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Citations to this article

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells
Masako Miura, … , Marian Young, Songtao Shi
Masako Miura, … , Marian Young, Songtao Shi
Published December 15, 2004
Citation Information: J Clin Invest. 2004;114(12):1704-1713. https://doi.org/10.1172/JCI20427.
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Article Bone biology

A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells

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Abstract

Caspase-3 is a critical enzyme for apoptosis and cell survival. Here we report delayed ossification and decreased bone mineral density in caspase-3–deficient (Casp3–/– and Casp3+/–) mice due to an attenuated osteogenic differentiation of bone marrow stromal stem cells (BMSSCs). The mechanism involved in the impaired differentiation of BMSSCs is due, at least partially, to the overactivated TGF-β/Smad2 signaling pathway and the upregulated expressions of p53 and p21 along with the downregulated expressions of Cdk2 and Cdc2, and ultimately increased replicative senescence. In addition, the overactivated TGF-β/Smad2 signaling may result in the compromised Runx2/Cbfa1 expression in preosteoblasts. Furthermore, we demonstrate that caspase-3 inhibitor, a potential agent for clinical treatment of human diseases, caused accelerated bone loss in ovariectomized mice, which is also associated with the overactivated TGF-β/Smad2 signaling in BMSSCs. This study demonstrates that caspase-3 is crucial for the differentiation of BMSSCs by influencing TGF-β/Smad2 pathway and cell cycle progression.

Authors

Masako Miura, Xiao-Dong Chen, Matthew R. Allen, Yanming Bi, Stan Gronthos, Byoung-Moo Seo, Saquib Lakhani, Richard A. Flavell, Xin-Hua Feng, Pamela Gehron Robey, Marian Young, Songtao Shi

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KA Johnson, W Yao, NE Lane, P Naquet, RA Terkeltaub
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Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents
T Yamaza, Y Miura, Y Bi, Y Liu, K Akiyama, W Sonoyama, V Patel, S Gutkind, M Young, S Gronthos, A Le, CY Wang, WJ Chen, S Shi
PloS one 2008
Is aspirin treatment an appropriate intervention to osteoporosis?
S Shi, T Yamaza, K Akiyama
Future Rheumatology 2008
Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue
L Cardoso, BC Herman, O Verborgt, D Laudier, RJ Majeska, MB Schaffler
Journal of Bone and Mineral Research 2008
NEU3 sialidase strictly modulates GM3 levels in skeletal myoblasts C2C12 thus favoring their differentiation and protecting them from apoptosis
L Anastasia, N Papini, F Colazzo, G Palazzolo, C Tringali, L Dileo, M Piccoli, E Conforti, C Sitzia, E Monti, M Sampaolesi, G Tettamanti, B Venerando
The Journal of biological chemistry 2008
No death without life: vital functions of apoptotic effectors
L Galluzzi, N Joza, E Tasdemir, MC Maiuri, M Hengartner, JM Abrams, N Tavernarakis, J Penninger, F Madeo, G Kroemer
Cell Death and Differentiation 2008
Hematopoietic Stem Cell Responsiveness to Exogenous Signals Is Limited by Caspase-3
V Janzen, HE Fleming, T Riedt, G Karlsson, MJ Riese, CL Celso, G Reynolds, CD Milne, CJ Paige, S Karlsson, M Woo, DT Scadden
Cell Stem Cell 2008
Major biological obstacles for persistent cell-based regeneration of articular cartilage
AF Steinert, SC Ghivizzani, A Rethwilm, RS Tuan, CH Evans, U Nöth
Arthritis Research & Therapy 2007
A high-throughput siRNA library screen identifies osteogenic suppressors in human mesenchymal stem cells
Y Zhao, S Ding
Proceedings of the National Academy of Sciences 2007
Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling
S Dey, CF Mactutus, RM Booze, DM Snow
Neuroscience 2007
Impaired posterior frontal sutural fusion in the biglycan/decorin double deficient mice
S Wadhwa, Y Bi, AT Ortiz, MC Embree, T Kilts, R Iozzo, LA Opperman, MF Young
Bone 2007
Caspase-8 and c-FLIPL Associate in Lipid Rafts with NF- B Adaptors during T Cell Activation
RS Misra, JQ Russell, A Koenig, JA Hinshaw-Makepeace, R Wen, D Wang, H Huo, DR Littman, U Ferch, J Ruland, M Thome, RC Budd
The Journal of biological chemistry 2007
Physiological functions of caspases beyond cell death
TQ Nhan, WC Liles, SM Schwartz
The American Journal of Pathology 2006
Cocaine exposure in vitro induces apoptosis in fetal locus coeruleus neurons by altering the Bax/Bcl-2 ratio and through caspase-3 apoptotic signaling.
Dey S, Mactutus CF, Booze RM, Snow DM
Neuroscience 2006
Defective osteogenesis of the stromal stem cells predisposes CD18-null mice to osteoporosis
Y Miura, M Miura, S Gronthos, MR Allen, C Cao, TE Uveges, Y Bi, D Ehirchiou, A Kortesidis, S Shi, L Zhang
Proceedings of the National Academy of Sciences 2005
Death receptors and caspases: role in lymphocyte proliferation, cell death, and autoimmunity.
Adam-Klages S, Adam D, Janssen O, Kabelitz D
Immunologic research 2005

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