reveals a Role in Motility and the Enzootic Life Cycle of Borrelia burgdorferi
SZ Sultan, JE Pitzer, T Boquoi, G Hobbs, MR Miller, MA Motaleb, A Camilli
Infection and immunity 2011
Lymphoadenopathy during lyme borreliosis is caused by spirochete migration-induced specific B cell activation
SS Tunev, CJ Hastey, E Hodzic, S Feng, SW Barthold, N Baumgarth
PLoS pathogens 2011
The BB0646 protein demonstrates lipase and haemolytic activity associated with Borrelia burgdorferi, the aetiological agent of Lyme disease
DK Shaw, JA Hyde, JT Skare
Molecular Microbiology 2011
Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity
JA Hyde, EH Weening, M Chang, JP Trzeciakowski, M Höök, JD Cirillo, JT Skare
Molecular Microbiology 2011
Oligopeptide Permease A5 Modulates Vertebrate Host-Specific Adaptation of Borrelia burgdorferi
BV Raju, MD Esteve-Gassent, SL Karna, CL Miller, TA Laar, J Seshu, AJ Bäumler
Infection and immunity 2011
Rapid decline of OspC borreliacidal antibodies following treatment of patients with early Lyme disease.
Jobe DA, Kowalski TJ, Bloemke M, Lovrich SD, Callister SM
Clinical and vaccine immunology : CVI 2011
A novel gene inactivation system reveals altered periplasmic flagellar orientation in a Borrelia burgdorferi fliL mutant.
Motaleb MA, Pitzer JE, Sultan SZ, Liu J
Journal of bacteriology 2011
Anti-Borrelia burgdorferi antibody profile in post-Lyme disease syndrome.
Chandra A, Wormser GP, Marques AR, Latov N, Alaedini A
Clinical and vaccine immunology : CVI 2011
Lyme disease and the orthopaedic implications of lyme arthritis.
Smith BG, Cruz AI Jr, Milewski MD, Shapiro ED
The Journal of the American Academy of Orthopaedic Surgeons 2011
The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the lyme disease spirochete.
Kenedy MR, Akins DR
Infection and immunity 2011
Functional analysis of Borrelia burgdorferi uvrA in DNA damage protection.
Sambir M, Ivanova LB, Bryksin AV, Godfrey HP, Cabello FC
FEMS Microbiology Letters 2011
Patterns and regulation of ribosomal RNA transcription in Borrelia burgdorferi.
Bugrysheva JV, Godfrey HP, Schwartz I, Cabello FC
BMC Microbiology 2011
Current drivers and future directions of global livestock disease dynamics
Perry BD, Grace D, Sones K
Proceedings of the National Academy of Sciences 2011
Localized Production of IL-10 Suppresses Early Inflammatory Cell Infiltration and Subsequent Development of IFN-γ-Mediated Lyme Arthritis
Sonderegger FL, Ma Y, Maylor-Hagan H, Brewster J, Huang X, Spangrude GJ, Zachary JF, Weis JH, Weis JJ
Journal of immunology (Baltimore, Md. : 1950) 2011
Adaptive and Innate Immune Responsiveness to Borrelia burgdorferi sensu lato in Exposed Asymptomatic Children and Children with Previous Clinical Lyme Borreliosis
Skogman BH, Hellberg S, Ekerfelt C, Jenmalm MC, Forsberg P, Ludvigsson J, Bergström S, Ernerudh J
Clinical and Developmental Immunology 2011
Evaluation of the preventive capacities of a topically applied azithromycin formulation against Lyme borreliosis in a murine model
Knauer J, Krupka I, Fueldner C, Lehmann J, Straubinger RK
Journal of Antimicrobial Chemotherapy 2011
Epitope Mapping of Antibodies to VlsE Protein of Borrelia burgdorferi in Post-Lyme Disease Syndrome
Chandra A, Latov N, Wormser GP, Marques AR, Alaedini A
Clinical Immunology 2011
Interferon-γ Influences the Composition of Leukocytic Infiltrates in Murine Lyme Carditis
Sabino GJ, Hwang SJ, McAllister SC, Mena P, Furie MB
The American Journal of Pathology 2011
Borrelia burgdorferi RST1 (OspC Type A) Genotype Is Associated with Greater Inflammation and More Severe Lyme Disease
Strle K, Jones KL, Drouin EE, Li X, Steere AC
The American Journal of Pathology 2011
Functional Analysis of the Borrelia burgdorferi bba64 Gene Product in Murine Infection via Tick Infestation
Patton TG, Dietrich G, Dolan MC, Piesman J, Carroll JA, Gilmore RD Jr
PloS one 2011

← Previous 1 2 Next →

Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts

Picked up by 2 news outlets
Referenced in 3 policy sources
Posted by 5 X users
Referenced in 5 patents
On 1 Facebook pages
Referenced in 4 Wikipedia pages
Mentioned in 1 Google+ posts
On 1 videos
Referenced in 1 clinical guideline sources
439 readers on Mendeley
4 readers on CiteULike
See more details